acetaminophen has been researched along with Allodynia in 65 studies
Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
paracetamol : A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared." | 9.15 | Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 7.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 5.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| "Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing." | 5.35 | Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008) |
| "To assess the efficacy of paracetamol (acetaminophen) for neonatal pain relief." | 5.17 | Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response. ( Bucher, HU; Bührer, C; Burkhardt, T; Hoesli, I; Jost, K; Krafft, A; Nelle, M; Schöbi, N; Surbek, D; Tinner, EM; Ulrich Megged, Y, 2013) |
| " The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings." | 5.15 | A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011) |
| " The effects of acetaminophen, tropisetron, the combination of both drugs, and saline on pain perception and central sensitization in healthy volunteers were compared." | 5.15 | Tropisetron blocks analgesic action of acetaminophen: a human pain model study. ( Bandschapp, O; Filitz, J; Koppert, W; Ruppen, W; Urwyler, A, 2011) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| " This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation." | 3.79 | Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013) |
| "We found that paracetamol 100 mg kg⁻¹ blocked the development of hyperalgesia and allodynia after fracture pain and ondansetron did not modify the antinociceptive effect of paracetamol in this model." | 3.77 | Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain. ( Fourcade, O; Girolami, JP; Mazoit, JX; Minville, V; Tack, I, 2011) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 3.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "The analgesic and anti-hyperalgesic effects of cannabinoid- and vanilloid-like compounds, plus the fatty acid amide hydrolase (FAAH) inhibitor Cyclohexylcarbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597), and acetaminophen, were evaluated in the phenyl-p-quinone (PPQ) pain model, using different routes of administration in combination with opioid and cannabinoid receptor antagonists." | 3.73 | Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice. ( Cichewicz, DL; Haller, VL; Welch, SP, 2006) |
| "Dipyrone blocked carrageenin-induced oedema and hyperalgesia in a dose-dependent manner." | 3.67 | Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia. ( Ferreira, SH; Lorenzetti, BB, 1985) |
| "The antinociceptive properties of suprofen [alpha-methyl-4-(thienylcarbonyl)benzene acetic acid] are described in a pathologically induced hyperalgesic model, the rat adjuvant arthritis flexion test." | 3.66 | Suprofen, a new peripheral analgesic. ( Capetola, RJ; Rosenthale, ME; Shriver, DA, 1980) |
