chlorine has been researched along with Allodynia in 11 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical allodynia - the misperception of light touch as painful - occurs when inhibition is compromised." | 1.51 | Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. ( Lee, KY; Prescott, SA; Ratté, S, 2019) |
| "The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling." | 1.51 | Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019) |
| "Using the spared nerve injury model of neuropathic pain in Long-Evans rats, we first discovered a significant increase in noradrenergic innervation within the mPFC of nerve-injured compared to control animals." | 1.48 | Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. ( Cordeiro Matos, S; Longo, G; Ribeiro-da-Silva, A; Séguéla, P; Zamfir, M, 2018) |
| "We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons." | 1.39 | Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. ( Beaulieu, JM; Beggs, S; Cahill, CM; Castonguay, A; De Koninck, Y; Del'Guidice, T; Doyon, N; Ferrini, F; Godin, AG; Laffray, S; Lorenzo, LE; Mattioli, TA; Mohr, D; Salter, MW; Trang, T; Vandal, K; Zhang, W, 2013) |
| " Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects." | 1.38 | Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. ( Balemba, OB; Brooks, EM; Galligan, JJ; Greenwood-Van Meerveld, B; Hoffman, JM; Johnson, AC; MacEachern, SJ; Mawe, GM; Moses, PL; Sharkey, KA; Swain, GM; Tyler, K; Zhao, H, 2012) |
| "Alleviation of thermal hyperalgesia was dose dependent in each case, although higher doses were required for i." | 1.30 | Zinc alleviates thermal hyperalgesia due to partial nerve injury. ( Liu, T; Tracey, DJ; Walker, JS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KY | 3 |
| Ratté, S | 1 |
| Prescott, SA | 4 |
| Cordeiro Matos, S | 1 |
| Zamfir, M | 1 |
| Longo, G | 1 |
| Ribeiro-da-Silva, A | 1 |
| Séguéla, P | 1 |
| Mapplebeck, JCS | 1 |
| Lorenzo, LE | 2 |
| Gauthier, C | 1 |
| Muley, MM | 1 |
| De Koninck, Y | 3 |
| Salter, MW | 3 |
| Tang, D | 1 |
| Qian, AH | 1 |
| Song, DD | 1 |
| Ben, QW | 1 |
| Yao, WY | 1 |
| Sun, J | 1 |
| Li, WG | 1 |
| Xu, TL | 1 |
| Yuan, YZ | 1 |
| Price, TJ | 1 |
| Cervero, F | 1 |
| Gold, MS | 1 |
| Hammond, DL | 1 |
| Hoffman, JM | 1 |
| Tyler, K | 1 |
| MacEachern, SJ | 1 |
| Balemba, OB | 1 |
| Johnson, AC | 1 |
| Brooks, EM | 1 |
| Zhao, H | 1 |
| Swain, GM | 1 |
| Moses, PL | 1 |
| Galligan, JJ | 1 |
| Sharkey, KA | 1 |
| Greenwood-Van Meerveld, B | 1 |
| Mawe, GM | 1 |
| Ferrini, F | 1 |
| Trang, T | 1 |
| Mattioli, TA | 1 |
| Laffray, S | 1 |
| Del'Guidice, T | 1 |
| Castonguay, A | 1 |
| Doyon, N | 1 |
| Zhang, W | 1 |
| Godin, AG | 1 |
| Mohr, D | 1 |
| Beggs, S | 2 |
| Vandal, K | 1 |
| Beaulieu, JM | 1 |
| Cahill, CM | 1 |
| Chan, CC | 1 |
| Keller, AF | 1 |
| Liu, T | 1 |
| Walker, JS | 1 |
| Tracey, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorine and Allodynia
| Article | Year |
|---|---|
Chloride regulation in the pain pathway.
Topics: Animals; Chloride Channels; Chlorides; Humans; Hyperalgesia; Ion Channel Gating; K Cl- Cotransporter | 2009 |
In vivo assays for COX-2.
Topics: Animals; Arthritis, Experimental; Carrageenan; Chlorides; Chromium Compounds; Chromium Radioisotopes | 2003 |
9 other studies available for chlorine and Allodynia
| Article | Year |
|---|---|
Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn.
Topics: Animals; Chlorides; Female; Hyperalgesia; K Cl- Cotransporters; Male; Models, Animal; Models, Biolog | 2019 |
Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex.
Topics: Adrenergic Agents; Animals; Barium Compounds; Chlorides; Disease Models, Animal; Dopamine beta-Hydro | 2018 |
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2019 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB | 2015 |
Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.
Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides; | 2015 |
Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
Topics: Administration, Oral; Analgesics; Animals; Chlorides; Chromosomes, Artificial, Bacterial; Colon; Dis | 2012 |
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
Topics: Animals; Biophysical Phenomena; Brain-Derived Neurotrophic Factor; CD11b Antigen; Chlorides; Down-Re | 2013 |
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Communication; Cells, Cultured; Chlorides; | 2007 |
Zinc alleviates thermal hyperalgesia due to partial nerve injury.
Topics: Animals; Behavior, Animal; Chlorides; Hot Temperature; Hyperalgesia; Ligation; Male; Rats; Rats, Wis | 1999 |