lidocaine and Allodynia studies

Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.

Research Excerpts

Excerpt	Relevance	Reference
"Intravenous perioperative lidocaine decreases the incidence and severity of PPSP after breast cancer surgery."	9.16	Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. ( Grigoras, A; Lee, P; Sattar, F; Shorten, G, 2012)
"This study evaluated the effects of topical lidocaine on skin sensation and on intradermal capsaicin-induced pain and hyperalgesia."	9.15	Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial. ( Lam, VY; Schulteis, G; Wallace, M, 2011)
"The aim of this research is to analyze analgesic efficacy of the 5% lidocaine medicated plaster in two randomized, double-blinded, placebo-controlled, crossover studies in 16 healthy volunteers using capsaicin and sunburn pain models."	9.15	Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers. ( Draxler, J; Gustorff, B; Hauer, D; Seis, A; Thaler, J, 2011)
"To investigate the effects of IV lidocaine on spontaneous and evoked pain (allodynia and hyperalgesia) due to peripheral nerve injury (postherpetic neuralgia or nerve trauma) using quantitative sensory testing."	9.11	Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. ( Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J, 2004)
"Although effective in neuropathic pain, the efficacy of systemic lidocaine in non-neuropathic pain remains uncertain."	9.09	The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. ( Dahl, JB; Dirks, J; Fabricius, P; Petersen, KL; Rowbotham, MC, 2000)
"Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain."	7.91	Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019)
" In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats."	7.83	Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016)
"Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy."	7.77	Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011)
"The present study investigated the effects of different doses of intrathecal lidocaine on established thermal hyperalgesia and tactile allodynia in the chronic constriction injury model of neuropathic pain, defined the effective drug dose range, the duration of pain-relief effects, and the influence of this treatment on the body and tissues."	7.75	Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. ( Gu, Y; Su, D; Tian, J; Wang, X; Wu, Y, 2009)
"These results indicate that pre-treatment with lidocaine attenuates referred hyperalgesia associated with cystitis."	7.75	Lidocaine prevents referred hyperalgesia associated with cystitis. ( Bjorling, DE; Boldon, K; Bushman, W; Guerios, SD; Wang, ZY, 2009)
"Amiodarone was found to produce a statistically significant decrease in heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain after intraperitoneal injection."	7.72	Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. ( Datta, S; Glusman, S; Torres, M; Waghray, T, 2004)
"Systemic lidocaine can relieve various forms of neuropathic pain that develop after nerve injury."	7.72	Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. ( Araujo, MC; Sinnott, CJ; Strichartz, GR, 2003)
" Specifically, the actions of brainstem cholecystokinin and the possible importance of sustained afferent input from injured nerve fibers were determined using pharmacological and physiological approaches in rats with SNL."	7.70	Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. ( Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Sun, H, 2000)
"Primary mechanical hyperalgesia at the shoulders and buttocks decreased significantly more after lidocaine than saline injections (p = 0."	6.79	Analgesic and anti-hyperalgesic effects of muscle injections with lidocaine or saline in patients with fibromyalgia syndrome. ( Bartley, E; Price, DD; Robinson, ME; Staud, R; Weyl, EE, 2014)
"Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice."	5.48	Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018)
"Lidocaine infusion reduced mechano-hyperalgesia but had no effect on mechano-allodynia or heat-hyperalgesia."	5.35	C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. ( Bennett, GJ; Xiao, WH, 2008)
"Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks."	5.29	Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996)
"A randomized, double-blind, three-period cross-over study was performed to characterize the sensory phenotype and pain demographics in patients with Morton neuroma (n=27) and to explore the effects of local administration (2mL) of placebo and lidocaine (1 and 10mg/mL) around the neuroma."	5.17	A pain model with a neuropathic somatosensory lesion: Morton neuroma. ( Åkermark, C; Jonzon, B; Quiding, H; Reinholdsson, I; Segerdahl, M; Svensson, H, 2013)
"Intravenous perioperative lidocaine decreases the incidence and severity of PPSP after breast cancer surgery."	5.16	Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. ( Grigoras, A; Lee, P; Sattar, F; Shorten, G, 2012)
"Topical lidocaine (5%) leads to sufficient pain relief in only 29%-80% of treated patients, presumably by small-fiber block."	5.16	Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers. ( Krumova, EK; Maier, C; Westermann, A; Zeller, M, 2012)
"This study evaluated the effects of topical lidocaine on skin sensation and on intradermal capsaicin-induced pain and hyperalgesia."	5.15	Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial. ( Lam, VY; Schulteis, G; Wallace, M, 2011)
"The aim of this research is to analyze analgesic efficacy of the 5% lidocaine medicated plaster in two randomized, double-blinded, placebo-controlled, crossover studies in 16 healthy volunteers using capsaicin and sunburn pain models."	5.15	Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers. ( Draxler, J; Gustorff, B; Hauer, D; Seis, A; Thaler, J, 2011)
"Lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in FM patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization in this chronic pain syndrome; similar to other persistent pain conditions such as irritable bowel syndrome and complex regional pain syndrome."	5.14	Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. ( Nagel, S; Price, DD; Robinson, ME; Staud, R, 2009)
" In this study, we evaluated the AMPA/GluR5 receptor antagonist NS1209 for efficacy, safety, and tolerability in comparison with placebo and lidocaine for the treatment of chronic neuropathic pain and allodynia in patients with peripheral nerve injury."	5.14	The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. ( Almqvist, PM; Finnerup, NB; Gormsen, L; Jensen, TS, 2009)
"To investigate the effects of IV lidocaine on spontaneous and evoked pain (allodynia and hyperalgesia) due to peripheral nerve injury (postherpetic neuralgia or nerve trauma) using quantitative sensory testing."	5.11	Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. ( Attal, N; Bouhassira, D; Brasseur, L; Chauvin, M; Rouaud, J, 2004)
" In both trials capsaicin, 20 microgram, was injected intradermally and time course of capsaicin-induced pain, allodynia and hyperalgesia as well as axon reflex flare was determined."	5.09	Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. ( Koppert, W; Ostermeier, N; Schmelz, M; Sittl, R; Weidner, C, 2000)
"Although effective in neuropathic pain, the efficacy of systemic lidocaine in non-neuropathic pain remains uncertain."	5.09	The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. ( Dahl, JB; Dirks, J; Fabricius, P; Petersen, KL; Rowbotham, MC, 2000)
" Alfentanil effectively inhibited electrically evoked pain and reduced pin prick hyperalgesia and allodynia during its infusion."	5.09	A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. ( Albrecht, S; Dern, SK; Koppert, W; Schmelz, M; Schüttler, J; Sittl, R, 2001)
" LCipsi inactivation with lidocaine increased cold allodynia 2 days after nerve injury but not later."	4.12	Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus-dorsal reticular nucleus pathway. ( Berrocoso, E; Bravo, L; Camarena-Delgado, C; Garcia-Partida, JA; Llorca-Torralba, M; López-Martín, C; Mico, JA; Suárez-Pereira, I, 2022)
"Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain."	3.91	Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019)