| " The secondary outcomes included 48-hour postoperative opioid consumption, incisional pain scores, opioid-related adverse effects, length of mechanical ventilation, length of intensive care unit stay, and the extent of wound hyperalgesia assessed at 24 and 48 hours postoperatively." | 2.82 | Intravenous Acetaminophen as an Adjunct Analgesic in Cardiac Surgery Reduces Opioid Consumption But Not Opioid-Related Adverse Effects: A Randomized Controlled Trial. ( Bollag, L; Bowdle, A; Cain, KC; Jelacic, S; Richebe, P; Rivat, C, 2016) |
| " However, dosing and differential effects on peripheral and central hyperalgesia are still to be determined." | 2.77 | Dose response of tramadol and its combination with paracetamol in UVB induced hyperalgesia. ( Gustorff, B; Margeta, K; Ortner, CM; Schulz, M; Steiner, I, 2012) |
| "The anesthestic protocol and postoperative pain management were the same in both groups." | 2.76 | Target-controlled dosing of remifentanil during cardiac surgery reduces postoperative hyperalgesia. ( Cahana, A; Calderon, J; Janvier, G; Jelacic, S; Mehta, S; Picard, W; Pouquet, O; Richebé, P; Rivat, C, 2011) |
| "Pre-treatment with fentanyl 1." | 2.73 | Administration of fentanyl before remifentanil-based anaesthesia has no influence on post-operative pain or analgesic consumption. ( Hoymork, SC; Lenz, H; Raeder, J, 2008) |
| "The prevalences of complex regional pain syndrome, phantom limb pain, chronic donor-site pain, and persistent pain following total joint arthroplasty are alarmingly high." | 2.44 | Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques. ( Buvanendran, A; Reuben, SS, 2007) |
| "A large subgroup of people with migraine had an inadequate response to their usual acute OTC migraine treatment 2- and 24-h after dosing." | 1.91 | Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine. ( Ezzati, A; Fanning, KM; Lipton, RB; Reed, ML, 2023) |
| "Acetaminophen (APAP) is a widely self-prescribed analgesic for mild to moderate pain, but overdose or repeat doses can lead to liver injury and death." | 1.62 | Evaluation of KP-1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects. ( Bunker, KD; Bynum, JA; Cap, AP; Cheppudira, BP; Christy, RJ; Garza, T; Hopkins, CD; Reddoch-Cardenas, KM; Slee, DH, 2021) |
| "Celecoxib had no effect on muscular mechanical hyperalgesia, when orally administered 24 h after lengthening contractions." | 1.51 | Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats. ( Mikoshiba, S; Shimodaira, T; Taguchi, T, 2019) |
| "GR consumption improved mechanical and thermal allodynia and mechanical hyperalgesia and improved behavioural changes related to cognitive disturbances, anxiety, and depression." | 1.48 | Ginger rhizome enhances the anti-inflammatory and anti-nociceptive effects of paracetamol in an experimental mouse model of fibromyalgia. ( De la Puerta, R; Fernandez-Arche, A; Garcia-Gimenez, MD; Montserrat-de la Paz, S; Quilez, AM, 2018) |
| "We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms." | 1.46 | Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. ( Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ, 2017) |
| "A reliable mechanical hyperalgesia was observed at 2 h post-surgery and lasted for 4 days." | 1.43 | Antinociceptive effects of vitexin in a mouse model of postoperative pain. ( Jiang, B; Li, JX; Liu, CP; Mao, LN; Sun, YH; Zhang, W; Zhu, Q, 2016) |
