thalidomide has been researched along with Allodynia in 18 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs." | 7.96 | Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. ( Coppi, E; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Marini, M; Marone, IM; Materazzi, S; Nassini, R; Padilha Dalenogare, D; Souza Monteiro de Araujo, D; Titiz, M; Trevisan, G, 2020) |
| "Thalidomide has been shown to selectively inhibit TNF-alpha production." | 5.31 | Analgesic effect of thalidomide on inflammatory pain. ( Cunha, FQ; Ferreira, SH; Ribeiro, RA; Vale, ML, 2000) |
| "Targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs." | 3.96 | Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4. ( Coppi, E; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Li Puma, S; Marini, M; Marone, IM; Materazzi, S; Nassini, R; Padilha Dalenogare, D; Souza Monteiro de Araujo, D; Titiz, M; Trevisan, G, 2020) |
| " To this end, we used Zucker diabetic fatty (ZDF) rats to examine the levels of TNFα, IL-1β, and NF-κB in the RVM during the development of neuropathic pain in type 2 diabetes, and evaluated the effects of intra-RVM microinjections of thalidomide on the levels of TNFα, IL-1β, and NF-κB in the RVM and mechanical allodynia and thermal hyperalgesia induced by type 2 diabetes." | 3.83 | Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats. ( Gu, K; Guan, J; Liu, J; Ma, P; Song, T; Yang, G; Yang, Y; Zhang, Z; Zhao, J, 2016) |
| "We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons." | 1.48 | Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain. ( Gu, K; Jiang, B; Li, Y; Ma, P; Ma, X; Song, T; Wang, C; Yang, Y; Zhao, J, 2018) |
| "On rat paw edema and hyperalgesia assays, compound 9, (1,4-phthalazinedione) demonstrated the highest in vivo anti-inflammatory activity." | 1.43 | Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents. ( Bollini, M; Bruno, AM; Casal, JJ; Lombardo, ME, 2016) |
| "G-CSF-induced mechanical hyperalgesia was inhibited by systemic and local treatment with etanercept and IL-1 receptor antagonist (IL-1ra) or TNF receptor 1 (TNFR1) deficiency and increased in IL-10 deficient mice." | 1.42 | Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10. ( Borghi, SM; Carvalho, TT; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Pinho-Ribeiro, FA; Verri, WA, 2015) |
| "Mechanical hyperalgesia was evaluated every 3 days by von Frey filaments and depressive-like behavior was assessed at the end of day 15, using the tail suspension test (TST) and the forced swimming test (FST)." | 1.42 | Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice. ( Borges, FR; Cremonese, RP; da Silva, MD; Luiz-Cerutti, M; Macedo-Júnior, SJ; Martins, DF; Nascimento, FP; Rodrigues, AL; Santos, AR, 2015) |
| "The management of patients with neuropathic pain is challenging." | 1.42 | Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide. ( Gu, K; Guan, J; Ma, P; Ma, X; Qi, Y; Song, T; Wang, C; Wang, H; Wang, W; Ya, J; Yan, R; Yang, L; Yang, Y; Zhao, J, 2015) |
| "Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively." | 1.38 | Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012) |
| "Thalidomide was the only treatment that attenuated these increases." | 1.38 | The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. ( Andrade, P; Buurman, WA; Daemen, MA; Del Rosario, JS; Hoogland, G; Steinbusch, HW; Visser-Vandewalle, V, 2012) |
| "Thalidomide has been shown to selectively inhibit TNF-alpha production." | 1.31 | Analgesic effect of thalidomide on inflammatory pain. ( Cunha, FQ; Ferreira, SH; Ribeiro, RA; Vale, ML, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 10 (55.56) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| De Logu, F | 1 |
| Trevisan, G | 1 |
| Marone, IM | 1 |
| Coppi, E | 1 |
| Padilha Dalenogare, D | 1 |
| Titiz, M | 1 |
| Marini, M | 1 |
| Landini, L | 1 |
| Souza Monteiro de Araujo, D | 1 |
| Li Puma, S | 1 |
| Materazzi, S | 1 |
| De Siena, G | 1 |
| Geppetti, P | 1 |
| Nassini, R | 1 |
| Song, T | 4 |
| Ma, X | 2 |
| Ma, P | 4 |
| Gu, K | 4 |
| Zhao, J | 4 |
| Yang, Y | 4 |
| Jiang, B | 1 |
| Li, Y | 1 |
| Wang, C | 2 |
| Carvalho, TT | 1 |
| Borghi, SM | 1 |
| Pinho-Ribeiro, FA | 1 |
| Mizokami, SS | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 3 |
