Page last updated: 2024-11-02

piracetam and Allodynia

piracetam has been researched along with Allodynia in 8 studies

Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.

Research Excerpts

ExcerptRelevanceReference
"Levetiracetam (200-1000 nmol/paw) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia and edema induced by carrageenan."7.78The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, ND, 2012)
"Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain."7.76The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. ( Micov, A; Popović, B; Stepanović-Petrović, R; Tomić, M, 2010)
"Levetiracetam is an anticonvulsant which is assumed to act by modulating neurotransmitter release via binding to the vesicle protein SV2A."6.77A randomized, placebo-controlled trial of levetiracetam in central pain in multiple sclerosis. ( Falah, M; Holbech, JV; Madsen, C; Sindrup, SH, 2012)
" These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain."3.80Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014)
" This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation."3.79Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013)
"Levetiracetam (200-1000 nmol/paw) produced a significant dose-dependent reduction of the paw inflammatory hyperalgesia and edema induced by carrageenan."3.78The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA; Ugrešić, ND, 2012)
"Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain."3.76The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action. ( Micov, A; Popović, B; Stepanović-Petrović, R; Tomić, M, 2010)
" The pharmacological profile of the novel antiepileptic drug, levetiracetam, suggests that it may reduce the intensity of the excitatory stages of anesthesia."3.74Levetiracetam reduces anesthetic-induced hyperalgesia in rats. ( Archer, DP; Davis, MJ; Lamberty, Y; Roth, SH; Samanani, N; Wang, B, 2007)
"Levetiracetam is an anticonvulsant which is assumed to act by modulating neurotransmitter release via binding to the vesicle protein SV2A."2.77A randomized, placebo-controlled trial of levetiracetam in central pain in multiple sclerosis. ( Falah, M; Holbech, JV; Madsen, C; Sindrup, SH, 2012)
"nefiracetam was also blocked by i."1.31Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice. ( Rashid, MH; Ueda, H, 2002)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tomić, MA3
Micov, AM3
Stepanović-Petrović, RM3
Kovacevic, JM1
Boškovic, BD1
Micov, A1
Tomić, M1
Popović, B1
Stepanović-Petrović, R1
Falah, M1
Madsen, C1
Holbech, JV1
Sindrup, SH1
Ugrešić, ND1
Rashid, MH1
Ueda, H1
Ardid, D1
Lamberty, Y2
Alloui, A1
Coudore-Civiale, MA1
Klitgaard, H1
Eschalier, A1
Archer, DP1
Wang, B1
Davis, MJ1
Samanani, N1
Roth, SH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687]46 participants (Actual)Interventional2008-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Standard Alcoholic Drinks Per Treatment Period

The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period

Interventionnumber of drinks per treatment period (Mean)
All Subjects (n = 46) Placebo41.2
All Subjects (n = 46) Levetiracetam45.4

Trials

1 trial available for piracetam and Allodynia

ArticleYear
A randomized, placebo-controlled trial of levetiracetam in central pain in multiple sclerosis.
    European journal of pain (London, England), 2012, Volume: 16, Issue:6

    Topics: Adult; Analgesics; Anticonvulsants; Chronic Pain; Cross-Over Studies; Female; Humans; Hyperalgesia;

2012

Other Studies

7 other studies available for piracetam and Allodynia

ArticleYear
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
    The journal of pain, 2013, Volume: 14, Issue:11

    Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr

2013
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce

2014
The antihyperalgesic effect of levetiracetam in an inflammatory model of pain in rats: mechanism of action.
    British journal of pharmacology, 2010, Volume: 161, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Hyperalgesia;

2010
The local peripheral antihyperalgesic effect of levetiracetam and its mechanism of action in an inflammatory pain model.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:6

    Topics: Adenosine A1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthetics, Local; Animals; Carrag

2012
Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Analgesia; Animals; Diabetes Mellitus, Experimental; Hyperalgesia; Male; Mice; Mice, Inbred Strains;

2002
Antihyperalgesic effect of levetiracetam in neuropathic pain models in rats.
    European journal of pharmacology, 2003, Jul-18, Volume: 473, Issue:1

    Topics: Acute Disease; Analgesics; Animals; Carbamazepine; Chronic Disease; Constriction, Pathologic; Diabet

2003
Levetiracetam reduces anesthetic-induced hyperalgesia in rats.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:1

    Topics: Anesthesia; Animals; Anticonvulsants; Hyperalgesia; Levetiracetam; Male; Models, Animal; Pain Thresh

2007