| "Acute postoperative pain remains a significant health care issue." | 1.42 | Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain. ( Bannerton, K; Bree, D; Broom, DC; Finn, DP; Kelly, JP; Moriarty, O; Morris, B; O'Mahony, CM; Roche, M, 2015) |
| "The efficacy of these combinations for neuropathic pain was not different from that for inflammatory pain." | 1.42 | Acetaminophen and non-steroidal anti-inflammatory drugs interact with morphine and tramadol analgesia for the treatment of neuropathic pain in rats. ( Nonaka, T; Shinozaki, T; Yamada, T; Yamamoto, T, 2015) |
| "Additionally, areas of flare and secondary hyperalgesia were mapped, and time course of hyperalgesia determined." | 1.40 | An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch. ( Henrich, F; Jürgens, TP; Magerl, W; May, A; Sawatzki, A, 2014) |
| "Mechanical allodynia was quantified by measuring the paw withdrawal threshold to stimuli with von Frey filaments." | 1.38 | The antinociceptive effect of acetaminophen in a rat model of neuropathic pain. ( Im, KS; Joo, CH; Jung, HJ; Kim, JB; Lee, JM; Moon, DE; Park, HJ, 2012) |
| "In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h." | 1.37 | Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011) |
| "Pretreatment with ketanserin significantly attenuated these effects." | 1.36 | Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache. ( le Grand, SM; Srikiatkhachorn, A; Supornsilpchai, W, 2010) |
| "Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)." | 1.35 | Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat. ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009) |
| "LPS-induced hyperalgesia was exhibited in nociceptive behaviors induced by formalin s." | 1.35 | The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models. ( Choi, HW; Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Nam, JS; Park, SH; Seo, YJ; Suh, HW, 2008) |
| "Acetaminophen is an analgesic and antipyretic drug believed to exert its effect through interruption of nociceptive processing." | 1.35 | Acetaminophen prevents hyperalgesia in central pain cascade. ( Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL, 2008) |
| "Inflammation was induced in one hind paw of rats by intraplantar injection of 250 microg lambda-carrageenan (CG) and the contralateral paw injected with saline." | 1.35 | Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain. ( Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM, 2008) |
| "The opiate tolerance was complicated by tactile hyperalgesia at the site of the surgical wound." | 1.35 | [Acute opiate tolerance and postoperative hyperalgesia after a brief infusion of remifentanil managed with multimodal analgesia]. ( Cortiñas Sáenz, M; Cortiñas Sáenz, ML; Gerónimo Pardo, M; Hernández Vallecillo, MT; Ibarra Martí, ML; Mateo Cerdán, CM, 2008) |
| " Following dosing of CFA-injected rats with rofecoxib (Vioxx) or paracetamol, there was a significant decrease in the number of ipsilateral CGRP-IR small and medium DRG neurones in rofecoxib- but not paracetamol-treated rats." | 1.34 | Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol. ( Bountra, C; Chessell, IP; Day, NC; Staton, PC; Wilson, AW, 2007) |