"Based on clinical study results, 5% lidocaine-medicated plaster (5% LMP) is currently recommended for the treatment of localized peripheral neuropathic pain, such as post-herpetic neuralgia (PHN)."	3.85	Efficacy and safety of 5% lidocaine-medicated plasters in localized pain with neuropathic and/or inflammatory characteristics: an observational, real-world study. ( Amato, F; Ciliberto, G; Consoletti, L; Duse, G; Firetto, V; Lo Presti, C; Mazza, M; Palmieri, V; Parigi, LA, 2017)
"Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus."	3.85	Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na ( Lewis, RJ; Malsch, P; Reeh, PW; Sattler, S; Touska, F; Zimmermann, K, 2017)
" In this study, we investigated spontaneous pain and mechanical allodynia in a preclinical model of oral ulcerative mucositis after systemic administration of the chemotherapy drug 5-fluorouracil, using our proprietary pain assay system for conscious rats."	3.83	Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. ( Goto, T; Harano, N; Hitomi, S; Inenaga, K; Inoue, H; Ito, M; Matoba, M; Miyano, K; Nodai, T; Ono, K; Uezono, Y; Watanabe, S; Yamaguchi, K, 2016)
" Facilitation of pain behaviour induced by GAL in the DMH was reversed by lidocaine in the DRt and by ondansetron, a 5HT3R antagonist, in the spinal cord."	3.81	Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. ( Almeida, A; Amorim, D; Pertovaara, A; Pinto-Ribeiro, F; Viisanen, H; Wei, H, 2015)
" We concluded that only peripheral blockade of transient receptor potential vanilloid receptor 1-expressing nociceptive afferents by the QX-314/capsaicin combination was effective at reducing neuropathic allodynia and hyperalgesia."	3.78	Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. ( Cheng, J; Fox, LE; Shen, J, 2012)
"Lidocaine is used clinically for tactile allodynia associated with diabetes-induced neuropathy."	3.77	Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. ( Hasegawa-Moriyama, M; Inada, E; Kamikubo, Y; Sakurai, T; Suzuki, N; Takahashi, Y, 2011)
" After recovery, rats received injections of lidocaine, GABA and glycine agonists or antagonists and their effects were assessed on behavioral tests of allodynia and hyperalgesia."	3.76	Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats. ( Al Amin, H; Atweh, SF; Jabbur, SJ; Saadé, NE; Tchachaghian, S, 2010)
"Remifentanil is being used increasingly as one component of total intravenous anesthesia."	3.75	Systemic lidocaine inhibits remifentanil-induced hyperalgesia via the inhibition of cPKCgamma membrane translocation in spinal dorsal horn of rats. ( Cui, W; Han, S; Jiang, J; Li, J; Li, S; Li, Y; Yang, W, 2009)
"These results indicate that pre-treatment with lidocaine attenuates referred hyperalgesia associated with cystitis."	3.75	Lidocaine prevents referred hyperalgesia associated with cystitis. ( Bjorling, DE; Boldon, K; Bushman, W; Guerios, SD; Wang, ZY, 2009)
"The present study investigated the effects of different doses of intrathecal lidocaine on established thermal hyperalgesia and tactile allodynia in the chronic constriction injury model of neuropathic pain, defined the effective drug dose range, the duration of pain-relief effects, and the influence of this treatment on the body and tissues."	3.75	Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. ( Gu, Y; Su, D; Tian, J; Wang, X; Wu, Y, 2009)
"Amiodarone was found to produce a statistically significant decrease in heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain after intraperitoneal injection."	3.72	Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. ( Datta, S; Glusman, S; Torres, M; Waghray, T, 2004)
"Systemic lidocaine can relieve various forms of neuropathic pain that develop after nerve injury."	3.72	Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. ( Araujo, MC; Sinnott, CJ; Strichartz, GR, 2003)
" Rats implanted subcutaneously with pellets or osmotic minipumps delivering morphine displayed time-related tactile allodynia and thermal hyperalgesia (i."	3.71	Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Suenaga, NM; Vanderah, TW, 2001)
" Specifically, the actions of brainstem cholecystokinin and the possible importance of sustained afferent input from injured nerve fibers were determined using pharmacological and physiological approaches in rats with SNL."	3.70	Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. ( Kovelowski, CJ; Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Sun, H, 2000)
"From day 7 onwards, dynamic mechanical allodynia diminished progressively of ≥ 30% over 3 months (P = 0."	2.90	Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial. ( Ganry, H; Macian, N; Pereira, B; Pickering, G; Voute, M, 2019)
"The area of hyperalgesia did not differ significantly between subgroups, nor did the hyperalgesia ratio which was 1."	2.87	Ropivacaine preperitoneal wound infusion for pain relief and prevention of incisional hyperalgesia after laparoscopic colorectal surgery: a randomized, triple-arm, double-blind controlled evaluation vs intravenous lidocaine infusion, the CATCH study. ( Beaussier, M; Cachanado, M; Guechot, J; Lescot, T; Parc, Y; Rousseau, A, 2018)
"Forty-six patients with neuropathic pain due to nerve injury or postherpetic neuralgia were randomised."	2.80	Pain relief with lidocaine 5% patch in localized peripheral neuropathic pain in relation to pain phenotype: a randomised, double-blind, and placebo-controlled, phenotype panel study. ( Demant, DT; Finnerup, NB; Jensen, TS; Lund, K; Maier, C; Segerdahl, MS; Sindrup, SH; Vollert, J, 2015)
"Primary mechanical hyperalgesia at the shoulders and buttocks decreased significantly more after lidocaine than saline injections (p = 0."	2.79	Analgesic and anti-hyperalgesic effects of muscle injections with lidocaine or saline in patients with fibromyalgia syndrome. ( Bartley, E; Price, DD; Robinson, ME; Staud, R; Weyl, EE, 2014)
"The area of punctate hyperalgesia was maintained in older adults over 4 h, while it declined in the young."	2.74	The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. ( Gibson, SJ; Helme, RD; McMeeken, JM; Zheng, Z, 2009)
"After induction of pin-prick hyperalgesia lidocaine or placebo was administered systemically using a double-blinded design."	2.74	Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia. ( Bschorer, K; De Col, R; Filitz, J; Koppert, W; Maihöfner, C; Peltz, E; Seifert, F, 2009)
"Flare, spontaneous pain, and primary and secondary hyperalgesia to punctate mechanical stimuli were assessed after the incision had been made."	2.70	Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin. ( Kawamata, M; Kawamata, T; Kozuka, Y; Namiki, A; Nishikawa, K; Omote, K; Takahashi, T; Watanabe, H, 2002)
"Primary hyperalgesia was defined as mechanical pain thresholds to von Frey hair stimuli (from 7 to 151 mN) in the injured area."	2.70	Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia. ( Kawamata, M; Kozuka, Y; Namiki, A; Narimatsu, E; Nawa, Y; Nishikawa, K; Takahashi, T; Watanabe, H, 2002)
"After 5 days of treatment, heat pain hyperalgesia persisted on both forearms; however, it was significantly less on the EMLA-treated forearm vs the vehicle-treated site (p < 0."	2.69	Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. ( Maibach, HI; Rowbotham, MC; Yosipovitch, G, 1999)
"Pain scores and areas of hyperalgesia were not affected when the contralateral site was infiltrated with ketamine or lidocaine."	2.69	Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans. ( Arendt-Nielsen, L; Bach, FW; Gottrup, H; Jensen, TS, 2000)
"Primary hyperalgesia was quantified by determining mechanical (von Frey hairs) and thermal (Peltier thermode) pain thresholds."	2.69	Effect of pre- or post-traumatically applied i.v. lidocaine on primary and secondary hyperalgesia after experimental heat trauma in humans. ( Holthusen, H; Irsfeld, S; Lipfert, P, 2000)
"Lidocaine is an amide local anaesthetic initially used intravenously as an antiarrhythmic agent."	2.58	Perioperative Use of Intravenous Lidocaine. ( Beaussier, M; Delbos, A; Ecoffey, C; Maurice-Szamburski, A; Mercadal, L, 2018)
"Enhanced somatic pains are accompanied by mechanical hyperalgesia and allodynia in FM patients as compared with healthy controls."	2.46	Is it all central sensitization? Role of peripheral tissue nociception in chronic musculoskeletal pain. ( Staud, R, 2010)
"Neuropathic pain is associated with abnormal tactile and thermal responses that may be extraterritorial to the injured nerve."	2.41	Spinal and supraspinal mechanisms of neuropathic pain. ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000)
