dexmedetomidine has been researched along with Allodynia in 42 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (21.43) | 29.6817 |
| 2010's | 23 (54.76) | 24.3611 |
| 2020's | 10 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, H; Jiang, H; Liu, Q; Nie, B | 1 |
| Guo, X; Ji, W; Liang, J; Qingshi, Z; Xue, Y | 1 |
| Baik, J; Do, W; Jeon, S; Kim, E; Kim, H; Kim, J; Lee, HJ; Lee, J | 1 |
| Chai, XQ; Chen, DY; Gao, W; Hu, R; Jin, Y; Long, DD; Mao, Y; Pan, TT; Wang, D; Zhang, Z | 1 |
| Choi, GJ; Kang, H; Kwon, JW; Lee, OH | 1 |
| Kong, Y; Pang, J; Pei, R; Wang, X; Wang, Z; Zhang, S; Zhuang, P | 1 |
| Li, L; Wang, F; Yao, L; Zhang, Z | 1 |
| Abrahm, JL; Hofherr, ML; Rickerson, E | 1 |
| Cao, L; Li, H; Lin, Q; Lin, W; Tan, H; Wu, Z; Yu, J; Zhang, T | 1 |
| Dunn, LK; Grant, MC | 1 |
| Fang, J; Fu, S; Li, M; Yuan, X | 1 |
| Aoyama, B; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M | 1 |
| Lin, B; Lu, Y; Zhong, J | 1 |
| Bai, X; Chen, X; Huang, J; Huang, Z; Nie, B; Ouyang, H; Zeng, W; Zhang, S; Zheng, Y | 1 |
| Chen, J; Li, H; Li, N; Lim, G; Ma, W; McCabe, MF; Yang, Y; Zhao, W | 1 |
| Feng, YX; Gu, R; Li, T; Li, W; Zhang, F; Zhang, M; Zhang, YL | 1 |
| Lu, B; Sun, JL; Xiao, C; Yao, J | 1 |
| Choi, JI; Kim, YO; Lee, HG; Yoon, MH | 1 |
| Ji, D; Li, H; Li, SS; Xiong, YC; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ; Zhou, YL | 1 |
| Dong, J; Tang, J; Yang, L; Zheng, J | 1 |
| Higuchi, H; Honda, Y; Ishii-Maruhama, M; Maeda, S; Matsuoka, Y; Miyawaki, T; Morimatsu, H; Tomoyasu, Y; Yabuki-Kawase, A | 1 |
| Lei, J; Niu, N; Sun, ZH; Xiao, Y; Yang, L; Ye, G; You, HJ | 1 |
| Abdel-Sater, KA; Farghaly, HS; Mahmoud, AM | 1 |
| Fang, H; Yang, M; Zhang, F; Zhang, J | 1 |
| Chen, Y; He, Y; Sun, Z; Wang, GL; Wang, Z; Xie, KL; Yu, YH; Yuan, Y; Zheng, Y | 1 |
| Deng, XM; Sun, S; Xu, B; Xu, H; Zhang, WS; Zhang, YQ | 1 |
| Deng, XM; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ | 1 |
| Deng, XM; Lû, N; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ | 1 |
| Belgrade, M; Hall, S | 1 |
| Chalkiadis, GA; Hallett, BR | 1 |
| Cui, S; Gu, X; Liu, Y; Ma, Z; Zhang, J; Zhang, W; Zheng, Y | 1 |
| Blaudszun, G; Elia, N; Lysakowski, C; Tramèr, MR | 1 |
| Kimura, M; Obata, H; Saito, S | 1 |
| Choi, JH; Kang, SH; Kim, YH; Koh, HJ; Moon, DE; Park, CS; Park, HJ | 1 |
| Donovan, DM; Mansikka, H; Pertovaara, A; Raja, SN; Zhou, L | 1 |
| Clark, JD; Davies, MF; Haimor, F; Lighthall, G | 1 |
| Angus, JA; Blake, DW; Scott, DA; Wright, CE | 1 |
| Fitzgerald, M; Howard, RF; Keay, KA; Walker, SM | 1 |
| Benedek, G; Dobos, I; Horvath, G; Kekesi, G; Klimscha, W | 1 |
| Apaydin, S; Guneli, E; Karabay Yavasoglu, NU; Uyar, M | 1 |
| Davies, FM; Guo, TZ; Kingery, WS; Limbird, L; Maze, M | 1 |
| Onttonen, T; Pertovaara, A | 1 |
1 review(s) available for dexmedetomidine and Allodynia
| Article | Year |
|---|---|
Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Anesthesia Recovery Period; Clonidine; Dexmedetomidine; Hemodynamics; Humans; Hyperalgesia; Hypotension; Morphine; Pain Measurement; Pain, Postoperative; Postoperative Nausea and Vomiting; Randomized Controlled Trials as Topic | 2012 |
3 trial(s) available for dexmedetomidine and Allodynia
| Article | Year |
|---|---|
Effects of an Intraoperative Intravenous Bolus Dose of Dexmedetomidine on Remifentanil-Induced Postinfusion Hyperalgesia in Patients Undergoing Thyroidectomy: A Double-Blind Randomized Controlled Trial.
