fomesafen has been researched along with Allodynia in 136 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.94) | 18.7374 |
| 1990's | 38 (27.94) | 18.2507 |
| 2000's | 52 (38.24) | 29.6817 |
| 2010's | 41 (30.15) | 24.3611 |
| 2020's | 1 (0.74) | 2.80 |
| Authors | Studies |
|---|---|
| Blockeel, AJ; Caspani, O; Di Lionardo, A; Di Pietro, G; Di Stefano, G; Falco, P; Garcia-Larrea, L; Leone, C; Mouraux, A; Phillips, KG; Treede, RD; Truini, A | 1 |
| Attal, N; Ernault, E; Gálvez, R; Maihöfner, C; Moyle, G; Navez, ML; Nurmikko, TJ; Stoker, M | 1 |
| Armendariz, A; Nazarian, A | 1 |
| Bell, A; Drummond, PD; Vo, L | 1 |
| Bhatia, R; Kumar, U; Mattoo, B; Tanwar, S | 1 |
| Delgado-Lezama, R; Elias-Viñas, D; Granados-Soto, V; Hernández-Reyes, JE; Raya-Tafolla, G; Salinas-Abarca, AB; Vidal-Cantú, GC | 1 |
| Bouhassira, D; Coffin, B; Duboc, H; Jouet, P; Moisset, X; Sabate, JM | 1 |
| Lei, J; You, HJ | 1 |
| Andersen, OK; Biurrun Manresa, JA; Curatolo, M; Moeslund, TB; Nguyen, GP | 1 |
| Frizzell, B; Hooper, RA; Jull, G; Schneider, G; Smith, AD; Sterling, M | 1 |
| Navarro, X; Redondo-Castro, E | 1 |
| Dong, YB; Shang, JJ; Tang, RZ; Xie, JQ; Xu, H; Yuan, JY | 1 |
| Lei, J; Lumb, BM; Sun, T; You, HJ | 1 |
| Donaldson, LF; Drake, RA; Hulse, RP; Lumb, BM | 1 |
| Grégoire, S; Ji, G; Medina, G; Neugebauer, V | 1 |
| Bravo, D; Constandil, L; Hernandez, A; Ibarra, P; Laurido, C; Pelissier, T; Retamal, J | 1 |
| Furukawa, A; Honda, K; Iwata, K; Kita, K; Noma, N; Shinoda, M | 1 |
| Kim, IJ; Kim, YO; Yoon, MH | 1 |
| Besson, M; Curatolo, M; Daali, Y; Desmeules, J; Matthey, A; Poncet, A; Vuillemier, P; Zeilhofer, HU | 1 |
| Ben, QW; Li, WG; Qian, AH; Song, DD; Sun, J; Tang, D; Xu, TL; Yao, WY; Yuan, YZ | 1 |
| Benard, M; Bridoux, V; Caremel, R; Dechelotte, P; Ducrotte, P; Gourcerol, G; Grise, P; Langlois, L; Leroi, AM; Meleine, M; Ouelaa, W | 1 |
| Fitzgerald, M; Hathway, GJ; Walker, SM | 1 |
| Lee, BH; Won, R | 1 |
| Birklein, F; Drummond, ES; Drummond, PD; Finch, PM; Maker, G | 1 |
| Honda, K; Iwata, K; Shinoda, M; Shirakawa, T; Suzuki, A | 1 |
| Etemadi, L; Garwicz, M; Jensen, T; Lind, G; Ljungquist, B; Petersson, P; Schouenborg, J; Thelin, J; Tsanakalis, F | 1 |
| Loomis, CW; O'Rielly, DD | 1 |
| Chang, L; Naliboff, BD; Truong, TT | 1 |
| Jiang, Y; Liu, HR; Shi, Y; Tan, LY; Wang, XM; Wu, HG; Yao, LQ; Zhang, LL; Zhong, YS; Zhou, EH | 1 |
| Ahn, DK; Hong, SD; Jung, SJ; Kim, JS; Kim, K; Kim, MJ; Oh, SB; Park, CK | 1 |
| Kluschina, O; Mayer, A; Obreja, O; Rukwied, R; Schley, M; Schmelz, M | 1 |
| Chatterjee, K; Datta, S; Kline, RH; Wiley, RG | 1 |
| Ennis, M; Wang, XM; Zhang, YH | 1 |
| Arendt-Nielsen, L; Huang, L; Lei, J; Sui, MY; Tan, YX; Tjølsen, A; You, HJ | 1 |
| Fernández, AP; Martínez, A; Martínez-Murillo, R; Serrano, J | 1 |
| Granmo, M; Jensen, T; Schouenborg, J | 1 |
| Chang, CH; Chen, GD; Hsieh, MC; Lai, CY; Lin, TB; Peng, HY; Wu, HC | 1 |
| Asato, M; Furuya, M; Imai, S; Konno, M; Kuzumaki, N; Matoba, M; Matsushima, Y; Miyoshi, K; Nanjo-Niikura, K; Narita, M; Niikura, K; Okutsu, D; Saeki, M; Shimizu, T; Suzuki, M; Suzuki, T; Tsukiyama, Y; Yamashita, A; Yomiya, K | 1 |
| Gotoh, M; Hotta, H; Kakiuchi, Y; Murakami-Murofushi, K; Murofushi, H; Nagai, J; Ogawa, T; Ueda, H | 1 |
| Brebbermann, J; Dohmann, H; Engau, I; Möller, JC; Mylius, V; Oertel, WH | 1 |
| Du, JQ; Han, M; Huo, FQ; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Lemons, LL; Wiley, RG | 1 |
| Bartley, EJ; Rhudy, JL | 1 |
| Baran, CA; Brewer, KL; Clemens, S; Keeler, BE | 1 |
| Meeus, M; Nijs, J; Paul, L; Van Oosterwijck, J | 1 |
| Goffaux, P; Grignon, S; Lévesque, M; Lipp, O; Marchand, S; Pierre, L; Potvin, S; Stip, E | 1 |
| Alfonsi, E; Cecchini, AP; Nappi, G; Sandrini, G; Tassorelli, C | 1 |
| Ahn, DK; Choi, HS; Ju, JS; Kim, BC; Lee, HJ; Park, JS | 1 |
| Atta, N; Attal, N; Bouhassira, D; Danziger, N; Guirimand, F | 1 |
| Baumgartner, E; Cedraschi, C; Cohen, P; Dayer, P; Desmeules, JA; Finckh, A; Rapiti, E; Vischer, TL | 1 |
| Alvarez, P; Hernández, A; Pelissier, T | 1 |
| Abrahams, LG; Jia, YP; Seybold, VS | 1 |
| Arendt-Nielsen, L; Chen, J; Mørch, CD; You, HJ | 1 |
| Delaney, A; Fleetwood-Walker, SM; Garry, EM; Mitchell, R; Moss, A; Rosie, R | 1 |
| Gear, RW; Green, PG; Khasar, SG; Levine, JD; Miao, FJ | 1 |
| Barlas, C; Diamond, J; Foerster, A; Holmes, M; Maysinger, D; Pertens, E | 1 |
| Alloui, A; Ardid, D; Constandil, L; Eschalier, A; Hernández, A; Laurido, C; Marchand, F; Pelissier, T; Soto-Moyano, R | 1 |
| ADAMS-RAY, J | 1 |
| Brueckl, V; Koppert, W; Schmelz, M; Weidner, C | 1 |
| Sun, RQ; Tu, Y; Willis, WD | 1 |
| Johanek, LM; Simone, DA | 1 |
| Anseloni, V; Dubner, R; Ennis, M; Ren, K | 1 |
| Chen, JH; Dougherty, PM; Weng, HR | 1 |
| Kalmari, J; Pertovaara, A | 1 |
