naltrexone has been researched along with Allodynia in 98 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (11.22) | 18.2507 |
| 2000's | 35 (35.71) | 29.6817 |
| 2010's | 41 (41.84) | 24.3611 |
| 2020's | 11 (11.22) | 2.80 |
| Authors | Studies |
|---|---|
| Araya, EI; Baggio, DF; Barroso, AR; Chichorro, JG; Koren, LO; Turnes, JM; Zanoveli, JM | 1 |
| Dieb, W; Durif, F; Hafidi, A; Hamdi, D; Lashin, M; Omara-Reda, H; Ouachikh, O | 1 |
| Baggio, DF; Chichorro, JG; Dos Santos, SMD; Ferreira, LEN; Hummig, W; Lopes, RV | 1 |
| Di Cerbo, A; Iannitti, T; Morales-Medina, JC; Pugliese, N; Zizzadoro, C | 1 |
| Bassani da Silva, B; Fernandes Magalhães, S; Gonçalves Dos Santos, G; Parada, CA; Tambeli, CH; Vendramini, PH; Vieira, WF | 1 |
| da Silva Torres, IL; de Oliveira, CL; de Oliveira, FF; de Souza, A; de Souza, VS; Lopes, BC; Marques, LX; Medeiros, LF | 1 |
| Baamonde, A; González-Rodríguez, S; Lastra, A; Machelska, H; Menéndez, L; Seitz, V; Stein, C | 1 |
| Cruz, JS; de Macedo, FHP; Duarte, IDG; Ferreira, RCM; Gonçalves, WA; Gualdron, M; Machado, FS; Mahecha, GAB; Perez, AC; Rezende, BM; Romero, TRL | 1 |
| Bilbrey, JA; Felix, JS; McCurdy, CR; McMahon, LR; Wilkerson, JL | 1 |
| Ballet, S; Bermudez, M; De Neve, J; Dumitrascuta, M; Spetea, M; Trovato, O; Wolber, G | 1 |
| Augusto, PSA; Brito, AMS; Coelho, MM; Costa, SOAM; Dutra, MGMB; Godin, AM; Goulart, FA; Ísis Morais, M; Machado, RR; Melo, ISF; Menezes, RR; Rodrigues, FF | 1 |
| Castor, MGME; Duarte, IDG; Guzzo, LS; Klein, A; Petrocchi, JA; Romero, TRL; Soares Santos, RR | 1 |
| Hein, M; Ji, G; Navratilova, E; Neugebauer, V; Phelps, C; Porreca, F; Qu, C; Yakhnitsa, V | 1 |
| Faraone, S; Johnson, B; Middleton, B; Oaks, Z; Stage, A | 1 |
| Bannister, K; Dickenson, AH; Navratilova, E; Phelps, CE; Porreca, F | 1 |
| Cami-Kobeci, G; Czoty, PW; DeLoid, HB; Ding, H; Hsu, FC; Husbands, SM; Kiguchi, N; Ko, MC; Sukhtankar, DD; Toll, L | 1 |
| Augusto, PSA; Batista, CRA; Braga, AV; Coelho, MM; Costa, SOAM; Dutra, MMGB; Goulart, FA; Machado, RR; Melo, ISF; Morais, MI; Rodrigues, FF | 1 |
| Custodio-Patsey, L; Donahue, RR; Fu, W; Lambert, J; Smith, BN; Taylor, BK | 1 |
| Ingram, SL; Lamberts, JT; Li, MH; Neubig, RR; Smith, CE; Traynor, JR | 1 |
| Hackel, D; Peng, F; Rittner, HL; Wang, Y | 1 |
| Carteret, AF; Cheong, YK; Dong, X; Guan, Y; He, SQ; Perez, FM; Raja, SN; Shechter, R; Sweitzer, SM; Xu, Q; Yang, F | 1 |
| Gibbons, CR; Levitch, BR; Liu, S; Moehlmann, SB; Quock, RM; Sayre, CL; Shirachi, DY; Zhang, Y | 1 |
| Corder, G; Donahue, RR; Doolen, S; He, Y; Hu, X; Jutras, BL; McCarson, KE; Mogil, JS; Storm, DR; Taylor, BK; Wang, ZJ; Wieskopf, JS; Winter, MK | 1 |
| Ellis, A; Falci, S; Favret, J; Johnson, KW; Maier, SF; Rice, KC; Watkins, LR; Wieseler, J | 1 |
| Arout, CA; Caldwell, M; Kest, B; McCloskey, DP | 1 |
| Clark, JD; Liang, DY; Sahbaie, P; Shi, XY; Sun, Y | 1 |
| Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC | 1 |
| Chen, L; Li, YQ; Mei, XP; Wang, K; Wang, W; Yang, T; Zhang, FX; Zhu, C | 1 |
| Hu, N; Li, Y; Shu, R; Wang, C; Wang, G; Wang, H; Xie, K; Yu, Y; Zhang, L | 1 |
| Arout, CA; Caldwell, M; Kest, B; Rossi, G | 1 |
| Egashira, N; Higuchi, H; Kawashiri, T; Ushio, S; Yamamoto, S | 1 |
| Harada, S; Kageyama, E; Matsuura, W; Tokuyama, S | 1 |
