Page last updated: 2024-10-26

doxepin and Allodynia

doxepin has been researched along with Allodynia in 6 studies

Doxepin: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
doxepin : A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.

Research Excerpts

ExcerptRelevanceReference
" The von Frey and Hargreaves' tests were used to assess mechanical allodynia and thermal hyperalgesia, respectively, after intraplantar (ipl) or subcutaneous (sc) administration of amitriptyline, doxepin, or venlafaxine, or their ipl co-administration with morphine on day 12-16 after injury."3.80Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. ( Jagla, G; Makuch, W; Mika, J; Obara, I; Przewlocka, B; Wordliczek, J, 2014)
"Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot."1.42The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain. ( Makuch, W; Mika, J; Przewlocka, B; Rojewska, E; Zychowska, M, 2015)
" Unexpectedly, chronic administration of doxepin or amitriptyline for 12 days produced allodynia and hyperalgesia in naïve mice."1.42Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model. ( Jurga, AM; Kwiatkowski, K; Makuch, W; Malek, N; Mika, J; Przewlocka, B; Rojewska, E; Starnowska, J; Wasylewski, M, 2015)
"Imipramine and doxepin have been reported to exhibit local anaesthetic properties."1.39Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation. ( Campmany, AC; Campos, FF; Naveros, BC; Sandig, AG; Villena, MJ, 2013)
"Allodynia and hyperalgesia were assessed after intraperitoneal administration of each drug alone or in combination."1.35Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. ( Obara, I; Przewlocka, B; Wordliczek, J; Wrzosek, A, 2009)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jagla, G1
Mika, J3
Makuch, W3
Obara, I2
Wordliczek, J2
Przewlocka, B4
Zychowska, M1
Rojewska, E2
Jurga, AM1
Starnowska, J1
Wasylewski, M1
Kwiatkowski, K1
Malek, N1
Wrzosek, A1
Sandig, AG1
Campmany, AC1
Campos, FF1
Villena, MJ1
Naveros, BC1
Biedermann, HJ1
Lapeer, GL1
Mauri, M1
McGhie, A1

Other Studies

6 other studies available for doxepin and Allodynia

ArticleYear
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Cyclohexanols; Disease Models, Animal; Do

2014
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
    European journal of pharmacology, 2015, Feb-15, Volume: 749

    Topics: Amitriptyline; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cyclohexanols; Cyclopropane

2015
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model.
    Neuroscience, 2015, May-21, Volume: 294

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Disease Models, Animal;

2015
Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009, Volume: 60, Issue:4

    Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc

2009
Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation.
    Colloids and surfaces. B, Biointerfaces, 2013, Mar-01, Volume: 103

    Topics: Administration, Cutaneous; Analgesics; Animals; Area Under Curve; Chemistry, Pharmaceutical; Doxepin

2013
Acupuncture and myofascial pain: treatment failure after administration of tricyclic antidepressants.
    Medical hypotheses, 1986, Volume: 19, Issue:4

    Topics: Acupuncture Therapy; Depressive Disorder; Doxepin; Endorphins; Female; Humans; Hyperalgesia; Middle

1986