| Dougherty, PM; Weng, HR | 1 |
| Handwerker, HO; Maihöfner, C; Namer, B; Seifert, F | 1 |
| Acosta-Rua, AJ; Johnson, RD; Vierck, CJ | 1 |
| Ji, Y; Tang, B; Traub, RJ | 1 |
| Cheppudira, BP | 1 |
| Audette, KM; Sluka, KA | 1 |
| Castañeda-Hernandez, G; Lawand, NB; Lin, Q; Valencia-de Ita, S; Willis, WD | 1 |
| DeBerry, JJ; Ness, TJ; Randich, A; Uzzell, T | 1 |
| Miyoshi, K; Narita, M; Suzuki, T; Takatsu, M | 1 |
| Ennis, M; Zhang, YH | 1 |
| de Novellis, V; Giannini, E; Lattanzi, R; Maione, S; Marabese, I; Melchiorri, P; Negri, L; Palazzo, E; Rossi, F; Vita, D | 1 |
| Aikawa, F; Donishi, T; Imbe, H; Kimura, A; Okamoto, K; Senba, E; Tamai, Y | 1 |
| Chang, HM; Chen, GD; Chen, MJ; Lai, CY; Lee, SD; Lin, TB; Pan, SF; Peng, ML; Tung, KC; Wang, PY | 1 |
| Asensio, E; Casals, L; Navarro, X; Puigdemasa, A; Udina, E; Vivó, M | 1 |
| Chen, J; Li, Z; Liu, MG; Lu, ZM; Ren, LY; Shang, GW; Yu, YQ | 1 |
| Kim, TY; Lee, JH; Shin, SC; Yang, JH; Yang, KH; Yoon, SW | 1 |
| Krushelnycky, D; Markus, H; Pomeranz, B | 1 |
| Coderre, TJ; Yashpal, K | 1 |
| Ho, KS; Mo, CJ; Sik, NH; Wook, YY; Yoon, C | 1 |
| Babbedge, R; Dray, A; Levers, T; Thompson, SW; Urban, L | 1 |
| Advokat, C; Ghorpade, A | 1 |
| Luo, L; Wiesenfeld-Hallin, Z | 1 |
| Furness, L; Goehler, LE; Maier, SF; Martinez, J; Mooney-Heiberger, K; Smith, KP; Watkins, LR; Wiertelak, EP | 1 |
| Dray, A; Thompson, SW; Urban, L | 1 |
| Hamann, SR; Martin, WR; Parvini, S | 1 |
| Lewin, GR; Mendell, LM; Ritter, AM | 1 |
| Andersen, OK; Arendt-Nielsen, L; Gracely, RH | 1 |
| Mansikka, H; Pertovaara, A | 2 |
| Cervero, F; Herrero, JF | 1 |
| Baldwin, AE; Cannon, TJ | 1 |
| Allard, BL; Gilchrist, HD; Simone, DA | 1 |
| Jia, YP; Seybold, VS | 1 |
| Kauppila, T | 1 |
| Cleland, CL; Gebhart, GF; Silva, E | 1 |
| Sagen, J; Siegan, JB | 1 |
| Bianchi, M; Panerai, AE | 1 |
| Jun, JH; Yaksh, TL | 1 |
| Hamamoto, DT; Honda, JM; Kajander, KC; Ortiz-González, XR | 1 |
| Bragard, D; Godfraind, JM; Le Bars, D; Plaghki, L; Willer, JC | 1 |
| Calejesan, AA; Ch'ang, MH; Zhuo, M | 1 |
| Carstens, E; Eisele, JH; Tabo, E | 1 |
| Gebhart, FG; Jiang, CM | 1 |
| Gold, MS; Khasar, SG; Levine, JD | 1 |
| Hwang, SW; Jung, JY; Kwak, JY; Lee, WT; Oh, U | 1 |
| Jia, YP; Linden, DR; Seybold, VS | 1 |
| Castellote, JM; Kingery, WS; Maze, M | 1 |
| Esser, MJ; Sawynok, J | 1 |
| Bennett, DL; Bradbury, EJ; Dassan, P; French, J; Kerr, BJ; McMahon, SB; Shelton, DB; Thompson, SW; Trivedi, PM | 1 |
| Kamei, J; Ohsawa, M | 1 |
| Diamond, J; Foerster, A; Holmes, M; Kril, Y; Pal, R; Pertens, E; Urschel-Gysbers, BA | 1 |
| Light, AR; Vierck, CJ | 1 |
| Blunk, JA; Koppert, W; Likar, R; Schmelz, M; Sittl, R; Zeck, S | 1 |
| Chen, J; Zheng, JH | 1 |
| Herrero, JF; Laird, JM; López-García, JA | 1 |
| Biella, G; Sotgiu, ML | 1 |
| Chen, HS; Chen, J; Sun, YY | 1 |
| Chen, J; Li, KC; Zheng, JH | 1 |
| Henry, JL; Pitcher, GM | 1 |
| Jaggar, SI; James, IF; Rice, AS; Scott, HC | 1 |
| Albrecht, S; Dern, SK; Koppert, W; Schmelz, M; Schüttler, J; Sittl, R | 1 |
| Gupta, Y; Kerr, BJ; McMahon, SB; Pope, R; Thompson, SWN; Wynick, D | 1 |
| Appenteng, K; Nokubi, T; Shigenaga, Y; Sugiyo, S; Takemura, M; Yonehara, N | 1 |
| Mishina, M; Seo, N; Takeuchi, T; Wainai, T | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JMA | 1 |
| Blackburn-Munro, G; Blakemore, JA; Dickinson, T; Fleetwood-Walker, SM; Garry, EM; Mitchell, R; Moss, A; Rosie, R | 1 |
| Bushnell, MC; Duncan, GH; Rainville, P | 1 |
| King, EW; Skyba, DA; Sluka, KA | 1 |
| Levine, JD; Taiwo, YO | 1 |
| Adcock, JJ; Garland, LG | 1 |
| Fitzgerald, M; MacIntosh, N; Millard, C | 1 |
| Walters, ET | 1 |
5 review(s) available for fomesafen and Allodynia
| Article | Year |
|---|---|
Novel techniques to study visceral hypersensitivity in irritable bowel syndrome.
Topics: Animals; Brain Mapping; Dilatation; Gastrointestinal Tract; Humans; Hyperalgesia; Irritable Bowel Syndrome; Pain Measurement; Pain Threshold; Perception; Reflex; Sensory Thresholds | 2008 |
Evidence for central sensitization in chronic whiplash: a systematic literature review.
Topics: Anesthetics, Local; Case-Control Studies; Central Nervous System Sensitization; Chronic Disease; Clinical Trials as Topic; Humans; Hyperalgesia; Pain; Pain Measurement; Physical Stimulation; Randomized Controlled Trials as Topic; Reflex; Research Design; Whiplash Injuries | 2013 |
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Topics: Afferent Pathways; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Humans; Hyperalgesia; Inflammation; Ion Transport; Models, Neurological; Morphine; Nerve Fibers; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Transmission; Viscera | 2000 |
Representation of acute and persistent pain in the human CNS: potential implications for chemical intolerance.