| Ayala, M; Ellis, A; Falci, S; Favret, J; Grace, PM; Hutchinson, MR; Maier, SF; Rice, KC; Skarda, B; Springer, K; Watkins, LR; Wieseler, J | 1 |
| Alongkronrusmee, D; Chiang, T; van Rijn, RM | 1 |
| Berg, KA; Chavera, TA; Clarke, WP; Jacobs, BA; Jamshidi, RJ; Sullivan, LC | 1 |
| Barres, BA; Bohlen, CJ; Clark, JD; Corder, G; Dickinson, JR; Low, SA; Scherrer, G; Sotoudeh, C; Sypek, EI; Tawfik, VL; Wang, D | 1 |
| Chen, SR; Pan, HL | 1 |
| Crain, SM; Shen, KF | 4 |
| Barnes, MJ; Bray, GA; Primeaux, SD | 1 |
| Arout, CA; Dahan, A; Kest, B; Kowalczyk, WJ; Morariu, AM; Sarton, EY; van Dorp, EL; Waxman, AR | 1 |
| Arout, C; Caldwell, M; Dahan, A; Kest, B; Waxman, AR | 1 |
| Hervera, A; Leánez, S; Negrete, R; Pol, O | 1 |
| Benedek, G; Horvath, G; Mecs, L; Nagy, E; Tuboly, G | 1 |
| Calò, G; Guerrini, R; Hu, E; Ko, MC | 1 |
| Arout, C; Cai, M; Dahan, A; Hruby, VJ; Juni, A; Kest, B; Klein, G; Mogil, JS; Stankova, M; Waxman, AR | 1 |
| Agostini, S; Broccardo, M; Bueno, L; Cartier, C; Eutamene, H; Ferrier, L; Houdeau, E; Improta, G; Petrella, C; Theodorou, V | 1 |
| Bakhle, YS; de Francischi, JN; dos Reis, WG; Ferreira-Alves, DL; Gassani, BC; Paiva-Lima, P; Rezende, RM | 1 |
| Akiyama, T; Carstens, E; Carstens, MI | 1 |
| Buechler, NL; Childers, SR; Ewan, EE; Kim, SA; Martin, TJ; Xiao, R | 1 |
| Cabañero, D; Campillo, A; García-Nogales, P; Puig, MM; Romero, A | 1 |
| Berman, BM; Lao, L; Li, A; Meng, X; Ren, K; Tan, M; Xin, J; Zhang, RX; Zhang, Y | 2 |
| Bihel, F; Bockel, F; Bourguignon, JJ; Elhabazi, K; Maldonado, R; Meziane, H; Mollereau, C; Moulédous, L; Petit-demoulière, B; Schmitt, M; Simonin, F; Trigo, JM; Zajac, JM | 1 |
| Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G | 1 |
| Ambriz-Tututi, M; Drucker-Colín, R; Sánchez-González, V | 1 |
| Arout, C; Beijnen, JH; Dahan, A; den Hartigh, J; Kest, B; Mooren, RA; Swartjes, M; van de Wetering, K; Waxman, AR | 1 |
| Johanek, LM; King, EW; Sato, KL; Sluka, KA | 1 |
| Lesniak, A; Lipkowski, AW; Ragan, AR; Sacharczuk, M; Sadowski, B; Szymanska, H | 1 |
| Francischi, JN; Lima-Paiva, P; Resende, MA; Santos, CM; Sluka, KA | 1 |
| Jones, T; Laurito, CE; Lu, Y; Wilson, SP; Yeomans, DC | 1 |
| Gewirtz, JC; Hanes, SL; Harris, AC | 1 |
| Alves, DP; Amarante, LH; Duarte, ID | 1 |
| Cândido, CR; Francischi, JN; Pereira, LS; Resende, MA; Sabino, GG | 1 |
| Castro, MS; Duarte, ID; Francischi, JN; Pacheco, DF; Perez, AC; Reis, GM | 1 |
| Baamonde, A; García, V; Hidalgo, A; Juárez, L; Lastra, A; Menéndez, L | 1 |
| Boulet, JM; Chaffer, SM; Garrison, AE; Gottshall, SL; Harrison, JE; Mark, L; Pearson, MS; Turchin, PI; Valenzano, KJ; Whiteside, GT | 1 |
| Juni, A; Kest, B; Klein, G | 1 |
| Bakhle, YS; Duarte, ID; Ferreira-Alves, DL; França, DS; Francischi, JN; Rezende, RM; Ribeiro, MC | 1 |
| Schwasinger, E; Terashvili, M; Tseng, LF; Wu, HE | 1 |
| Jhamandas, K; McNaull, B; Sutak, M; Trang, T | 1 |
| Bruchas, MR; Chavkin, C; Gendron, L; Ippolito, DL; Xu, M | 1 |
| Bova, MP; Butelman, ER; Chavez, RA; Chen, L; Dreyer, M; Fukuda, JY; Garofalo, AW; Hawkinson, JE; Holcomb, R; Hom, DS; Ko, MC; Liao, A; Malmberg, AB; Ruslim, L; Samant, B; Simmonds, S; Szoke, BG; Wadsworth, A; Zeitz, KP; Zhang, H; Zmolek, W | 1 |
