muscimol has been researched along with Allodynia in 32 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice." | 7.80 | Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. ( Alves, RS; Bezerra, DP; De Lucca Júnior, W; Gelain, DP; Guimarães, AG; Melo, NS; Mendonça Júnior, FJ; Quintans Júnior, LJ; Scotti, L; Scotti, MT, 2014) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 7.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| "The present study investigated the involvement of mediodorsal thalamic (MD) GABA-A receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic pain." | 4.31 | Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain. ( Alijanpour, S; Asgharpour-Masouleh, N; Delphi, L; Rezayof, A, 2023) |
| "The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice." | 3.80 | Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study. ( Alves, RS; Bezerra, DP; De Lucca Júnior, W; Gelain, DP; Guimarães, AG; Melo, NS; Mendonça Júnior, FJ; Quintans Júnior, LJ; Scotti, L; Scotti, MT, 2014) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 3.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| "Mechanical and cold allodynia, thermal and mechanical hyperalgesia were evaluated before injection and 15 and 60 min after injection." | 1.56 | Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury. ( Hosseini, M; Janzadeh, A; Karami, Z; Nasirinezhad, F; Yousefifard, M; Zamani, E, 2020) |
| "Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naïve rats." | 1.48 | The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. ( Antunes, GF; Assis, DV; Gouveia, F; Kuroki, M; Martinez, RCR; Oliveira, CC; Pagano, RL; Santos, LCT; Seno, MDJ, 2018) |
| "These phases of neuropathic pain involve changes in the GABAergic control of descending pathways that travel through the dorsolateral funiculus (DLF)." | 1.43 | The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats. ( Dias, QM; Prado, WA, 2016) |
| "However, RVM inactivation blocked the hyperalgesia produced upon removal from the EPM." | 1.38 | Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia. ( Cornélio, AM; Morgan, MM; Nunes-de-Souza, RL, 2012) |
| "Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe symptom of chronic pain often produced by damage to peripheral nerves." | 1.37 | Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. ( Barth, DS; Benison, AM; Chumachenko, S; Falci, SP; Harrison, JA; Maier, SF; Watkins, LR, 2011) |
| "The SP-induced hyperalgesia was both GABA(A) and NMDA receptor-dependent after pre- and post-treatment with selective antagonists at the spinal level." | 1.36 | Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. ( Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K, 2010) |
| "In animals exhibiting maximal thermal hyperalgesia as one sign of neuropathic pain 7 days after loose ligation of the sciatic nerve, spinal application of muscimol (5, 10 or 20 microg) before the high-frequency (50 Hz) tetanus produced a long-lasting depression (rather than potentiation) of spinal dorsal horn field potentials." | 1.32 | Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1. ( Draganic, P; Miletic, G; Miletic, V; Pankratz, MT, 2003) |
| "0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.31 | The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001) |
| "To clarify the mechanism of the hyperalgesia in SART mice and the mode of the antinociceptive action of neurotropin in this model, the influence of systemically administered neurotransmitter related drugs was studied." | 1.28 | Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin. ( Hata, T; Kawamura, M; Miura, T; Namimatsu, A; Ohara, H; Yoneda, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (9.38) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 21 (65.63) | 24.3611 |
