Page last updated: 2024-10-17

chlorine and Allodynia

chlorine has been researched along with Allodynia in 11 studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Research Excerpts

ExcerptRelevanceReference
"Mechanical allodynia - the misperception of light touch as painful - occurs when inhibition is compromised."1.51Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. ( Lee, KY; Prescott, SA; Ratté, S, 2019)
"The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling."1.51Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019)
"Using the spared nerve injury model of neuropathic pain in Long-Evans rats, we first discovered a significant increase in noradrenergic innervation within the mPFC of nerve-injured compared to control animals."1.48Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. ( Cordeiro Matos, S; Longo, G; Ribeiro-da-Silva, A; Séguéla, P; Zamfir, M, 2018)
"We found that hyperalgesia-inducing treatment with morphine resulted in downregulation of the K(+)-Cl(-) co-transporter KCC2, impairing Cl(-) homeostasis in rat spinal lamina l neurons."1.39Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis. ( Beaulieu, JM; Beggs, S; Cahill, CM; Castonguay, A; De Koninck, Y; Del'Guidice, T; Doyon, N; Ferrini, F; Godin, AG; Laffray, S; Lorenzo, LE; Mattioli, TA; Mohr, D; Salter, MW; Trang, T; Vandal, K; Zhang, W, 2013)
" Colon-targeted, intraluminal delivery of 5-HT(4)R agonists might be used to promote motility and alleviate visceral pain, while restricting systemic bioavailability and resulting adverse side effects."1.38Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity. ( Balemba, OB; Brooks, EM; Galligan, JJ; Greenwood-Van Meerveld, B; Hoffman, JM; Johnson, AC; MacEachern, SJ; Mawe, GM; Moses, PL; Sharkey, KA; Swain, GM; Tyler, K; Zhao, H, 2012)
"Alleviation of thermal hyperalgesia was dose dependent in each case, although higher doses were required for i."1.30Zinc alleviates thermal hyperalgesia due to partial nerve injury. ( Liu, T; Tracey, DJ; Walker, JS, 1999)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's3 (27.27)29.6817
2010's7 (63.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, KY3
Ratté, S1
Prescott, SA4
Cordeiro Matos, S1
Zamfir, M1
Longo, G1
Ribeiro-da-Silva, A1
Séguéla, P1
Mapplebeck, JCS1
Lorenzo, LE2
Gauthier, C1
Muley, MM1
De Koninck, Y3
Salter, MW3
Tang, D1
Qian, AH1
Song, DD1
Ben, QW1
Yao, WY1
Sun, J1
Li, WG1
Xu, TL1
Yuan, YZ1
Price, TJ1
Cervero, F1
Gold, MS1
Hammond, DL1
Hoffman, JM1
Tyler, K1
MacEachern, SJ1
Balemba, OB1
Johnson, AC1
Brooks, EM1
Zhao, H1
Swain, GM1
Moses, PL1
Galligan, JJ1
Sharkey, KA1
Greenwood-Van Meerveld, B1
Mawe, GM1
Ferrini, F1
Trang, T1
Mattioli, TA1
Laffray, S1
Del'Guidice, T1
Castonguay, A1
Doyon, N1
Zhang, W1
Godin, AG1
Mohr, D1
Beggs, S2
Vandal, K1
Beaulieu, JM1
Cahill, CM1
Chan, CC1
Keller, AF1
Liu, T1
Walker, JS1
Tracey, DJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938]Phase 450 participants (Actual)Interventional2016-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for chlorine and Allodynia

ArticleYear
Chloride regulation in the pain pathway.
    Brain research reviews, 2009, Volume: 60, Issue:1

    Topics: Animals; Chloride Channels; Chlorides; Humans; Hyperalgesia; Ion Channel Gating; K Cl- Cotransporter

2009
In vivo assays for COX-2.
    Methods in molecular biology (Clifton, N.J.), 2003, Volume: 225

    Topics: Animals; Arthritis, Experimental; Carrageenan; Chlorides; Chromium Compounds; Chromium Radioisotopes

2003

Other Studies

9 other studies available for chlorine and Allodynia

ArticleYear
Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn.
    eLife, 2019, 11-19, Volume: 8

    Topics: Animals; Chlorides; Female; Hyperalgesia; K Cl- Cotransporters; Male; Models, Animal; Models, Biolog

2019
Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex.
    Brain structure & function, 2018, Volume: 223, Issue:3

    Topics: Adrenergic Agents; Animals; Barium Compounds; Chlorides; Disease Models, Animal; Dopamine beta-Hydro

2018
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
    Cell reports, 2019, 07-16, Volume: 28, Issue:3

    Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides;

2019
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
    American journal of physiology. Gastrointestinal and liver physiology, 2015, May-01, Volume: 308, Issue:9

    Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB

2015
Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.
    Pain, 2015, Volume: 156, Issue:12

    Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides;

2015
Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.
    Gastroenterology, 2012, Volume: 142, Issue:4

    Topics: Administration, Oral; Analgesics; Animals; Chlorides; Chromosomes, Artificial, Bacterial; Colon; Dis

2012
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.
    Nature neuroscience, 2013, Volume: 16, Issue:2

    Topics: Animals; Biophysical Phenomena; Brain-Derived Neurotrophic Factor; CD11b Antigen; Chlorides; Down-Re

2013
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain.
    Molecular pain, 2007, Sep-27, Volume: 3

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Communication; Cells, Cultured; Chlorides;

2007
Zinc alleviates thermal hyperalgesia due to partial nerve injury.
    Neuroreport, 1999, Feb-25, Volume: 10, Issue:3

    Topics: Animals; Behavior, Animal; Chlorides; Hot Temperature; Hyperalgesia; Ligation; Male; Rats; Rats, Wis

1999