Page last updated: 2024-11-05

thalidomide and Allodynia

thalidomide has been researched along with Allodynia in 18 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs."7.96Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. ( Coppi, E; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Marini, M; Marone, IM; Materazzi, S; Nassini, R; Padilha Dalenogare, D; Souza Monteiro de Araujo, D; Titiz, M; Trevisan, G, 2020)
"Thalidomide has been shown to selectively inhibit TNF-alpha production."5.31Analgesic effect of thalidomide on inflammatory pain. ( Cunha, FQ; Ferreira, SH; Ribeiro, RA; Vale, ML, 2000)
"Targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs."3.96Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. ( Coppi, E; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Marini, M; Marone, IM; Materazzi, S; Nassini, R; Padilha Dalenogare, D; Souza Monteiro de Araujo, D; Titiz, M; Trevisan, G, 2020)
" To this end, we used Zucker diabetic fatty (ZDF) rats to examine the levels of TNFα, IL-1β, and NF-κB in the RVM during the development of neuropathic pain in type 2 diabetes, and evaluated the effects of intra-RVM microinjections of thalidomide on the levels of TNFα, IL-1β, and NF-κB in the RVM and mechanical allodynia and thermal hyperalgesia induced by type 2 diabetes."3.83Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats. ( Gu, K; Guan, J; Liu, J; Ma, P; Song, T; Yang, G; Yang, Y; Zhang, Z; Zhao, J, 2016)
"We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons."1.48Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain. ( Gu, K; Jiang, B; Li, Y; Ma, P; Ma, X; Song, T; Wang, C; Yang, Y; Zhao, J, 2018)
"On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity."1.43Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents. ( Bollini, M; Bruno, AM; Casal, JJ; Lombardo, ME, 2016)
"G-CSF-induced mechanical hyperalgesia was inhibited by systemic and local treatment with etanercept and IL-1 receptor antagonist (IL-1ra) or TNF receptor 1 (TNFR1) deficiency and increased in IL-10 deficient mice."1.42Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10. ( Borghi, SM; Carvalho, TT; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pinho-Ribeiro, FA; Verri, WA, 2015)
"Mechanical hyperalgesia was evaluated every 3 days by von Frey filaments and depressive-like behavior was assessed at the end of day 15, using the tail suspension test (TST) and the forced swimming test (FST)."1.42Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice. ( Borges, FR; Cremonese, RP; da Silva, MD; Luiz-Cerutti, M; Macedo-Júnior, SJ; Martins, DF; Nascimento, FP; Rodrigues, AL; Santos, AR, 2015)
"The management of patients with neuropathic pain is challenging."1.42Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide. ( Gu, K; Guan, J; Ma, P; Ma, X; Qi, Y; Song, T; Wang, C; Wang, H; Wang, W; Ya, J; Yan, R; Yang, L; Yang, Y; Zhao, J, 2015)
"Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively."1.38Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012)
"Thalidomide was the only treatment that attenuated these increases."1.38The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. ( Andrade, P; Buurman, WA; Daemen, MA; Del Rosario, JS; Hoogland, G; Steinbusch, HW; Visser-Vandewalle, V, 2012)
"Thalidomide has been shown to selectively inhibit TNF-alpha production."1.31Analgesic effect of thalidomide on inflammatory pain. ( Cunha, FQ; Ferreira, SH; Ribeiro, RA; Vale, ML, 2000)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (11.11)18.2507
2000's5 (27.78)29.6817
2010's10 (55.56)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
De Logu, F1
Trevisan, G1
Marone, IM1
Coppi, E1
Padilha Dalenogare, D1
Titiz, M1
Marini, M1
Landini, L1
Souza Monteiro de Araujo, D1
Li Puma, S1
Materazzi, S1
De Siena, G1
Geppetti, P1
Nassini, R1
Song, T4
Ma, X2
Ma, P4
Gu, K4
Zhao, J4
Yang, Y4
Jiang, B1
Li, Y1
Wang, C2
Carvalho, TT1
Borghi, SM1
Pinho-Ribeiro, FA1
Mizokami, SS1
Cunha, TM1
Ferreira, SH3
Cunha, FQ3
Casagrande, R1
Verri, WA1
Nascimento, FP1
Macedo-Júnior, SJ1
Borges, FR1
Cremonese, RP1
da Silva, MD1
Luiz-Cerutti, M1
Martins, DF1
Rodrigues, AL1
Santos, AR1
Wang, W2
Wang, H2
Yang, L1
Yan, R1
Guan, J2
Qi, Y1
Ya, J1
Casal, JJ1
Bollini, M1
Lombardo, ME1
Bruno, AM1
Zhang, Z2
Liu, J2
Yang, G1
Shen, L1
Cata, JP2
Weng, HR2
Dougherty, PM2
Ren, WJ1
Liu, Y1
Zhou, LJ1
Li, W1
Zhong, Y1
Pang, RP1
Xin, WJ2
Wei, XH2
Wang, J1
Zhu, HQ1
Wu, CY2
Qin, ZH1
Liu, G1
Liu, XG2
Taliyan, R1
Sharma, PL1
Andrade, P1
Visser-Vandewalle, V1
Del Rosario, JS1
Daemen, MA1
Buurman, WA1
Steinbusch, HW1
Hoogland, G1
Xu, JT1
Ge, YX1
Liu, YL1
Zang, Y1
Zhang, T1
Li, YY1
Sommer, C1
Marziniak, M1
Myers, RR1
Ribeiro, RA1
Vale, ML1
Youle, M1
Hawkins, D1
Gazzard, B1

