amitriptyline has been researched along with Allodynia in 56 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated." | 9.08 | Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 7.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 7.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 7.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "Amitriptyline was associated with reduced pain related cerebral activations in the perigenual ACC and the left posterior parietal cortex, but only during stress." | 6.71 | Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. ( Gautam, S; Kessler, R; Mertz, H; Morgan, V; Pickens, D, 2005) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 5.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2." | 5.48 | The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 5.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "Amitriptyline has widely been used in patients with painful neuropathy." | 5.38 | Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats. ( Egashira, N; Kawashiri, T; Oishi, R; Sada, H; Shirahama, M; Ushio, S, 2012) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 5.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "The CCI procedure produced mechanical allodynia and increased depressive-like behavior in the FST." | 5.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| " These data do not support the use of acute systemic administration of amitriptyline for acute pain, hyperalgesia, and allodynia, although the roles of chronic treatment and spinal administration are being investigated." | 5.08 | Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans. ( Curry, R; Eisenach, JC; Hood, DD; Tong, C, 1997) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats." | 3.81 | Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. ( Kim, HJ, 2015) |
| " As the impact of inflammatory pain upon mood-like disorders in animal models is not well known, our objective was to assess whether prolonged experimental monoarthritis (ARTH) induced the development of anxiety and depressive-like behaviours in rodents and if amitriptyline, an antidepressant commonly used in the treatment of chronic pain, could reverse both nociceptive and mood-like impairments." | 3.80 | Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. ( Almeida, A; Amorim, D; David-Pereira, A; Pertovaara, A; Pinto-Ribeiro, F, 2014) |
| " The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury." | 3.80 | Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| " The aim of the present investigation was to evaluate, firstly, the peripheral and systemic effects of amitriptyline on tactile allodynia in the streptozotocin (STZ)-induced diabetic rat model of neuropathic pain and, secondly, whether caffeine coadministration affects the actions of amitriptyline." | 3.71 | Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats. ( Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A, 2002) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "In the present study, we sought to determine whether administration of caffeine, a non-selective adenosine receptor antagonist, would affect the thermal antihyperalgesic efficacy of acute amitriptyline in a rat model of neuropathic pain." | 3.70 | Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. ( Esser, MJ; Sawynok, J, 2000) |
| "The allodynia was related to the duration of illness, frequency, severity of migraine, and female gender." | 2.78 | Allodynia in migraine: clinical observation and role of prophylactic therapy. ( Bhoi, SK; Kalita, J; Misra, UK, 2013) |