Topics: Acute Disease; Analgesia; Brain; Brain Mapping; Cerebral Cortex; Chronic Disease; Cognition; Diagnostic Imaging; Environmental Exposure; Fibromyalgia; Gyrus Cinguli; Humans; Hyperalgesia; Hypnosis; Multiple Chemical Sensitivity; Neural Pathways; Neuralgia; Pain; Perception; Placebo Effect; Reflex; Somatosensory Cortex; Thalamus | 2001 |
New approaches to the attenuation of sensory reflexes in airway inflammation.
Topics: Analgesics; Animals; Asthma; Humans; Hyperalgesia; Inflammation; Lung; Nervous System Physiological Phenomena; Neurons; Reflex; Respiratory Hypersensitivity; Respiratory Tract Diseases; Sensation | 1991 |
12 trial(s) available for fomesafen and Allodynia
| Article | Year |
|---|---|
Capsaicin 8% Patch Repeat Treatment in Nondiabetic Peripheral Neuropathic Pain: A 52-Week, Open-Label, Single-Arm, Safety Study.
Topics: Aged; Analgesics, Non-Narcotic; Capsaicin; Female; Humans; Hyperalgesia; Male; Middle Aged; Neuralgia; Prospective Studies; Reflex; Sensation; Transdermal Patch; Treatment Outcome | 2017 |
Can aberrant spinal nociception be a marker of chronicity of pain in fibromyalgia syndrome?
Topics: Adult; Chronic Disease; Female; Fibromyalgia; Humans; Hyperalgesia; Male; Middle Aged; Nociception; Pain; Pain Threshold; Reflex | 2019 |
GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers.
Topics: Adolescent; Adult; Benzodiazepines; Clobazam; Clonazepam; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Double-Blind Method; Female; GABA Modulators; Genotype; Healthy Volunteers; Humans; Hyperalgesia; Male; Middle Aged; Neuropsychological Tests; Pain Threshold; Reflex; Saccades; Skin; Time Factors; Ultraviolet Rays; Young Adult | 2015 |
NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin.
Topics: Adult; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Middle Aged; Nerve Growth Factor; Pain Measurement; Pain Threshold; Reflex; Skin; Time Factors; Vasodilation | 2010 |
Effects of nimesulide on nitric oxide-induced hyperalgesia in humans--a neurophysiological study.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Electric Stimulation; Female; Humans; Hyperalgesia; Isoenzymes; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Prostaglandin-Endoperoxide Synthases; Reflex; Spinal Cord; Sulfonamides; Vasodilator Agents | 2002 |
Comparison of the pain suppressive effects of clinical and experimental painful conditioning stimuli.
Topics: Adult; Aged; Cold Temperature; Electromyography; Female; Humans; Hyperalgesia; Male; Middle Aged; Nociceptors; Pain; Peripheral Nerve Injuries; Physical Stimulation; Pressure; Reflex; Sensory Thresholds | 2003 |
Neurophysiologic evidence for a central sensitization in patients with fibromyalgia.
Topics: Female; Fibromyalgia; Humans; Hyperalgesia; Male; Middle Aged; Nociceptors; Outpatients; Pain; Pain Measurement; Pain Threshold; Quality of Life; Reflex; Self Care; Sickness Impact Profile; Surveys and Questionnaires | 2003 |
Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine.
Topics: Adult; Axons; Burns; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Routes; Erythema; Female; Humans; Hyperalgesia; Lidocaine; Male; Nociceptors; Physical Stimulation; Reflex; Regional Blood Flow; Sensory Receptor Cells; Ultraviolet Rays | 2004 |
TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.
Topics: Acrolein; Adult; Axons; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Ion Channels; Laser-Doppler Flowmetry; Male; Menthol; Neoplasm Proteins; Pain; Pain Measurement; Pain Threshold; Reflex; Time Factors; TRPM Cation Channels; Vasodilation | 2005 |
The effects of intradermal fentanyl and ketamine on capsaicin-induced secondary hyperalgesia and flare reaction.
Topics: Adult; Analgesics; Analgesics, Opioid; Axons; Capsaicin; Erythema; Female; Fentanyl; Humans; Hyperalgesia; Injections, Intradermal; Ketamine; Male; Middle Aged; Nociceptors; Reflex | 1999 |
A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine.
Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Axons; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Female; Humans; Hyperalgesia; Ketamine; Lidocaine; Male; Middle Aged; Models, Biological; Pain Measurement; Reflex; Skin Physiological Phenomena | 2001 |
Hyperalgesia in premature infants.
Topics: Humans; Hyperalgesia; Hyperesthesia; Infant, Newborn; Infant, Premature; Pain; Reflex; Sensory Thresholds | 1988 |
119 other study(ies) available for fomesafen and Allodynia
| Article | Year |
|---|---|
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.
Topics: Adult; Capsaicin; Central Nervous System Sensitization; Electric Stimulation; Female; Humans; Hyperalgesia; Male; Models, Theoretical; Nociception; Pain Threshold; Physical Stimulation; Reflex; Sensory System Agents; Sural Nerve | 2021 |
Morphine antinociception on thermal sensitivity and place conditioning in male and female rats treated with intraplantar complete freund's adjuvant.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Morphine; Nociceptive Pain; Rats, Sprague-Dawley; Reflex; Sex Characteristics; Spatial Behavior | 2018 |
Painful stimulation of a sensitized site in the forearm inhibits ipsilateral trigeminal nociceptive blink reflexes.
Topics: Adult; Female; Forehead; Functional Laterality; Humans; Hyperalgesia; Male; Middle Aged; Nociception; Pain; Physical Stimulation; Psychophysics; Reflex; Skin; Ultraviolet Rays; Young Adult | 2018 |
α5GABAA receptors play a pronociceptive role and avoid the rate-dependent depression of the Hoffmann reflex in diabetic neuropathic pain and reduce primary afferent excitability.
Topics: Animals; Axons; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; GABA-A Receptor Agonists; Ganglia, Spinal; Hyperalgesia; Neural Inhibition; Rats, Wistar; Receptors, GABA-A; Reflex; Spinal Cord Dorsal Horn | 2019 |
Changes in the modulation of spinal pain processing are related to severity in irritable bowel syndrome.
Topics: Adult; Brain; Female; Humans; Hyperalgesia; Image Interpretation, Computer-Assisted; Irritable Bowel Syndrome; Magnetic Resonance Imaging; Manometry; Pain; Pain Threshold; Reflex; Spinal Cord | 2013 |
Endogenous descending facilitation and inhibition differ in control of formalin intramuscularly induced persistent muscle nociception.
Topics: Animals; Formaldehyde; Hyperalgesia; Injections, Intramuscular; Male; Motor Activity; Muscle, Skeletal; Nociception; Pain Measurement; Physical Stimulation; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Spinothalamic Tracts; Thalamic Nuclei | 2013 |
Probabilistic model for individual assessment of central hyperexcitability using the nociceptive withdrawal reflex: a biomarker for chronic low back and neck pain.
Topics: Artificial Intelligence; Electric Stimulation; Electromyography; Female; Humans; Hyperalgesia; Low Back Pain; Male; Models, Neurological; Models, Statistical; Neck Pain; Reflex | 2013 |
Cervical radiofrequency neurotomy reduces central hyperexcitability and improves neck movement in individuals with chronic whiplash.
