Page last updated: 2024-11-13

epiisopiloturine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

epiisopiloturine: an antischistosomal agent isolated from Pilocarpus microphyllus; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
PilocarpusgenusA plant genus of the family RUTACEAE that is the natural source of PILOCARPINE.[MeSH]RutaceaeA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID72502163
MeSH IDM0578187

Synonyms (2)

Synonym
epiisopiloturine
2(3h)-furanone, dihydro-3-((s)-hydroxyphenylmethyl)-4-((1-methyl-1h-im idazol-4-yl)methyl)-, (3s,4r)-

Research Excerpts

Overview

Epiisopiloturine is an imidazole alkaloid isolated from the leaves of Pilocarpus microphyllus (Rutaceae), a native plant from Brazil.

ExcerptReferenceRelevance
"Epiisopiloturine (EPI) is an important imidazole alkaloid because of its pharmacological properties. "( Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
Barbosa, ALDR; da Silva Martins, C; de Aguiar Magalhãres, D; de Brito, TV; de Sousa de Almeida Leite, JR; Fernando Pereira Vasconcelos, D; Guimarães Sousa, S; José Dias Júnior, G; Maria Costa Véras, L; Oliveira Silva, R; Rodolfo Pereira da Silva, F; Rodrigues de Carvalho, L; Santos Martins, D; Simião da C Júnior, J; Soares de Oliveira, J, 2018
)
3.37
"Epiisopiloturine is an imidazole alkaloid isolated from the leaves of Pilocarpus microphyllus (Rutaceae), a native plant from Brazil."( Activity of epiisopiloturine against Schistosoma mansoni.
Batista, MC; Campelo, YD; Guimaraes, MA; Kuckelhaus, SS; Leite, JR; Lima, DF; Moraes, J; Nakano, E; Nascimento, C; Vasconcelos, L; Veras, LM; Vieira, MM, 2012
)
1.48

Bioavailability

ExcerptReferenceRelevance
"SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg."( Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.
Azevedo, RB; de Lima, LI; de Souza de Almeida Leite, JR; Figueiró Longo, JP; Guimarães, MA; Jiang, CS; Mafud, AC; Mascarenhas, YP; Moraes, J; Muehlmann, LA; Py-Daniel, KR, 2018
)
0.7
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's14 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.80 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]