| "Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold." | 1.34 | Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007) |
| "Paracetamol dose-dependently decreased mechanical allodynia and lowered nociceptive scores associated with hyperalgesia testing." | 1.34 | The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. ( Beaulieu, P; Dani, M; Guindon, J; Lambert, C, 2007) |
| "Acetaminophen was less potent than SCP-1 and SCP-M1." | 1.33 | Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. ( Bazan, N; Chen, C; Cui, JG; Zhang, X; Zhao, YH, 2006) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "We conclude that ET hyperalgesia is mediated by both prostaglandin-sensitive and prostaglandin-independent mechanisms." | 1.30 | Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. ( Abdelnoor, AM; Atweh, SF; Haddad, JJ; Jabbur, SJ; Kanaan, SA; Saadé, NE; Safieh-Garabedian, B, 1997) |
| " They were found fairly potent in rat tail flick and mouse phenylquinone writhing assays but the dose-response curves were rather shallow as compared to that of morphine." | 1.30 | Apparent antinociceptive and anti-inflammatory effects of GYKI 52466. ( Kedves, R; Máté, I; Székely, JI; Tarnawa, I; Török, K, 1997) |
| "However, this drug was unable to block hyperalgesia when already established." | 1.30 | Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol. ( Bianchi, M; Panerai, AE, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.08) | 18.7374 |
| 1990's | 4 (6.15) | 18.2507 |
| 2000's | 20 (30.77) | 29.6817 |
| 2010's | 33 (50.77) | 24.3611 |
| 2020's | 6 (9.23) | 2.80 |
| Authors | Studies |
|---|---|
| Juri, T | 1 |
| Fujimoto, Y | 1 |
| Suehiro, K | 1 |
| Nishikawa, K | 1 |
| Mori, T | 1 |
| Ezzati, A | 1 |
| Fanning, KM | 1 |
| Reed, ML | 1 |
| Lipton, RB | 1 |
| Sodano, F | 1 |
| Lazzarato, L | 1 |
| Rolando, B | 1 |
| Spyrakis, F | 1 |
| De Caro, C | 1 |
| Magliocca, S | 1 |
| Marabello, D | 1 |
| Chegaev, K | 1 |
| Gazzano, E | 1 |
| Riganti, C | 1 |
| Calignano, A | 1 |
| Russo, R | 1 |
| Rimoli, MG | 1 |
| Shimodaira, T | 1 |
| Mikoshiba, S | 1 |
| Taguchi, T | 1 |
| Yoshizawa, K | 1 |
| Arai, N | 1 |
| Suzuki, Y | 1 |
| Fujita, A | 1 |
| Takahashi, Y | 1 |
| Kawano, Y | 1 |
| Hanawa, T | 1 |
| Li, T | 1 |
| Wang, T | 1 |
| Wang, L | 1 |
| Liu, R | 1 |
| Zhang, L | 1 |
| Zhai, R | 1 |
| Fu, F | 1 |
| Yamaguchi, C | 1 |
| Yamamoto, D | 1 |
| Fujimaru, Y | 1 |
| Asano, T | 1 |
| Takaoka, A | 1 |
| Reddoch-Cardenas, KM | 1 |
| Cheppudira, BP | 1 |
| Garza, T | 1 |
| Hopkins, CD | 1 |
| Bunker, KD | 1 |
| Slee, DH | 1 |
| Cap, AP | 1 |
| Bynum, JA | 1 |
| Christy, RJ | 1 |
| Montilla-García, Á | 1 |
| Tejada, MÁ | 1 |
| Perazzoli, G | 1 |
| Entrena, JM | 1 |
| Portillo-Salido, E | 1 |
| Fernández-Segura, E | 1 |
| Cañizares, FJ | 1 |
| Cobos, EJ | 1 |
| Fukushima, A | 1 |
| Mamada, K | 1 |
| Iimura, A | 1 |
| Ono, H | 1 |
| Chen, Z | 1 |
| Wei, H | 1 |
| Pertovaara, A | 1 |
| Wang, J | 1 |
| Carlson, S | 1 |
| Montserrat-de la Paz, S | 1 |
| Garcia-Gimenez, MD | 1 |