Topics: Adolescent; Adult; Aged; Axotomy; Brachial Plexus; Catheter Ablation; Cohort Studies; Female; Head Movements; Hot Temperature; Humans; Hyperalgesia; Male; Median Nerve; Median Neuropathy; Middle Aged; Neck Muscles; Nociception; Pain Measurement; Pain Threshold; Pressure; Prospective Studies; Range of Motion, Articular; Reflex; Treatment Outcome; Whiplash Injuries; Young Adult | 2014 |
Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium-Binding Proteins; Evoked Potentials, Motor; Evoked Potentials, Somatosensory; Female; Glial Fibrillary Acidic Protein; Hyperalgesia; Ibuprofen; Locomotion; Microfilament Proteins; Neural Conduction; Neuralgia; Pain Measurement; Pain Threshold; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord Injuries | 2014 |
Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression.
Topics: Analgesics; Animals; Behavior, Animal; Colon; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Reflex; RNA, Messenger; Stress, Psychological; Substance P; TRPV Cation Channels; Visceral Afferents | 2013 |
Roles of the periaqueductal gray in descending facilitatory and inhibitory controls of intramuscular hypertonic saline induced muscle nociception.
Topics: Afferent Pathways; Animals; Electrolytes; Hyperalgesia; Injections, Intramuscular; Male; Muscle, Skeletal; Neural Inhibition; Nociception; Oncogene Proteins v-fos; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex; Saline Solution, Hypertonic; Time Factors | 2014 |
The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input.
Topics: Afferent Pathways; Animals; Hot Temperature; Hyperalgesia; Male; Nociception; Nociceptors; Peripheral Nerves; Rats; Rats, Wistar; Reflex; Skin; Spinal Cord; Touch; Wool | 2014 |
Nasal application of neuropeptide S inhibits arthritis pain-related behaviors through an action in the amygdala.
Topics: Administration, Intranasal; Amygdala; Analgesics; Animals; Arthritis; Carrageenan; Disease Models, Animal; Hyperalgesia; Kaolin; Knee Joint; Male; Maze Learning; Neurons; Neuropeptides; Pain; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Vocalization, Animal | 2014 |
Pannexin 1: a novel participant in neuropathic pain signaling in the rat spinal cord.
Topics: Animals; Carbenoxolone; Connexins; Hyperalgesia; Male; Nerve Tissue Proteins; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Posterior Horn Cells; Probenecid; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord | 2014 |
TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.
Topics: Acetanilides; Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Cold Temperature; Electromyography; Face; Facial Pain; Hot Temperature; Hyperalgesia; Injections, Intradermal; Male; Neural Conduction; Neurons; Physical Stimulation; Purines; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents; Synaptic Transmission; Trigeminal Ganglion; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2014 |
Antiallodynic effect through spinal endothelin-B receptor antagonism in rat models of complex regional pain syndrome.
Topics: Animals; Causalgia; Endothelin B Receptor Antagonists; Endothelin-1; Hyperalgesia; Male; Oligopeptides; Pain Threshold; Peptides, Cyclic; Physical Stimulation; Piperidines; Rats, Sprague-Dawley; Reflex; Reflex Sympathetic Dystrophy; Spinal Cord; Touch | 2015 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GABAergic Neurons; gamma-Aminobutyric Acid; Homeostasis; Hyperalgesia; Indenes; Inhibitory Postsynaptic Potentials; K Cl- Cotransporters; Male; Mechanotransduction, Cellular; Nociception; Pressure; Rats, Wistar; Reflex; Spine; Stress, Psychological; Symporters; Time Factors; Visceral Pain | 2015 |
Acute sacral nerve stimulation reduces visceral mechanosensitivity in Rat through spinal opioid pathway.
Topics: Animals; Arterial Pressure; Colon; Dilatation; Electric Stimulation; Enzyme Inhibitors; Hyperalgesia; Lumbosacral Plexus; Naloxone; Narcotic Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Reflex; Sacrococcygeal Region; Sensory Thresholds; Spinal Cord; Visceral Pain | 2015 |
Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla.
Topics: Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Electric Stimulation; Female; Foot; Hyperalgesia; Male; Medulla Oblongata; Nerve Block; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Sensory Thresholds | 2015 |
Contralateral Metabolic Activation Related to Plastic Changes in the Spinal Cord after Peripheral Nerve Injury in Rats.
Topics: Activation, Metabolic; Animals; Autoradiography; Behavior, Animal; Deoxyglucose; Disease Progression; Functional Laterality; Hyperalgesia; Male; Neuralgia; Neuronal Plasticity; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord | 2015 |
Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome.
Topics: Administration, Topical; Adrenergic alpha-1 Receptor Antagonists; Adult; Complex Regional Pain Syndromes; Female; Forearm; Humans; Hyperalgesia; Male; Middle Aged; Prazosin; Reflex; Vasodilation | 2016 |
Regulation of transient receptor potential vanilloid 1 expression in trigeminal ganglion neurons via methyl-CpG binding protein 2 signaling contributes tongue heat sensitivity and inflammatory hyperalgesia in mice.
Topics: Animals; Anoctamin-1; Chloride Channels; Female; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Methyl-CpG-Binding Protein 2; Mice, Inbred C57BL; Neurons; Pain Threshold; Reflex; Signal Transduction; Time Factors; Tongue; Trigeminal Ganglion; TRPM Cation Channels; TRPV Cation Channels | 2016 |
Discrepancies between cortical and behavioural long-term readouts of hyperalgesia in awake freely moving rats.
Topics: Animals; Disease Models, Animal; Hot Temperature; Hyperalgesia; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex | 2016 |
Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia.
Topics: Analysis of Variance; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dose-Response Relationship, Radiation; Electric Stimulation; Electromyography; Functional Laterality; Hyperalgesia; Ibuprofen; Ligation; Male; NF-kappa B; Pain Measurement; Pain Threshold; Prostaglandins; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Spinal Nerves; Time Factors | 2008 |
Suspended moxibustion relieves chronic visceral hyperalgesia via serotonin pathway in the colon.
Topics: Animals; Animals, Newborn; Colon; Disease Models, Animal; Down-Regulation; Hyperalgesia; Irritable Bowel Syndrome; Male; Moxibustion; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Reflex; Serotonin; Treatment Outcome; Visceral Afferents | 2009 |
Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Eugenol; Gene Expression Regulation; Hyperalgesia; Jaw; Lectins; Male; Masticatory Muscles; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Reflex; Sodium Channels; Tetrodotoxin; Tooth; Trigeminal Ganglion; Trigeminal Nerve; TRPV Cation Channels | 2009 |
Behavioral and anatomical characterization of the bilateral sciatic nerve chronic constriction (bCCI) injury: correlation of anatomic changes and responses to cold stimuli.
Topics: Acetone; Analgesics; Animals; Biomarkers; Cholecystokinin; Chronic Disease; Cold Temperature; Disease Models, Animal; Female; Functional Laterality; Hyperalgesia; Immunohistochemistry; Ligation; Neuropeptide Y; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Posterior Horn Cells; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Reflex; Sciatic Neuropathy | 2010 |
Effects of neonatal inflammation on descending modulation from the rostroventromedial medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Biophysics; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agonists; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Pain Threshold; Pregnancy; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 2010 |
Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception.
