fenclonine has been researched along with Allodynia in 11 studies
Fenclonine: A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical and thermal hyperalgesia were reduced significantly with enriched diet and/or companionship." | 1.62 | Diet and companionship modulate pain via a serotonergic mechanism. ( Badgaiyan, RD; Gupta, K; Jarrett, S; Palzer, EF; Sagi, V; Tran, H, 2021) |
| "Therapeutic potential of agomelatine on neuropathic pain was suppressed with α-methyl-para-tyrosine methyl ester (an inhibitor of catecholamine synthesis), phentolamine (a nonselective α-adrenoceptor antagonist), and propranolol (a nonselective β-adrenoceptor antagonist) administrations." | 1.43 | Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. ( Aydın, TH; Can, ÖD; Demir Özkay, Ü; Turan, N, 2016) |
| "The behavioral signs of cold allodynia in Sprague-Dawley (SD) rats were induced by a single injection of oxaliplatin (6 mg/kg, i." | 1.40 | Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats. ( Go, D; Kim, SK; Lee, JH; Li, DX; Min, BI; Quan, FS; Yoon, H, 2014) |
| "The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine." | 1.39 | Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors. ( Cidral-Filho, FJ; Martins, DF; Mazzardo-Martins, L; Santos, AR; Stramosk, J, 2013) |
| "Wild-type mice reproducibly developed thermal hyperalgesia and paw edema for 5 days after CFA injection." | 1.37 | 5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice. ( Chen, Y; Gerlach, M; Lesch, KP; Moessner, R; Palm, F; Sommer, C, 2011) |
| "Prolonged hyperalgesia was induced by OVX, and the antinociceptive effect of ECT was proved because peripherally and repeatedly administered ECT improved hyperalgesia." | 1.31 | Analgesic mechanism of calcitonin. ( Yoshimura, M, 2000) |
| "To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied." | 1.28 | Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Tran, H | 1 |
| Sagi, V | 1 |
| Jarrett, S | 1 |
| Palzer, EF | 1 |
| Badgaiyan, RD | 1 |
| Gupta, K | 1 |
| Lee, JH | 1 |
| Li, DX | 1 |
| Yoon, H | 1 |
| Go, D | 1 |
| Quan, FS | 1 |
| Min, BI | 1 |
| Kim, SK | 2 |
| Martins, DF | 2 |
| Emer, AA | 1 |
| Batisti, AP | 1 |
| Donatello, N | 1 |
| Carlesso, MG | 1 |
| Mazzardo-Martins, L | 2 |
| Venzke, D | 1 |
| Micke, GA | 1 |
| Pizzolatti, MG | 1 |
| Piovezan, AP | 1 |
| dos Santos, AR | 1 |
| Aydın, TH | 1 |
| Can, ÖD | 1 |
| Demir Özkay, Ü | 1 |
| Turan, N | 1 |
| Takayama, B | 1 |
| Kikuchi, S | 1 |
| Konno, S | 1 |
| Sekiguchi, M | 1 |
| Qin, HY | 1 |
| Luo, JL | 1 |
| Qi, SD | 1 |
| Xu, HX | 1 |
| Sung, JJ | 1 |
| Bian, ZX | 1 |
| Chen, Y | 1 |
| Palm, F | 1 |
| Lesch, KP | 1 |
| Gerlach, M | 1 |
| Moessner, R | 1 |
| Sommer, C | 1 |
| Eto, K | 1 |
| Nabekura, J | 1 |
| Ishibashi, H | 1 |
| Cidral-Filho, FJ | 1 |
| Stramosk, J | 1 |
| Santos, AR | 1 |
| Yoshimura, M | 1 |
| Ohara, H | 1 |
| Kawamura, M | 1 |
| Namimatsu, A | 1 |
| Miura, T | 1 |
| Yoneda, R | 1 |
| Hata, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Atlas Cedarwood Essential Oil Aromatherapy on Sleep Quality Among Patients With Coronary Heart Disease: a Randomized Controlled Trial[NCT03830554] | 96 participants (Actual) | Interventional | 2018-07-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for fenclonine and Allodynia
| Article | Year |
|---|---|
Diet and companionship modulate pain via a serotonergic mechanism.
Topics: Analgesics, Opioid; Anemia, Sickle Cell; Animals; Chronic Pain; Diet; Disease Models, Animal; Duloxe | 2021 |
Serotonergic mechanism of the relieving effect of bee venom acupuncture on oxaliplatin-induced neuropathic cold allodynia in rats.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Apitherapy; Bee Venoms; Cold Temperature; Fenclo | 2014 |
Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain.
Topics: Administration, Inhalation; Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Analgesic | 2015 |
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms.
Topics: Acetamides; Animals; Blood Glucose; Catecholamines; Diabetes Mellitus, Experimental; Diabetic Neurop | 2016 |
An immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized rats.
Topics: Analgesics; Animals; Biomarkers; Calcitonin; Central Nervous System; Disease Models, Animal; Female; | 2008 |
Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon.
Topics: Animals; Capsaicin; Colon; Fenclonine; Ganglia, Spinal; Hyperalgesia; Hypersensitivity; Male; Pain; | 2010 |
5-hydroxyindolacetic acid (5-HIAA), a main metabolite of serotonin, is responsible for complete Freund's adjuvant-induced thermal hyperalgesia in mice.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Fenclonine; Freund's Adjuvant; Hydr | 2011 |
Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain.
Topics: Adrenergic Agents; Animals; Biogenic Monoamines; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Ankle joint mobilization affects postoperative pain through peripheral and central adenosine A1 receptors.
Topics: Adenosine; Analysis of Variance; Animals; Ankle Joint; Caffeine; Clonidine; Disease Models, Animal; | 2013 |
Analgesic mechanism of calcitonin.
Topics: Analgesics; Animals; Calcitonin; Disease Models, Animal; Female; Fenclonine; Hyperalgesia; Models, B | 2000 |
Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin.
Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Drug Interactions; Fenclonine; Haloperidol; Hyperalg | 1991 |