| Quilez, AM | 1 |
| De la Puerta, R | 1 |
| Fernandez-Arche, A | 1 |
| Petersen, KK | 1 |
| Olesen, AE | 1 |
| Simonsen, O | 1 |
| Arendt-Nielsen, L | 1 |
| de Almeida, AS | 1 |
| Rigo, FK | 1 |
| De Prá, SD | 1 |
| Milioli, AM | 1 |
| Dalenogare, DP | 1 |
| Pereira, GC | 1 |
| Ritter, CDS | 1 |
| Peres, DS | 1 |
| Antoniazzi, CTD | 1 |
| Stein, C | 1 |
| Moresco, RN | 1 |
| Oliveira, SM | 1 |
| Trevisan, G | 1 |
| Tomić, MA | 3 |
| Micov, AM | 2 |
| Stepanović-Petrović, RM | 3 |
| Kovacevic, JM | 1 |
| Boškovic, BD | 1 |
| Gupta, D | 1 |
| Christensen, C | 1 |
| Soskin, V | 1 |
| Jürgens, TP | 1 |
| Sawatzki, A | 1 |
| Henrich, F | 1 |
| Magerl, W | 1 |
| May, A | 1 |
| Shinozaki, T | 1 |
| Yamada, T | 1 |
| Nonaka, T | 1 |
| Yamamoto, T | 1 |
| Dalmann, R | 1 |
| Daulhac, L | 1 |
| Antri, M | 1 |
| Eschalier, A | 4 |
| Mallet, C | 1 |
| Bree, D | 1 |
| Moriarty, O | 1 |
| O'Mahony, CM | 1 |
| Morris, B | 1 |
| Bannerton, K | 1 |
| Broom, DC | 1 |
| Kelly, JP | 1 |
| Roche, M | 1 |
| Finn, DP | 1 |
| Bellei, E | 1 |
| Monari, E | 1 |
| Bergamini, S | 1 |
| Cuoghi, A | 1 |
| Tomasi, A | 1 |
| Guerzoni, S | 1 |
| Ciccarese, M | 1 |
| Pini, LA | 1 |
| Siemian, JN | 1 |
| Li, J | 1 |
| Zhang, Y | 1 |
| Li, JX | 2 |
| Zhu, Q | 1 |
| Mao, LN | 1 |
| Liu, CP | 1 |
| Sun, YH | 1 |
| Jiang, B | 1 |
| Zhang, W | 1 |
| Jelacic, S | 2 |
| Bollag, L | 1 |
| Bowdle, A | 1 |
| Rivat, C | 2 |
| Cain, KC | 1 |
| Richebe, P | 2 |
| Crawley, B | 1 |
| Saito, O | 1 |
| Malkmus, S | 1 |
| Fitzsimmons, B | 1 |
| Hua, XY | 1 |
| Yaksh, TL | 1 |
| Seo, YJ | 1 |
| Kwon, MS | 1 |
| Choi, HW | 1 |
| Choi, SM | 1 |
| Nam, JS | 1 |
| Lee, JK | 1 |
| Jung, JS | 1 |
| Park, SH | 1 |
| Suh, HW | 1 |
| Füredi, R | 1 |
| Bölcskei, K | 2 |
| Szolcsányi, J | 2 |
| Petho, G | 2 |
| Supornsilpchai, W | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| Vucković, SM | 1 |
| Ugresić, ND | 1 |
| Prostran, MS | 1 |
| Bosković, B | 1 |
| Minville, V | 1 |
| Fourcade, O | 1 |
| Mazoit, JX | 1 |
| Girolami, JP | 1 |
| Tack, I | 1 |
| Toussaint, K | 1 |
| Yang, XC | 1 |
| Zielinski, MA | 1 |
| Reigle, KL | 1 |
| Sacavage, SD | 1 |
| Nagar, S | 1 |
| Raffa, RB | 1 |
| Girard, P | 1 |
| Niedergang, B | 1 |
| Pansart, Y | 1 |
| Coppé, MC | 1 |
| Verleye, M | 1 |
| Bandschapp, O | 1 |
| Filitz, J | 1 |
| Urwyler, A | 1 |
| Koppert, W | 2 |
| Ruppen, W | 1 |
| Ing Lorenzini, K | 2 |
| Besson, M | 2 |
| Daali, Y | 2 |
| Salomon, D | 2 |
| Dayer, P | 2 |
| Desmeules, J | 2 |
| Pouquet, O | 1 |
| Mehta, S | 1 |
| Calderon, J | 1 |
| Picard, W | 1 |
| Cahana, A | 1 |
| Janvier, G | 1 |
| Dogrul, A | 1 |
| Seyrek, M | 1 |
| Akgul, EO | 1 |
| Cayci, T | 1 |
| Kahraman, S | 1 |
| Bolay, H | 1 |
| Ortner, CM | 1 |
| Steiner, I | 1 |
| Margeta, K | 1 |
| Schulz, M | 1 |
| Gustorff, B | 1 |
| Im, KS | 1 |
| Jung, HJ | 1 |
| Kim, JB | 1 |
| Lee, JM | 1 |
| Park, HJ | 1 |
| Joo, CH | 1 |
| Moon, DE | 1 |
| Yalcin, N | 1 |
| Uzun, ST | 1 |
| Reisli, R | 1 |
| Borazan, H | 1 |
| Otelcioglu, S | 1 |
| Tinner, EM | 1 |
| Hoesli, I | 1 |
| Jost, K | 1 |
| Schöbi, N | 1 |
| Ulrich Megged, Y | 1 |
| Burkhardt, T | 1 |
| Krafft, A | 1 |
| Bucher, HU | 1 |