| Chavkin, C; Gendron, L; Pintar, JE | 1 |
| Bakhle, YS; dos Reis, WG; França, DS; Francischi, JN; Menezes, GB; Rezende, RM | 1 |
| Bian, ZX; Leung, WM; Li, Z; Liu, L; Xu, HX; Zhang, XJ | 1 |
| Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A | 1 |
| Burns, LH; Guo, W; Largent-Milnes, TM; Vanderah, TW; Wang, HY | 1 |
| Huang, FS; Tang, JS; Wang, JY; Yuan, YK; Zhao, M | 1 |
| Goettl, VM; Larson, AA | 1 |
| Hammond, DL; Stewart, PE | 1 |
| Al, Y; Butelman, ER; Negus, SS; Woods, JH | 1 |
| Alcaraz, C; Milanés, MV; Vargas, ML | 1 |
| Apfel, SC; Dormia, C; Kessler, JA; Newel, M | 1 |
| Iwatsubo, K; Kawabata, A; Takagi, H; Takaya, S | 1 |
| Baldwin, AE; Cannon, TJ | 1 |
| Hao, JX; Xu, XJ; Yu, W | 1 |
| Coudoré-Civiale, MA; Courteix, C; Eschalier, A; Fialip, J; Privat, AM; Zajac, JM | 1 |
| Hori, T; Hosoi, M; Kamikawa, H; Katafuchi, T; Yamamoto, T | 1 |
| Dubner, R; Qiu, C; Ren, K; Sora, I; Uhl, G | 1 |
| Eissenberg, T; Harkins, SW; Riggins, EC; Weaver, MF | 1 |
| Agrewala, JN; Kulkarni, SK; Raghavendra, V | 1 |
| Lutfy, K; Maidment, NT | 1 |
| Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I | 1 |
| Kalra, A; Sluka, KA; Urban, MO | 1 |
| Kawabata, A; Nishimura, Y; Takagi, H | 1 |
1 trial(s) available for naltrexone and Allodynia
| Article | Year |
|---|---|
A clinical laboratory model for direct assessment of medication-induced antihyperalgesia and subjective effects: initial validation study.
Topics: Adult; Affect; Analgesics; Analgesics, Opioid; Double-Blind Method; Emotions; Female; Hot Temperature; Humans; Hyperalgesia; Male; Models, Psychological; Naltrexone; Narcotic Antagonists; Oxycodone; Pain Measurement; Pupil; Reproducibility of Results; Research Design; Ultraviolet Rays | 2000 |
97 other study(ies) available for naltrexone and Allodynia
| Article | Year |
|---|---|
Blockade of kappa opioid receptors reduces mechanical hyperalgesia and anxiety-like behavior in a rat model of trigeminal neuropathic pain.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Nociception; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Trigeminal Neuralgia | 2022 |
Naltrexone promotes mechanical allodynia in humans and rats.
Topics: Animals; Humans; Hyperalgesia; Naltrexone; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn | 2022 |
Antinociceptive effect of ultra-low dose naltrexone in a pre-clinical model of postoperative orofacial pain.
Topics: Analgesics, Opioid; Animals; Facial Pain; Female; Hyperalgesia; Lipopolysaccharides; Male; Naltrexone; Pain, Postoperative; Rats; Toll-Like Receptor 4 | 2023 |
Evidence for Endogenous Opioid Dependence Related to Latent Sensitization in a Rat Model of Chronic Inflammatory Pain.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Inverse Agonism; Hyperalgesia; Inflammation; Mice; Naltrexone; Opioid Peptides; Opioid-Related Disorders; Rats; Rats, Wistar | 2023 |
Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB
Topics: Analgesics; Animals; Cannabinoid Receptor Antagonists; Carrageenan; Dipyrone; Hydrolysis; Hyperalgesia; Indoles; Male; Naloxone; Naltrexone; Narcotic Antagonists; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Somatostatin | 2020 |
LOW-DOSE NALTREXONE REVERSES FACIAL MECHANICAL ALLODYNIA IN A RAT MODEL OF TRIGEMINAL NEURALGIA.