| "Amitriptyline was associated with reduced pain related cerebral activations in the perigenual ACC and the left posterior parietal cortex, but only during stress." | 2.71 | Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. ( Gautam, S; Kessler, R; Mertz, H; Morgan, V; Pickens, D, 2005) |
| "Therefore, antidepressants attenuate neuropathic pain predominantly by inhibiting primary afferent input to the spinal cord via activating both α1- and α2-adrenergic receptors." | 1.91 | Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors. ( Chen, H; Chen, SR; Huang, Y; Pan, HL, 2023) |
| "Neuropathic pain was induced by sciatic nerve constriction (chronic constriction injury [CCI]) model, and nociceptive threshold was measured by von Frey filaments test." | 1.62 | Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats. ( Barros, CM; Boralli, VB; Costa, LH; Galdino, G; Kawano, T; Placido, RV; Podesta, MHMC; Rodrigues, RF; Santos, RS, 2021) |
| "Morphine dependency was induced using the oral method, and then, amitriptyline-induced antinociceptive effects were measured at 4 doses (2." | 1.48 | The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia? ( Akbari, E; Haghparast, A; Mirzaei, E; Rezaee, L; Zarrabian, S, 2018) |
| "Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin." | 1.48 | Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline. ( Furgała, A; Sałat, K; Sałat, R, 2018) |
| "L-acetylcarnitine treatment enhanced mGlu2/3 receptor protein levels in the dorsal region of the spinal cord." | 1.46 | Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. ( Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C, 2017) |
| "We hypothesized that in Toxoplasma gondii infection, communication among immune cells promotes neuroinflammation through cytokine networks and induces pain sensitivity under conditions of neuropathic pain." | 1.43 | Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice. ( Esmaeilpour, K; Ghazvini, H; Keshavarz, H; Mahmoudvand, H; Sheibani, V; Shojaee, S; Ziaali, N, 2016) |
| " Whereas acute treatments were ineffective, chronic administration of amitriptyline reduced CCI-SN-induced hyperalgesia-like behavior, and this effect was markedly enhanced by co-administration of mefloquine, which was inactive on its own." | 1.43 | Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats. ( Bourgoin, S; Charvériat, M; Duchêne, A; Ezan, P; Giaume, C; Hamon, M; Jeanson, T; Mouthon, F; Picoli, C; Richard, D, 2016) |
| "Opioid-induced hyperalgesia was defined as an increase in mechanical nociceptive thresholds after opioid administration." | 1.42 | Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: a randomised laboratory study. ( Abreu, M; Aguado, D; Benito, J; García-Fernández, J; Gómez de Segura, IA, 2015) |
| "The induction of neuropathic pain following L5-L6 spinal nerve ligation (SNL) resulted in robust mechanical and cold allodynia and heat hyperalgesia in both sham and OB vehicle-treated animals." | 1.42 | Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype. ( Burke, NN; Finn, DP; Roche, M, 2015) |
| "Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot." | 1.42 | The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain. ( Makuch, W; Mika, J; Przewlocka, B; Rojewska, E; Zychowska, M, 2015) |
| "Neuropathic pain is a severe clinical problem, often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system." | 1.42 | Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015) |
| "In the PGE2-induced allodynia model, AS1069562 and duloxetine significantly suppressed allodynia, whereas amitriptyline did not." | 1.40 | Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. ( Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M, 2014) |
