Page last updated: 2024-11-02

fenclonine and Allodynia

fenclonine has been researched along with Allodynia in 11 studies

Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.

Research Excerpts

ExcerptRelevanceReference
"Mechanical and thermal hyperalgesia were reduced significantly with enriched diet and/or companionship."1.62Diet and companionship modulate pain via a serotonergic mechanism. ( Badgaiyan, RD; Gupta, K; Jarrett, S; Palzer, EF; Sagi, V; Tran, H, 2021)
"Therapeutic potential of agomelatine on neuropathic pain was suppressed with α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis), phentolamine (a nonselective α-adrenoceptor antagonist), and propranolol (a nonselective β-adrenoceptor antagonist) administrations."1.43Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. ( Aydın, TH; Can, ÖD; Demir Özkay, Ü; Turan, N, 2016)
"The behavioral signs of cold allodynia in Sprague-Dawley (SD) rats were induced by a single injection of oxaliplatin (6 mg/kg, i."1.40Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats. ( Go, D; Kim, SK; Lee, JH; Li, DX; Min, BI; Quan, FS; Yoon, H, 2014)
"The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine."1.39Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013)
"Wild-type mice reproducibly developed thermal hyperalgesia and paw edema for 5 days after CFA injection."1.375-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice. ( Chen, Y; Gerlach, M; Lesch, KP; Moessner, R; Palm, F; Sommer, C, 2011)
"Prolonged hyperalgesia was induced by OVX, and the antinociceptive effect of ECT was proved because peripherally and repeatedly administered ECT improved hyperalgesia."1.31Analgesic mechanism of calcitonin. ( Yoshimura, M, 2000)
"To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied."1.28Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's7 (63.64)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Tran, H1
Sagi, V1
Jarrett, S1
Palzer, EF1
Badgaiyan, RD1
Gupta, K1
Lee, JH1
Li, DX1
Yoon, H1
Go, D1
Quan, FS1
Min, BI1
Kim, SK2
Martins, DF2
Emer, AA1
Batisti, AP1
Donatello, N1
Carlesso, MG1
Mazzardo-Martins, L2
Venzke, D1
Micke, GA1
Pizzolatti, MG1
Piovezan, AP1
dos Santos, AR1
Aydın, TH1
Can, ÖD1
Demir Özkay, Ü1
Turan, N1
Takayama, B1
Kikuchi, S1
Konno, S1
Sekiguchi, M1
Qin, HY1
Luo, JL1
Qi, SD1
Xu, HX1
Sung, JJ1
Bian, ZX1
Chen, Y1
Palm, F1
Lesch, KP1
Gerlach, M1
Moessner, R1
Sommer, C1
Eto, K1
Nabekura, J1
Ishibashi, H1
Cidral-Filho, FJ1
Stramosk, J1
Santos, AR1
Yoshimura, M1
Ohara, H1
Kawamura, M1
Namimatsu, A1
Miura, T1
Yoneda, R1
Hata, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Atlas Cedarwood Essential Oil Aromatherapy on Sleep Quality Among Patients With Coronary Heart Disease: a Randomized Controlled Trial[NCT03830554]96 participants (Actual)Interventional2018-07-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

11 other studies available for fenclonine and Allodynia

ArticleYear
Diet and companionship modulate pain via a serotonergic mechanism.
    Scientific reports, 2021, 02-01, Volume: 11, Issue:1

    Topics: Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chronic Pain; Diet; Disease Models, Animal; Duloxe

2021
Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.
    BMC complementary and alternative medicine, 2014, Dec-06, Volume: 14

    Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Apitherapy; Bee Venoms; Cold Temperature; Fenclo

2014
Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.
    Journal of ethnopharmacology, 2015, Dec-04, Volume: 175

    Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Analgesic

2015
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms.
    Fundamental & clinical pharmacology, 2016, Volume: 30, Issue:6

    Topics: Acetamides; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetic Neurop

2016
An immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized rats.
    BMC musculoskeletal disorders, 2008, Dec-15, Volume: 9

    Topics: Analgesics; Animals; Biomarkers; Calcitonin; Central Nervous System; Disease Models, Animal; Female;

2008
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
    European journal of pharmacology, 2010, Nov-25, Volume: 647, Issue:1-3

    Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain;

2010
5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice.
    Molecular pain, 2011, Mar-30, Volume: 7

    Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Fenclonine; Freund's Adjuvant; Hydr

2011
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
    Brain research, 2011, Sep-26, Volume: 1414

    Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship,

2011
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
    Physical therapy, 2013, Volume: 93, Issue:3

    Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal;

2013
Analgesic mechanism of calcitonin.
    Journal of bone and mineral metabolism, 2000, Volume: 18, Issue:4

    Topics: Analgesics; Animals; Calcitonin; Disease Models, Animal; Female; Fenclonine; Hyperalgesia; Models, B

2000
Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Drug Interactions; Fenclonine; Haloperidol; Hyperalg

1991