"The results showed that CCI-ION induced hyperalgesia, which was attenuated by lidocaine or carbamazepine, developed anxiety-like behavior, which was reduced only by midazolam, and displayed a reduced number of 50-kHz calls, compared to sham."	1.72	Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs. ( Araya, EI; Baggio, DF; Chichorro, JG; Koren, LO; Schwarting, RKW, 2022)
"QST indicated allodynia and hyperalgesia in response to mechanical and thermal stimuli in both her gingiva and forearm, and cold hyperalgesia in her forearm only."	1.56	Somatosensory profile of a patient with mixed connective tissue disease and Sjögren syndrome. ( Imamura, Y; Khan, J; Nishihara, C; Noma, N; Ozasa, K; Sim, C; Watanabe, K; Yamamoto, A; Young, A, 2020)
"Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice."	1.48	Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018)
"Primary hyperalgesia was characterized by pronounced gain for heat, pressure and pinprick pain, and mild thermal sensory loss."	1.48	Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. ( Baron, R; Binder, A; Enax-Krumova, EK; Geisslinger, G; Gierthmühlen, J; Henrich, F; Hüllemann, P; Klein, T; Lötsch, J; Magerl, W; Maier, C; Oertel, B; Schuh-Hofer, S; Tölle, TR; Treede, RD; Vollert, J, 2018)
"The effect of AMN082 on mechanical allodynia and glutamate release was blocked by 6-(2,4-dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone (ADX71743), a selective mGluR7 negative allosteric modulator."	1.48	Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats. ( Boccella, S; de Novellis, V; Farina, A; Guida, F; Iannotta, M; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Serra, N, 2018)
"Latent sensitization is a model of chronic pain in which an injury triggers a period of hyperalgesia followed by an apparent recovery, but in which pain sensitization persists but is suppressed by opioid and adrenergic receptors."	1.48	Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. ( Chen, W; Marvizón, JC; Taché, Y, 2018)
"Heat facial hyperalgesia was assessed on day 6 after the inoculation, and on this time point rats were submitted to the elevated plus maze and the light-dark transition tests."	1.43	Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer. ( Chichorro, JG; Dos Reis, RC; Gambeta, E; Kopruszinski, CM; Zanoveli, JM, 2016)
"Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians."	1.43	CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016)
"Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain."	1.42	Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. ( Bang, S; Berta, T; Ji, RR; Kim, YH; Oh, SB; Wang, F; Xu, ZZ; Zhang, Y, 2015)
"The management of patients with neuropathic pain is challenging."	1.42	Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide. ( Gu, K; Guan, J; Ma, P; Ma, X; Qi, Y; Song, T; Wang, C; Wang, H; Wang, W; Ya, J; Yan, R; Yang, L; Yang, Y; Zhao, J, 2015)
"Fourteen patients with neuropathic pain (7 with unilateral foot pain due to peripheral nerve injury and 7 with bilateral pain in the feet due to distal polyneuropathy) underwent comprehensive characterization of somatosensory function by quantitative sensory testing."	1.40	Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. ( Bendtsen, TF; Finnerup, NB; Haroutounian, S; Hasselstrøm, JB; Jensen, TS; Kristensen, AD; Nikolajsen, L, 2014)
"Mechanisms underlying the chronicity of neuropathic pain are not well understood."	1.39	Descending facilitation maintains long-term spontaneous neuropathic pain. ( De Felice, M; Guo, W; King, T; Ossipov, MH; Porreca, F; Wang, R, 2013)
"Levobupivacaine was more potent than lidocaine in all tests employed on diabetic rats."	1.39	Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. ( Gunay, I; Gunes, Y; Mert, T, 2013)
"Maximum lidocaine effects on mechanical hyperalgesia were recorded at day 21 in NGF skin (pain reduction to VAS 37 ± 4, p < 0."	1.38	Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans. ( Obreja, O; Rukwied, R; Schmelz, M; Weinkauf, B, 2012)
"Chronic pain is often a symptom after local anaesthetic-induced nerve injury."	1.36	Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. ( Adey-Viscuso, D; Meechan, JG; Renton, T; Yilmaz, Z, 2010)
"Deep mechanical hyperalgesia observed after RCS at -3 degrees C lasted longer ( approximately 6 weeks) and was severer than RCS at 4 degrees C."	1.36	Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. ( Mizumura, K; Nasu, T; Taguchi, T, 2010)
"Mechanical and heat hyperalgesia were defined as a decrease in withdrawal response threshold or latency, respectively."	1.35	NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. ( Beitz, AJ; Khasabov, SG; Pacharinsak, C; Simone, DA, 2008)
"Lidocaine infusion reduced mechano-hyperalgesia but had no effect on mechano-allodynia or heat-hyperalgesia."	1.35	C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. ( Bennett, GJ; Xiao, WH, 2008)
"Animals demonstrated hyperalgesia on the ipsilateral paw up to 4 days after lidocaine injection into the DRG but not after injection into the spinal nerve."	1.35	Lidocaine injection into the rat dorsal root ganglion causes neuroinflammation. ( Hogan, QH; Kojundzic, SL; Puljak, L; Sapunar, D, 2009)
"Measuring primary hyperalgesia from deep somatic tissue (ie, muscle and joint) is difficult in laboratory animals but clinically important."	1.33	Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. ( Radhakrishnan, R; Skyba, DA; Sluka, KA, 2005)
"Hyperalgesia was induced in rats by inflaming one knee joint with 3% kaolin-carrageenan and assessed by measuring paw withdrawal latency to heat before and 4 hours after injection."	1.33	Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. ( Radhakrishnan, R; Sluka, KA, 2005)
"We evaluated mechanical allodynia in sham-operated animals and a disc herniation model."	1.33	Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats. ( Doya, H; Inoue, G; Ito, T; Koshi, T; Moriya, H; Ohtori, S; Saito, T; Takahashi, K, 2006)
"The areas of allodynia and punctate hyperalgesia were marked at the end of the stimulation period."	1.32	Central origin of secondary mechanical hyperalgesia. ( Handwerker, HO; Klede, M; Schmelz, M, 2003)
"The incisional allodynia and the carrageenan-induced hyperalgesia were intensified by the microinjection of 2% lidocaine into the contralateral, but not ipsilateral APtN, the effect being significantly stronger when a large incision or a higher carrageenan concentration was utilized."	1.32	Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. ( Del Bel, EA; Prado, WA; Villarreal, CF, 2003)
"Neuropathic pain is often associated with the appearance of pain in regions not related to the injured nerve."	1.31	Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. ( Bian, D; Gardell, LR; Ibrahim, M; Lai, J; Malan, TP; Ossipov, MH; Porreca, F, 2000)
"Secondary hyperalgesia, an exaggerated response to stimuli applied to undamaged tissue surrounding an injury, is a common consequence of tissue injury and inflammation."	1.31	Persistent secondary hyperalgesia after gastrocnemius incision in the rat. ( Brennan, TJ; Niemeier, JS; Pogatzki, EM, 2002)
"These results indicate that tactile allodynia after peripheral nerve injury is dependent upon inputs to supraspinal sites."	1.31	Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. ( Lai, J; Malan, TP; Ossipov, MH; Porreca, F; Ren, K; Sun, H; Zhong, CM, 2001)
"Inflammatory hyperalgesia was induced by injection of carrageenan into the rat paw."	1.30	Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. ( Bradley, EL; Kissin, I; Lee, SS, 1998)
"The development of mechanical hyperalgesia (pressure threshold) of the hindpaw was assessed during a 5-wk period."	1.30	Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve. ( Bradley, EL; Kissin, I; Lee, SS, 1999)
"The effect of lidocaine pretreatment on thermal hyperalgesia and thermal skin asymmetries provoked by experimental mononeuropathy was investigated in rats."	1.29	Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy. ( Castagna, A; Lacerenza, M; Marchettini, P; Sotgiu, ML, 1995)
"Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks."	1.29	Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996)