| "Mechanical allodynia was fully developed by 28-30days post-immunization (p." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "The best analgesic drugs for neuropathic pain have a long duration of action, can be given via multiple routes, and can be used preemptively." | 1.39 | Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain. ( Cheng, KI; Chu, CC; Huang, KL; Lin, MT; Shieh, JP; Wang, JJ; Yeh, MY, 2013) |
| "Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days)." | 1.39 | The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents. ( Edafiogho, IO; Masocha, W; Thangamani, D, 2013) |
| "At doses alleviating neuropathic pain, amitriptyline showed alteration of behavioral response possibly related to either alteration of basal pain sensitivity or sedative effect or both." | 1.39 | Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. ( Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR, 2013) |
| "It significantly reduced thermal allodynia in the cold (4°C) plate test (MED=2." | 1.37 | Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain. ( Bardin, L; Berrocoso, E; Depoortère, R; Ladure, P; Mico, JA; Newman-Tancredi, A; Vitton, O, 2011) |
| "Then, behavioral signs of neuropathic pain were observed for 8 weeks." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| "The CCI procedure produced mechanical allodynia and increased depressive-like behavior in the FST." | 1.36 | Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion. ( Jesse, CR; Nogueira, CW; Wilhelm, EA, 2010) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| "Sleep deprivation has been associated with hyperalgesia in humans and in animal models." | 1.35 | Systemic amitriptyline administration does not prevent the increased thermal response induced by paradoxical sleep deprivation. ( Araújo, PC; Damasceno, F; de Almeida, OM; Gomes, A; Skinner, GO, 2009) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| "The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)." | 1.33 | Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006) |
| "Gabapentin has been shown to be useful in treatment of different conditions which may be caused by increased neuronal excitability." | 1.32 | Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. ( Haller, H; Leblhuber, F; Schmidhammer, R; Trenkler, J, 2003) |
| "Bupivacaine (1." | 1.32 | Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation. ( Ecoffey, C; Estebe, JP; Gentili, ME; Le Corre, P; Leduc, C; Moulinoux, JP, 2004) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "Thermal hyperalgesia was measured using a focused light beam directed at the ventral surface of the paw while tactile allodynia was determined using Semmes-Weinstein monofilaments applied to the ventral surface of the paw." | 1.30 | Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. ( Esser, MJ; Sawynok, J, 1999) |
| "Intrathecal amitriptyline reversed thermal hyperalgesia in a dose-dependent manner, but had no effect on withdrawal latency of the contralateral, noninjected paw." | 1.29 | Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. ( Eisenach, JC; Gebhart, GF, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.14) | 18.2507 |
| 2000's | 18 (32.14) | 29.6817 |
| 2010's | 32 (57.14) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Bollenbach, M | 1 |
| Lugnier, C | 1 |
| Kremer, M | 1 |
| Salvat, E | 1 |
| Megat, S | 1 |
| Bihel, F | 1 |
| Bourguignon, JJ | 1 |
| Barrot, M | 2 |
| Schmitt, M | 1 |
