Page last updated: 2024-11-04

sevoflurane and Allodynia

sevoflurane has been researched along with Allodynia in 14 studies

Sevoflurane: A non-explosive inhalation anesthetic used in the induction and maintenance of general anesthesia. It does not cause respiratory irritation and may also prevent PLATELET AGGREGATION.
sevoflurane : An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.

Research Excerpts

ExcerptRelevanceReference
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial."9.14Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010)
"Two hundred and fourteen women undergoing breast cancer surgery under remifentanil-based general anaesthesia were randomly included in this prospective and double-blind trial."5.14Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery. ( Byeon, GJ; Cho, AR; Kim, HJ; Kim, KH; Kwon, JY; Lee, HJ; Shin, SW; Yoon, JW, 2010)
"Hyperalgesia was not detected 3 or 7 days after the administration of remifentanil."2.94Determination of acute tolerance and hyperalgesia to remifentanil constant rate infusion in dogs undergoing sevoflurane anaesthesia. ( Domínguez, JM; Fernández-Sarmiento, JA; Gómez-Villamandos, RJ; Granados, MM; Morgaz, J; Muñoz-Rascón, P; Navarrete-Calvo, R; Quirós-Carmona, S; Ruíz-López, P, 2020)
"Postoperative pain was managed by sufentanil titration in the postanesthetic care unit, followed by sufentanil infusion via patient-controlled analgesia."2.84Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial. ( Li, Y; Shu, R; Wang, C; Wang, G; Wang, H; Yu, Y; Zhang, L; Zhao, Q, 2017)
"Opioid-induced hyperalgesia was defined as an increase in mechanical nociceptive thresholds after opioid administration."1.42Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: a randomised laboratory study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015)
"Opioid-induced hyperalgesia was associated with an increase in the MAC in normal rats who had not undergone surgery."1.42Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Segura, IA, 2015)
"Tramadol-induced hyperalgesia in the rat lasted for several weeks and was associated with an increase in the MAC of sevoflurane."1.42Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015)
"Hyperalgesia was considered to be a decrease in mechanical thresholds, whereas opioid tolerance was considered to be a decrease in sevoflurane MAC reduction by remifentanil."1.39Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats. ( Abreu, M; Aguado, D; Benito, J; Garcia-Fernandez, J; Gómez de Segura, IA, 2013)
"Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia."1.38The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats. ( Abreu, M; Aguado, D; Benito, J; Garcia-Fernandez, J; Gómez de Segura, IA, 2012)
"Sevoflurane effects on opioid-induced hyperalgesia have not been yet evaluated in vivo."1.35Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. ( Janvier, G; Laulin, JP; Maurette, P; Richebé, P; Rivalan, B; Rivat, C; Simonnet, G, 2009)
"However, halothane-induced hyperalgesia during learning clouds interpreting enhanced retention performance solely as a memory consolidation effect."1.33Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats. ( Alkire, MT; McReynolds, JR; Nathan, SV, 2005)
"Opioid-induced hyperalgesia has been demonstrated in awake animals."1.32Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia. ( Boulanger, V; Collet, V; De Kock, M; Docquier, MA; Lavand'homme, P, 2004)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (28.57)29.6817
2010's8 (57.14)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Su, X1
Zhu, W1
Tian, Y1
Tan, L1
Wu, H1
Wu, L1
Ruíz-López, P1
Navarrete-Calvo, R1
Morgaz, J1
Domínguez, JM1
Quirós-Carmona, S1
Muñoz-Rascón, P1
Gómez-Villamandos, RJ1
Fernández-Sarmiento, JA1
Granados, MM1
Aguado, D5
Abreu, M5
Benito, J6
Garcia-Fernandez, J5
Gómez de Segura, IA5
Segura, IA1
Zhang, L1
Shu, R1
Zhao, Q1
Li, Y1
Wang, C1
Wang, H1
Yu, Y1
Wang, G1
Ruiz-Pérez, D1
Largo, C1
Polo, G1
Canfrán, S1
Richebé, P1
Rivalan, B1
Rivat, C1
Laulin, JP1
Janvier, G1
Maurette, P1
Simonnet, G1
Shin, SW1
Cho, AR1
Lee, HJ1
Kim, HJ1
Byeon, GJ1
Yoon, JW1
Kim, KH1
Kwon, JY1
Docquier, MA1
Lavand'homme, P1
Boulanger, V1
Collet, V1
De Kock, M1
Weber, NC1
Toma, O1
Awan, S1
Frässdorf, J1
Preckel, B1
Schlack, W1
Alkire, MT1
Nathan, SV1
McReynolds, JR1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Ultra-low Dose Naloxone on Remifentanil-Induced Hyperalgesia[NCT03066739]Phase 2105 participants (Anticipated)Interventional2023-02-25Recruiting
A Prospective Study Comparing Total Intravenous Anesthesia With Propofol and Remifentanil vs. Propofol and Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion and Instrumentation[NCT06096181]Phase 2120 participants (Anticipated)Interventional2023-12-31Not yet recruiting
[NCT02495363]50 participants (Actual)Observational2015-03-31Completed
Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285]15 participants (Actual)Observational2018-09-29Terminated (stopped due to Outbreak COVID 19)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for sevoflurane and Allodynia