Research

Studies (128)

Authors

Clinical Trials (24)

Trial Overview

Trial Outcomes

The Cumulative Dose of Oxaliplatin

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (1.56)	18.7374
1990's	10 (7.81)	18.2507
2000's	49 (38.28)	29.6817
2010's	63 (49.22)	24.3611
2020's	4 (3.13)	2.80

Authors	Studies
Camarena-Delgado, C	1
Llorca-Torralba, M	1
Suárez-Pereira, I	1
Bravo, L	1
López-Martín, C	1
Garcia-Partida, JA	1
Mico, JA	1
Berrocoso, E	1
Araya, EI	2
Baggio, DF	1
Koren, LO	1
Schwarting, RKW	1
Chichorro, JG	3
Ozasa, K	1
Nishihara, C	1
Watanabe, K	1
Young, A	1
Khan, J	1
Sim, C	1
Yamamoto, A	1
Imamura, Y	1
Noma, N	1
Costa, YM	1
Exposto, FG	1
Castrillon, EE	1
Conti, PCR	1
Bonjardim, LR	1
Svensson, P	1
Allen, J	1
Imbert, I	1
Havelin, J	1
Henderson, T	1
Stevenson, G	1
Liaw, L	1
King, T	3
Gessner, DM	1
Sang, CN	1
Touska, F	1
Sattler, S	1
Malsch, P	1
Lewis, RJ	1
Reeh, PW	1
Zimmermann, K	1
Amato, F	1
Duse, G	1
Consoletti, L	1
Lo Presti, C	1
Firetto, V	1
Ciliberto, G	1
Parigi, LA	1
Palmieri, V	1
Mazza, M	1
Wright, L	1
Baptista-Hon, D	1
Bull, F	1
Dalgaty, F	1
Gallacher, M	1
Ibbotson, SH	1
Hales, TG	1
Remeniuk, B	1
Sukhtankar, D	1
Nippert, A	1
Li, N	1
Li, F	1
Cheng, K	1
Rice, KC	1
Porreca, F	8
Beaussier, M	2
Parc, Y	1
Guechot, J	1
Cachanado, M	1
Rousseau, A	1
Lescot, T	1
Contreras-Hernández, E	1
Chávez, D	1
Hernández, E	1
Velázquez, E	1
Reyes, P	1
Béjar, J	1
Martín, M	1
Cortés, U	1
Glusman, S	2
Rudomin, P	1
Vollert, J	2
Magerl, W	1
Baron, R	2
Binder, A	1
Enax-Krumova, EK	1
Geisslinger, G	1
Gierthmühlen, J	1
Henrich, F	1
Hüllemann, P	1
Klein, T	1
Lötsch, J	1
Maier, C	3
Oertel, B	1
Schuh-Hofer, S	1
Tölle, TR	1
Treede, RD	1
Marabese, I	1
Boccella, S	1
Iannotta, M	1
Luongo, L	1
de Novellis, V	1
Guida, F	1
Serra, N	1
Farina, A	1
Maione, S	1
Palazzo, E	1
Naja, Z	1
Naja, AS	1
Ankouni, T	1
Mugharbil, A	1
Chen, W	2
Taché, Y	1
Marvizón, JC	2
Cooper, AH	1
Brightwell, JJ	1
Hedden, NS	1
Taylor, BK	2
Delbos, A	1
Maurice-Szamburski, A	1
Ecoffey, C	1
Mercadal, L	1
de Oliveira, SB	1
Gambeta, E	2
Ferreira, LEN	1
Franz-Montan, M	1
Claudino, RF	1
Pickering, G	1
Voute, M	1
Macian, N	1
Ganry, H	1
Pereira, B	1
Hasuo, H	1
Sakuma, H	1
Uchitani, K	1
Ohue, K	1
Fukunaga, M	1
Fu, W	1
García-Hernández, L	1
Navarrete-Vázquez, G	1
González-Trujano, ME	1
López-Muñoz, FJ	1
Déciga-Campos, M	1
Wang, R	1
De Felice, M	2
Guo, W	1
Ossipov, MH	7
Madsen, CS	1
Johnsen, B	1
Fuglsang-Frederiksen, A	1
Jensen, TS	7
Finnerup, NB	4
Eyde, N	1
Dodick, D	1
Dussor, GO	1
Fields, HL	1
Quiding, H	1
Åkermark, C	1
Segerdahl, M	1
Reinholdsson, I	1
Svensson, H	1
Jonzon, B	1
Song, Z	1
Ansah, OB	1
Meyerson, BA	1
Pertovaara, A	3
Linderoth, B	1
Staud, R	3
Weyl, EE	1
Bartley, E	1
Price, DD	3
Robinson, ME	3
Peters, CM	1
Ririe, D	1
Houle, TT	1
Aschenbrenner, CA	1
Eisenach, JC	1
Haroutounian, S	1
Nikolajsen, L	1
Bendtsen, TF	1
Kristensen, AD	1
Hasselstrøm, JB	1
Rossaneis, AC	1
Genaro, K	1
Dias, QM	1
Guethe, LM	1
Fais, RS	1
Del Bel, EA	2
Prado, WA	2
Cui, W	2
Wang, S	1
Han, R	1
Wang, Q	1
Li, J	2
Demant, DT	1
Lund, K	1
Segerdahl, MS	1
Sindrup, SH	1
Song, T	1
Gu, K	1
Wang, W	1
Wang, H	1
Yang, Y	1
Yang, L	1
Ma, P	1
Ma, X	1
Zhao, J	1
Yan, R	1
Guan, J	1
Wang, C	1
Qi, Y	1
Ya, J	1
Xu, ZZ	1
Kim, YH	1
Bang, S	1
Zhang, Y	1
Berta, T	1
Wang, F	1
Oh, SB	1
Ji, RR	1
Peirs, C	1
Seal, RP	1
Amorim, D	1
Viisanen, H	1
Wei, H	2
Almeida, A	1
Pinto-Ribeiro, F	1
Kingwell, K	1
Yamaguchi, K	1
Ono, K	1
Hitomi, S	2
Ito, M	1
Nodai, T	1
Goto, T	1
Harano, N	1
Watanabe, S	1
Inoue, H	1
Miyano, K	1
Uezono, Y	1
Matoba, M	1
Inenaga, K	1
Kopruszinski, CM	1
Dos Reis, RC	1
Zanoveli, JM	1
Ko, JS	1
Eddinger, KA	1
Angert, M	1
Chernov, AV	1
Dolkas, J	1
Strongin, AY	1
Yaksh, TL	4
Shubayev, VI	1
Gritsch, S	1
Bali, KK	1
Kuner, R	1
Vardeh, D	1
Xie, W	1
Chen, S	1
Strong, JA	1
Li, AL	1
Lewkowich, IP	1
Zhang, JM	2
He, Y	1
Chen, Y	1
Tian, X	1
Yang, C	1
Lu, J	1
Xiao, C	1
DeSimone, J	1
Wilkie, DJ	1
Molokie, RE	1
Wang, ZJ	1
Lam, DK	1
Sessle, BJ	1
Hu, JW	1
Puljak, L	1
Kojundzic, SL	1