Topics: Analgesics, Non-Narcotic; Animals; Brain-Derived Neurotrophic Factor; Carbamazepine; Disease Models, Animal; Facial Pain; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Spinal Cord; Trigeminal Neuralgia | 2020 |
A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Cell Line, Tumor; Fentanyl; Hydrogen-Ion Concentration; Hyperalgesia; Ligands; Male; Melanoma, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Morphinans; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, mu | 2020 |
Endogenous opioid and cannabinoid systems modulate the muscle pain: A pharmacological study into the peripheral site.
Topics: Animals; Arachidonic Acids; Carrageenan; Cinnamates; Endocannabinoids; Hyperalgesia; Male; Monoacylglycerol Lipases; Morphine Derivatives; Myalgia; Naloxone; Naltrexone; Pain Measurement; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2021 |
Characterization of a mouse neuropathic pain model caused by the highly active antiviral therapy (HAART) Stavudine.
Topics: Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Neuralgia; Stavudine | 2021 |
Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking.
Topics: Acute Pain; Analgesics; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Cycloheptanes; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Mice; Models, Molecular; Molecular Docking Simulation; Morphine; Movement; Naloxone; Naltrexone; Nociceptin; Oligopeptides; Opioid Peptides; Pain Management; Piperidines; Receptors, Opioid, mu | 2021 |
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
Topics: Animals; Chemokine CXCL1; Glyburide; Hyperalgesia; Isoxazoles; Leflunomide; Male; Mice; Naltrexone; Neuralgia; Tumor Necrosis Factor-alpha | 2018 |
Noradrenaline induces peripheral antinociception by endogenous opioid release.
Topics: Analgesics; Animals; Cinnamates; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Leucine; Male; Morphine Derivatives; Naltrexone; Norepinephrine; Opioid Peptides; Pain Measurement; Prazosin; Propranolol; Rats; Yohimbine | 2018 |
Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.
Topics: Animals; Central Amygdaloid Nucleus; Chronic Pain; Disease Models, Animal; Hyperalgesia; In Vitro Techniques; Male; Membrane Potentials; Naltrexone; Narcotic Antagonists; Neural Inhibition; Neuralgia; Neurons; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Synaptic Transmission | 2019 |
Clinical utility of the cold pressor test: evaluation of pain patients, treatment of opioid-induced hyperalgesia and fibromyalgia with low dose naltrexone.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Pain; Dose-Response Relationship, Drug; Female; Fibromyalgia; Humans; Hyperalgesia; Male; Middle Aged; Naltrexone; Opioid-Related Disorders; Pain Management; Pain Measurement; Pain Threshold; Predictive Value of Tests; Retrospective Studies; Young Adult | 2018 |
Kappa opioid signaling in the right central amygdala causes hind paw specific loss of diffuse noxious inhibitory controls in experimental neuropathic pain.
Topics: Amygdala; Animals; Chronic Pain; Diffuse Noxious Inhibitory Control; Electrophysiological Phenomena; Functional Laterality; Hindlimb; Hyperalgesia; Ligation; Male; Naltrexone; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Signal Transduction; Spinal Nerves | 2019 |
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Tolerance; Hyperalgesia; Injections, Spinal; Isoquinolines; Macaca mulatta; Male; Naltrexone; Nociception; Opioid-Related Disorders; Pain Threshold; Phenylpropionates | 2019 |
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Glyburide; Hyperalgesia; Metformin; Mice; Naltrexone; Neuralgia; Nociception; Psychomotor Performance; Receptors, Opioid | 2019 |
Sex differences in kappa opioid receptor inhibition of latent postoperative pain sensitization in dorsal horn.
Topics: Animals; Benzamides; Extracellular Signal-Regulated MAP Kinases; Female; Hyperalgesia; Male; Mice, Inbred C57BL; Naltrexone; Pain, Postoperative; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Factors; Somatostatin; Spinal Cord Dorsal Horn | 2020 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Hyperalgesia; Inhibitory Postsynaptic Potentials; Isotopes; Male; Methadone; Mice; Mice, Transgenic; Morphine; Mutation; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Oligopeptides; Pain Measurement; Patch-Clamp Techniques; Pertussis Toxin; Protein Binding; Reaction Time; RGS Proteins; Signal Transduction; Spinal Cord | 2013 |
Long-term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free-moving rats with inflammatory hyperalgesia.