| Huang, Y | 1 |
| Chen, H | 1 |
| Chen, SR | 1 |
| Pan, HL | 1 |
| Rodrigues, RF | 1 |
| Kawano, T | 1 |
| Placido, RV | 1 |
| Costa, LH | 1 |
| Podesta, MHMC | 1 |
| Santos, RS | 1 |
| Galdino, G | 1 |
| Barros, CM | 1 |
| Boralli, VB | 1 |
| Notartomaso, S | 1 |
| Mascio, G | 1 |
| Bernabucci, M | 1 |
| Zappulla, C | 1 |
| Scarselli, P | 1 |
| Cannella, M | 1 |
| Imbriglio, T | 1 |
| Gradini, R | 1 |
| Battaglia, G | 1 |
| Bruno, V | 1 |
| Nicoletti, F | 1 |
| Chen, M | 1 |
| Hoshino, H | 2 |
| Saito, S | 2 |
| Yang, Y | 1 |
| Obata, H | 2 |
| Akbari, E | 1 |
| Mirzaei, E | 1 |
| Rezaee, L | 1 |
| Zarrabian, S | 1 |
| Haghparast, A | 1 |
| Furgała, A | 1 |
| Sałat, R | 1 |
| Sałat, K | 1 |
| Patel, D | 1 |
| Naik, S | 1 |
| Chuttani, K | 1 |
| Mathur, R | 1 |
| Mishra, AK | 1 |
| Misra, A | 1 |
| Calixto-Campos, C | 1 |
| Zarpelon, AC | 1 |
| Corrêa, M | 1 |
| Cardoso, RD | 1 |
| Pinho-Ribeiro, FA | 1 |
| Cecchini, R | 1 |
| Moreira, EG | 1 |
| Crespigio, J | 1 |
| Bernardy, CC | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Thangamani, D | 1 |
| Edafiogho, IO | 1 |
| Masocha, W | 1 |
| Amorim, D | 1 |
| David-Pereira, A | 1 |
| Pertovaara, A | 1 |
| Almeida, A | 1 |
| Pinto-Ribeiro, F | 1 |
| Murai, N | 1 |
| Tsukamoto, M | 1 |
| Tamura, S | 1 |
| Aoki, T | 1 |
| Matsuoka, N | 1 |
| Aguado, D | 1 |
| Abreu, M | 1 |
| Benito, J | 1 |
| García-Fernández, J | 1 |
| Gómez de Segura, IA | 1 |
| Jagla, G | 1 |
| Mika, J | 3 |
| Makuch, W | 3 |
| Obara, I | 1 |
| Wordliczek, J | 1 |
| Przewlocka, B | 3 |
| Khan, N | 1 |
| Woodruff, TM | 1 |
| Smith, MT | 1 |
| Burke, NN | 1 |
| Finn, DP | 1 |
| Roche, M | 1 |
| Zychowska, M | 1 |
| Rojewska, E | 2 |
| Kim, HJ | 1 |
| Jurga, AM | 1 |
| Starnowska, J | 1 |
| Wasylewski, M | 1 |
| Kwiatkowski, K | 1 |
| Malek, N | 1 |
| Mahmoudvand, H | 1 |
| Ziaali, N | 1 |
| Ghazvini, H | 1 |
| Shojaee, S | 1 |
| Keshavarz, H | 1 |
| Esmaeilpour, K | 1 |
| Sheibani, V | 1 |
| Yin, K | 1 |
| Deuis, JR | 1 |
| Lewis, RJ | 1 |
| Vetter, I | 1 |
| Jeanson, T | 1 |
| Duchêne, A | 1 |
| Richard, D | 1 |
| Bourgoin, S | 1 |
| Picoli, C | 1 |
| Ezan, P | 1 |
| Mouthon, F | 1 |
| Giaume, C | 1 |
| Hamon, M | 1 |
| Charvériat, M | 1 |
| Sanna, MD | 1 |
| Ghelardini, C | 1 |
| Galeotti, N | 1 |
| Damasceno, F | 1 |
| Skinner, GO | 1 |
| Gomes, A | 1 |
| Araújo, PC | 1 |
| de Almeida, OM | 1 |
| Arsenault, A | 1 |
| Sawynok, J | 5 |
| Furuta, S | 1 |
| Shimizu, T | 1 |
| Narita, M | 2 |
| Matsumoto, K | 1 |
| Kuzumaki, N | 1 |
| Horie, S | 1 |
| Suzuki, T | 1 |
| Densmore, VS | 1 |
| Kalous, A | 1 |
| Keast, JR | 1 |
| Osborne, PB | 1 |
| Jesse, CR | 1 |
| Wilhelm, EA | 1 |
| Nogueira, CW | 1 |
| Berrocoso, E | 1 |
| Mico, JA | 1 |
| Vitton, O | 1 |
| Ladure, P | 1 |
| Newman-Tancredi, A | 1 |
| Depoortère, R | 1 |
| Bardin, L | 1 |
| Gunduz, O | 1 |
| Oltulu, C | 1 |
| Guven, R | 1 |
| Buldum, D | 1 |
| Ulugol, A | 2 |
| Fais, RS | 1 |
| Reis, GM | 1 |
| Silveira, JW | 1 |
| Dias, QM | 1 |
| Rossaneis, AC | 1 |
| Prado, WA | 1 |
| Sada, H | 1 |
| Egashira, N | 1 |
| Ushio, S | 1 |
| Kawashiri, T | 1 |
| Shirahama, M | 1 |
| Oishi, R | 1 |
| Cheng, KI | 2 |
| Wang, HC | 1 |
| Chang, LL | 1 |
| Wang, FY | 1 |
| Lai, CS | 1 |
| Chou, CW | 1 |
| Tsai, HP | 1 |
| Kwan, AL | 1 |
| Suter, MR | 1 |
| Kirschmann, G | 1 |
| Laedermann, CJ | 1 |
| Abriel, H | 1 |
| Decosterd, I | 1 |
| Misra, UK | 1 |
| Kalita, J | 1 |
| Bhoi, SK | 1 |
| Huang, KL | 1 |
| Shieh, JP | 1 |
| Chu, CC | 1 |
| Wang, JJ | 1 |
| Lin, MT | 1 |
| Yeh, MY | 1 |
| Karadag, HC | 1 |
| Tamer, M | 1 |
| Firat, Z | 1 |
| Aslantas, A | 1 |