Topics: Animals; Capsaicin; Dihydroxytryptamines; Hot Temperature; Hyperalgesia; Male; Models, Animal; Muscle, Skeletal; Naloxone; Nerve Fibers, Unmyelinated; Nociceptors; Rats; Rats, Sprague-Dawley; Reflex; Saline Solution, Hypertonic; Sciatic Nerve; Time Factors | 2010 |
Lack of adrenomedullin in the central nervous system results in apparently paradoxical alterations on pain sensitivity.
Topics: Adrenomedullin; Animals; Behavior, Animal; Central Nervous System; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Knockout; Neuropeptides; Organ Specificity; Pain; Pain Measurement; Receptors, Adrenomedullin; Receptors, Peptide; Reflex; Somatosensory Disorders; Spinal Cord | 2010 |
Altered nociceptive C fibre input to primary somatosensory cortex in an animal model of hyperalgesia.
Topics: Analgesics, Opioid; Animals; Brain Mapping; Electroencephalography; Evoked Potentials; Forelimb; Hindlimb; Hyperalgesia; Lasers; Nerve Fibers, Unmyelinated; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Somatosensory Cortex; Tramadol; Ultraviolet Rays | 2011 |
EphrinB2 induces pelvic-urethra reflex potentiation via Src kinase-dependent tyrosine phosphorylation of NR2B.
Topics: Animals; Ephrin-B2; Female; Hyperalgesia; Pelvis; Phosphorylation; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; src-Family Kinases; Tyrosine; Urethra | 2011 |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyography; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Gyrus Cinguli; Hyperalgesia; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microdialysis; Midazolam; Nipecotic Acids; Pain Measurement; Pain Threshold; Physical Stimulation; Pyridines; Reflex; RNA, Messenger; Sciatic Neuropathy; Sleep Wake Disorders; Zolpidem | 2011 |
Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain.
Topics: Acute Disease; Anesthesia; Animals; Behavior, Animal; Chronic Disease; Cyclic P-Oxides; Disease Models, Animal; Electric Stimulation; Formaldehyde; Hyperalgesia; In Vitro Techniques; Injections, Intravenous; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Nociceptors; Pain; Phosphatidic Acids; Rats; Rats, Wistar; Reflex; Sympathetic Nervous System; Temperature | 2011 |
Pain sensitivity and clinical progression in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Disease Progression; Electric Stimulation; Electromyography; Female; Humans; Hyperalgesia; Male; Middle Aged; Pain; Pain Measurement; Pain Threshold; Parkinson Disease; Reflex; Somatosensory Disorders; Spinal Cord; Surveys and Questionnaires | 2011 |
Chemical lesioning and glutamate administration reveal a major role for the nucleus tractus solitarius in the cardiac-somatic reflex in rats.
Topics: Animals; Cardiovascular Physiological Phenomena; Denervation; Glutamic Acid; Hyperalgesia; Male; Microinjections; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reflex; Solitary Nucleus | 2012 |
Neuropeptide Y receptor-expressing dorsal horn neurons: role in nocifensive reflex and operant responses to aversive cold after CFA inflammation.
Topics: Analgesics; Animals; Behavior, Animal; Cold Temperature; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Morphine; Neuropeptide Y; Pain; Posterior Horn Cells; Rats; Rats, Long-Evans; Receptors, Neuropeptide Y; Reflex; Spinal Cord | 2012 |
Comparing pain sensitivity and the nociceptive flexion reflex threshold across the mid-follicular and late-luteal menstrual phases in healthy women.
Topics: Electromyography; Female; Humans; Hyperalgesia; Ischemia; Menstrual Cycle; Nociception; Pain; Pain Measurement; Pain Threshold; Pressure; Reflex; Skin; Women's Health | 2013 |
Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Animals, Newborn; Biophysical Phenomena; Biophysics; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Unmyelinated; Pain; Pain Threshold; Pregabalin; Reaction Time; Receptors, Dopamine D3; Reflex; Spinal Cord; Spinal Nerve Roots; Time Factors | 2012 |
Pain perception in schizophrenia: evidence of a specific pain response profile.
Topics: Adult; Case-Control Studies; Electromyography; Female; Humans; Hyperalgesia; Male; Pain Measurement; Pain Perception; Pain Threshold; Psychotic Disorders; Reflex; Schizophrenia, Paranoid; Sural Nerve; Transcutaneous Electric Nerve Stimulation | 2012 |
Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats.
Topics: Animals; Behavior, Animal; Electromyography; Formaldehyde; Hyperalgesia; Interleukin 1 Receptor Antagonist Protein; Interleukin-6; Jaw; Male; Masticatory Muscles; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Reflex; Sialoglycoproteins | 2003 |
Effect of long-term ketamine administration on vocalization to paw pressure and on spinal wind-up activity in monoarthritic rats.
Topics: Analgesics; Analysis of Variance; Animals; Arthritis, Experimental; Arthritis, Infectious; Chronic Disease; Freund's Adjuvant; Hyperalgesia; Infusion Pumps, Implantable; Injections, Subcutaneous; Ketamine; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Nociceptors; Pain; Pain Measurement; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Regression Analysis; Vocalization, Animal | 2003 |
Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation.
Topics: Action Potentials; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Stimulation; Foot; Freund's Adjuvant; Hyperalgesia; Ibuprofen; Inflammation; Isoenzymes; Male; Muscle, Skeletal; Nerve Fibers; Neurons; Nociceptors; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Reflex; Sensory Thresholds; Spinal Cord; Sural Nerve | 2003 |
Differential antinociceptive effects induced by a selective cyclooxygenase-2 inhibitor (SC-236) on dorsal horn neurons and spinal withdrawal reflexes in anesthetized spinal rats.
Topics: Action Potentials; Anesthesia; Animals; Bee Venoms; Cyclooxygenase Inhibitors; Drug Interactions; Electric Stimulation; Electromyography; Electrophysiology; Hindlimb; Hyperalgesia; Inflammation; Male; Muscle, Skeletal; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Pyrazoles; Rats; Rats, Wistar; Reflex; Spinal Cord; Spinal Cord Injuries; Sulfonamides | 2003 |
Specific involvement in neuropathic pain of AMPA receptors and adapter proteins for the GluR2 subunit.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Carrier Proteins; Cell Membrane; Chronic Disease; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Hyperalgesia; Male; N-Ethylmaleimide-Sensitive Proteins; Neuralgia; Nuclear Proteins; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Protein Binding; Protein Subunits; Protein Transport; Rats; Rats, Wistar; Receptors, AMPA; Recombinant Fusion Proteins; Reflex; RNA, Messenger; Synaptic Transmission; Vesicular Transport Proteins | 2003 |
Vagal modulation of bradykinin-induced mechanical hyperalgesia in the female rat.
Topics: Adrenal Medulla; Animals; Behavior, Animal; Bradykinin; Dose-Response Relationship, Drug; Female; Hyperalgesia; Nociceptors; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Vagotomy; Vagus Nerve | 2003 |
Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin.
