suramin has been researched along with Allodynia in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Suramin was administered by using an osmotic pump attached to an intrathecal catheter." | 1.32 | Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection. ( Light, AR; Maixner, W; Willcockson, HH; Wu, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Lu, ZY | 1 |
| Yu, LH | 1 |
| Burnstock, G | 1 |
| Deng, XM | 1 |
| Ma, B | 1 |
| Gadotti, VM | 1 |
| Caballero, AG | 1 |
| Berger, ND | 1 |
| Gladding, CM | 1 |
| Chen, L | 1 |
| Pfeifer, TA | 1 |
| Zamponi, GW | 1 |
| Wu, Y | 1 |
| Willcockson, HH | 1 |
| Maixner, W | 1 |
| Light, AR | 1 |
| Liu, T | 1 |
| Tracey, DJ | 1 |
4 other studies available for suramin and Allodynia
| Article | Year |
|---|---|
Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain.
Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Dru | 2014 |
Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Calcium Channels, T-Type; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; | 2015 |
Suramin inhibits spinal cord microglia activation and long-term hyperalgesia induced by formalin injection.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Female; Hot Temperature; Hyperalgesia; Inje | 2004 |
ATP P2X receptors play little role in the maintenance of neuropathic hyperalgesia.
Topics: Aggression; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyperalges | 2000 |