| 2020's | 4 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Nagasaka, K | 1 |
| Takashima, I | 1 |
| Matsuda, K | 1 |
| Higo, N | 1 |
| Asgharpour-Masouleh, N | 1 |
| Rezayof, A | 1 |
| Alijanpour, S | 1 |
| Delphi, L | 1 |
| Maegawa, H | 1 |
| Usami, N | 1 |
| Kudo, C | 1 |
| Hanamoto, H | 1 |
| Niwa, H | 1 |
| Hosseini, M | 1 |
| Karami, Z | 1 |
| Yousefifard, M | 1 |
| Janzadeh, A | 1 |
| Zamani, E | 1 |
| Nasirinezhad, F | 1 |
| Seno, MDJ | 1 |
| Assis, DV | 1 |
| Gouveia, F | 1 |
| Antunes, GF | 1 |
| Kuroki, M | 1 |
| Oliveira, CC | 1 |
| Santos, LCT | 1 |
| Pagano, RL | 1 |
| Martinez, RCR | 1 |
| Whitt, JL | 1 |
| Masri, R | 2 |
| Pulimood, NS | 1 |
| Keller, A | 1 |
| Ma, X | 1 |
| Bao, W | 1 |
| Wang, X | 1 |
| Wang, Z | 1 |
| Liu, Q | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Jiang, H | 2 |
| Cui, S | 1 |
| Guimarães, AG | 1 |
| Scotti, L | 1 |
| Scotti, MT | 1 |
| Mendonça Júnior, FJ | 1 |
| Melo, NS | 1 |
| Alves, RS | 1 |
| De Lucca Júnior, W | 1 |
| Bezerra, DP | 1 |
| Gelain, DP | 1 |
| Quintans Júnior, LJ | 1 |
| Fang, D | 1 |
| Kong, LY | 1 |
| Jin, ZR | 1 |
| Cai, J | 2 |
| Kang, XJ | 1 |
| Wan, Y | 2 |
| Xing, GG | 1 |
| Okada-Ogawa, A | 1 |
| Nakaya, Y | 1 |
| Imamura, Y | 1 |
| Kobayashi, M | 1 |
| Shinoda, M | 1 |
| Kita, K | 1 |
| Sessle, BJ | 1 |
| Iwata, K | 1 |
| Dias, QM | 1 |
| Prado, WA | 1 |
| Chiou, CS | 1 |
| Chen, CC | 1 |
| Tsai, TC | 1 |
| Huang, CC | 1 |
| Chou, D | 1 |
| Hsu, KS | 1 |
| Geng, KW | 1 |
| He, T | 1 |
| Wang, RR | 1 |
| Li, CL | 1 |
| Luo, WJ | 1 |
| Wu, FF | 1 |
| Wang, Y | 1 |
| Li, Z | 1 |
| Lu, YF | 1 |
| Guan, SM | 1 |
| Chen, J | 1 |
| Huang, YJ | 2 |
| Lee, KH | 2 |
| Murphy, L | 1 |
| Garraway, SM | 1 |
| Grau, JW | 2 |
| Zhang, C | 1 |
| Chen, RX | 1 |
| Zhang, Y | 1 |
| Wang, J | 1 |
| Liu, FY | 1 |
| Liao, FF | 1 |
| Xu, FQ | 1 |
| Yi, M | 1 |
| Lee, IO | 2 |
| Lim, ES | 2 |
| Wei, H | 1 |
| Hao, B | 1 |
| Huang, JL | 1 |
| Ma, AN | 1 |
| Li, XY | 1 |
| Wang, YX | 1 |
| Pertovaara, A | 1 |
| Lagraize, SC | 1 |
| Guo, W | 1 |
| Yang, K | 1 |
| Wei, F | 1 |
| Ren, K | 1 |
| Dubner, R | 1 |
| Benison, AM | 1 |
| Chumachenko, S | 1 |
| Harrison, JA | 1 |
| Maier, SF | 1 |
| Falci, SP | 1 |
| Watkins, LR | 1 |
| Barth, DS | 1 |
| Son, JK | 1 |
| Kim, YS | 1 |
| Reichl, S | 1 |
| Augustin, M | 1 |
| Zahn, PK | 1 |
| Pogatzki-Zahn, EM | 1 |
| Naik, AK | 1 |
| Latham, JR | 1 |
| Obradovic, A | 1 |
| Jevtovic-Todorovic, V | 1 |
| Cornélio, AM | 1 |
| Nunes-de-Souza, RL | 1 |
| Morgan, MM | 1 |
| Cha, M | 1 |
| Ji, Y | 1 |
| Miletic, G | 1 |
| Draganic, P | 1 |
| Pankratz, MT | 1 |
| Miletic, V | 1 |
| Yano, S | 1 |
| Suzuki, Y | 1 |
| Yuzurihara, M | 1 |
| Kase, Y | 1 |
| Takeda, S | 1 |
| Watanabe, S | 1 |
| Aburada, M | 1 |
| Miyamoto, K | 1 |
| Anseloni, VC | 1 |
| Gold, MS | 1 |
| Hwang, JH | 2 |
| Yaksh, TL | 1 |
| Manning, BH | 1 |
| Hwang, KS | 1 |
| Kim, JU | 1 |
| Choi, IC | 1 |
| Park, PH | 1 |
| Han, SM | 1 |
| Ohara, H | 1 |
| Kawamura, M | 1 |
| Namimatsu, A | 1 |
| Miura, T | 1 |
| Yoneda, R | 1 |
| Hata, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
32 other studies available for muscimol and Allodynia
| Article | Year |
|---|---|
Pharmacological inactivation of the primate posterior insular/secondary somatosensory cortices attenuates thermal hyperalgesia.