Topics: Acupuncture Analgesia; Acupuncture Points; Animals; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Naloxone; Naltrexone; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid; Time | 2013 |
Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Ligation; Loperamide; Male; Naltrexone; Narcotic Antagonists; Phosphorylation; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Spinal Nerves | 2013 |
Involvement of brain opioid receptors in the anti-allodynic effect of hyperbaric oxygen in rats with sciatic nerve crush-induced neuropathic pain.
Topics: Animals; Hyperalgesia; Hyperbaric Oxygenation; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Sciatic Nerve; Spinal Cord | 2013 |
Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence.
Topics: Acute Pain; Adenosine Monophosphate; Adenylyl Cyclases; Animals; Chronic Pain; Disease Models, Animal; Freund's Adjuvant; Hyperalgesia; Isoflurane; Male; Mice; Naltrexone; Nociceptive Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome | 2013 |
Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Neuroglia; Neuroprotective Agents; Phosphodiesterase Inhibitors; Pyridines; Radiculopathy; Rats; Rats, Sprague-Dawley; Xanthines | 2014 |
C-Fos activation in the periaqueductal gray following acute morphine-3β-D-glucuronide or morphine administration.
Topics: Animals; Central Nervous System Stimulants; Hyperalgesia; Immunohistochemistry; Male; Mice, Inbred Strains; Microscopy, Confocal; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Narcotics; Neurons; Pain Threshold; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Random Allocation | 2014 |
Epigenetic regulation of spinal cord gene expression controls opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Antineoplastic Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dynorphins; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Spinal Cord; Vorinostat | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inhibition, Psychological; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Self Stimulation | 2014 |
Downregulation of spinal endomorphin-2 correlates with mechanical allodynia in a rat model of tibia cancer.
Topics: Analgesics; Animals; Bone Neoplasms; Disease Models, Animal; Down-Regulation; Female; Hyperalgesia; Morphine; Naltrexone; Narcotic Antagonists; Oligopeptides; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tibia | 2015 |
Inhibition of DOR prevents remifentanil induced postoperative hyperalgesia through regulating the trafficking and function of spinal NMDA receptors in vivo and in vitro.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Hot Temperature; Hyperalgesia; Lumbar Vertebrae; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Threshold; Pain, Postoperative; Piperidines; Posterior Horn Cells; Random Allocation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Remifentanil; Spinal Cord; Tissue Culture Techniques; Touch | 2015 |
Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Brain Stem; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Ovariectomy; Pain Measurement; Progesterone; Progestins; Reaction Time; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Spinal Cord | 2015 |
Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor.
Topics: Aconitum; Animals; Bortezomib; Drugs, Chinese Herbal; Hyperalgesia; Male; Naltrexone; Phytotherapy; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Tramadol | 2015 |
Unique action mechanisms of tramadol in global cerebral ischemia-induced mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Tramadol | 2016 |
Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Male; Morphine; Naltrexone; Neuralgia; Rats, Sprague-Dawley; Spinal Cord Injuries; Toll-Like Receptor 4 | 2016 |
Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Ethanol; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; Pain Management; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome | 2016 |
Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons.
Topics: Animals; Dinoprostone; Enzyme Activation; Hyperalgesia; JNK Mitogen-Activated Protein Kinases; Ligands; Male; Naltrexone; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensory Receptor Cells; Signal Transduction; Time Factors | 2016 |
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Drug Tolerance; Gene Deletion; Hyperalgesia; Long-Term Potentiation; Mice; Mice, Knockout; Microglia; Morphine; Naltrexone; Nociception; Nociceptors; Pain, Postoperative; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Signal Transduction; Spinal Cord | 2017 |
Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Gene Expression Regulation; Hyperalgesia; Male; Naltrexone; Oligopeptides; Pain Threshold; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Sensory Receptor Cells; Spinal Cord; Tritium; TRPV Cation Channels | 2008 |
Low doses of cyclic AMP-phosphodiesterase inhibitors rapidly evoke opioid receptor-mediated thermal hyperalgesia in naïve mice which is converted to prominent analgesia by cotreatment with ultra-low-dose naltrexone.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Analgesia; Analgesics; Animals; Cyclic AMP; Dipeptides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Mice; Naltrexone; Narcotic Antagonists; Nociceptors; Phosphodiesterase Inhibitors; Receptors, G-Protein-Coupled; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Signal Transduction; Time Factors | 2008 |
Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Dietary Fats; Eating; Food Deprivation; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ventromedial Hypothalamic Nucleus | 2008 |
Morphine-6beta-glucuronide rapidly increases pain sensitivity independently of opioid receptor activity in mice and humans.