Topics: Aminobenzoates; Animals; Antibodies; Binding Sites; Female; Ganglia, Spinal; Glycoproteins; Hyperalgesia; Hypoxanthine; Hypoxanthines; Lectins; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nerve Regeneration; Neuronal Plasticity; Neurons, Afferent; Nociceptors; Peripheral Nerves; Peripheral Nervous System Diseases; Phosphorylation; Purines; Rats; Rats, Wistar; Receptor, trkA; Reflex | 2003 |
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Cyclohexanols; Depression; Dose-Response Relationship, Drug; Drug Synergism; Fever; Hyperalgesia; Infusion Pumps, Implantable; Male; Oligonucleotides, Antisense; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Reflex; Regression, Psychology; Sciatic Neuropathy; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Antagonists; Time Factors; Venlafaxine Hydrochloride | 2004 |
Physiological cutaneous hyperalgesia associated with the bladder-distension reflex; a contribution to the question of the physiology of visceral pain.
Topics: Dilatation, Pathologic; Humans; Hyperalgesia; Hyperesthesia; Reflex; Urinary Bladder; Urinary Retention; Visceral Pain | 1952 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interactions; Hyperalgesia; Injections, Intramuscular; Injections, Spinal; Male; Melatonin; Neural Inhibition; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Cord; Spinal Cord Injuries; Tetrahydronaphthalenes; Tryptamines | 2004 |
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury.
Topics: Animals; Benzoxazines; Burns; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Hot Temperature; Hyperalgesia; Indoles; Male; Morpholines; Naphthalenes; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Reflex; Skin | 2004 |
Ontogeny of analgesia elicited by non-nutritive suckling in acute and persistent neonatal rat pain models.
Topics: Acute Disease; Afferent Pathways; Analgesia; Animals; Animals, Newborn; Animals, Suckling; Behavior, Animal; Central Nervous System; Chronic Disease; Disease Models, Animal; Female; Hyperalgesia; Inflammation; Male; Mechanoreceptors; Mouth; Neural Inhibition; Pain; Pain Management; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Skin; Sucking Behavior; Touch | 2004 |
Sensitization of dorsal root reflexes in vitro and hyperalgesia in neonatal rats produced by capsaicin.
Topics: Aging; Animals; Animals, Newborn; Capsaicin; Hyperalgesia; Membrane Potentials; Organ Culture Techniques; Rats; Reflex; Spinal Cord; Spinal Nerve Roots | 2004 |
Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation.
Topics: Animals; Burns; Colitis; Colon; Conditioning, Psychological; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Hyperalgesia; Inflammation; Male; Neural Inhibition; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Receptors, N-Methyl-D-Aspartate; Rectum; Reflex; Skin; Synaptic Transmission; Visceral Afferents | 2004 |
Response properties of dorsal root reflexes in cutaneous C fibers before and after intradermal capsaicin injection in rats.
Topics: Action Potentials; Alanine; Animals; Capsaicin; Drug Interactions; Edema; Extremities; GABA Plasma Membrane Transport Proteins; Hyperalgesia; Injections, Intradermal; Laminectomy; Male; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Fibers, Unmyelinated; Neural Conduction; Neural Inhibition; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Skin; Spinal Nerve Roots; Time Factors | 2005 |
Bilateral chronic constriction of the sciatic nerve: a model of long-term cold hyperalgesia.
Topics: Animals; Chronic Disease; Denervation; Disease Models, Animal; Female; Functional Laterality; Hot Temperature; Hyperalgesia; Ligation; Nociceptors; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Long-Evans; Reaction Time; Reflex; Sciatic Nerve; Sciatic Neuropathy; Time Factors | 2005 |
Modulatory effects of estrogen and progesterone on colorectal hyperalgesia in the rat.
Topics: Action Potentials; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Colitis; Disease Models, Animal; Electromyography; Estrogens; Female; Hyperalgesia; Neurons; Ovariectomy; Physical Stimulation; Pressure; Progesterone; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord | 2005 |
Characterization of hind paw licking and lifting to noxious radiant heat in the rat with and without chronic inflammation.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Freund's Adjuvant; Grooming; Hot Temperature; Hyperalgesia; Inflammation; Inflammation Mediators; Male; Movement; Neurophysiology; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 2006 |
Activation of protein kinase C in the spinal cord produces mechanical hyperalgesia by activating glutamate receptors, but does not mediate chronic muscle-induced hyperalgesia.
Topics: Animals; Chronic Disease; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Inflammation Mediators; Male; Muscle, Skeletal; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Synaptic Transmission | 2006 |
Role of the Na+-K+-2Cl- cotransporter in the development of capsaicin-induced neurogenic inflammation.
Topics: Animals; Bumetanide; Capsaicin; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Rats; Rats, Sprague-Dawley; Reflex; Sodium-Potassium-Chloride Symporters; Vasodilation | 2006 |
Neonatal urinary bladder inflammation produces adult bladder hypersensitivity.
Topics: Abdominal Muscles; Age Factors; Aging; Animals; Animals, Newborn; Cystitis; Disease Models, Animal; Electromyography; Evans Blue; Female; Hyperalgesia; Inflammation Mediators; Muscle Contraction; Pain Threshold; Pelvic Pain; Rats; Rats, Sprague-Dawley; Reflex; Urinary Bladder; Urinary Bladder, Neurogenic; Urination Disorders; Visceral Afferents | 2006 |
mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption.
Topics: Alcoholic Neuropathy; Analysis of Variance; Animals; Central Nervous System Depressants; Ethanol; Hyperalgesia; Male; Neuralgia; Nociceptors; Pain; Pain Measurement; Pain Threshold; Protein Kinase C; Rats; Rats, Inbred F344; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reflex | 2007 |
Inactivation of the periaqueductal gray attenuates antinociception elicited by stimulation of the rat medial preoptic area.
Topics: Analgesia; Anesthetics, Local; Animals; Homocysteine; Hyperalgesia; Lidocaine; Male; Microinjections; Neural Inhibition; Neural Pathways; Nociceptors; Pain; Pain Threshold; Periaqueductal Gray; Preoptic Area; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 2007 |
The prokineticin receptor agonist Bv8 increases GABA release in the periaqueductal grey and modifies RVM cell activities and thermoceptive reflexes in the rat.
Topics: Action Potentials; Animals; Autoradiography; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gastrointestinal Hormones; Hyperalgesia; In Situ Hybridization; In Vitro Techniques; Male; Medulla Oblongata; Microdialysis; Neurons; Neuropeptides; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Reflex; Tail | 2007 |
Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation.
Topics: Animals; Efferent Pathways; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 3; Pain Threshold; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Reticular Formation; Sensory Receptor Cells | 2008 |
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic GMP-Dependent Protein Kinases; Electromyography; Enzyme Inhibitors; Hyperalgesia; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Reflex; Signal Transduction; Spinal Cord | 2008 |
Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Hyperalgesia; Lectins; Nerve Regeneration; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Reaction Time; Recovery of Function; Reflex; Sciatic Neuropathy; Spinal Cord; Substance P; Time Factors | 2008 |
Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom-induced pain behaviors.
Topics: Animals; Bee Venoms; Disability Evaluation; Disease Models, Animal; Efferent Pathways; Gyrus Cinguli; Hyperalgesia; Male; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord | 2008 |
Anti-hyperalgesic and anti-inflammatory effects of ketorolac tromethamine gel using pulsed ultrasound in inflamed rats.
Topics: Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Gels; Hyperalgesia; Ketorolac Tromethamine; Male; Pain Measurement; Pain Threshold; Phonophoresis; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Time Factors | 2008 |
Spread of saphenous somatotopic projection map in spinal cord and hypersensitivity of the foot after chronic sciatic denervation in adult rat.