| Dokmeci, I | 1 |
| Oatway, M | 1 |
| Reid, A | 1 |
| Haller, H | 1 |
| Leblhuber, F | 1 |
| Trenkler, J | 1 |
| Schmidhammer, R | 1 |
| Estebe, JP | 1 |
| Gentili, ME | 1 |
| Le Corre, P | 1 |
| Leduc, C | 1 |
| Moulinoux, JP | 1 |
| Ecoffey, C | 1 |
| Waldron, JB | 1 |
| Reid, AR | 1 |
| Morgan, V | 1 |
| Pickens, D | 1 |
| Gautam, S | 1 |
| Kessler, R | 1 |
| Mertz, H | 1 |
| Yasuda, T | 2 |
| Miki, S | 1 |
| Yoshinaga, N | 1 |
| Senba, E | 2 |
| Walczak, JS | 1 |
| Pichette, V | 1 |
| Leblond, F | 1 |
| Desbiens, K | 1 |
| Beaulieu, P | 1 |
| McCarson, KE | 1 |
| Ralya, A | 1 |
| Reisman, SA | 1 |
| Enna, SJ | 1 |
| Son, BC | 1 |
| Lee, SW | 1 |
| Choi, ES | 1 |
| Sung, JH | 1 |
| Hong, JT | 1 |
| Loram, LC | 1 |
| Mitchell, D | 1 |
| Skosana, M | 1 |
| Fick, LG | 1 |
| Gil, DW | 1 |
| Cheevers, CV | 1 |
| Donello, JE | 1 |
| Benbouzid, M | 1 |
| Choucair-Jaafar, N | 1 |
| Yalcin, I | 1 |
| Waltisperger, E | 1 |
| Muller, A | 1 |
| Freund-Mercier, MJ | 1 |
| Eisenach, JC | 2 |
| Gebhart, GF | 1 |
| Hood, DD | 1 |
| Curry, R | 1 |
| Tong, C | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Esser, MJ | 2 |
| Takasaki, I | 1 |
| Andoh, T | 1 |
| Nitta, M | 1 |
| Takahata, H | 1 |
| Nemoto, H | 1 |
| Shiraki, K | 1 |
| Nojima, H | 1 |
| Kuraishi, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preemptive Analgesia With Amitryptyline for Prevention of Post-operative Pain in Women After Total Abdominal Hysterectomy: a Randomized Clinical Trial[NCT03587025] | Phase 3 | 150 participants (Actual) | Interventional | 2015-06-01 | Completed | ||
| Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893] | Phase 1 | 12 participants | Interventional | 2005-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for amitriptyline and Allodynia
| Article | Year |
|---|---|
Allodynia in migraine: clinical observation and role of prophylactic therapy.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Child; Comorbidity; Female; Humans; Hype | 2013 |
Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Brain; Brain Mappi | 2005 |
Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans.
Topics: Adult; Alfentanil; Amitriptyline; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Capsaicin; D | 1997 |
53 other studies available for amitriptyline and Allodynia
| Article | Year |
|---|---|
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.
Topics: Analgesics; Animals; Hyperalgesia; Male; Mice, Inbred C57BL; Molecular Structure; Neuralgia; Phospho | 2019 |
Duloxetine and Amitriptyline Reduce Neuropathic Pain by Inhibiting Primary Sensory Input to Spinal Dorsal Horn Neurons via α1- and α2-Adrenergic Receptors.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Duloxetine Hydrochloride; Hyperalgesia; N | 2023 |
Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Duloxetine Hydrochloride; Hyperalgesia; | 2021 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigen | 2017 |
Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclopropanes; Disease Models, Animal; Do | 2017 |
The effect of amitriptyline administration on pain-related behaviors in morphine-dependent rats: Hypoalgesia or hyperalgesia?
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Dr | 2018 |
Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Disease Models, Animal; Hype | 2018 |
Intranasal delivery of cyclobenzaprine hydrochloride-loaded thiolated chitosan nanoparticles for pain relief.
Topics: Administration, Intranasal; Amitriptyline; Animals; Brain; Cell Line, Tumor; Cell Survival; Chemistr | 2013 |
The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.