Topics: Adolescent; Adult; Animals; Dizocilpine Maleate; Female; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Pain Measurement; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Young Adult | 2009 |
Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Knockout; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Time Factors | 2009 |
The peripheral administration of a nitric oxide donor potentiates the local antinociceptive effects of a DOR agonist during chronic inflammatory pain in mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Drug Therapy, Combination; Enkephalin, D-Penicillamine (2,5)-; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Naltrexone; Narcotic Antagonists; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Pain Measurement; Receptors, Opioid, delta; Time Factors | 2009 |
The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.
Topics: Analgesics, Opioid; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Carrageenan; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Intra-Articular; Injections, Subcutaneous; Kynurenic Acid; Ligands; Male; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Time Factors | 2009 |
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
Topics: Analgesics; Animals; Benzimidazoles; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Naltrexone; Nociceptin; Opioid Peptides; Pain Measurement; Pain Threshold; Piperidines | 2010 |
Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.
Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Naltrexone; Narcotic Antagonists; Receptor, Melanocortin, Type 1; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2010 |
Evidence of central and peripheral sensitization in a rat model of narcotic bowel-like syndrome.
Topics: Abdominal Pain; Animals; CD11b Antigen; Chymases; Colon; Delayed-Action Preparations; Disease Models, Animal; Gastrointestinal Transit; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Mast Cells; Microglia; Minocycline; Morphine; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Spinal Cord; Syndrome; Thioxanthenes; Time Factors; Ubiquitin Thiolesterase; Xanthones | 2010 |
Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Topics: Acetazolamide; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2010 |
Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Hindlimb; Hyperalgesia; Male; Mice; Morphine; Naltrexone; Pain Measurement; Pruritus; Skin | 2010 |
Involvement of the lateral amygdala in the antiallodynic and reinforcing effects of heroin in rats after peripheral nerve injury.
Topics: Amygdala; Analgesics, Opioid; Animals; Behavior, Animal; Brain; Conditioning, Operant; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Heroin; Hyperalgesia; Infusions, Intravenous; Male; Naltrexone; Narcotic Antagonists; Peripheral Nerve Injuries; Rats; Rats, Inbred F344; Reinforcement, Psychology; Self Administration; Spinal Nerves | 2011 |
Delayed postoperative latent pain sensitization revealed by the systemic administration of opioid antagonists in mice.
Topics: Animals; Dizocilpine Maleate; Dynorphins; Hyperalgesia; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Piperidines; Postoperative Complications; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Remifentanil; Spinal Cord | 2011 |
Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia.
Topics: Affect; Animals; Avoidance Learning; Conditioning, Classical; Disease Models, Animal; Electroacupuncture; Freund's Adjuvant; Gyrus Cinguli; Hyperalgesia; Inflammation; Male; Naltrexone; Pain Management; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2011 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug Tolerance; Fentanyl; Hot Temperature; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain; Receptors, Neuropeptide; Substance Withdrawal Syndrome | 2012 |
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Swimming; Time Factors | 2011 |
Chromaffin cell transplant in spinal cord reduces secondary allodynia induced by formalin in the rat. Role of opioid receptors and α₂-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cell Survival; Chromaffin Cells; Female; Formaldehyde; Hyperalgesia; Naltrexone; Narcotic Antagonists; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Spinal Cord; Yohimbine | 2011 |
The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.
Topics: Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Electroacupuncture; Hyperalgesia; Male; Naltrexone; Narcotic Antagonists; Paclitaxel; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Somatostatin | 2011 |
Morphine induces hyperalgesia without involvement of μ-opioid receptor or morphine-3-glucuronide.
Topics: Animals; Hyperalgesia; Male; Mice; Morphine; Morphine Derivatives; Naltrexone; Reaction Time; Receptors, Opioid, mu | 2012 |
Spinal cord stimulation reduces hypersensitivity through activation of opioid receptors in a frequency-dependent manner.
Topics: Analgesics, Opioid; Animals; Hyperalgesia; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Spinal Cord Stimulation | 2013 |
Distinct susceptibility to inoculated melanoma and sensitivity to cancer pain in mouse lines with high and low sensitivity to stress.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Genetic Predisposition to Disease; Genotype; Hyperalgesia; Male; Melanoma; Mice; Models, Animal; Naltrexone; Narcotic Antagonists; Opioid Peptides; Skin Neoplasms; Stress, Physiological; Swimming | 2012 |
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin.
