pioglitazone has been researched along with Allodynia in 18 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify the role of peroxisome proliferator activated receptor gamma (PPARgamma) in neuropathic pain, we examined the effect of pioglitazone, a PPARgamma agonist, on tactile allodynia and thermal hyperalgesia in a neuropathic pain model." | 7.74 | Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury. ( Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T; Ozaki, M, 2008) |
| " 2) Systemic administration of a PPARγ agonist, pioglitazone (PIO), attenuates whisker pad mechanical allodynia at doses of 300 mg/kg i." | 3.85 | PPARγ Agonists Attenuate Trigeminal Neuropathic Pain. ( Danaher, RJ; Lyons, DN; Miller, CS; Westlund, KN; Zhang, L, 2017) |
| "Co-administration of pioglitazone or metformin with low-dose fluoxetine improved mechanical allodynia, thermal hyperalgesia, and neurohistopathological changes while co-administration of pioglitazone, but not metformin, improved the depressive-like behavior in the peripheral nerve injury model of neuropathic pain in rats." | 3.81 | Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats. ( Ayuob, N; Murad, H, 2015) |
| "To clarify the role of peroxisome proliferator activated receptor gamma (PPARgamma) in neuropathic pain, we examined the effect of pioglitazone, a PPARgamma agonist, on tactile allodynia and thermal hyperalgesia in a neuropathic pain model." | 3.74 | Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury. ( Kiguchi, N; Kishioka, S; Kobayashi, Y; Maeda, T; Ozaki, M, 2008) |
| "First, employing neuropathic pain models with chronic duration is critical since they can encompass the continuum of molecular and brain circuitry alterations arising over time when pain persists, providing greater relevance to clinical pain syndromes." | 2.66 | Building and Testing PPARγ Therapeutic ELB00824 with an Improved Therapeutic Window for Neuropathic Pain. ( Westlund, KN; Zhang, M, 2020) |
| "The duration of mechanical allodynia in male rats was shortened by intracisternal administration of minocycline." | 1.72 | Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats. ( Hayashi, Y; Hitomi, S; Iwata, K; Otsuji, J; Shibuta, I; Shinoda, M; Shirakawa, T; Soma, C; Soma, K, 2022) |
| "Rats were tested for thermal hyperalgesia and mechanical allodynia." | 1.56 | Neuroprotective effects of ranolazine versus pioglitazone in experimental diabetic neuropathy: Targeting Nav1.7 channels and PPAR-γ. ( El-Gawly, HW; El-Sherbeeny, NA; Elaidy, SM; Elkholy, SE; Toraih, EA, 2020) |
| "Cisplatin produced mechanical and cold hyperalgesia and decreased electrical thresholds of Aδ and C fibers, which were attenuated by coadministration of pioglitazone (10 mg/kg, intraperitoneally [i." | 1.51 | Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress. ( Albino-Ramírez, AM; Khasabov, SG; Khasabova, IA; Kim, AH; Olson, JK; Seybold, VS; Simone, DA; Uhelski, ML; Wagner, CL, 2019) |
| " Therefore, we tested the hypothesis that chronic administration of pioglitazone would reduce PDN in Zucker Diabetic Fatty (ZDF(fa/fa) [ZDF]) rats." | 1.43 | Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes. ( Adkins, BG; Anderson, KL; Donahue, RR; Griggs, RB; Taylor, BK; Thibault, O, 2016) |
| "Pioglitazone inhibited hyperalgesia within 5 minutes of injection, consistent with a nongenomic mechanism." | 1.42 | Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms. ( Donahue, RR; Grace, PM; Griggs, RB; Morgenweck, J; Sutton, A; Taylor, BK; Watkins, LR, 2015) |
| "Pioglitazone or vehicle was administered 1h before operation and continued daily to day 14 after operation." | 1.39 | Spinal neuroimmune activation inhibited by repeated administration of pioglitazone in rats after L5 spinal nerve transection. ( Ji, Q; Jia, HB; Liu, XY; Qiu, LL; Shen, JC; Wang, XM; Yang, JJ, 2013) |
| "Mechanical hyperalgesia was measured using Von-Frey filament tests before and after the surgery." | 1.36 | Repeated administration of pioglitazone attenuates development of hyperalgesia in a rat model of neuropathic pain. ( Duan, M; Hui, K; Ji, Q; Jia, H; Li, W; Xu, J; Zhu, S, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 6 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Santos, DFS | 1 |
| Donahue, RR | 4 |
| Laird, DE | 1 |
| Oliveira, MCG | 1 |
| Taylor, BK | 4 |
| Bian, J | 1 |
| Zhang, B | 1 |
| Zhang, Y | 1 |
| Tian, Y | 1 |
| Yin, L | 1 |
| Zou, W | 1 |
| Otsuji, J | 1 |
| Hayashi, Y | 1 |
| Hitomi, S | 1 |
| Soma, C | 1 |
| Soma, K | 1 |
| Shibuta, I | 1 |
| Iwata, K | 1 |
| Shirakawa, T | 1 |
| Shinoda, M | 1 |
| Huang, Y | 1 |
| Wang, C | 1 |
| Tian, X | 1 |
| Mao, Y | 1 |
| Hou, B | 1 |
| Sun, Y | 1 |
| Gu, X | 1 |
| Ma, Z | 1 |
| Westlund, KN | 3 |