Hogan, QH	1
Sapunar, D	1
Guerios, SD	1
Wang, ZY	1
Boldon, K	1
Bushman, W	1
Bjorling, DE	1
Gormsen, L	1
Almqvist, PM	1
Umbrain, V	1
Smolders, I	1
Poelaert, J	1
Zheng, Z	1
Gibson, SJ	1
Helme, RD	1
McMeeken, JM	1
Seifert, F	1
Bschorer, K	1
De Col, R	1
Filitz, J	1
Peltz, E	1
Koppert, W	5
Maihöfner, C	1
Nagel, S	1
Nasu, T	1
Taguchi, T	1
Mizumura, K	1
Chen, JJ	1
Lue, JH	1
Lin, LH	1
Huang, CT	1
Chiang, RP	1
Chen, CL	2
Tsai, YJ	2
Li, Y	2
Li, S	1
Yang, W	1
Jiang, J	1
Han, S	1
Saadé, NE	3
Al Amin, H	2
Tchachaghian, S	1
Jabbur, SJ	3
Atweh, SF	3
Zhang, LY	1
Dong, X	1
Liu, ZL	1
Mo, JZ	1
Fang, JY	1
Xiao, SD	1
Chen, SL	1
Lin, SC	1
Yeh, JH	1
Chou, SH	1
Lam, VY	1
Wallace, M	1
Schulteis, G	1
Renton, T	1
Adey-Viscuso, D	1
Meechan, JG	1
Yilmaz, Z	1
Kaneko, M	1
Kaneko, T	1
Kaneko, R	1
Chokechanachaisakul, U	1
Kawamura, J	1
Sunakawa, M	1
Okiji, T	1
Suda, H	1
Rose, K	1
Ooi, L	1
Dalle, C	1
Robertson, B	1
Wood, IC	1
Gamper, N	1
Gustorff, B	1
Hauer, D	1
Thaler, J	1
Seis, A	1
Draxler, J	1
Suzuki, N	1
Hasegawa-Moriyama, M	1
Takahashi, Y	1
Kamikubo, Y	1
Sakurai, T	1
Inada, E	1
Echevarría, G	1
Elgueta, F	1
Fierro, C	1
Bugedo, D	1
Faba, G	1
Iñiguez-Cuadra, R	1
Muñoz, HR	1
Cortínez, LI	1
Mert, T	2
Gunes, Y	2
Gunay, I	1
Krumova, EK	1
Zeller, M	1
Westermann, A	1
Weinkauf, B	1
Obreja, O	1
Schmelz, M	6
Rukwied, R	1
Bosshard, SC	1
Grandjean, J	1
Schroeter, A	1
Baltes, C	1
Zeilhofer, HU	1
Rudin, M	1
Birkelund, T	1
Revenfeld, TS	1
Møller, JF	1
Grigoras, A	1
Lee, P	1
Sattar, F	1
Shorten, G	1
Shen, J	1
Fox, LE	1
Cheng, J	1
Zakir, HM	1
Mostafeezur, RM	1
Suzuki, A	1
Suzuki, I	1
Maeda, T	1
Seo, K	1
Yamada, Y	1
Yamamura, K	1
Lev, S	1
Binshtok, AM	1
Iwata, K	1
Kitagawa, J	1
Pogatzki, EM	1
Niemeier, JS	1
Brennan, TJ	1
Kawamata, M	3
Watanabe, H	2
Nishikawa, K	2
Takahashi, T	2
Kozuka, Y	2
Kawamata, T	1
Omote, K	1
Namiki, A	3
Nawa, Y	1
Narimatsu, E	2
Araujo, MC	1
Sinnott, CJ	1
Strichartz, GR	1
Villarreal, CF	1
Katz, J	2
Cohen, L	2
Schmid, R	1
Chan, VW	1
Wowk, A	1
Klede, M	1
Handwerker, HO	1
Baliki, M	1
Al-Amin, HA	1
Jaber, M	1
Hawwa, N	1
Apkarian, AV	1
Verne, GN	1
Vase, L	1
Datta, S	1
Waghray, T	1
Torres, M	1
Attal, N	2
Rouaud, J	1
Brasseur, L	2
Chauvin, M	2
Bouhassira, D	2
Gottrup, H	3
Bach, FW	2
Brueckl, V	1
Weidner, C	2
Skyba, DA	1
Radhakrishnan, R	2
Sluka, KA	2
Abdel Baki, S	1
Safieh-Garabedian, B	1
Sugino, S	1
Yamauchi, M	1
Kiya, T	1
Furuse, S	1
Mayer, EA	1
Ohtori, S	1
Inoue, G	1
Koshi, T	1
Ito, T	1
Doya, H	1
Saito, T	1
Moriya, H	1
Takahashi, K	1
Gammaitoni, AR	1
Wasner, G	1
Naleschinski, D	1
Zhang, YH	1
Ennis, M	1
Xiao, WH	1
Bennett, GJ	1
Pacharinsak, C	1
Khasabov, SG	1
Beitz, AJ	1
Simone, DA	1
Tian, J	1
Gu, Y	1
Su, D	1
Wu, Y	1
Wang, X	1
Sotgiu, ML	1
Castagna, A	1
Lacerenza, M	1
Marchettini, P	1
Abram, SE	1
Kurvers, HA	1
Tangelder, GJ	1
De Mey, JG	1
Slaaf, DW	1
Beuk, RJ	1
van den Wildenberg, FA	1
Kitslaar, PJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Postoperative Pain Control With Systemic Lidocaine vs. Regional Anesthesia in Renal Transplant Patients[NCT05044429]	Phase 4	100 participants (Anticipated)	Interventional	2021-03-16	Recruiting
Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785]	Phase 2/Phase 3	80 participants (Anticipated)	Interventional	2021-11-15	Recruiting
Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs[NCT04741880]	Phase 2/Phase 3	66 participants (Anticipated)	Interventional	2021-06-17	Recruiting
Impact of 5% Lidocaine Medicated Plaster on Allodynic Symptoms of Localized Neuropathic Pain After Knee Surgery[NCT02763592]	Phase 2	37 participants (Actual)	Interventional	2016-05-31	Completed
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]		301 participants (Anticipated)	Interventional	2022-11-01	Recruiting
The Significance of Peripheral Input in Patients With Post Surgery Neuropathic Pain: Evaluation of Trigger Point Anesthesia. A Double-blind, Randomized, Controlled Exploratory Study[NCT04764045]		12 participants (Anticipated)	Interventional	2019-11-20	Recruiting
