nefopam has been researched along with Allodynia in 12 studies
Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 7.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| "In carrageenan-induced tactile allodynia, coadministration of weak analgesic doses of nefopam (10 and 30 mg/kg) with a nonanalgesic dose (1 mg/kg) or moderately analgesic dose (3 mg/kg) of morphine significantly reduced or reversed allodynia, respectively." | 5.32 | Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat. ( Gillardin, JM; Girard, P; Pansart, Y, 2004) |
| "3-mg/kg bolus of nefopam at the induction of anesthesia followed by a continuous infusion of 0." | 5.17 | Effects of nefopam on early postoperative hyperalgesia after cardiac surgery. ( Branchard, O; Cahana, A; Janvier, G; Jelacic, S; Leproust, S; Picard, W; Richebé, P; Rivat, C, 2013) |
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 3.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| " The primary outcome was the dosage of fentanyl-nefopam IV-PCA infused over 24 h postoperatively." | 3.11 | Effect of remifentanil on post-operative analgesic consumption in patients undergoing shoulder arthroplasty after interscalene brachial plexus block: a randomized controlled trial. ( Bae, H; Kim, JT; Kim, Y; Lim, YJ; Park, SK; Sakura, S; Yoo, S, 2022) |
| "Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management." | 1.48 | Nefopam hydrochloride loaded microspheres for post-operative pain management: synthesis, physicochemical characterization and in-vivo evaluation. ( Arora, S; Madan, J; Sharma, N, 2018) |
| "Nefopam hydrochloride is a centrally acting compound that induces antinociceptive and antihyperalgesic properties in neuropathic pain models." | 1.43 | The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model. ( Bang, JY; Kim, SG; Koh, WU; Shin, JW; Song, JG, 2016) |
| "Nefopam has a pharmacologic profile distinct from that of opioids or other anti-inflammatory drugs." | 1.42 | Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model. ( Baek, SH; Byeon, GJ; Kim, HY; Kim, KH; Koo, ST; Shin, SW, 2015) |
| "Nefopam is a non-opioid analgesic drug, used widely in European countries to control postoperative pain." | 1.40 | Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. ( Dam, LJ; Ha, YM; Hai, L, 2014) |
| "In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h." | 1.37 | Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011) |
| "In the postoperative pain model, at 30 mg x kg(-1) nefopam augmented the endpoint to thermal threshold, 60 and 90 minutes after administration compared to the threshold recorded after the incision." | 1.31 | Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat. ( Coppe, MC; Gillardin, JM; Girard, P; Pansart, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, Y | 1 |
| Bae, H | 1 |
| Yoo, S | 1 |
| Park, SK | 1 |
| Lim, YJ | 1 |
| Sakura, S | 1 |
| Kim, JT | 1 |
| Sharma, N | 1 |
| Arora, S | 1 |
| Madan, J | 1 |
| Dam, LJ | 1 |
| Hai, L | 1 |
| Ha, YM | 1 |
| Kim, KH | 1 |
| Byeon, GJ | 1 |
| Kim, HY | 1 |
| Baek, SH | 1 |
| Shin, SW | 1 |
| Koo, ST | 1 |
| Koh, WU | 1 |
| Shin, JW | 1 |
| Bang, JY | 1 |
| Kim, SG | 1 |
| Song, JG | 1 |
| Verleye, M | 2 |
| Gillardin, JM | 4 |
| Laboureyras, E | 1 |
| Chateauraynaud, J | 1 |
| Richebé, P | 2 |
| Simonnet, G | 1 |
| Girard, P | 4 |
| Niedergang, B | 1 |
| Pansart, Y | 4 |
| Coppé, MC | 3 |
| Picard, W | 1 |
| Rivat, C | 1 |
| Jelacic, S | 1 |
| Branchard, O | 1 |
| Leproust, S | 1 |
| Cahana, A | 1 |
| Janvier, G | 1 |
| Verniers, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT01833728] | 16 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Study of the Effects of Nefopam on Hyperalgesia Following Sternotomy in Cardiac Surgery[NCT00413257] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nefopam and Allodynia
| Article | Year |
|---|---|
Effect of remifentanil on post-operative analgesic consumption in patients undergoing shoulder arthroplasty after interscalene brachial plexus block: a randomized controlled trial.
Topics: Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Shoulder; Brachial Plexus Block; Delirium | 2022 |
Effects of nefopam on early postoperative hyperalgesia after cardiac surgery.
Topics: Aged; Analgesics, Non-Narcotic; Anesthesia; Cardiac Surgical Procedures; Coronary Artery Bypass; Dou | 2013 |
10 other studies available for nefopam and Allodynia
| Article | Year |
|---|---|
Nefopam hydrochloride loaded microspheres for post-operative pain management: synthesis, physicochemical characterization and in-vivo evaluation.
Topics: Analgesics; Animals; Behavior, Animal; Chemical Phenomena; Chemistry Techniques, Synthetic; Drug Car | 2018 |
Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina | 2014 |
Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model.
Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina | 2015 |
The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model.
Topics: Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Hyperalgesia; KATP Channels; Male; Nefopa | 2016 |
Contribution of transient receptor potential vanilloid subtype 1 to the analgesic and antihyperalgesic activity of nefopam in rodents.
Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultu | 2009 |
Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Carrageenan; Chronic Disease; Fentanyl; Hyper | 2009 |
Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, An | 2011 |
Nefopam potentiates morphine antinociception in allodynia and hyperalgesia in the rat.
Topics: Analgesics; Animals; Drug Synergism; Hyperalgesia; Male; Morphine; Nefopam; Pain Threshold; Rats; Ra | 2004 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Nefopam reduces thermal hypersensitivity in acute and postoperative pain models in the rat.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Hot Temperature; Hyperalgesia; Male; Morphine | 2001 |