Topics: Animals; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Methysergide; Naltrexone; Narcotic Antagonists; Nociception; Pizotyline; Rats; Serotonin; Serotonin Antagonists; Transcutaneous Electric Nerve Stimulation | 2013 |
Reversal of ongoing thermal hyperalgesia in mice by a recombinant herpesvirus that encodes human preproenkephalin.
Topics: Administration, Cutaneous; Animals; Enkephalins; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesviridae; Hyperalgesia; Immunohistochemistry; Mice; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Pertussis Toxin; Protein Precursors; Receptors, Opioid, mu; Receptors, sigma; Somatostatin | 2004 |
Potentiated startle and hyperalgesia during withdrawal from acute morphine: effects of multiple opiate exposures.
Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome | 2004 |
Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.
Topics: 4-Aminopyridine; Analgesics; Animals; ATP-Binding Cassette Transporters; Benzomorphans; Charybdotoxin; Cyclic GMP; Dequalinium; Glyburide; Hyperalgesia; KATP Channels; Male; Naltrexone; Nitric Oxide; Peripheral Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction; Tetraethylammonium; Tolbutamide | 2004 |
Local transcutaneous electrical stimulation (TENS) effects in experimental inflammatory edema and pain.
Topics: Animals; Carrageenan; Edema; Female; Foot; Hyperalgesia; Naltrexone; Narcotic Antagonists; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Transcutaneous Electric Nerve Stimulation | 2004 |
delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine/nitric oxide/cyclic GMP pathway.
Topics: Analgesics; Animals; Arginine; Benzamides; Benzylidene Compounds; Cyclic GMP; Dinoprostone; Enzyme Inhibitors; Hyperalgesia; Male; Naltrexone; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Piperazines; Rats; Receptors, Opioid, delta | 2005 |
Effects of the local administration of selective mu-, delta-and kappa-opioid receptor agonists on osteosarcoma-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hyperalgesia; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Osteosarcoma; Receptors, Opioid | 2005 |
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Opioid; Sciatic Nerve | 2005 |
Morphine hyperalgesia in mice is unrelated to opioid activity, analgesia, or tolerance: evidence for multiple diverse hyperalgesic systems.
Topics: Analgesia; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Antagonists; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Naltrexone; Narcotic Antagonists; Nociceptors; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 2006 |
Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.
Topics: Analgesics; Analgesics, Opioid; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Tolerance; Edema; Endorphins; Foot; Hyperalgesia; Indomethacin; Injections; Injections, Subcutaneous; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Species Specificity | 2006 |
Paradoxical hyperalgesia induced by mu-opioid receptor agonist endomorphin-2, but not endomorphin-1, microinjected into the centromedial amygdala of the rat.
Topics: Amygdala; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dynorphins; Excitatory Amino Acid Antagonists; Hyperalgesia; Immune Sera; Male; Microinjections; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rabbits; Rats; Receptors, Opioid, mu; Time Factors | 2007 |
Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Somatostatin; Theophylline | 2007 |
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Hyperesthesia; Imidazoles; In Vitro Techniques; Ligation; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord | 2007 |
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
Topics: Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bradykinin; Bradykinin B1 Receptor Antagonists; Calcium; Carrageenan; Cell Line; Cell Membrane Permeability; Fibroblasts; Humans; Hyperalgesia; Kallidin; Macaca mulatta; Mice; Mice, Knockout; Microsomes, Liver; Molecular Structure; Naltrexone; Naproxen; Narcotic Antagonists; Rats; Receptor, Bradykinin B1; Species Specificity; Spiro Compounds; Transfection | 2007 |
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.
Topics: Analgesics, Opioid; Animals; Chronic Disease; Dipeptides; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; G(M1) Ganglioside; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Receptors, Opioid, kappa; Substance Withdrawal Syndrome | 2007 |
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Carrageenan; Dipyrone; Disease Models, Animal; Hyperalgesia; Inflammation; Injections, Intralesional; Injections, Subcutaneous; Male; Naltrexone; Narcotic Antagonists; Opioid Peptides; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Rats, Wistar; Research Design; Time Factors | 2008 |
The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats.
Topics: Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Female; Glucosides; Hyperalgesia; Male; Maternal Deprivation; Monoterpenes; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Pregnancy; Rats; Rats, Sprague-Dawley; Yohimbine | 2008 |
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2008 |
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Naltrexone; Narcotic Antagonists; Neuralgia; Oxycodone; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Signal Transduction; Spinal Nerves | 2008 |
Mu-opioid receptor in the nucleus submedius: involvement in opioid-induced inhibition of mirror-image allodynia in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hyperalgesia; Ligation; Male; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Neuralgia; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Nerves; Thalamic Nuclei | 2008 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
Activation of spinal delta-1 or delta-2 opioid receptors reduces carrageenan-induced hyperalgesia in the rat.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Male; Naltrexone; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord | 1994 |
Prostaglandin E2-induced thermal hyperalgesia and its reversal by morphine in the warm-water tail-withdrawal procedure in rhesus monkeys.
