chlorine has been researched along with Allodynia in 11 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Excerpt | Relevance | Reference |
---|---|---|
"Mechanical allodynia - the misperception of light touch as painful - occurs when inhibition is compromised." | 1.51 | Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. ( Lee, KY; Prescott, SA; Ratté, S, 2019) |
"The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling." | 1.51 | Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019) |
"Using the spared nerve injury model of neuropathic pain in Long-Evans rats, we first discovered a significant increase in noradrenergic innervation within the mPFC of nerve-injured compared to control animals." | 1.48 | Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. ( Cordeiro Matos, S; Longo, G; Ribeiro-da-Silva, A; Séguéla, P; Zamfir, M, 2018) |
"We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons." | 1.39 | Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. ( Beaulieu, JM; Beggs, S; Cahill, CM; Castonguay, A; De Koninck, Y; Del'Guidice, T; Doyon, N; Ferrini, F; Godin, AG; Laffray, S; Lorenzo, LE; Mattioli, TA; Mohr, D; Salter, MW; Trang, T; Vandal, K; Zhang, W, 2013) |
" Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects." | 1.38 | Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. ( Balemba, OB; Brooks, EM; Galligan, JJ; Greenwood-Van Meerveld, B; Hoffman, JM; Johnson, AC; MacEachern, SJ; Mawe, GM; Moses, PL; Sharkey, KA; Swain, GM; Tyler, K; Zhao, H, 2012) |
"Alleviation of thermal hyperalgesia was dose dependent in each case, although higher doses were required for i." | 1.30 | Zinc alleviates thermal hyperalgesia due to partial nerve injury. ( Liu, T; Tracey, DJ; Walker, JS, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (9.09) | 18.2507 |
2000's | 3 (27.27) | 29.6817 |
2010's | 7 (63.64) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Lee, KY | 3 |
Ratté, S | 1 |
Prescott, SA | 4 |
Cordeiro Matos, S | 1 |
Zamfir, M | 1 |
Longo, G | 1 |
Ribeiro-da-Silva, A | 1 |
Séguéla, P | 1 |
Mapplebeck, JCS | 1 |
Lorenzo, LE | 2 |
Gauthier, C | 1 |
Muley, MM | 1 |
De Koninck, Y | 3 |
Salter, MW | 3 |
Tang, D | 1 |
Qian, AH | 1 |
Song, DD | 1 |
Ben, QW | 1 |
Yao, WY | 1 |
Sun, J | 1 |
Li, WG | 1 |
Xu, TL | 1 |
Yuan, YZ | 1 |
Price, TJ | 1 |
Cervero, F | 1 |
Gold, MS | 1 |
Hammond, DL | 1 |
Hoffman, JM | 1 |
Tyler, K | 1 |
MacEachern, SJ | 1 |
Balemba, OB | 1 |
Johnson, AC | 1 |
Brooks, EM | 1 |
Zhao, H | 1 |
Swain, GM | 1 |
Moses, PL | 1 |
Galligan, JJ | 1 |
Sharkey, KA | 1 |
Greenwood-Van Meerveld, B | 1 |
Mawe, GM | 1 |
Ferrini, F | 1 |
Trang, T | 1 |
Mattioli, TA | 1 |
Laffray, S | 1 |
Del'Guidice, T | 1 |
Castonguay, A | 1 |
Doyon, N | 1 |
Zhang, W | 1 |
Godin, AG | 1 |
Mohr, D | 1 |
Beggs, S | 2 |
Vandal, K | 1 |
Beaulieu, JM | 1 |
Cahill, CM | 1 |
Chan, CC | 1 |
Keller, AF | 1 |
Liu, T | 1 |
Walker, JS | 1 |
Tracey, DJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for chlorine and Allodynia
Article | Year |
---|---|
Chloride regulation in the pain pathway.
Topics: Animals; Chloride Channels; Chlorides; Humans; Hyperalgesia; Ion Channel Gating; K Cl- Cotransporter | 2009 |
In vivo assays for COX-2.
Topics: Animals; Arthritis, Experimental; Carrageenan; Chlorides; Chromium Compounds; Chromium Radioisotopes | 2003 |
9 other studies available for chlorine and Allodynia
Article | Year |
---|---|
Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn.
Topics: Animals; Chlorides; Female; Hyperalgesia; K Cl- Cotransporters; Male; Models, Animal; Models, Biolog | 2019 |
Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex.
Topics: Adrenergic Agents; Animals; Barium Compounds; Chlorides; Disease Models, Animal; Dopamine beta-Hydro | 2018 |
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2019 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB | 2015 |
Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2015 |
Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
Topics: Administration, Oral; Analgesics; Animals; Chlorides; Chromosomes, Artificial, Bacterial; Colon; Dis | 2012 |
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
Topics: Animals; Biophysical Phenomena; Brain-Derived Neurotrophic Factor; CD11b Antigen; Chlorides; Down-Re | 2013 |
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Communication; Cells, Cultured; Chlorides; | 2007 |
Zinc alleviates thermal hyperalgesia due to partial nerve injury.
Topics: Animals; Behavior, Animal; Chlorides; Hot Temperature; Hyperalgesia; Ligation; Male; Rats; Rats, Wis | 1999 |