diazepam has been researched along with Allodynia in 21 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that intrathecal application of bicuculline, a GABA(A) receptor antagonist, to remove the inhibition readily elicited mechanical allodynia in naive mice, which could be dose-dependently attenuated by NMDARs antagonist D-APV." | 3.77 | GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn. ( Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X; Zheng, CR, 2011) |
| "We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 3.74 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| " Both nocebo hyperalgesia and HPA hyperactivity were antagonized by the benzodiazepine diazepam, suggesting that anxiety played a major role in these effects." | 3.73 | The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. ( Amanzio, M; Asteggiano, G; Benedetti, F; Vighetti, S, 2006) |
| "Further, large areas of mechanical hyperalgesia to pinprick adjacent to the erythema spots developed in all subjects." | 2.71 | The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers. ( Felouzis, E; Gustorff, B; Hoechtl, K; Kress, HG; Lehr, S; Sycha, T, 2004) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: (1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), (2) a decrease in number of central squares visited in the open field (OF), and (3) a reduction in active social interactions in the social interaction test (SI)." | 1.38 | Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. ( Beaudet, N; Beaudry, H; Bergeron, J; Bérubé, P; Drolet, G; Gendron, L; Parent, AJ; Sarret, P, 2012) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "The induction of hyperalgesia by co-exposure to MFs and diazepam was also blocked by flumazenil." | 1.33 | Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields. ( Choi, KB; Jeong, JH; Moon, NJ; Park, ES; Sohn, UD, 2005) |
| "Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet." | 1.29 | Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Bruni, F | 1 |
| Selleri, S | 1 |
| Martini, C | 1 |
| Daniele, S | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Costanzo, A | 1 |
| Lima, Mda S | 1 |
| Evangelista, AF | 1 |
| Santos, GG | 1 |
| Ribeiro, IM | 1 |
| Tomassini, TC | 1 |
| Pereira Soares, MB | 1 |
| Villarreal, CF | 1 |
| Soares, AS | 1 |
| Barbosa, FL | 1 |
| Rüdiger, AL | 1 |
| Hughes, DL | 1 |
| Salvador, MJ | 1 |
| Zampronio, AR | 1 |
| Stefanello, MÉA | 1 |
| Wilkerson, JL | 1 |
| Curry, ZA | 1 |
| Kinlow, PD | 1 |
| Mason, BL | 1 |
| Hsu, KL | 1 |
| van der Stelt, M | 1 |
| Cravatt, BF | 1 |
| Lichtman, AH | 1 |
| Obradović, ALj | 1 |
| Joksimović, S | 1 |
| Poe, MM | 2 |
| Ramerstorfer, J | 1 |
| Varagic, Z | 1 |
| Namjoshi, O | 1 |
| Batinić, B | 1 |
| Radulović, T | 1 |
| Marković, B | 1 |
| Roth, BL | 1 |
| Sieghart, W | 1 |
| Cook, JM | 2 |
| Savić, MM | 1 |
| Ralvenius, WT | 1 |
| Benke, D | 1 |
| Acuña, MA | 1 |
| Rudolph, U | 3 |
| Zeilhofer, HU | 3 |
| Fischer, BD | 1 |
| Schlitt, RJ | 1 |
| Hamade, BZ | 1 |
| Rehman, S | 1 |
| Ernst, M | 1 |
| Li, G | 1 |
| Kodali, R | 1 |
| Arnold, LA | 1 |
| Knabl, J | 1 |
| Zeilhofer, UB | 1 |
| Crestani, F | 1 |
| Cao, J | 1 |
| Yang, X | 1 |
| Liu, YN | 1 |
| Suo, ZW | 1 |
| Shi, L | 1 |
| Zheng, CR | 1 |
| Yang, HB | 1 |
| Li, S | 1 |
| Hu, XD | 1 |
| Witschi, R | 1 |
| Punnakkal, P | 1 |
| Paul, J | 1 |
| Walczak, JS | 1 |
| Cervero, F | 1 |
| Fritschy, JM | 1 |
| Kuner, R | 1 |
| Keist, R | 1 |
| Quintero, L | 2 |
| Cardenas, R | 1 |
| Suarez-Roca, H | 2 |
| Parent, AJ | 1 |
