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phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Allodynia

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide has been researched along with Allodynia in 15 studies

phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide: cyclic somatostatin octapeptide analog with high affinity & selectivity toward mu opioid receptors

Research Excerpts

ExcerptRelevanceReference
" Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model."7.77The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011)
" Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect of electroacupuncture (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model."3.77The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy. ( Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y, 2011)
"We tested the hypothesis that chronic pain development (pain chronification) and ongoing chronic pain (chronic pain) reduce the activity and induce plastic changes in an endogenous analgesia circuit, the ascending nociceptive control."1.42Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats. ( Athie, M; Dias, EV; Lamana, SM; Miranda, J; Parada, CA; Tambeli, CH, 2015)
"This also reversed hyperalgesia in behaving animals."1.38Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration. ( Benrath, J; Drdla-Schutting, R; Sandkühler, J; Wunderbaldinger, G, 2012)
"Our experiments show that acute thermal hyperalgesia is blocked in periaqueductal gray with the microOR antagonist CTOP, the NMDA antagonist MK801 and the protein kinase C inhibitor chelerythrine."1.35Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception. ( Bianchi, E; Galeotti, N; Ghelardini, C; Guarna, M; Norcini, M; Stefano, GB; Vivoli, E; Zhu, W, 2008)
"However, OFQ dose-dependently produced hyperalgesia in rats pretreated with naloxone, implying that OFQ can indeed produce hyperalgesia once an endogenous opioidergic tone is inhibited."1.31Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test. ( Lutfy, K; Maidment, NT, 2000)
"To determine whether 1DMe could correct hyperalgesia and restore morphine efficacy in mononeuropathic (MN) and diabetic (D) rats we examined the spinal effect of 1DMe in MN and D rats without and after spinal blockade of mu- and delta-opioid receptors with CTOP and naltrindole, respectively."1.30Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats. ( Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM, 1999)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (13.33)18.2507
2000's5 (33.33)29.6817
2010's6 (40.00)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Gonçalves Dos Santos, G1
Vieira, WF1
Vendramini, PH1
Bassani da Silva, B1
Fernandes Magalhães, S1
Tambeli, CH2
Parada, CA2
Custodio-Patsey, L1
Donahue, RR1
Fu, W1
Lambert, J1
Smith, BN1
Taylor, BK1
Kwok, CHT1
Devonshire, IM1
Bennett, AJ1
Hathway, GJ1
Miranda, J1
Lamana, SM1
Dias, EV1
Athie, M1
Bianchi, E2
Norcini, M2
Smrcka, A1
Ghelardini, C2
Zhang, Y2
Meng, X2
Li, A2
Xin, J2
Berman, BM2
Lao, L2
Tan, M2
Ren, K2
Zhang, RX2
Heinl, C1
Drdla-Schutting, R2
Xanthos, DN1
Sandkühler, J2
Benrath, J1
Wunderbaldinger, G1
Back, SK1
Lee, J1
Hong, SK1
Na, HS1
Galeotti, N1
Vivoli, E1
Zhu, W1
Stefano, GB1
Guarna, M1
Gendron, L1
Pintar, JE1
Chavkin, C1
Hao, JX1
Yu, W1
Xu, XJ1
Courteix, C1
Coudoré-Civiale, MA1
Privat, AM1
Zajac, JM1
Eschalier, A1
Fialip, J1
Lutfy, K1
Maidment, NT1

Other Studies

15 other studies available for phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide and Allodynia

ArticleYear
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
    European journal of pharmacology, 2020, May-05, Volume: 874

    Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalges

2020
Sex differences in kappa opioid receptor inhibition of latent postoperative pain sensitization in dorsal horn.
    Neuropharmacology, 2020, Volume: 163

    Topics: Animals; Benzamides; Extracellular Signal-Regulated MAP Kinases; Female; Hyperalgesia; Male; Mice, I

2020
Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat.
    Pain, 2014, Volume: 155, Issue:1

    Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Enkephalin, Ala(2)

2014
Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats.
    Neuroscience, 2015, Feb-12, Volume: 286

    Topics: Analgesics; Animals; Capsaicin; Chronic Pain; Dinoprostone; Hyperalgesia; Male; Nociception; Nucleus

2015
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia.
    Journal of neurochemistry, 2009, Volume: 111, Issue:1

    Topics: Animals; Cyclohexanes; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Explor

2009
Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Affect; Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Electroacupunc

2011
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
    Brain research, 2011, Sep-26, Volume: 1414

    Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacu

2011
Distinct mechanisms underlying pronociceptive effects of opioids.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela

2011
Erasure of a spinal memory trace of pain by a brief, high-dose opioid administration.
    Science (New York, N.Y.), 2012, Jan-13, Volume: 335, Issue:6065

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Evoked Potentials; Hyperalgesia; Long-Term Potentiat

2012
Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Axotomy; Disease Models, Animal; Hyperalgesia; Injections, Intraperito

2006
Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.
    Journal of neurochemistry, 2008, Volume: 105, Issue:1

    Topics: Alkaloids; Analysis of Variance; Animals; Behavior, Animal; Benzophenanthridines; Dizocilpine Maleat

2008
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
    Neuroscience, 2007, Dec-19, Volume: 150, Issue:4

    Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvan

2007
Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.
    Experimental brain research, 1998, Volume: 118, Issue:2

    Topics: Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Female; Hyperalgesia; Injections, Spin

1998
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
    British journal of pharmacology, 1999, Volume: 127, Issue:6

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimenta

1999
Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Injections, Intrav

2000