Topics: Animals; Behavior, Animal; Denervation; Electric Conductivity; Electric Stimulation; Evoked Potentials; Hindlimb; Hyperalgesia; Interneurons; Male; Muscles; Peripheral Nerves; Rats; Rats, Inbred Strains; Reflex; Sciatic Nerve; Spinal Cord | 1984 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Cold Temperature; Denervation; Disease Models, Animal; Foot; Hyperalgesia; Male; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Spinal Nerves; Sympathectomy | 1994 |
No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Electric Stimulation; Hyperalgesia; In Vitro Techniques; N-Methylaspartate; Nerve Fibers; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Reflex; Spinal Cord; Spinal Nerve Roots | 1995 |
Evidence of a role for N-methyl-D-aspartate (NMDA) receptors in the facilitation of tail withdrawal after spinal transection.
Topics: Analgesics; Animals; Cordotomy; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ketamine; Male; Morphine; Movement; Pain Measurement; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex | 1994 |
Genetic factors may influence the development of spinal reflex hyperexcitability following sciatic nerve section in the rat.
Topics: Animals; Electric Stimulation; Genes, fos; Hyperalgesia; Nerve Fibers; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Self Mutilation; Species Specificity; Spinal Cord | 1994 |
Neurocircuitry of illness-induced hyperalgesia.
Topics: Animals; Basal Ganglia; Behavior, Animal; Decerebrate State; Formaldehyde; Ganglia, Sympathetic; Ganglionectomy; Hyperalgesia; Injections, Intraperitoneal; Lipopolysaccharides; Lithium Chloride; Male; Nervous System; Neural Pathways; Pain Measurement; Proto-Oncogene Proteins c-fos; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reflex; Vagotomy | 1994 |
Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro.
Topics: Animals; Differential Threshold; Electric Stimulation; Electrophysiology; Hot Temperature; Hyperalgesia; In Vitro Techniques; Nerve Fibers; Nerve Fibers, Myelinated; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord Injuries; Ultraviolet Rays | 1994 |
Pharmacologic characteristics of a medullary hyperalgesic center.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Ethylketocyclazocine; Female; Hyperalgesia; Medulla Oblongata; Morphine; Nicotine; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex | 1993 |
Nerve growth factor-induced hyperalgesia in the neonatal and adult rat.
Topics: Aging; Animals; Animals, Newborn; Female; Foot; Hot Temperature; Hyperalgesia; Male; Nerve Growth Factors; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Sensory Thresholds | 1993 |
Facilitation of the human nociceptive reflex by stimulation of A beta-fibres in a secondary hyperalgesic area sustained by nociceptive input from the primary hyperalgesic area.
Topics: Adrenergic Fibers; Adult; Analysis of Variance; Capsaicin; Foot; Humans; Hyperalgesia; Pain Measurement; Pain Threshold; Reflex | 1995 |
Influence of selective alpha 2-adrenergic agents on mustard oil-induced central hyperalgesia in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Imidazoles; Male; Medetomidine; Mustard Plant; Nociceptors; Pain Measurement; Pain Threshold; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex | 1995 |
Changes in nociceptive reflex facilitation during carrageenan-induced arthritis.
Topics: Action Potentials; Animals; Arthritis; Carrageenan; Electric Stimulation; Electrophysiology; Female; Hyperalgesia; Knee Joint; Nociceptors; Rats; Rats, Wistar; Reflex; Time Factors | 1996 |
Sensitization of the tail-flick reflex following exposure to either a single prolonged test trial or behavioral testing under the analgesic influence of morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Hot Temperature; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Restraint, Physical; Tail; Time Factors | 1996 |
Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Foot; Hot Temperature; Hyperalgesia; Injections; Male; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 1996 |
Spinal NK2 receptors contribute to the increased excitability of the nociceptive flexor reflex during persistent peripheral inflammation.
Topics: Animals; Evoked Potentials; Hyperalgesia; Inflammation; Injections, Spinal; Male; Neurokinin A; Nociceptors; Peripheral Nervous System; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Reflex; Spinal Cord | 1997 |
Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex.
Topics: Animals; Capsaicin; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Ganglia, Spinal; Hindlimb; Hot Temperature; Hyperalgesia; Immersion; Male; Mechanoreceptors; Nerve Fibers; Nerve Regeneration; Neuralgia; Neurites; Neurons, Afferent; Nociceptors; Physical Stimulation; Plasma; Rats; Rats, Wistar; Reflex; Sciatic Nerve | 1997 |
Spinalization increases the mechanical stimulation-induced withdrawal reflex threshold after a sciatic cut in the rat.
Topics: Animals; Cordotomy; Hot Temperature; Hyperalgesia; Male; Physical Stimulation; Rats; Reflex; Sciatic Nerve; Sensory Thresholds; Spinal Cord | 1997 |
Contributions of glutamate receptors to the maintenance of mustard oil-induced hyperalgesia in spinalized rats.
Topics: Animals; Decerebrate State; Electric Stimulation; Electromyography; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Movement; Mustard Plant; Plant Extracts; Plant Oils; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex | 1997 |
Adrenal medullary transplants attenuate sensorimotor dysfunction in rats with peripheral neuropathy.
Topics: Adrenal Medulla; Animals; Hyperalgesia; Male; Pain; Peripheral Nervous System Diseases; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reflex; Stress, Mechanical; Subarachnoid Space | 1998 |
Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol.
Topics: 2-Amino-5-phosphonovalerate; Acetaminophen; Analgesics, Non-Narcotic; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex | 1997 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Injections, Spinal; Male; Pain; Pregabalin; Rats; Rats, Sprague-Dawley; Reflex; Serine; Stereoisomerism; Structure-Activity Relationship | 1998 |
Intraplantar injection of hyaluronic acid at low pH into the rat hindpaw produces tissue acidosis and enhances withdrawal responses to mechanical stimuli.
Topics: Acidosis; Animals; Behavior, Animal; Hindlimb; Hyaluronic Acid; Hydrogen-Ion Concentration; Hyperalgesia; Male; Microelectrodes; Physical Stimulation; Protons; Rats; Rats, Sprague-Dawley; Reflex | 1998 |
Facilitation of a nociceptive flexion reflex in man by nonnoxious radiant heat produced by a laser.
Topics: Adult; Conditioning, Classical; Electromyography; Electroshock; Female; Foot; Hot Temperature; Humans; Hyperalgesia; Knee; Lasers; Male; Middle Aged; Nerve Fibers; Nociceptors; Reaction Time; Reflex; Skin; Skin Temperature; Sural Nerve | 1998 |
Spinal serotonergic receptors mediate facilitation of a nociceptive reflex by subcutaneous formalin injection into the hindpaw in rats.
Topics: Animals; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reflex; Spinal Cord | 1998 |
Force of limb withdrawals elicited by graded noxious heat compared with other behavioral measures of carrageenan-induced hyperalgesia and allodynia.
Topics: Animals; Behavior, Animal; Carrageenan; Disease Models, Animal; Drug Administration Schedule; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Muscle Contraction; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Skin Physiological Phenomena; Stress, Mechanical; Weight-Bearing | 1998 |
Development of mustard oil-induced hyperalgesia in rats.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Female; Hyperalgesia; Male; Mustard Plant; Nociceptors; Pain Measurement; Plant Extracts; Plant Oils; Plants, Medicinal; Pregnancy; Rats; Rats, Sprague-Dawley; Reflex; Tail | 1998 |
A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat.