| Cunha, FQ | 3 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Nascimento, FP | 1 |
| Macedo-Júnior, SJ | 1 |
| Borges, FR | 1 |
| Cremonese, RP | 1 |
| da Silva, MD | 1 |
| Luiz-Cerutti, M | 1 |
| Martins, DF | 1 |
| Rodrigues, AL | 1 |
| Santos, AR | 1 |
| Wang, W | 2 |
| Wang, H | 2 |
| Yang, L | 1 |
| Yan, R | 1 |
| Guan, J | 2 |
| Qi, Y | 1 |
| Ya, J | 1 |
| Casal, JJ | 1 |
| Bollini, M | 1 |
| Lombardo, ME | 1 |
| Bruno, AM | 1 |
| Zhang, Z | 2 |
| Liu, J | 2 |
| Yang, G | 1 |
| Shen, L | 1 |
| Cata, JP | 2 |
| Weng, HR | 2 |
| Dougherty, PM | 2 |
| Ren, WJ | 1 |
| Liu, Y | 1 |
| Zhou, LJ | 1 |
| Li, W | 1 |
| Zhong, Y | 1 |
| Pang, RP | 1 |
| Xin, WJ | 2 |
| Wei, XH | 2 |
| Wang, J | 1 |
| Zhu, HQ | 1 |
| Wu, CY | 2 |
| Qin, ZH | 1 |
| Liu, G | 1 |
| Liu, XG | 2 |
| Taliyan, R | 1 |
| Sharma, PL | 1 |
| Andrade, P | 1 |
| Visser-Vandewalle, V | 1 |
| Del Rosario, JS | 1 |
| Daemen, MA | 1 |
| Buurman, WA | 1 |
| Steinbusch, HW | 1 |
| Hoogland, G | 1 |
| Xu, JT | 1 |
| Ge, YX | 1 |
| Liu, YL | 1 |
| Zang, Y | 1 |
| Zhang, T | 1 |
| Li, YY | 1 |
| Sommer, C | 1 |
| Marziniak, M | 1 |
| Myers, RR | 1 |
| Ribeiro, RA | 1 |
| Vale, ML | 1 |
| Youle, M | 1 |
| Hawkins, D | 1 |
| Gazzard, B | 1 |
1 review available for thalidomide and Allodynia
| Article | Year |
|---|---|
Peripheral hyperalgesic cytokines.
Topics: Analgesics; Animals; Bradykinin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhib | 2003 |
17 other studies available for thalidomide and Allodynia
| Article | Year |
|---|---|
Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4.
Topics: Animals; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Pain; Rats; Rats, Sprague-D | 2020 |
Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.
Topics: Analgesics; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists | 2018 |
Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10.
Topics: Analgesics, Opioid; Animals; Etanercept; Granulocyte Colony-Stimulating Factor; Hyperalgesia; Immuno | 2015 |
Thalidomide reduces mechanical hyperalgesia and depressive-like behavior induced by peripheral nerve crush in mice.
Topics: Animals; Depression; Hindlimb Suspension; Hyperalgesia; Male; Mice; Nerve Crush; Pain Measurement; P | 2015 |
Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cytokines; Delayed-Action Preparations; Graphite; Huma | 2015 |
Thalidomide analogues: Tumor necrosis factor-alpha inhibitors and their evaluation as anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Carrageenan; Edema; Foot; Hyperalge | 2016 |
Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats.
Topics: Animals; Blood Glucose; Body Weight; Cytokines; Diabetic Neuropathies; Hyperalgesia; Immunosuppressi | 2016 |
Thalidomide Promotes Morphine Efficacy and Prevents Morphine-Induced Tolerance in Rats with Diabetic Neuropathy.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; | 2016 |
The effects of thalidomide and minocycline on taxol-induced hyperalgesia in rats.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Hyperalgesia; Immunosuppressive Agents; Locomotion | 2008 |
Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregulation of TNF-α in rodents.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocamp | 2011 |
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 2012 |
The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Measurement; | 2012 |
Cyclooxygenase inhibitors and thalidomide ameliorate vincristine-induced hyperalgesia in rats.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Hot Temperature; Hyperalgesia; Physical | 2004 |
p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.
Topics: Animals; Denervation; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Hypesthes | 2007 |
The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve.
Topics: Analysis of Variance; Animals; Chronic Disease; Constriction; Disease Models, Animal; Female; Hypera | 1998 |
Analgesic effect of thalidomide on inflammatory pain.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Carrageenan; Edema | 2000 |
Thalidomide in hyperalgic pharyngeal ulceration of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Hyperalgesia; Hyperesthesia; Pharyngeal Diseases; Stomat | 1990 |