vincosamide: isolated from Anthocephalus cadamba; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Anthocephalus | genus | [no description available] | Rubiaceae | The Madder plant family of the order Gentianales (formerly Rubiales), subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 10163855 |
| CHEMBL ID | 4447303 |
| CHEBI ID | 141963 |
| MeSH ID | M000606607 |
| Synonym |
|---|
| vincosamide |
| CHEBI:141963 |
| 23141-27-7 |
| CHEMBL4447303 , |
| vincosamide, >=90% (lc/ms-elsd) |
| AKOS032961753 |
| HY-N1089 |
| FS-9630 |
| CS-0016377 |
| (1r,18s,19r,20s)-19-ethenyl-18-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15-pentaen-14-one |
| oxayohimban-21-one, 19,20-didehydro-16-ethenyl-17-(beta-d-glucopyranosyloxy)-, (3beta,15beta,16alpha,17beta)- |
| ac-lys(ac)-d-ala-d-lacticacid |
| YAA14127 |
| bdbm50531280 |
| DTXSID601316670 |
| E80772 |
| Class | Description |
|---|---|
| monoterpenoid indole alkaloid | A terpenoid indole alkaloid which is biosynthesised from L-tryptophan and diisoprenoid (usually secolaganin) building blocks. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 (µMol) | 100.0000 | 0.0001 | 0.2571 | 8.0000 | AID1617782 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| G protein-coupled serotonin receptor activity | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| protein binding | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| receptor-receptor interaction | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| neurotransmitter receptor activity | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| serotonin binding | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| synapse | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| plasma membrane | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| dendrite | 5-hydroxytryptamine receptor 1A | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1541625 | Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Glucoconjugated Monoterpene Indole Alkaloids from |
| AID1541624 | Cytotoxicity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Glucoconjugated Monoterpene Indole Alkaloids from |
| AID1617782 | Agonist activity at human 5HT1A receptor expressed in CHOK1 cells incubated for 16 hrs followed by forskolin-stimulation and measured after 2 hrs by dual-glo luciferase reporter gene assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Uncarialins A-I, Monoterpenoid Indole Alkaloids from |
| AID1541626 | Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay | 2019 | Journal of natural products, 12-27, Volume: 82, Issue:12 | Glucoconjugated Monoterpene Indole Alkaloids from |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.19) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||