Topics: Animals; Antisense Elements (Genetics); Dinoprostone; Drug Resistance; Electric Conductivity; Hindlimb; Hyperalgesia; Inflammation; Male; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex; Sodium Channels; Tetrodotoxin | 1998 |
A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance.
Topics: Animals; Capsaicin; Carrageenan; Functional Laterality; Hindlimb; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Drug; Reflex; Spinal Cord | 1998 |
Spinal neurokin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Motor Neurons; Movement; Nitric Oxide; Nociceptors; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Reflex; Spinal Cord; Substance P | 1999 |
Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.
Topics: Animals; Anti-Inflammatory Agents; Axotomy; Dose-Response Relationship, Drug; Edema; Evans Blue; Glucocorticoids; Hindlimb; Hyperalgesia; Male; Methylprednisolone; Neurogenic Inflammation; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Substance P | 1999 |
Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Hot Temperature; Hyperalgesia; Ligation; Male; Nerve Compression Syndromes; Neuralgia; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reflex; Spinal Nerve Roots | 1999 |
Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carrageenan; Excipients; Excitatory Amino Acid Agonists; Hyperalgesia; Immunoglobulin G; Injections, Spinal; Male; Membrane Potentials; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nociceptors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, Nerve Growth Factor; Reflex; Spinal Cord | 1999 |
Role of intracellular calcium in thermal allodynia and hyperalgesia in diabetic mice.
Topics: Animals; Calcium; Capsaicin; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain Threshold; Reaction Time; Reflex; Ryanodine; Spinal Cord; Thapsigargin | 1999 |
Intraspinal and behavioral consequences of nerve growth factor-induced nociceptive sprouting and nerve growth factor-induced hyperalgesia compared in adult rats.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Hyperalgesia; Muscles; Nerve Growth Factors; Neuronal Plasticity; Nociceptors; Peripheral Nerves; Proto-Oncogene Proteins c-fos; Rats; Reflex; Skin; Spinal Cord | 1999 |
Effects of combined hemotoxic and anterolateral spinal lesions on nociceptive sensitivity.
Topics: Animals; Conditioning, Operant; Cordotomy; Electric Stimulation; Escape Reaction; Female; Hemorrhage; Hindlimb; Hyperalgesia; Pain Measurement; Rats; Rats, Long-Evans; Reflex; Spinal Cord Diseases; Vocalization, Animal | 1999 |
Modulatory roles of the adenosine triphosphate P2x-purinoceptor in generation of the persistent nociception induced by subcutaneous bee venom injection in the conscious rat.
Topics: Adenosine Triphosphate; Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Injections, Subcutaneous; Nociceptors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Reflex; Spinal Cord | 2000 |
Differential effects of MK-801, a N-methyl-D-aspartate non-competitive antagonist, on the dorsal horn neuron hyperactivity and hyperexcitability in neuropathic rats.
Topics: Animals; Dizocilpine Maleate; Hot Temperature; Hyperalgesia; Male; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Sciatic Neuropathy | 2000 |
Contralateral heat hyperalgesia induced by unilaterally intraplantar bee venom injection is produced by central changes: a behavioral study in the conscious rat.
Topics: Animals; Bee Venoms; Female; Foot; Functional Laterality; Hyperalgesia; Hyperthermia, Induced; Male; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord | 2000 |
Involvement of spinal protein kinase C in induction and maintenance of both persistent spontaneous flinching reflex and contralateral heat hyperalgesia induced by subcutaneous bee venom in the conscious rat.
Topics: Animals; Bee Venoms; Behavior, Animal; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Nociceptors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord | 2000 |
Cellular mechanisms of hyperalgesia and spontaneous pain in a spinalized rat model of peripheral neuropathy: changes in myelinated afferent inputs implicated.
Topics: Action Potentials; Animals; Chronic Disease; Electrophysiology; Hindlimb; Hot Temperature; Hyperalgesia; Male; Nerve Fibers, Myelinated; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Posterior Horn Cells; Pressure; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve | 2000 |
The capsaicin analogue SDZ249-665 attenuates the hyper-reflexia and referred hyperalgesia associated with inflammation of the rat urinary bladder.
Topics: Algorithms; Analgesics; Animals; Capsaicin; Cystitis; Dose-Response Relationship, Drug; Hyperalgesia; Male; Rats; Rats, Wistar; Reflex; Time Factors; Turpentine; Urea; Urination | 2001 |
Endogenous galanin potentiates spinal nociceptive processing following inflammation.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Female; Galanin; Hyperalgesia; Male; Mice; Mice, Knockout; Myelitis; Pain Measurement; Posterior Horn Cells; Reflex | 2001 |
Effects of intrathecal c-fos antisense oligodeoxynucleotide on adjuvant-induced thermal hyperalgesia.
Topics: Animals; Behavior, Animal; Freund's Adjuvant; Gene Expression; Hyperalgesia; Injections, Spinal; Male; Nociceptors; Oligodeoxyribonucleotides, Antisense; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex | 2001 |
Regulation of acute nociceptive responses by the NMDA receptor GluRepsilon2 subunit.
Topics: Acute Disease; Animals; Central Nervous System; Electric Stimulation; Female; Glutamic Acid; Heterozygote; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reflex; Synaptic Transmission | 2001 |
Vasodilatation in hyperalgesic rat skin evoked by stimulation of afferent A beta-fibers: further evidence for a role of dorsal root reflexes in allodynia.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Electric Stimulation; Female; Hyperalgesia; Miotics; Mustard Plant; Nerve Fibers, Myelinated; Peptide Fragments; Plant Extracts; Plant Oils; Rats; Rats, Wistar; Reflex; Regional Blood Flow; Rhizotomy; Skin; Spinal Nerve Roots; Sural Nerve; Vasodilation | 2001 |
A role of the ubiquitin-proteasome system in neuropathic pain.
Topics: Action Potentials; Animals; Behavior, Animal; Cysteine Endopeptidases; Disease Models, Animal; Electrophysiology; Enzyme Inhibitors; Hyperalgesia; In Situ Hybridization; Injections, Spinal; Iontophoresis; Ligation; Male; Multienzyme Complexes; Pain; Pain Measurement; Posterior Horn Cells; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Reflex; RNA, Messenger; Sciatic Neuropathy; Thiolester Hydrolases; Ubiquitin; Ubiquitin Thiolesterase | 2002 |
Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline.
Topics: 2-Amino-5-phosphonovalerate; Acids; Animals; Drug Administration Schedule; Drug Combinations; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Intramuscular; Male; Motor Activity; Muscle, Skeletal; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reflex; Sodium Chloride | 2002 |
Serotonin is a directly-acting hyperalgesic agent in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hyperalgesia; Indomethacin; Male; Nociceptors; Oxidopamine; Pain; Quinoxalines; Rats; Rats, Inbred Strains; Reflex; Sensory Thresholds; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
Site-specific sensitization of defensive reflexes in Aplysia: a simple model of long-term hyperalgesia.
Topics: Animals; Aplysia; Conditioning, Classical; Denervation; Electric Stimulation; Hyperalgesia; Memory; Physical Stimulation; Reflex; Stereotyped Behavior; Tail | 1987 |