| Zhang, M | 1 |
| Elkholy, SE | 1 |
| Elaidy, SM | 1 |
| El-Sherbeeny, NA | 1 |
| Toraih, EA | 1 |
| El-Gawly, HW | 1 |
| Lyons, DN | 2 |
| Zhang, L | 2 |
| Danaher, RJ | 2 |
| Miller, CS | 2 |
| Pandya, JD | 1 |
| Ma, F | 1 |
| Sullivan, PG | 1 |
| Sirbu, C | 1 |
| Khasabova, IA | 1 |
| Khasabov, SG | 1 |
| Olson, JK | 1 |
| Uhelski, ML | 1 |
| Kim, AH | 1 |
| Albino-Ramírez, AM | 1 |
| Wagner, CL | 1 |
| Seybold, VS | 1 |
| Simone, DA | 1 |
| Nozu, T | 1 |
| Miyagishi, S | 1 |
| Nozu, R | 1 |
| Takakusaki, K | 1 |
| Okumura, T | 1 |
| Morgenweck, J | 2 |
| Griggs, RB | 3 |
| Zadina, JE | 1 |
| Jia, HB | 1 |
| Wang, XM | 1 |
| Qiu, LL | 1 |
| Liu, XY | 1 |
| Shen, JC | 1 |
| Ji, Q | 2 |
| Yang, JJ | 1 |
| Jin, HY | 1 |
| Lee, KA | 1 |
| Wu, JZ | 1 |
| Baek, HS | 1 |
| Park, TS | 1 |
| Grace, PM | 1 |
| Sutton, A | 1 |
| Watkins, LR | 1 |
| Murad, H | 1 |
| Ayuob, N | 1 |
| Adkins, BG | 1 |
| Anderson, KL | 1 |
| Thibault, O | 1 |
| Maeda, T | 1 |
| Kiguchi, N | 1 |
| Kobayashi, Y | 1 |
| Ozaki, M | 1 |
| Kishioka, S | 1 |
| Jia, H | 1 |
| Zhu, S | 1 |
| Hui, K | 1 |
| Duan, M | 1 |
| Xu, J | 1 |
| Li, W | 1 |
1 review available for pioglitazone and Allodynia
| Article | Year |
|---|---|
Building and Testing PPARγ Therapeutic ELB00824 with an Improved Therapeutic Window for Neuropathic Pain.
Topics: Animals; Humans; Hyperalgesia; Mice; Neuralgia; Pioglitazone; PPAR gamma; Rats; Rosiglitazone; Thiaz | 2020 |
17 other studies available for pioglitazone and Allodynia
| Article | Year |
|---|---|
The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful diabetic neuropathy.
Topics: Analgesics; Animals; Diabetic Neuropathies; Disease Models, Animal; Female; Hyperalgesia; Male; Mice | 2022 |
FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain via PPAR-γ/NF-κB Signaling.
Topics: Analgesics; Animals; Fibroblast Growth Factor 10; Hyperalgesia; Lipopolysaccharides; Neuralgia; NF-k | 2022 |
Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats.
Topics: Animals; Female; Hyperalgesia; Male; Minocycline; Pioglitazone; PPAR gamma; Rats; Rats, Sprague-Dawl | 2022 |
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Topics: Animals; Colitis; Hyperalgesia; Hypoglycemic Agents; Inflammation Mediators; Intestinal Mucosa; Male | 2020 |
Neuroprotective effects of ranolazine versus pioglitazone in experimental diabetic neuropathy: Targeting Nav1.7 channels and PPAR-γ.
Topics: Animals; Behavior, Animal; Comorbidity; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet | 2020 |
PPARγ Agonists Attenuate Trigeminal Neuropathic Pain.
Topics: Analgesics, Non-Narcotic; Anilides; Animals; Disease Models, Animal; Facial Pain; Hyperalgesia; Male | 2017 |
Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Brain; Chronic Pain; Cognition; Cycloserine; Dise | 2018 |
Pioglitazone, a PPARγ agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cisplatin; Disease Models, Animal; Female; Ganglia, | 2019 |
Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome.
Topics: Animals; Colon; Disease Models, Animal; Hyperalgesia; Hypoglycemic Agents; Irritable Bowel Syndrome; | 2019 |
PPARγ activation blocks development and reduces established neuropathic pain in rats.
Topics: Anilides; Animals; Ataxia; CD11b Antigen; Dose-Response Relationship, Drug; Drug Administration Sche | 2013 |
Spinal neuroimmune activation inhibited by repeated administration of pioglitazone in rats after L5 spinal nerve transection.
Topics: Animals; Cytokines; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Neuralgia; Neuroimmunomodul | 2013 |
The neuroprotective benefit from pioglitazone (PIO) addition on the alpha lipoic acid (ALA)-based treatment in experimental diabetic rats.
Topics: Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, | 2014 |
Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms.
Topics: Analysis of Variance; Animal Diseases; Animals; Area Under Curve; Astrocytes; Capsaicin; Glial Fibri | 2015 |
Co-Administration of Pioglitazone Improves Fluoxetine's Antinociceptive, Neuroprotective, and Antidepressant Effects in Chronic Constriction Injury in Rats.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Chronic Pain; Constriction, Pathologi | 2015 |
Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes.
Topics: Administration, Oral; Analgesics; Animals; Central Nervous System Sensitization; Cold Temperature; D | 2016 |
Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.
Topics: Adipocytes; Analgesics; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2008 |
Repeated administration of pioglitazone attenuates development of hyperalgesia in a rat model of neuropathic pain.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Hyperalgesia; Interleukin-1beta; Male; Neuralgia; | 2010 |