Topics: Administration, Intravenous; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Analgesics, Opioid; China; Dexmedetomidine; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain Threshold; Pain, Postoperative; Prospective Studies; Remifentanil; Thyroidectomy; Time Factors; Treatment Outcome; Young Adult | 2021 |
[Effect of dexmedetomidine in acute postoperative pain relief is independent of suppressing the hyperalgesia induced by remifentanil].
Topics: Adult; Aged; Dexmedetomidine; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain Threshold; Pain, Postoperative; Piperidines; Remifentanil | 2013 |
Preoperative and intraoperative continuous use of dexmedetomidine on hyperalgesia after patients' remifentanil anesthesia.
Topics: Adult; Aged; Anesthesia, General; Atracurium; Dexmedetomidine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hyperalgesia; Hypnotics and Sedatives; Intraoperative Care; Male; Middle Aged; Neuromuscular Blocking Agents; Piperidines; Preoperative Care; Remifentanil; Treatment Outcome | 2017 |
38 other study(ies) available for dexmedetomidine and Allodynia
| Article | Year |
|---|---|
Dexmedetomidine alleviates hyperalgesia in arthritis rats through inhibition of the p38MAPK signaling pathway.
Topics: Animals; Anisomycin; Arthritis; Dexmedetomidine; Freund's Adjuvant; Hyperalgesia; Inflammation; MAP Kinase Signaling System; Rats; Rats, Sprague-Dawley | 2022 |
Effects of administration of α
Topics: Adrenergic Agonists; Analgesics; Animals; Dexmedetomidine; Freund's Adjuvant; Hyperalgesia; Inflammation; Low Back Pain; Muscles; Rats; Receptors, Adrenergic | 2022 |
Intrathecal dexmedetomidine attenuates mechanical allodynia through the downregulation of brain-derived neurotrophic factor in a mild traumatic brain injury rat model.
Topics: Animals; Brain Concussion; Brain-Derived Neurotrophic Factor; Dexmedetomidine; Down-Regulation; Hyperalgesia; Propofol; Rats; Rats, Sprague-Dawley | 2023 |
Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing thehyperactivity of glutamatergic neurons in the anterior cingulate cortex.
Topics: Animals; Anxiety; Chronic Pain; Dexmedetomidine; Gyrus Cinguli; Hyperalgesia; Mice; Neurons; Peripheral Nerve Injuries | 2022 |
Effect of Immature
Topics: Analgesics; Animals; Dexmedetomidine; Hyperalgesia; Interleukin-6; Male; Naloxone; Pain, Postoperative; Plant Extracts; Rats; Rats, Sprague-Dawley; Rubus; Yohimbine | 2023 |
The effect of dexmedetomidine on expression of neuronal nitric oxide synthase in spinal dorsal cord in a rat model with chronic neuropathic pain.
Topics: Animals; Dexmedetomidine; Hyperalgesia; Male; Neuralgia; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Spinal Cord | 2023 |
Knock-down of JAK2 and PTEN on pain behavior in rat model of trigeminal neuropathic pain.
Topics: Animals; Dental Implants; Dexamethasone; Dexmedetomidine; Disease Models, Animal; Gene Knockdown Techniques; Hyperalgesia; Janus Kinase 2; Male; Neuralgia; Pain Measurement; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Trigeminal Neuralgia | 2019 |
Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life.
Topics: Analgesics, Opioid; Death; Delirium; Dexmedetomidine; Humans; Hyperalgesia; Hypnotics and Sedatives; Intensive Care Units; Pain, Intractable | 2020 |
Perioperative Precedex: Whole New Ball Game or Whole New Ball of Wax?