Topics: Animals; Hyperalgesia; Muscimol; Neuralgia; Primates; Somatosensory Cortex | 2022 |
Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain.
Topics: Animals; Cetirizine; Chronic Pain; Disease Models, Animal; GABA-A Receptor Agonists; Glial Fibrillar | 2023 |
Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.
Topics: Animals; Cranial Nerves; Dopamine; Extracellular Signal-Regulated MAP Kinases; Facial Nerve Injuries | 2020 |
Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.
Topics: Animals; Hyperalgesia; Injections, Spinal; Muscimol; Neuralgia; Oligopeptides; Rats; Spinal Cord; Sp | 2020 |
The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Basolateral Nuclear Complex; Central Amygdaloid Nucle | 2018 |
Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain.
Topics: Action Potentials; Afferent Pathways; Animals; Disease Models, Animal; Functional Laterality; GABA-A | 2013 |
Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A | 2014 |
Evidence for the involvement of descending pain-inhibitory mechanisms in the attenuation of cancer pain by carvacrol aided through a docking study.
Topics: Analgesics; Animals; Cymenes; Dose-Response Relationship, Drug; Hyperalgesia; Interleukin-10; Male; | 2014 |
Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.
Topics: Action Potentials; Animals; Anxiety; Apoptosis; Behavior, Animal; Bicuculline; Blotting, Western; Ca | 2014 |
Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.
Topics: Acetates; Action Potentials; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2015 |
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal | 2016 |
Alleviating Bone Cancer-induced Mechanical Hypersensitivity by Inhibiting Neuronal Activity in the Anterior Cingulate Cortex.
Topics: Animals; Bone Neoplasms; Disease Models, Animal; Gyrus Cinguli; Hyperalgesia; Male; Mice; Mice, Inbr | 2016 |
Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex.
Topics: Animals; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Dep | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; | 2016 |
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cadherins; Capsaicin; Disease Models, Animal; Electrosho | 2017 |
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric | 2017 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In | 2010 |
Intrathecal administration of a gap junction decoupler, an inhibitor of Na(+)-K(+)-2Cl(-) cotransporter 1, or a GABA(A) receptor agonist attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat.
Topics: Animals; Behavior, Animal; Bumetanide; Carbenoxolone; Chloride Channels; GABA Agonists; Gap Junction | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilp | 2010 |
Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biotin; Brain Mapping; Cerebral Cortex; Dextrans; D | 2011 |
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; | 2011 |
Peripheral and spinal GABAergic regulation of incisional pain in rats.
Topics: Animals; Baclofen; Behavior, Animal; Chronic Pain; gamma-Aminobutyric Acid; Hyperalgesia; Muscimol; | 2012 |
Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats.
Topics: Animals; Female; GABA-A Receptor Agonists; Ganglia, Spinal; Hyperalgesia; Muscimol; Myelin Proteins; | 2012 |
Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia.
Topics: Animals; Anxiety; GABA-A Receptor Agonists; Hyperalgesia; Male; Medulla Oblongata; Muscimol; Pain Me | 2012 |
Motor cortex stimulation activates the incertothalamic pathway in an animal model of spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Mapping; Disease Models, Animal; GABA-A Rece | 2013 |
Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1.
Topics: Action Potentials; Animals; Carrier Proteins; Chronic Disease; Electric Stimulation; GABA Plasma Mem | 2003 |
Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase 1; C | 2006 |
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat.
Topics: Animals; Antineoplastic Agents; Flumazenil; Freund's Adjuvant; GABA Agonists; GABA Antagonists; GABA | 2008 |
The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat.
Topics: Animals; Bicuculline; Catheterization; GABA Agonists; GABA Antagonists; Hyperalgesia; Injections, Sp | 1997 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, D | 1998 |
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G | 2001 |
Mechanism of hyperalgesia in SART stressed (repeated cold stress) mice: antinociceptive effect of neurotropin.
Topics: 5-Hydroxytryptophan; Animals; Cold Temperature; Drug Interactions; Fenclonine; Haloperidol; Hyperalg | 1991 |