Reviews

1 review available for thalidomide and Allodynia

ArticleYear
Peripheral hyperalgesic cytokines.
    Advances in experimental medicine and biology, 2003, Volume: 521

    Topics: Analgesics; Animals; Bradykinin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib

2003

Other Studies

17 other studies available for thalidomide and Allodynia

ArticleYear
Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4.
    BMC biology, 2020, 12-14, Volume: 18, Issue:1

    Topics: Animals; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Pain; Rats; Rats, Sprague-D

2020
Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.
    Journal of neuroscience research, 2018, Volume: 96, Issue:2

    Topics: Analgesics; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists

2018
Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10.
    European journal of pharmacology, 2015, Feb-15, Volume: 749

    Topics: Analgesics, Opioid; Animals; Etanercept; Granulocyte Colony-Stimulating Factor; Hyperalgesia; Immuno

2015
Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice.
    Neuroscience, 2015, Sep-10, Volume: 303

    Topics: Animals; Depression; Hindlimb Suspension; Hyperalgesia; Male; Mice; Nerve Crush; Pain Measurement; P

2015
Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:11

    Topics: Anesthetics, Local; Animals; Cells, Cultured; Cytokines; Delayed-Action Preparations; Graphite; Huma

2015
Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Feb-15, Volume: 83

    Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Carrageenan; Edema; Foot; Hyperalge

2016
Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats.
    Brain research bulletin, 2016, Volume: 125

    Topics: Animals; Blood Glucose; Body Weight; Cytokines; Diabetic Neuropathies; Hyperalgesia; Immunosuppressi

2016
Thalidomide Promotes Morphine Efficacy and Prevents Morphine-Induced Tolerance in Rats with Diabetic Neuropathy.
    Neurochemical research, 2016, Volume: 41, Issue:12

    Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism;

2016
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.
    Brain research, 2008, Sep-10, Volume: 1229

    Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Hyperalgesia; Immunosuppressive Agents; Locomotion

2008
Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-α in rodents.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:5

    Topics: Animals; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocamp

2011
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
    Inflammopharmacology, 2012, Volume: 20, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe

2012
The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain.
    Brain research, 2012, Apr-23, Volume: 1450

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Measurement;

2012
Cyclooxygenase inhibitors and thalidomide ameliorate vincristine-induced hyperalgesia in rats.
    Cancer chemotherapy and pharmacology, 2004, Volume: 54, Issue:5

    Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Hot Temperature; Hyperalgesia; Physical

2004
p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Animals; Denervation; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Hypesthes

2007
The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve.
    Pain, 1998, Volume: 74, Issue:1

    Topics: Analysis of Variance; Animals; Chronic Disease; Constriction; Disease Models, Animal; Female; Hypera

1998
Analgesic effect of thalidomide on inflammatory pain.
    European journal of pharmacology, 2000, Mar-10, Volume: 391, Issue:1-2

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Carrageenan; Edema

2000
Thalidomide in hyperalgic pharyngeal ulceration of AIDS.
    Lancet (London, England), 1990, Jun-30, Volume: 335, Issue:8705

    Topics: Acquired Immunodeficiency Syndrome; Humans; Hyperalgesia; Hyperesthesia; Pharyngeal Diseases; Stomat

1990