Brain Activation During Accommodation to Painful Stimulation With Functional Imaging of Pain[NCT01242540]		15 participants (Actual)	Observational	2010-11-30	Completed
What Determines a Positive Outcome of Spinal Manipulation for Persistent Low Back Pain: Stiffness or Pain Sensitivity? A Randomized Trial[NCT04086667]		132 participants (Actual)	Interventional	2017-11-01	Completed
Dry Needling in Patients With Fibromyalgia: Analysis of Its Therapeutic Effectiveness[NCT04942444]		120 participants (Anticipated)	Interventional	2011-01-10	Recruiting
Is the Direct Inferior Alveolar Nerve Block Required for Third Lower Molar Extraction?[NCT03443726]		120 participants (Actual)	Interventional	2017-06-10	Completed
Administration of Acetazolamide to Prevent Remifentanil Induced Hyperalgesia: Randomize Double Blind Clinical Trial[NCT02992938]	Phase 4	50 participants (Actual)	Interventional	2016-12-31	Completed
Randomized Double Blind Clinical Trial on the Effect of Levobupivacaine Infiltration Versus Placebo on the Post Partum Perineal Pain in Episiotomy in Primiparous Women After Instrumental Delivery[NCT02796547]	Phase 2	0 participants (Actual)	Interventional	2016-07-14	Withdrawn (stopped due to Lack of human ressources)
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain : A Pilot Study[NCT02217267]	Phase 3	29 participants (Actual)	Interventional	2014-08-01	Completed
Intravenous Lidocaine for Preventing Painful Oxaliplatin-induced Peripheral Neuropathy (OIPN)[NCT03254394]	Phase 1/Phase 2	26 participants (Actual)	Interventional	2017-09-15	Completed
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573]		10,000 participants (Anticipated)	Observational	2012-08-03	Active, not recruiting
Somatosensory Electrical Stimulation to Improve Motor Control in Patients Suffering From Knee Osteoarthritis[NCT02854176]	Phase 2	20 participants (Anticipated)	Interventional	2016-09-30	Not yet recruiting
High-frequency Sinusoidal Neurostimulation (BioWave) Versus Transcutaneous Electrical Nerve Stimulation (TENS) for the Treatment of Chronic Low Back Pain[NCT05511181]		120 participants (Actual)	Interventional	2022-08-15	Completed
Effects of Lidocaine Patch on Intradermal Capsaicin Induced Pain and Hyperalgesia[NCT00373893]	Phase 1	12 participants	Interventional	2005-12-31	Completed
Intravenous Lidocaine to Decrease Postoperative Pain in Pediatric Patients Undergoing Tonsillectomy: A Randomized, Double Blind, Placebo Controlled Trial[NCT02595463]	Phase 2/Phase 3	90 participants (Anticipated)	Interventional	2015-11-30	Recruiting
A Randomized Controlled Trial of Lidocaine Patch for Lower Limb Amputation Pain[NCT02696720]	Phase 2	0 participants (Actual)	Interventional	2016-05-13	Withdrawn (stopped due to Lack of recruitment)
Lidocaine Infusions for Children Undergoing Combined Tonsillectomy and Adenoidectomy: A Double-Blinded, Randomized, Placebo-Controlled Trial[NCT03902314]	Phase 4	70 participants (Actual)	Interventional	2019-05-07	Completed
Double Blind Trial Investigating the Role of Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients[NCT03847311]	Phase 2	40 participants (Anticipated)	Interventional	2021-05-03	Recruiting
Toward Personalized Treatment of Chronic Pain Using Transcranial Direct Current Stimulation Paired With Deep Learning[NCT05863494]		40 participants (Anticipated)	Interventional	2023-06-01	Recruiting
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091]	Phase 2	10 participants (Actual)	Interventional	2009-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The cumulative dose of oxaliplatin received over the course (up to 12 cycles) of mFOLFOX6 treatment regimen. It corresponds to the absolute summed up quantity of Oxaliplatin administered to the patient over time. There is no range for this measure. Since this is a dose-limiting neuropathy prevention study, the higher value can be interpreted as better outcome. (NCT03254394)
Timeframe: 24 weeks