ArticleYear
Regulatory effects of propofol on high-dose remifentanil-induced hyperalgesia.
    Physiological research, 2020, 02-19, Volume: 69, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholecystectomy, Lapar

2020
Determination of acute tolerance and hyperalgesia to remifentanil constant rate infusion in dogs undergoing sevoflurane anaesthesia.
    Veterinary anaesthesia and analgesia, 2020, Volume: 47, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Cross-Over Studies; Dog Diseases; Dogs; Drug T

2020
Preoperative But Not Postoperative Flurbiprofen Axetil Alleviates Remifentanil-induced Hyperalgesia After Laparoscopic Gynecological Surgery: A Prospective, Randomized, Double-blinded, Trial.
    The Clinical journal of pain, 2017, Volume: 33, Issue:5

    Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Female

2017
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010
Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery.
    British journal of anaesthesia, 2010, Volume: 105, Issue:5

    Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Breast Neoplasms

2010

Other Studies

10 other studies available for sevoflurane and Allodynia

ArticleYear
Effects of naloxone on opioid-induced hyperalgesia and tolerance to remifentanil under sevoflurane anesthesia in rats.
    Anesthesiology, 2013, Volume: 118, Issue:5

    Topics: Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal; Drug

2013
Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: a randomised laboratory study.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:4

    Topics: Amitriptyline; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Dose-Response

2015
Hyperalgesia and increased sevoflurane minimum alveolar concentration induced by opioids in the rat: a randomised experimental study.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:4

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Buprenorphine; Hyperalgesia;

2015
Tramadol-induced hyperalgesia and its prevention by ketamine in rats: A randomised experimental study.
    European journal of anaesthesiology, 2015, Volume: 32, Issue:10

    Topics: Analgesics; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Hyperalgesia; Ketamine; Male; Meth

2015
Metamizole (dipyrone) effects on sevoflurane requirements and postoperative hyperalgesia in rats.
    Laboratory animals, 2017, Volume: 51, Issue:4

    Topics: Animals; Dipyrone; Hyperalgesia; Male; Methyl Ethers; Nociception; Pain Threshold; Prospective Studi

2017
Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2009, Volume: 56, Issue:2

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Carrageenan; Disease Models, Animal; Dose-Resp

2009
The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:1

    Topics: Adjuvants, Anesthesia; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Ani

2012
Questioning the cardiocirculatory excitatory effects of opioids under volatile anaesthesia.
    British journal of anaesthesia, 2004, Volume: 93, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Drug Interactions; Excitatory Amino Acid Antag

2004
Effects of nitrous oxide on the rat heart in vivo: another inhalational anesthetic that preconditions the heart?
    Anesthesiology, 2005, Volume: 103, Issue:6

    Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag

2005
Memory enhancing effect of low-dose sevoflurane does not occur in basolateral amygdala-lesioned rats.
    Anesthesiology, 2005, Volume: 103, Issue:6

    Topics: Amygdala; Anesthetics, Inhalation; Animals; Avoidance Learning; Desflurane; Excitatory Amino Acid Ag

2005