kynurenic acid has been researched along with Allodynia in 9 studies
Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool.
kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1." | 1.46 | Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms. ( Blandini, F; Demartini, C; Fülöp, F; Greco, R; Nappi, G; Pampalone, S; Redavide, E; Sandrini, G; Tassorelli, C; Toldi, J; Vécsei, L; Zanaboni, AM, 2017) |
| "Kynurenic acid alone was ineffective, while adenosine and agmatine alone caused a slight increase in pain threshold." | 1.32 | Dose-independent antinociceptive interaction of endogenous ligands at the spinal level. ( Benedek, G; Csullog, E; Horvath, G; Joo, G; Kekesi, G; Peter-Szabo, M, 2004) |
| "Magnesium (Mg)-deficient rats develop a mechanical hyperalgesia which is reversed by a N-Methyl-D-Aspartate (NMDA) receptor antagonist." | 1.31 | Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. ( Begon, S; Dubray, C; Eschalier, A; Mazur, A; Pickering, G; Rayssiguier, Y, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yaksh, TL | 1 |
| Schwarcz, R | 1 |
| Snodgrass, HR | 1 |
| Resta, F | 1 |
| Masi, A | 1 |
| Sili, M | 1 |
| Laurino, A | 1 |
| Moroni, F | 1 |
| Mannaioni, G | 1 |
| Greco, R | 1 |
| Demartini, C | 1 |
| Zanaboni, AM | 1 |
| Redavide, E | 1 |
| Pampalone, S | 1 |
| Toldi, J | 1 |
| Fülöp, F | 1 |
| Blandini, F | 1 |
| Nappi, G | 1 |
| Sandrini, G | 1 |
| Vécsei, L | 1 |
| Tassorelli, C | 1 |
| Mecs, L | 1 |
| Tuboly, G | 1 |
| Nagy, E | 1 |
| Benedek, G | 3 |
| Horvath, G | 3 |
| Zhang, YQ | 1 |
| Ji, GC | 1 |
| Wu, GC | 1 |
| Zhao, ZQ | 1 |
| Kekesi, G | 2 |
| Joo, G | 2 |
| Csullog, E | 2 |
| Peter-Szabo, M | 1 |
| Begon, S | 1 |
| Pickering, G | 1 |
| Eschalier, A | 1 |
| Mazur, A | 1 |
| Rayssiguier, Y | 1 |
| Dubray, C | 1 |
| Dobos, I | 1 |
| Klimscha, W | 1 |
| Toth, K | 1 |
| Ren, K | 1 |
| Williams, GM | 1 |
| Hylden, JL | 1 |
| Ruda, MA | 1 |
| Dubner, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients[NCT01433081] | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty?[NCT02581683] | Phase 4 | 130 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Opioid consumption after discharge (NCT01433081)
Timeframe: 24 hours
| Intervention | miligram morphine equivalents (Median) |
|---|---|
| Magnesium Sulfate Infusion | 10 |
| Placebo | 30 |
Quality of recovery scores post operative. Scored on a scale of 40 (poor recovery) to 200 (good recovery). (NCT01433081)
Timeframe: 24 hours post operative
| Intervention | units on scale 40 (low) - 200 (high) (Mean) |
|---|---|
| Magnesium Sulfate Infusion | 183 |
| Placebo | 159 |
9 other studies available for kynurenic acid and Allodynia
| Article | Year |
|---|---|
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine | 2017 |
Kynurenic acid and zaprinast induce analgesia by modulating HCN channels through GPR35 activation.
Topics: Analgesia; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Sp | 2016 |
Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Kynurenic Acid; Male; Migraine Disorders; | 2017 |
The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model.
Topics: Analgesics, Opioid; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Carrageenan; Dos | 2009 |
Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenan-injected rats.
Topics: Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Electroacupuncture; | 2003 |
Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Carrageenan; Dose-Response Relationship, Drug; Drug Combin | 2004 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
The antinociceptive effect of intrathecal kynurenic acid and its interaction with endomorphin-1 in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Hot Temper | 2002 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; C | 1992 |