Area Under the Curve (AUC) of Intensity of Oxaliplatin-induced Cold Pain/Unpleasantness vs Time

Intervention	mg (Mean)
Placebo + FOLFOX	1161.8
Lidocaine + FOLFOX	1294.8

"The intensity of cold pain and cold unpleasantness is evaluated separately, assessed daily on a 0-10 scale, upon holding a pre-cooled (~8°C) metal cylinder for 10 seconds. the area under the curve of cold pain and cold unpleasantness vs time is calculated per chemotherapy cycle (every two weeks) and serves as a primary outcome measure.~For intervention (lidocaine+FOLFOX) and control (placebo+FOLFOX) groups, the average of cold pain AUC and cold unpleasantness AUC over 7 cycles was calculated. The average AUCs over 7 cycles were compared between study arms.~The AUC is measured as a score on a 0-10 scale multiplied by 14 days and may range between 0 and 140. Higher AUC values represent more intense cold pain/unpleasantness." (NCT03254394)
Timeframe: 14 weeks

Changes in NPSI Score.

Intervention	score on a scale*days (Mean)
	pain AUC	unpleasantness AUC
Lidocaine + FOLFOX	9.5	25.4
Placebo + FOLFOX	16.4	33.1

Changes in Neuropathic Pain Symptom Inventory (NPSI) descriptors of neuropathic pain over time from baseline to cycle 3(6 weeks), cycle 6 (12 weeks), and the last follow-up (34-36 weeks). The total NPSI score ranges from 0 to 100; a higher NPSI total score represents a worse neuropathy outcome. The changes in scores from baseline are compared between study arms. (NCT03254394)
Timeframe: 6 weeks, 12 weeks, 34-36 weeks

CIPN Score on EORTC QLQ-CIPN20

Intervention	score on a scale (Median)
	6 weeks visit	12 weeks visit	last follow-up visit
Lidocaine + FOLFOX	0	0	13.5
Placebo + FOLFOX	0	0	3.0

"Change in CIPN (Chemotherapy-induced peripheral Neuropathy) score (on EORTC QLQ-CIPN20 tool ) from baseline to the Cycle 6 (12 weeks), and from baseline to last follow-up (34-36 weeks). EORTC QLQ-CIPN20 ranges from 0 (no symptoms) to 100 (worst symptoms). A higher score represents worse neuropathy. The changes in scores are compared between study arms.~EORTC QLQ-CIPN20 tool is a quality of life questionnaire (QLQ) from the European Organization for Research and Treatment of Cancer (EORTC) for evaluation of CIPN." (NCT03254394)
Timeframe: 12 weeks and 34-36 weeks

Objective Opioid Withdrawal Scale (OOWS)

Intervention	score on a scale (Median)
	12	34-36 weeks
Lidocaine + FOLFOX	4	37.0
Placebo + FOLFOX	2	17.0

OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

Intervention	units on a scale (Mean)
	Pretreatment	30 min prior to REM infusion	15 min after start of REM infusion	40 min after start of REM infusion	5 minutes after finish of REM infusion	15 minutes after finish of REM infusion	75 minutes after finish of REM infusion
Placebo	1.1	1.1	0.8	0.5	1.8	2.1	1.6
Propranolol	1.2	1.1	0.1	0.8	3	2.8	1.7

A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

Article	Year
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Perioperative Use of Intravenous Lidocaine. Drugs, 2018, Volume: 78, Issue:12 Topics: Administration, Intravenous; Analgesics; Analgesics, Opioid; Anesthetics, Local; Animals; Humans; Hy	2018
Is it all central sensitization? Role of peripheral tissue nociception in chronic musculoskeletal pain. Current rheumatology reports, 2010, Volume: 12, Issue:6 Topics: Anesthetics, Local; Exercise Therapy; Fibromyalgia; Humans; Hyperalgesia; Lidocaine; Muscle, Skeleta	2010
Commentary on peripheral and central contributions to hyperalgesia in irritable bowel syndrome. The journal of pain, 2006, Volume: 7, Issue:8 Topics: Administration, Rectal; Anesthetics, Local; Central Nervous System; Chronic Disease; Humans; Hyperal	2006
Spinal and supraspinal mechanisms of neuropathic pain. Annals of the New York Academy of Sciences, 2000, Volume: 909 Topics: Animals; Dizocilpine Maleate; Dynorphins; Humans; Hyperalgesia; Lidocaine; Morphine; Pain; Spinal Co	2000