| Surbek, D | 1 |
| Nelle, M | 1 |
| Bührer, C | 1 |
| Wehrfritz, A | 1 |
| Körber, N | 1 |
| Sittl, R | 1 |
| Albrecht, S | 1 |
| Schüttler, J | 1 |
| Schmelz, M | 1 |
| Millecamps, M | 2 |
| Etienne, M | 2 |
| Jourdan, D | 2 |
| Ardid, D | 2 |
| Gaitán, G | 1 |
| Ahuir, FJ | 1 |
| Herrero, JF | 2 |
| Sahin, F | 1 |
| Yilmaz, F | 1 |
| Kotevoglu, N | 1 |
| Kuran, B | 1 |
| Leger, S | 1 |
| Chassaing, C | 1 |
| Schmidt, J | 1 |
| Cardot, JM | 1 |
| Dubray, C | 1 |
| Staton, PC | 1 |
| Wilson, AW | 1 |
| Bountra, C | 1 |
| Chessell, IP | 1 |
| Day, NC | 1 |
| Alfonso Romero-Sandoval, E | 1 |
| Molina, C | 1 |
| Haller, VL | 1 |
| Cichewicz, DL | 1 |
| Welch, SP | 1 |
| Cui, JG | 1 |
| Zhang, X | 1 |
| Zhao, YH | 1 |
| Chen, C | 1 |
| Bazan, N | 1 |
| Bianchi, M | 2 |
| Martucci, C | 1 |
| Ferrario, P | 1 |
| Franchi, S | 1 |
| Sacerdote, P | 1 |
| Horváth, D | 1 |
| Reuben, SS | 1 |
| Buvanendran, A | 1 |
| Dani, M | 1 |
| Guindon, J | 1 |
| Lambert, C | 1 |
| Beaulieu, P | 1 |
| Lenz, H | 1 |
| Raeder, J | 1 |
| Hoymork, SC | 1 |
| Rezende, RM | 1 |
| França, DS | 1 |
| Menezes, GB | 1 |
| dos Reis, WG | 1 |
| Bakhle, YS | 1 |
| Francischi, JN | 1 |
| Cortiñas Sáenz, M | 1 |
| Gerónimo Pardo, M | 1 |
| Cortiñas Sáenz, ML | 1 |
| Hernández Vallecillo, MT | 1 |
| Ibarra Martí, ML | 1 |
| Mateo Cerdán, CM | 1 |
| Capetola, RJ | 1 |
| Shriver, DA | 1 |
| Rosenthale, ME | 1 |
| Björkman, R | 1 |
| Hallman, KM | 1 |
| Hedner, J | 1 |
| Hedner, T | 1 |
| Henning, M | 1 |
| Kanaan, SA | 1 |
| Safieh-Garabedian, B | 1 |
| Haddad, JJ | 1 |
| Atweh, SF | 1 |
| Abdelnoor, AM | 1 |
| Jabbur, SJ | 1 |
| Saadé, NE | 1 |
| Székely, JI | 1 |
| Kedves, R | 1 |
| Máté, I | 1 |
| Török, K | 1 |
| Tarnawa, I | 1 |
| Panerai, AE | 1 |
| Lorenzetti, BB | 1 |
| Ferreira, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT01833728] | 16 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739] | Phase 2 | 105 participants (Anticipated) | Interventional | 2023-02-25 | Recruiting | ||
| Is Paracetamol an Effective Treatment for Chronic Moderate Pain in the Newborn After Operative Vaginal Delivery?[NCT00488540] | Phase 4 | 280 participants (Anticipated) | Interventional | 2007-06-30 | Completed | ||
| Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain[NCT04034836] | Phase 4 | 132 participants (Anticipated) | Interventional | 2019-10-12 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for acetaminophen and Allodynia
| Article | Year |
|---|---|
What do we (not) know about how paracetamol (acetaminophen) works?
Topics: Acetaminophen; Acetanilides; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammat | 2010 |
Preventing the development of chronic pain after orthopaedic surgery with preventive multimodal analgesic techniques.
Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesia, Epidural; Analgesics; Anesthetics, Local; Anima | 2007 |
12 trials available for acetaminophen and Allodynia
| Article | Year |
|---|---|
Intravenous Acetaminophen as an Adjunct Analgesic in Cardiac Surgery Reduces Opioid Consumption But Not Opioid-Related Adverse Effects: A Randomized Controlled Trial.