Topics: Amitriptyline; Animals; Behavior, Animal; Carcinoma, Ehrlich Tumor; Cell Proliferation; Disease Mode | 2013 |
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female; | 2013 |
Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Arthritis; Carrageenan; Disease Models, Animal; Ex | 2014 |
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Rel | 2014 |
Amitriptyline, minocycline and maropitant reduce the sevoflurane minimum alveolar concentration and potentiate remifentanil but do not prevent acute opioid tolerance and hyperalgesia in the rat: a randomised laboratory study.
Topics: Amitriptyline; Analgesics, Opioid; Anesthetics, Inhalation; Animals; Behavior, Animal; Dose-Response | 2015 |
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do | 2014 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Depression; Disease Models, Animal; Glial | 2015 |
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cyclohexanols; Cyclopropane | 2015 |
Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
Topics: Amitriptyline; Analgesics; Animals; Berberine; Cold Temperature; Constriction; Disease Models, Anima | 2015 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2015 |
Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: Influence of descending noradrenergic plasticity.
Topics: Amitriptyline; Analgesics; Animals; Duloxetine Hydrochloride; Hyperalgesia; Lumbosacral Region; Male | 2015 |
Toxoplasma gondii Infection Promotes Neuroinflammation Through Cytokine Networks and Induced Hyperalgesia in BALB/c Mice.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Cytokines; Disease Models, Animal; Hyperalgesia; I | 2016 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Potentiation of Amitriptyline Anti-Hyperalgesic-Like Action By Astroglial Connexin 43 Inhibition in Neuropathic Rats.
Topics: Amitriptyline; Animals; Astrocytes; Connexin 43; Gap Junctions; Hyperalgesia; Male; Neuralgia; Rats; | 2016 |
Spinal astrocytic c-Jun N-terminal kinase (JNK) activation as counteracting mechanism to the amitriptyline analgesic efficacy in painful peripheral neuropathies.
Topics: Amitriptyline; Analgesics; Animals; Astrocytes; Biocatalysis; Enzyme Activation; Gene Expression Reg | 2017 |
Systemic amitriptyline administration does not prevent the increased thermal response induced by paradoxical sleep deprivation.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Body Tempe | 2009 |
Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain-Derived Neurotroph | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Bupropion; Depression; | 2010 |
Evaluation of milnacipran, in comparison with amitriptyline, on cold and mechanical allodynia in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Behavior, Animal; Cold Temperature; Constriction; Cyclopropanes; | 2011 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
Amitriptyline prolongs the antihyperalgesic effect of 2- or 100-Hz electro-acupuncture in a rat model of post-incision pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Combined Modality Therapy; Electroacupuncture; Hyp | 2012 |
Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats.
Topics: Amitriptyline; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Organoplatinum Compoun | 2012 |
Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Hyperalgesia; Injections, Intraperitoneal; Injecti | 2012 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, | 2013 |
Prolonged analgesic effect of amitriptyline base on thermal hyperalgesia in an animal model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Ligation; Male; Neuralgia; | 2013 |
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes | 2002 |
Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat.
Topics: Administration, Topical; Amitriptyline; Anesthetics, Dissociative; Animals; Antidepressive Agents, T | 2003 |
Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Arm; Carbamazepine; Central Cord Syndrome; Cervical Ver | 2003 |
Contralateral effect of amitriptyline and bupivacaine for sciatic nerve block in an animal model of inflammation.
Topics: Amitriptyline; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Hypera | 2004 |
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima | 2004 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Hot Temperature; Hyperalgesia; Male; Pain Threshol | 2005 |
Motor cortex stimulation for central pain following a traumatic brain injury.
Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju | 2006 |
Tramadol is more effective than morphine and amitriptyline against ischaemic pain but not thermal pain in rats.
Topics: Amitriptyline; Analgesics; Animals; Female; Hot Temperature; Hyperalgesia; Ischemia; Male; Morphine; | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amitriptyline; Analgesics, Opioid; Anima | 1995 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Hot Temperature; Hyperalgesia; Ligation; M | 1999 |
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |