Page last updated: 2024-11-12

benzoylaconine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

benzoylaconine: alkaloid isolated from Aconitum carmichaeli [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

benzoylaconine : A diterpene alkaloid with formula C32H45NO10 that is isolated from several Aconitum species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
AconitumgenusA plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH]RanunculaceaeThe buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH]

Cross-References

ID SourceID
PubMed CID20055771
CHEMBL ID2062825
CHEBI ID132633
SCHEMBL ID2977326
MeSH IDM0136695

Synonyms (15)

Synonym
picraconitine
benzoylaconine
isaconitine
aconine benzoate
CHEBI:132633
14-o-benzoylaconine
(1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-20-ethyl-3,8,13,15-tetrahydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl benzoate
aconine 14-benzoate
14-benzoylaconine
466-24-0
20-ethyl-3alpha,8,13,15alpha-tetrahydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitan-14alpha-yl benzoate
CHEMBL2062825
benzoylaconitine
SCHEMBL2977326
[(1s,2r,3r,4r,5r,6s,7s,8r,9r,13r,14r,16s,17s,18r)-11-ethyl-5,7,8,14-tetrahydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The validated method was employed to simultaneous quantitation and successfully used for the first time for the pharmacokinetic evaluation of the six Aconitum alkaloids after intravenous drop administration of "SHEN-FU" injectable powder in phase I clinical trial."( Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of "SHEN-FU" injectable powder.
Chen, LJ; Duan, JG; Li, R; Tang, MH; Wang, XH; Wei, YQ; Zhang, F; Zhao, X, 2008
)
0.58
"05), while T1/2, AUC0-t and Cmax of BAC, BHA increased (P<0."( The effects of Rhizoma Zingiberis on pharmacokinetics of six Aconitum alkaloids in herb couple of Radix Aconiti Lateralis-Rhizoma Zingiberis.
Cai, BC; Cui, XB; Li, JS; Li, W; Peng, WW; Wen, HM; Yang, GM; Zhang, YX, 2013
)
0.39
" Compared with single-herb extracts, alkaloids in plasma (except methylephedrine, benzoylmesaconine and benzoylhypaconine) showed slower elimination (the mean residence time or half-life was longer), although the maximum plasma concentration and area under the plasma concentration curve values decreased."( Simultaneous quantification and pharmacokinetics of alkaloids in Herba Ephedrae-Radix Aconiti Lateralis extracts.
Huo, H; Li, H; Luo, J; Song, S; Tang, Q; Xing, X,
)
0.13

Compound-Compound Interactions

ExcerptReferenceRelevance
" The potential risk of drug-drug interactions (DDIs) arising from co-administration of Aconitum alkaloids and other drugs against specific targets such as P-glycoprotein (P-gp) must be evaluated."( Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug-drug interactions.
Feng, L; He, S; Li, F; Li, N; Lin, N; Liu, L; Liu, S; Liu, Z; Lu, L; Ou, R; Wu, J; Zhang, G; Zhu, Y, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
phytotoxinAny toxin produced by a plant.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (9)

ClassDescription
benzoate esterEsters of benzoic acid or substituted benzoic acids.
bridged compoundA polycyclic compound in which two rings have two or more atoms in common.
diterpene alkaloid
organic heteropolycyclic compound
polyetherAny ether that contains more than one ether linkage.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
tetrolA polyol that contains 4 hydroxy groups.
tertiary amino compoundA compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID676146Antiinflammatory activity in mouse peritoneal macrophages assessed as inhibition of nitric oxide production at 10 uM2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676148Cytotoxicity against human A549 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676145Hepatoprotective activity against DL-galactosamine-induced cell death in rat WB-F344 cells at 10 uM incubated for 1 hr prior to DL-galactosamine-challenge measured after 24 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676144Antioxidant activity in rat liver microsome assessed as inhibition of FeSO4-induced lipid peroxidation at 10 uM incubated for 15 mins prior to FeSO4-challenge measured after 15 mins by modified thiobarbituric acid method2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676152Cytotoxicity against human HCT8 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676150Cytotoxicity against human Ketr3 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676147Cytotoxicity against human BGC823 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676151Cytotoxicity against human Bel7402 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676149Cytotoxicity against human MCF7 cells at 10 uM after 96 hrs by MTT assay2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
AID676143Neuroprotective activity against serum starvation-induced cell death in rat PC12 cells assessed as cell viability at 10 uM incubated for 24 hrs prior to serum starvation measured after 24 hrs by MTT assay (Rvb = 55.1+/-4.2%)2012Journal of natural products, Jun-22, Volume: 75, Issue:6
Diterpenoid alkaloids from the lateral root of Aconitum carmichaelii.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (27)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (3.70)18.7374
1990's1 (3.70)18.2507
2000's6 (22.22)29.6817
2010's14 (51.85)24.3611
2020's5 (18.52)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.60 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index5.36 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.45%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other28 (96.55%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]