Topics: Acetaminophen; Administration, Intravenous; Adolescent; Adult; Aged; Analgesia; Analgesics, Non-Narc | 2016 |
Tropisetron blocks analgesic action of acetaminophen: a human pain model study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents; Cross-Over | 2011 |
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over | 2011 |
Target-controlled dosing of remifentanil during cardiac surgery reduces postoperative hyperalgesia.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Anesthesia, General; Anesthesia, Intravenous; Blood Pressur | 2011 |
Dose response of tramadol and its combination with paracetamol in UVB induced hyperalgesia.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cold Temperature; Cross-Over Stu | 2012 |
A comparison of ketamine and paracetamol for preventing remifentanil induced hyperalgesia in patients undergoing total abdominal hysterectomy.
Topics: Acetaminophen; Adult; Analgesics, Opioid; Female; Humans; Hyperalgesia; Hysterectomy; Ketamine; Midd | 2012 |
Rectal paracetamol in newborn infants after assisted vaginal delivery may increase pain response.
Topics: Acetaminophen; Administration, Rectal; Analgesics, Non-Narcotic; Double-Blind Method; Extraction, Ob | 2013 |
Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2012 |
The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase | 2004 |
Efficacy of salmon calcitonin in complex regional pain syndrome (type 1) in addition to physical therapy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Calcitonin; Female; Humans; Hyperalgesia; Male; Middle Aged | 2006 |
Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers.
Topics: Acetaminophen; Administration, Oral; Administration, Topical; Adult; Analgesics, Non-Narcotic; Area | 2006 |
Administration of fentanyl before remifentanil-based anaesthesia has no influence on post-operative pain or analgesic consumption.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics; Anesthesia, Intra | 2008 |
51 other studies available for acetaminophen and Allodynia
| Article | Year |
|---|---|
Participation of the descending noradrenergic inhibitory system in the anti-hyperalgesic effect of acetaminophen in a rat model of inflammation.
Topics: Acetaminophen; Animals; Carrageenan; Disease Models, Animal; Hyperalgesia; Inflammation; Locus Coeru | 2021 |
Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Female | 2023 |
Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carcinoma, Hepatocellular; Cell Proliferation; Gal | 2019 |
Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Hypera | 2019 |
Synergistic Antinociceptive Activity of Tramadol/Acetaminophen Combination Mediated by μ-Opioid Receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Drug Synergism; Drug Therapy, | 2020 |
Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Carrageenan; Delayed-Action Preparations; Dise | 2021 |
Acetaminophen Exerts an Analgesic Effect on Muscular Hyperalgesia in Repeated Cold-Stressed Rats through the Enhancement of the Descending Pain Inhibitory System Involving Spinal 5-HT
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cold Temperature; Cold-Shock Response; Cyclooxygen | 2021 |
Evaluation of KP-1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Hemostasis; Humans; Hyperalgesia; Male; Ra | 2021 |
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female | 2017 |
Supraspinal-selective TRPV1 desensitization induced by intracerebroventricular treatment with resiniferatoxin.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Diterpenes; Gene Expression; Hyp | 2017 |
Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats.
Topics: Acetaminophen; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Dose | 2018 |
Ginger rhizome enhances the anti-inflammatory and anti-nociceptive effects of paracetamol in an experimental mouse model of fibromyalgia.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Chronic Pain; Disease Models, Animal; Drug Synergi | 2018 |
Mechanistic pain profiling as a tool to predict the efficacy of 3-week nonsteroidal anti-inflammatory drugs plus paracetamol in patients with painful knee osteoarthritis.
Topics: Acetaminophen; Activities of Daily Living; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-S | 2019 |
Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.
Topics: Acetaminophen; Analgesics; Animals; Benzoxazines; Bone Neoplasms; Calcium; Cannabinoids; Cell Line, | 2019 |
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr | 2013 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Marked variability in peri-partum anesthetic management of patients on buprenorphine maintenance therapy (BMT): can there be an underlying acute opioid induced hyperalgesia precipitated by neuraxial opioids in BMT patients?