Topics: Dexmedetomidine; Double-Blind Method; Humans; Hyperalgesia; Remifentanil; Thyroidectomy | 2021 |
Effects of dexmedetomidine on behavior of and expressions of spinal cord P38 MAPK and spinal cord-related cytokines in rats with neuropathic pain.
Topics: Animals; Cytokines; Dexmedetomidine; Hyperalgesia; Neuralgia; p38 Mitogen-Activated Protein Kinases; Rats; Spinal Cord | 2022 |
The preventive effects of dexmedetomidine on endotoxin-induced exacerbated post-incisional pain in rats.
Topics: Animals; Dexmedetomidine; Endotoxins; Hyperalgesia; Imidazoles; Lipopolysaccharides; Male; Pain, Postoperative; Rats; Rats, Wistar; Signal Transduction | 2017 |
The Therapeutic Effect of Dexmedetomidine on Rat Diabetic Neuropathy Pain and the Mechanism.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Apoptosis; Cytokines; Dexmedetomidine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glutamic Acid; Hyperalgesia; Inflammation; Interleukin-1beta; Male; Microglia; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord; Tumor Necrosis Factor-alpha; Yohimbine | 2017 |
Synergistic Interaction Between Dexmedetomidine and Ulinastatin Against Vincristine-Induced Neuropathic Pain in Rats.
Topics: Analgesics, Non-Narcotic; Animals; Dexmedetomidine; Disease Models, Animal; Drug Synergism; Ganglia, Spinal; Glycoproteins; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Interleukin-10; Male; Neuralgia; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Specific Pathogen-Free Organisms; Touch; Trypsin Inhibitors; Vincristine | 2017 |
Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats.
Topics: Animals; Dexmedetomidine; Disease Models, Animal; Hedgehog Proteins; Hyperalgesia; Male; Midazolam; Neuralgia; Peripheral Nerve Injuries; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord Dorsal Horn; Thalamus | 2018 |
[Dexmedetomidine suppresses mechanical allodynia by inhibiting hyperpolarization-activated inward current].
Topics: Animals; Dexmedetomidine; Ganglia, Spinal; Hyperalgesia; Neuralgia; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley | 2018 |
The role of alpha-2 adrenoceptor subtype in the antiallodynic effect of intraplantar dexmedetomidine in a rat spinal nerve ligation model.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Non-Narcotic; Animals; Axotomy; Dexmedetomidine; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Nerves | 2013 |
Involvement of spinal microglia and interleukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI.
Topics: Analgesics, Non-Narcotic; Animals; Cells, Cultured; Chronic Disease; Constriction, Pathologic; Dexmedetomidine; Hyperalgesia; Interleukin-18; Male; Microglia; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Spinal Cord Injuries; Touch | 2014 |
Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Disease Models, Animal; Forelimb; Functional Laterality; G-Protein-Coupled Receptor Kinase 2; Gene Expression Regulation; Hyperalgesia; Hypnotics and Sedatives; Ischemia; Neurons; Pain Threshold; Rats; Reperfusion Injury; Statistics, Nonparametric; Superior Cervical Ganglion; Time Factors | 2015 |
The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Carrageenan; Dexmedetomidine; Hyperalgesia; Injections; Male; Nociception; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine | 2015 |
Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dexmedetomidine; Fentanyl; Hyperalgesia; Imidazoles; Male; Neural Inhibition; Nociception; Pain Threshold; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Thalamic Nuclei | 2016 |
Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of interleukin-6 and tumor necrosis factor-α.
Topics: Animals; Body Weight; Cold-Shock Response; Dexmedetomidine; Disease Models, Animal; Hyperalgesia; Interleukin-6; Male; Neuralgia; Nociception; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Sympathetic Nervous System; Tumor Necrosis Factor-alpha | 2016 |
Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chemoprevention; Dexmedetomidine; Hyperalgesia; Male; Pain Management; Pain, Postoperative; Phosphorylation; Piperidines; Postoperative Period; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Signal Transduction; Spinal Cord | 2017 |
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Analysis of Variance; Animals; Ankle Joint; Arthritis, Experimental; Cyclohexanecarboxylic Acids; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Inflammation; Injections, Intra-Articular; Male; Motor Activity; Pain Measurement; Pain Threshold; Random Allocation; Rats; Rats, Sprague-Dawley | 2009 |
Dexmedetomidine blocks thermal hyperalgesia and spinal glial activation in rat model of monoarthritis.
