Page last updated: 2024-11-04

suramin and Allodynia

suramin has been researched along with Allodynia in 4 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Research Excerpts

ExcerptRelevanceReference
"Suramin was administered by using an osmotic pump attached to an intrathecal catheter."1.32Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. ( Light, AR; Maixner, W; Willcockson, HH; Wu, Y, 2004)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, N1
Lu, ZY1
Yu, LH1
Burnstock, G1
Deng, XM1
Ma, B1
Gadotti, VM1
Caballero, AG1
Berger, ND1
Gladding, CM1
Chen, L1
Pfeifer, TA1
Zamponi, GW1
Wu, Y1
Willcockson, HH1
Maixner, W1
Light, AR1
Liu, T1
Tracey, DJ1

Other Studies

4 other studies available for suramin and Allodynia

ArticleYear
Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain.
    Molecular pain, 2014, Mar-18, Volume: 10

    Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Dru

2014
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.
    Molecular pain, 2015, Mar-14, Volume: 11

    Topics: Analgesics; Animals; Calcium Channels, T-Type; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation;

2015
Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection.
    The journal of pain, 2004, Volume: 5, Issue:1

    Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Female; Hot Temperature; Hyperalgesia; Inje

2004
ATP P2X receptors play little role in the maintenance of neuropathic hyperalgesia.
    Neuroreport, 2000, Jun-05, Volume: 11, Issue:8

    Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyperalges

2000