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sulpiride and Allodynia

sulpiride has been researched along with Allodynia in 10 studies

Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Research Excerpts

ExcerptRelevanceReference
"Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models."7.91Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019)
"Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist."5.46Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017)
"Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)."5.28L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992)
"Metformin attenuated the visceral allodynia and increased gut permeability in animal IBS models."3.91Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats. ( Kumei, S; Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019)
"The visceral pain was assessed by electrophysiologically measuring the threshold of abdominal muscle contractions in response to colonic distention."1.51Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome. ( Miyagishi, S; Nozu, R; Nozu, T; Okumura, T; Takakusaki, K, 2019)
"Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist."1.46Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017)
"Levodopa has been shown to produce analgesia in various clinical and experimental settings, but its use for chronic pain treatment has not been established."1.36Levodopa analgesia in experimental neuropathic pain. ( Cobacho, N; De la Calle, JL; González-Escalada, JR; Paíno, CL, 2010)
" Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception."1.33Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006)
"This hyperalgesia was antagonized by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801, suggesting involvement of NMDA receptors."1.29Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats. ( Paalzow, GH, 1994)
"Moreover, profound hyperalgesia is revealed by either dopamine (DA) D1 and D2 receptor blockade by means of SCH 23390 [R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetra-hydro-1H- 3-benzazepine hydrochloride] or (-)-sulpiride, respectively, as well as after a reduction of the presynaptic synthesis of catecholamines after pretreatment of the animals with the tyrosine hydroxylase inhibitor alpha-methyl-DL-p-tyrosine (alpha-MPT)."1.28L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. ( Paalzow, GH, 1992)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nozu, T2
Miyagishi, S2
Nozu, R2
Takakusaki, K2
Okumura, T2
Chen, M1
Hoshino, H1
Saito, S1
Yang, Y1
Obata, H1
Espinosa-Juárez, JV1
Jaramillo-Morales, OA1
López-Muñoz, FJ1
Kumei, S1
Kim, JY1
Tillu, DV1
Quinn, TL1
Mejia, GL1
Shy, A1
Asiedu, MN1
Murad, E1
Schumann, AP1
Totsch, SK1
Sorge, RE1
Mantyh, PW1
Dussor, G1
Price, TJ1
Cobacho, N1
De la Calle, JL1
González-Escalada, JR1
Paíno, CL1
Barchini, J1
Tchachaghian, S1
Shamaa, F1
Jabbur, SJ1
Meyerson, BA1
Song, Z1
Linderoth, B1
Saadé, NE1
Pelissier, T1
Laurido, C1
Hernandez, A1
Constandil, L1
Eschalier, A1
Paalzow, GH2

Other Studies

10 other studies available for sulpiride and Allodynia

ArticleYear
Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome.
    Scientific reports, 2019, 12-20, Volume: 9, Issue:1

    Topics: Animals; Butyrates; Colon; Disease Models, Animal; Electrodes; Hyperalgesia; Inflammation; Irritable

2019
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
    Neuroscience letters, 2017, 05-10, Volume: 649

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do

2017
Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6

    Topics: Amines; Analgesics; Animals; Antipsychotic Agents; Chronic Disease; Constriction, Pathologic; Cycloh

2017
Metformin inhibits visceral allodynia and increased gut permeability induced by stress in rats.
    Journal of gastroenterology and hepatology, 2019, Volume: 34, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Colon; Disease Models, Animal; Domperidone; Dopamine Antagon

2019
Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Apr-22, Volume: 35, Issue:16

    Topics: Animals; Benzazepines; Carrageenan; Dinoprostone; Dopaminergic Neurons; Hyperalgesia; Interleukin-6;

2015
Levodopa analgesia in experimental neuropathic pain.
    Brain research bulletin, 2010, Nov-20, Volume: 83, Issue:6

    Topics: Analgesics; Animals; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug;

2010
Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.
    Neuroscience, 2012, Jul-26, Volume: 215

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Baclofen;

2012
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
    European journal of pharmacology, 2006, Sep-28, Volume: 546, Issue:1-3

    Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2

2006
Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.
    European journal of pharmacology, 1994, Jan-24, Volume: 252, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-Agonists; Adrenergic alpha-Antagonist

1994
L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2

    Topics: Analgesics; Animals; Benzazepines; Catecholamines; Drug Interactions; Electric Stimulation; Hyperalg

1992