Topics: Acetaminophen; Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Buprenorphine; Cesarea | 2013 |
An improved model of heat-induced hyperalgesia--repetitive phasic heat pain causing primary hyperalgesia to heat and secondary hyperalgesia to pinprick and light touch.
Topics: Acetaminophen; Adolescent; Adult; Aged; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle | 2014 |
Acetaminophen and non-steroidal anti-inflammatory drugs interact with morphine and tramadol analgesia for the treatment of neuropathic pain in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non- | 2015 |
Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context.
Topics: Acetaminophen; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Brain; Carrageenan; Hyperalgesia; | 2015 |
Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain.
Topics: Acetaminophen; Acute Pain; Analgesics; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal | 2015 |
Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Chronic Disea | 2015 |
Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Benzofurans; Conditioning | 2016 |
Antinociceptive effects of vitexin in a mouse model of postoperative pain.
Topics: Acetaminophen; Analgesics; Animals; Apigenin; Disease Models, Animal; Dose-Response Relationship, Dr | 2016 |
Acetaminophen prevents hyperalgesia in central pain cascade.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Dinoprostone; Hyperalgesia; | 2008 |
The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Injecti | 2008 |
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, An | 2009 |
Involvement of pro-nociceptive 5-HT2A receptor in the pathogenesis of medication-overuse headache.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dise | 2010 |
Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.
Topics: Acetaminophen; Acetic Acid; Algorithms; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Carbamaz | 2010 |
Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antiemetics; Disease Models, Animal; Drug Interact | 2011 |
Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, An | 2011 |
Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT₇ receptors.
Topics: Acetaminophen; Administration, Oral; Analgesics; Animals; Hyperalgesia; Male; Mice; Mice, Inbred BAL | 2012 |
The antinociceptive effect of acetaminophen in a rat model of neuropathic pain.
Topics: Acetaminophen; Alanine Transaminase; Analgesics; Animals; Aspartate Aminotransferases; Behavior, Ani | 2012 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non- | 2005 |
Circadian pattern of spontaneous behavior in monarthritic rats: a novel global approach to evaluation of chronic pain and treatment effectiveness.
Topics: Acetaminophen; Activity Cycles; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthri | 2005 |
Changes in dorsal root ganglion CGRP expression in a chronic inflammatory model of the rat knee joint: differential modulation by rofecoxib and paracetamol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Calcitonin Gene-Related P | 2007 |
Enhancement of the analgesic activity of paracetamol and nitroparacetamol by the oral administration of all-trans retinoic acid.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analysis of Variance; Animals; Antineoplastic Agent | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; | 2006 |
Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain.
Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Calcium Channel Blockers; Hot Temperature; Hyp | 2006 |
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anima | 2007 |
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela | 2007 |
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonist | 2007 |
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyp | 2008 |
[Acute opiate tolerance and postoperative hyperalgesia after a brief infusion of remifentanil managed with multimodal analgesia].
Topics: Acetaminophen; Adnexal Diseases; Amides; Analgesia, Epidural; Analgesics, Non-Narcotic; Analgesics, | 2008 |
Suprofen, a new peripheral analgesic.
Topics: Acetaminophen; Analgesics; Animals; Arachidonic Acids; Arthritis, Experimental; Biological Assay; Ca | 1980 |
Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P.
Topics: Acetaminophen; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior | 1994 |
Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Dexamethasone; Endotoxins; Hyperalgesi | 1997 |
Apparent antinociceptive and anti-inflammatory effects of GYKI 52466.
Topics: Acetaminophen; Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Arthritis, Experi | 1997 |
Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol.
Topics: 2-Amino-5-phosphonovalerate; Acetaminophen; Analgesics, Non-Narcotic; Animals; Excitatory Amino Acid | 1997 |
Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Bucladesine; Carrageenan; Dinoprostone; Di | 1985 |