Topics: Animals; Azocines; Data Interpretation, Statistical; Dinoprostone; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Macaca mulatta; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Measurement; Sodium Chloride; Temperature | 1993 |
Chronic kappa opioid receptor antagonism produces supersensitivity to U-50,488H at the hypothalamo-pituitary-adrenocortical (HPA) axis level.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Body Weight; Corticosterone; Dose-Response Relationship, Drug; Hyperalgesia; Hypothalamo-Hypophyseal System; Male; Naloxone; Naltrexone; Pituitary-Adrenal System; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Sensitivity and Specificity; Sodium Chloride | 1993 |
Kappa opioid receptors participate in nerve growth factor-induced hyperalgesia.
Topics: Animals; Female; Humans; Hyperalgesia; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nerve Growth Factors; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Recombinant Proteins | 1995 |
Central antinociceptive effect of L-ornithine, a metabolite of L-arginine, in rats and mice.
Topics: Analgesia; Animals; Arginine; Carrageenan; Citrulline; Dipeptides; Dose-Response Relationship, Drug; Excipients; Hyperalgesia; Injections, Intraventricular; Leucine; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Ornithine; Pain Measurement; Protease Inhibitors; Rats | 1996 |
Sensitization of the tail-flick reflex following exposure to either a single prolonged test trial or behavioral testing under the analgesic influence of morphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Hot Temperature; Hyperalgesia; Male; Morphine; Naltrexone; Narcotic Antagonists; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Restraint, Physical; Tail; Time Factors | 1996 |
Evidence that spinal endogenous opioidergic systems control the expression of chronic pain-related behaviors in spinally injured rats.
Topics: Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Female; Hyperalgesia; Injections, Spinal; Naltrexone; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Self Mutilation; Somatostatin; Spinal Cord Injuries; Stress, Mechanical | 1998 |
Spinal effect of a neuropeptide FF analogue on hyperalgesia and morphine-induced analgesia in mononeuropathic and diabetic rats.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hyperalgesia; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Nervous System Diseases; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Somatostatin; Time Factors; Vocalization, Animal | 1999 |
Hyperalgesic response to noxious stimulation in genetically polydipsic mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Drinking; Drinking Behavior; Hot Temperature; Hyperalgesia; Locomotion; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Nociceptors; Pain Measurement; Reaction Time; Water Deprivation | 1999 |
Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice.
Topics: Analgesia; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Receptors, Opioid, delta; Receptors, Opioid, mu | 2000 |
Melatonin reversal of lipopolysacharides-induced thermal and behavioral hyperalgesia in mice.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dexamethasone; Hyperalgesia; Lipopolysaccharides; Macrophages, Peritoneal; Male; Melatonin; Mice; Mice, Inbred BALB C; Naltrexone; Nitric Oxide; Pain Measurement; Pain Threshold; Tumor Necrosis Factor-alpha | 2000 |
Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptin; Opioid Peptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, mu; Somatostatin | 2000 |
Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Hot Temperature; Hyperalgesia; Male; Mice; Morphine; Morphine Dependence; Naltrexone; Narcotic Antagonists; Pain Threshold; Receptors, Opioid | 2001 |
Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Drug Tolerance; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Simplex; Herpesvirus 1, Human; Hyperalgesia; Mice; Mice, Inbred BALB C; Motor Activity; Naltrexone; Narcotic Antagonists; Pain | 2001 |
Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Hot Temperature; Hyperalgesia; Male; Medulla Oblongata; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Transcutaneous Electric Nerve Stimulation | 2001 |
Cholera toxin-B subunit blocks excitatory opioid receptor-mediated hyperalgesic effects in mice, thereby unmasking potent opioid analgesia and attenuating opioid tolerance/dependence.
Topics: Adjuvants, Immunologic; Administration, Oral; Analgesics, Opioid; Animals; Cells, Cultured; Cholera Toxin; Drug Administration Schedule; Drug Tolerance; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Opioid-Related Disorders; Pain Measurement; Receptors, Opioid; Substance Withdrawal Syndrome | 2001 |
L-leucyl-L-arginine, naltrindole and D-arginine block antinociception elicited by L-arginine in mice with carrageenin-induced hyperalgesia.
Topics: Analgesics; Animals; Arginine; Brain; Carrageenan; Dipeptides; Endorphins; Hyperalgesia; Indoles; Injections, Subcutaneous; Male; Mice; Morphinans; Naltrexone; Narcotic Antagonists; Pain Measurement; Stereoisomerism | 1992 |