nitrous oxide has been researched along with Allodynia in 7 studies
Nitrous Oxide: Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
dinitrogen oxide : A nitrogen oxide consisting of linear unsymmetrical molecules with formula N2O. While it is the most used gaseous anaesthetic in the world, its major commercial use, due to its solubility under pressure in vegetable fats combined with its non-toxicity in low concentrations, is as an aerosol spray propellant and aerating agent for canisters of 'whipped' cream.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrous oxide significantly reduced hyperalgesia, allodynia and pain intensity aggravated after remifentanil administration in a human volunteer model." | 9.22 | A randomized phase I trial evaluating the effects of inhaled 50-50% N2 O-O2 on remifentanil-induced hyperalgesia and allodynia in human volunteers. ( Apiou-Sbirlea, G; Bessiere, B; Noel, N; Richebé, P; Schaefer, S; Schuettler, J; Simonnet, G; Troester, A; Wehrfritz, A, 2016) |
| "Administration of 35% N2O significantly reduced hyperalgesia, allodynia and pain intensity induced after remifentanil." | 5.41 | Evaluation of antihyperalgesic and analgesic effects of 35% nitrous oxide when combined with remifentanil: A randomised phase 1 trial in volunteers. ( Bauer, M; Bessiere, B; Ihmsen, H; Noel, N; Prottengeier, J; Ramirez-Gil, JF; Schüttler, J; Wehrfritz, A, 2021) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 5.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "Nitrous oxide significantly reduced hyperalgesia, allodynia and pain intensity aggravated after remifentanil administration in a human volunteer model." | 5.22 | A randomized phase I trial evaluating the effects of inhaled 50-50% N2 O-O2 on remifentanil-induced hyperalgesia and allodynia in human volunteers. ( Apiou-Sbirlea, G; Bessiere, B; Noel, N; Richebé, P; Schaefer, S; Schuettler, J; Simonnet, G; Troester, A; Wehrfritz, A, 2016) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 1.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "In fentanyl-treated rats with inflammatory or incisional pain, nitrous oxide strongly limited both magnitude and duration of hyperalgesia." | 1.33 | Nitrous oxide revisited: evidence for potent antihyperalgesic properties. ( Creton, C; Laulin, JP; Lemaire, M; Maurette, P; Richebé, P; Rivat, C; Simonnet, G, 2005) |
| "Hyperalgesia was assessed as a decrease in the time to withdrawal of a rat hind paw exposed to heat." | 1.31 | Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. ( Dutton, RC; Eger, EI; Sonner, JM; Zhang, Y, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Wehrfritz, A | 2 |
| Bauer, M | 1 |
| Noel, N | 2 |
| Ramirez-Gil, JF | 1 |
| Ihmsen, H | 1 |
| Prottengeier, J | 1 |
| Schüttler, J | 1 |
| Bessiere, B | 3 |
| Schaefer, S | 1 |
| Troester, A | 1 |
| Apiou-Sbirlea, G | 1 |
| Simonnet, G | 3 |
| Schuettler, J | 1 |
| Richebé, P | 3 |
| Echevarría, G | 1 |
| Elgueta, F | 1 |
| Fierro, C | 1 |
| Bugedo, D | 1 |
| Faba, G | 1 |
| Iñiguez-Cuadra, R | 1 |
| Muñoz, HR | 1 |
| Cortínez, LI | 1 |
| Martinez, V | 1 |
| Fletcher, D | 1 |
| Rivat, C | 1 |
| Creton, C | 1 |
| Laulin, JP | 2 |
| Maurette, P | 1 |
| Lemaire, M | 1 |
| Laboureyras, E | 1 |
| Contarino, A | 1 |
| Zhang, Y | 1 |
| Eger, EI | 1 |
| Dutton, RC | 1 |
| Sonner, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938] | Phase 4 | 50 participants (Actual) | Interventional | 2016-12-31 | Completed | ||
| Intranasal Nicotine for Postoperative Pain Treatment: A Comparison of Its Effects in the Context of Isoflurane-induced Anesthesia Versus Propofol Anesthesia[NCT00232817] | Phase 4 | 80 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| The Effects of Propofol vs. Sevoflurane Administered During Anesthesia Maintenance on Early and Late Recovery After Gynecological Surgery[NCT01755234] | Phase 4 | 90 participants (Actual) | Interventional | 2012-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total opioid use in the post operative care unit (Mg of morphine equivalents) (NCT01755234)
Timeframe: PACU admission to discharge
| Intervention | miligrams of morphine equivalents (Median) |
|---|---|
| Sevoflurane | 9 |
| Propofol | 9.4 |
Opioid use in mg of morphine equivalents from discharge from the post anesthesia care unit to 24 hours after PACU discharge. (NCT01755234)
Timeframe: Discharge from PACU to 24 hours post operative after PACU discharge.
| Intervention | mg morphine equivalents (Median) |
|---|---|
| Sevoflurane | 30 |
| Propofol | 25 |
"Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score * min). A higher value indicates more pain and time in the Post Anesthesia Care Unit.~The range is 0 pain to x time in minutes x 1 hour to 5 hour ( 60-300 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC." (NCT01755234)
Timeframe: Time in the post anesthesia care unit
| Intervention | Pain Score * minutes in PACU (Median) |
|---|---|
| Sevoflurane | 270 |
| Propofol | 240 |
Quality of recovery score 24 hours after the surgical procedure.Score of 40 is poor recovery and a score of 200 is good recovery. (NCT01755234)
Timeframe: 24 hours after the surgical procedure
| Intervention | units on a scale (Median) |
|---|---|
| Sevoflurane | 175 |
| Propofol | 176 |
2 trials available for nitrous oxide and Allodynia
| Article | Year |
|---|---|
Evaluation of antihyperalgesic and analgesic effects of 35% nitrous oxide when combined with remifentanil: A randomised phase 1 trial in volunteers.
Topics: Analgesics, Opioid; Double-Blind Method; Healthy Volunteers; Humans; Hyperalgesia; Male; Nitrous Oxi | 2021 |
A randomized phase I trial evaluating the effects of inhaled 50-50% N2 O-O2 on remifentanil-induced hyperalgesia and allodynia in human volunteers.
Topics: Adult; Analgesics, Opioid; Cross-Over Studies; Double-Blind Method; Healthy Volunteers; Humans; Hype | 2016 |
5 other studies available for nitrous oxide and Allodynia
| Article | Year |
|---|---|
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Lidoc | 2011 |
Prevention of opioid-induced hyperalgesia in surgical patients: does it really matter?
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Male; Nitrous Oxide; Pai | 2012 |
Nitrous oxide revisited: evidence for potent antihyperalgesic properties.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagon | 2005 |
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats.
Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models | 2007 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |
Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration.
Topics: Anesthetics, Inhalation; Animals; Chlorofluorocarbons; Cyclobutanes; Ether; Halothane; Hyperalgesia; | 2000 |