| Beaudet, N | 1 |
| Beaudry, H | 1 |
| Bergeron, J | 1 |
| Bérubé, P | 1 |
| Drolet, G | 1 |
| Sarret, P | 1 |
| Gendron, L | 1 |
| Hansen, RR | 1 |
| Erichsen, HK | 1 |
| Brown, DT | 1 |
| Mirza, NR | 1 |
| Munro, G | 1 |
| Gustorff, B | 1 |
| Hoechtl, K | 1 |
| Sycha, T | 1 |
| Felouzis, E | 1 |
| Lehr, S | 1 |
| Kress, HG | 1 |
| Nielsen, AN | 1 |
| Mathiesen, C | 1 |
| Blackburn-Munro, G | 1 |
| Jeong, JH | 1 |
| Choi, KB | 1 |
| Moon, NJ | 1 |
| Park, ES | 1 |
| Sohn, UD | 1 |
| Benedetti, F | 1 |
| Amanzio, M | 1 |
| Vighetti, S | 1 |
| Asteggiano, G | 1 |
| Leal, L | 1 |
| Silva, JA | 1 |
| Pinerua-Shuhaibar, L | 1 |
| Cartmell, SM | 1 |
| Mitchell, D | 1 |
| Klepstad, P | 1 |
| Borchgrevink, P | 1 |
| Hval, B | 1 |
| Flaat, S | 1 |
| Kaasa, S | 1 |
1 trial available for diazepam and Allodynia
| Article | Year |
|---|---|
The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.
Topics: Acetates; Adult; Amines; Analgesics, Opioid; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diazep | 2004 |
20 other studies available for diazepam and Allodynia
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Development of ligands at γ-aminobutyrric acid type A (GABAA) receptor subtype as new agents for pain relief.
Topics: Animals; Anti-Anxiety Agents; Cattle; Hyperalgesia; Male; Mice; Pain; Pentylenetetrazole; Radioligan | 2011 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Naphthoquinones of Sinningia reitzii and Anti-inflammatory/Antinociceptive Activities of 8-Hydroxydehydrodunnione.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dinoprostone; Edema; Hyperalgesia; Magno | 2017 |
Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diazepam; Disease Models, | 2018 |
Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Binding Sites; Brain; Diazepam; GABA Modulators; GABA-A | 2014 |
Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.
Topics: Analgesia; Animals; Arginine; Benzodiazepines; Diazepam; GABA Modulators; Gene Expression; Histidine | 2015 |
Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABA
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; gamm | 2017 |
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Respons | 2009 |
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Drug Interactions; Excitatory Amino Aci | 2011 |
Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control.
Topics: Animals; Diazepam; Gene Expression Regulation; Hyperalgesia; Injections, Spinal; Membrane Potentials | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dark Adaptation; Diaze | 2012 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxy | 2012 |
Pharmacological characterisation of acid-induced muscle allodynia in rats.
Topics: Acids; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Carbazoles; Chr | 2004 |
Benzodiazepine system is involved in hyperalgesia in rats induced by the exposure to extremely low frequency magnetic fields.
Topics: Animals; Anti-Anxiety Agents; Baclofen; Bicuculline; Diazepam; Electromagnetic Fields; Flumazenil; G | 2005 |
The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect.
Topics: Adrenocorticotropic Hormone; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Anxiety; Cholecystokinin | 2006 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper | 2008 |
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R | 1993 |
Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor.
Topics: Analgesia, Patient-Controlled; Analgesics; Brain Stem; Cervical Vertebrae; Child; Diazepam; Drug Res | 2001 |