mecamylamine has been researched along with Allodynia in 11 studies
Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 7.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| " Subsequently, a single intraperitoneal injection of the nicotinic receptor antagonist mecamylamine induced behavioral symptoms of withdrawal measured as increased grooming, chewing, scratching, and shaking, plus the appearance of some unique behaviors such as jumping, leg tremors, and cage scratching." | 3.72 | Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit. ( De Biasi, M; Pieri, F; Salas, R, 2004) |
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 3.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| " Because nucleus accumbens nicotinic receptors are important in nicotine addiction and because nicotinic activity can interact with opioid action, we investigated the contribution of nucleus accumbens nicotinic receptors to opioid-mediated analgesia/antinociception." | 3.71 | Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens. ( Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH, 2001) |
| "The nicotine plasma levels were also measured with or without methoxsalen pretreatment." | 1.40 | Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. ( Bagdas, D; Damaj, MI; Muldoon, PP; Tyndale, RF; Zhu, AZ, 2014) |
| " This hypothesis was further established with methyllycaconitine completely inhibited the agonist effect when dosed intrathecally (1% +/- 7%)." | 1.35 | Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action. ( Billinton, A; Bingham, S; Chessell, IP; Clayton, NM; Hatcher, JP; Hille, CJ; Medhurst, SJ, 2008) |
| "Mecamylamine treatment caused a biphasic nociceptive response similar to that caused by isoflurane." | 1.31 | Isoflurane hyperalgesia is modulated by nicotinic inhibition. ( Coates, KM; Flood, P; Gong, D; Sonner, JM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Tobaldini, G | 1 |
| Andersen, EOL | 1 |
| Polato, JJ | 1 |
| Guilhen, VA | 1 |
| Gaspar, JC | 1 |
| Lazzarim, MK | 1 |
| Sardi, NF | 1 |
| Fischer, L | 1 |
| Hirotsu, C | 1 |
| Pedroni, MN | 1 |
| Berro, LF | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Bagdas, D | 1 |
| Muldoon, PP | 1 |
| Zhu, AZ | 1 |
| Tyndale, RF | 1 |
| Damaj, MI | 1 |
| Albers, KM | 1 |
| Zhang, XL | 1 |
| Diges, CM | 1 |
| Schwartz, ES | 1 |
| Yang, CI | 1 |
| Davis, BM | 1 |
| Gold, MS | 1 |
| Motta, PG | 1 |
| Perez, AC | 1 |
| Alves, DP | 1 |
| Duarte, ID | 1 |
| Flood, P | 1 |
| Sonner, JM | 1 |
| Gong, D | 1 |
| Coates, KM | 1 |
| Salas, R | 1 |
| Pieri, F | 1 |
| De Biasi, M | 1 |
| Medhurst, SJ | 1 |
| Hatcher, JP | 1 |
| Hille, CJ | 1 |
| Bingham, S | 1 |
| Clayton, NM | 1 |
| Billinton, A | 1 |
| Chessell, IP | 1 |
| Lawand, NB | 1 |
| Lu, Y | 1 |
| Westlund, KN | 1 |
| Gilbert, SD | 1 |
| Clark, TM | 1 |
| Flores, CM | 1 |
| Schmidt, BL | 1 |
| Tambeli, CH | 1 |
| Gear, RW | 1 |
| Levine, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intranasal Nicotine for Postoperative Pain Treatment: A Comparison of Its Effects in the Context of Isoflurane-induced Anesthesia Versus Propofol Anesthesia[NCT00232817] | Phase 4 | 80 participants (Actual) | Interventional | 2003-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 other studies available for mecamylamine and Allodynia
| Article | Year |
|---|---|
Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia.
Topics: Analgesia; Animals; Capsaicin; Cholinergic Neurons; Hyperalgesia; Male; Mecamylamine; Nicotine; Noci | 2020 |
Nicotine and sleep deprivation: impact on pain sensitivity and immune modulation in rats.
Topics: Animals; Hyperalgesia; Immunity; Interleukin-4; Interleukin-6; Male; Mecamylamine; Nicotine; Pain; P | 2018 |
Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice.
Topics: Animals; Anxiety; Aryl Hydrocarbon Hydroxylases; Conditioning, Psychological; Cytochrome P450 Family | 2014 |
Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons.
Topics: Animals; Female; Ganglia, Spinal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic F | 2014 |
Modulation of peripheral inflammatory pain thresholds by M(1) and nicotinic receptor antagonists.
Topics: Acetylcholine; Animals; Carrageenan; Dinoprostone; Hyperalgesia; Inflammation; Male; Mecamylamine; N | 2011 |
Isoflurane hyperalgesia is modulated by nicotinic inhibition.
Topics: Animals; Female; Hyperalgesia; Isoflurane; Mecamylamine; Mice; Nicotine; Nicotinic Antagonists; Rece | 2002 |
Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Female; Genotype; Grooming; Hype | 2004 |
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzofurans; Dose-Res | 2008 |
Nicotinic cholinergic receptors: potential targets for inflammatory pain relief.
Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Behavior, Animal; Bridged Bicyclo Compou | 1999 |
Antihyperalgesic activity of epibatidine in the formalin model of facial pain.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationsh | 2001 |
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.
Topics: Analgesia; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; | 2001 |