doxepin has been researched along with Allodynia in 6 studies
Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury." | 3.80 | Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014) |
| "Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot." | 1.42 | The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain. ( Makuch, W; Mika, J; Przewlocka, B; Rojewska, E; Zychowska, M, 2015) |
| " Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice." | 1.42 | Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015) |
| "Imipramine and doxepin have been reported to exhibit local anaesthetic properties." | 1.39 | Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation. ( Campmany, AC; Campos, FF; Naveros, BC; Sandig, AG; Villena, MJ, 2013) |
| "Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination." | 1.35 | Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. ( Obara, I; Przewlocka, B; Wordliczek, J; Wrzosek, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jagla, G | 1 |
| Mika, J | 3 |
| Makuch, W | 3 |
| Obara, I | 2 |
| Wordliczek, J | 2 |
| Przewlocka, B | 4 |
| Zychowska, M | 1 |
| Rojewska, E | 2 |
| Jurga, AM | 1 |
| Starnowska, J | 1 |
| Wasylewski, M | 1 |
| Kwiatkowski, K | 1 |
| Malek, N | 1 |
| Wrzosek, A | 1 |
| Sandig, AG | 1 |
| Campmany, AC | 1 |
| Campos, FF | 1 |
| Villena, MJ | 1 |
| Naveros, BC | 1 |
| Biedermann, HJ | 1 |
| Lapeer, GL | 1 |
| Mauri, M | 1 |
| McGhie, A | 1 |
6 other studies available for doxepin and Allodynia
| Article | Year |
|---|---|
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do | 2014 |
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cyclohexanols; Cyclopropane | 2015 |
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal; | 2015 |
Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc | 2009 |
Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation.
Topics: Administration, Cutaneous; Analgesics; Animals; Area Under Curve; Chemistry, Pharmaceutical; Doxepin | 2013 |
Acupuncture and myofascial pain: treatment failure after administration of tricyclic antidepressants.
Topics: Acupuncture Therapy; Depressive Disorder; Doxepin; Endorphins; Female; Humans; Hyperalgesia; Middle | 1986 |