Topics: Adrenergic alpha-Agonists; Animals; Arthritis, Experimental; Astrocytes; Calcium-Binding Proteins; Dexmedetomidine; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Microfilament Proteins; Microglia; Rats; Rats, Sprague-Dawley; Spinal Cord | 2010 |
Evidence for suppression of spinal glial activation by dexmedetomidine in a rat model of monoarthritis.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Arthritis, Experimental; Dexmedetomidine; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Injections, Intra-Articular; Male; Neuroglia; Rats; Rats, Sprague-Dawley; Spinal Cord | 2010 |
Dexmedetomidine infusion for the management of opioid-induced hyperalgesia.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Algorithms; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Dexmedetomidine; Drug Tolerance; Female; Humans; Hyperalgesia; Male; Middle Aged; Young Adult | 2010 |
Suspected opioid-induced hyperalgesia in an infant.
Topics: Abdominal Wall; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Dexmedetomidine; Digestive System Surgical Procedures; Fentanyl; Humans; Hyperalgesia; Hypnotics and Sedatives; Infant, Newborn; Irritable Mood; Jejunostomy; Ketamine; Laparotomy; Male; Midazolam; Morphine; Pain Clinics; Pain Measurement; Photophobia; Reoperation | 2012 |
Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Blotting, Western; Dexmedetomidine; Disease Models, Animal; Hyperalgesia; Male; Pain, Postoperative; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Spinal Cord; Tyrosine | 2012 |
Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Animals; Dexmedetomidine; Hyperalgesia; Male; Neuralgia; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Spinal Cord | 2012 |
Analgesic effects of dexmedetomidine in vincristine-evoked painful neuropathic rats.
Topics: Analgesics; Animals; Behavior, Animal; Dexmedetomidine; Disease Models, Animal; Hyperalgesia; Injections, Intraperitoneal; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Vincristine | 2012 |
The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carrageenan; Decerebrate State; Dexmedetomidine; Foot; Hindlimb; Hot Temperature; Hyperalgesia; Imidazoles; Inflammation; Mice; Mice, Knockout; Nociceptors; Physical Stimulation; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Reference Values | 2002 |
Dexmedetomidine fails to cause hyperalgesia after cessation of chronic administration.
Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Dexmedetomidine; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Ion Channels; Male; Mice; Mice, Inbred C57BL; Morphine; Pain Threshold; Physical Stimulation; Substance Withdrawal Syndrome | 2003 |
Synergy between intrathecal omega-conotoxin CVID and dexmedetomidine to attenuate mechanical hypersensitivity in the rat.
Topics: Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Drug Synergism; Hyperalgesia; Injections, Spinal; Male; omega-Conotoxins; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Nerves; Touch | 2005 |
Developmental age influences the effect of epidural dexmedetomidine on inflammatory hyperalgesia in rat pups.
Topics: Age Factors; Analgesia, Epidural; Animals; Animals, Newborn; Dexmedetomidine; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley | 2005 |
Long-term changes in the antinociceptive potency of morphine or dexmedetomidine after a single treatment.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Area Under Curve; Carrageenan; Dexmedetomidine; Drug Tolerance; Foot; Hot Temperature; Hyperalgesia; Inflammation; Male; Morphine; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Time Factors | 2005 |
Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Constriction, Pathologic; Dexmedetomidine; Drug Combinations; Hot Temperature; Hyperalgesia; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Postural Balance; Rats; Rats, Wistar; Reaction Time; Sciatica; Time Factors; Tramadol | 2007 |
The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Brain Chemistry; Dexmedetomidine; Hot Temperature; Hyperalgesia; Isoflurane; Mice; Mice, Inbred Strains; Neurons; Nociceptors; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Physical Stimulation; Receptors, Adrenergic, alpha-2; Sympathectomy; Sympathetic Fibers, Postganglionic; Tibial Nerve | 2000 |
The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2 -adrenoceptor agonist, in a rat model of postoperative pain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Dexmedetomidine; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Indans; Injections, Spinal; Male; Motor Activity; Pain Measurement; Pain, Postoperative; Physical Stimulation; Postural Balance; Rats; Rats, Wistar; Time Factors | 2000 |