Article	Year
Local anaesthesia decreases nerve growth factor induced masseter hyperalgesia. Scientific reports, 2020, 09-22, Volume: 10, Issue:1 Topics: Adult; Anesthetics, Local; Case-Control Studies; Double-Blind Method; Facial Pain; Female; Humans; H	2020
Ropivacaine preperitoneal wound infusion for pain relief and prevention of incisional hyperalgesia after laparoscopic colorectal surgery: a randomized, triple-arm, double-blind controlled evaluation vs intravenous lidocaine infusion, the CATCH study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2018, Volume: 20, Issue:6 Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Local; Colectomy; Double-Blind Method; Female; Humans;	2018
Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial. Pain, 2019, Volume: 160, Issue:5 Topics: Aged; Anesthetics, Local; Arthroplasty, Replacement, Knee; Double-Blind Method; Female; Humans; Hype	2019
Short-Term Effects of 10% Lidocaine Ointment on Allodynia in Cancer Pain: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. Journal of palliative medicine, 2019, Volume: 22, Issue:11 Topics: Aged; Cancer Pain; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Lidocaine;	2019
A pain model with a neuropathic somatosensory lesion: Morton neuroma. Pain, 2013, Volume: 154, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Cold Temperature; Cross-Over Studies	2013
Analgesic and anti-hyperalgesic effects of muscle injections with lidocaine or saline in patients with fibromyalgia syndrome. European journal of pain (London, England), 2014, Volume: 18, Issue:6 Topics: Adult; Anesthetics, Local; Double-Blind Method; Female; Fibromyalgia; Humans; Hyperalgesia; Injectio	2014
Pain relief with lidocaine 5% patch in localized peripheral neuropathic pain in relation to pain phenotype: a randomised, double-blind, and placebo-controlled, phenotype panel study. Pain, 2015, Volume: 156, Issue:11 Topics: Adult; Aged; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalges	2015
The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Adult; Aged; Analgesia; Anesthetics, Local; Chronic Disease; Cross-Over Studies; Double-Blind Method	2009
The effect of local anaesthetic on age-related capsaicin-induced mechanical hyperalgesia--a randomised, controlled study. Pain, 2009, Volume: 144, Issue:1-2 Topics: Adult; Aged; Aging; Analysis of Variance; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesi	2009
Medial prefrontal cortex activity is predictive for hyperalgesia and pharmacological antihyperalgesia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, May-13, Volume: 29, Issue:19 Topics: Adult; Anesthetics, Local; Brain; Brain Mapping; Cross-Over Studies; Double-Blind Method; Electric S	2009
Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain, 2009, Volume: 145, Issue:1-2 Topics: Adult; Afferent Pathways; Analysis of Variance; Anesthetics, Local; Arm; Double-Blind Method; Female	2009
Effects of lidocaine patch on intradermal capsaicin-induced pain: a double-blind, controlled trial. The journal of pain, 2011, Volume: 12, Issue:3 Topics: Anesthetics, Local; Capsaicin; Double-Blind Method; Humans; Hyperalgesia; Injections, Intradermal; L	2011
Antihyperalgesic efficacy of 5% lidocaine medicated plaster in capsaicin and sunburn pain models--two randomized, double-blinded, placebo-controlled crossover trials in healthy volunteers. Expert opinion on pharmacotherapy, 2011, Volume: 12, Issue:18 Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dose-Response R	2011
Lidocaine patch (5%) produces a selective, but incomplete block of Aδ and C fibers. Pain, 2012, Volume: 153, Issue:2 Topics: Adult; Aged; Anesthetics, Local; Double-Blind Method; Female; Humans; Hyperalgesia; Lidocaine; Male;	2012
Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. The Clinical journal of pain, 2012, Volume: 28, Issue:7 Topics: Administration, Intravenous; Adult; Aged; Anesthetics, Local; Back Pain; Breast Neoplasms; Chronic D	2012
Different mechanisms of development and maintenance of experimental incision-induced hyperalgesia in human skin. Anesthesiology, 2002, Volume: 97, Issue:3 Topics: Adult; Anesthetics, Local; Double-Blind Method; Erythema; Female; Forearm; Humans; Hyperalgesia; Lid	2002
Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia. Pain, 2002, Volume: 100, Issue:1-2 Topics: Adult; Anesthetics, Local; Double-Blind Method; Female; Humans; Hyperalgesia; Injections, Intravenou	2002
Postoperative morphine use and hyperalgesia are reduced by preoperative but not intraoperative epidural analgesia: implications for preemptive analgesia and the prevention of central sensitization. Anesthesiology, 2003, Volume: 98, Issue:6 Topics: Adaptation, Psychological; Adult; Affect; Analgesia, Epidural; Analgesia, Patient-Controlled; Analge	2003
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Systemic lidocaine in pain due to peripheral nerve injury and predictors of response. Neurology, 2004, Jan-27, Volume: 62, Issue:2 Topics: Adult; Aged; Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Hot Temp	2004
Differential effects of peripheral ketamine and lidocaine on skin flux and hyperalgesia induced by intradermal capsaicin in humans. Clinical physiology and functional imaging, 2004, Volume: 24, Issue:2 Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Bli	2004
Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine. European journal of pain (London, England), 2004, Volume: 8, Issue:3 Topics: Adult; Axons; Burns; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug	2004
Preventive analgesia is associated with reduced pain disability 3 weeks but not 6 months after major gynecologic surgery by laparotomy. Anesthesiology, 2004, Volume: 101, Issue:1 Topics: Adaptation, Psychological; Adult; Affect; Analgesia; Analgesics, Opioid; Anesthesia, General; Anesth	2004
Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effects on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology, 1997, Volume: 86, Issue:6 Topics: Adolescent; Adult; Anesthetics, Local; Blood Pressure; Capsaicin; Dose-Response Relationship, Drug;	1997
Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans. Anesthesiology, 1998, Volume: 89, Issue:6 Topics: Adult; Anesthetics, Local; Axons; Body Temperature; Double-Blind Method; Female; Histamine; Hot Temp	1998
Effect of EMLA pre-treatment on capsaicin-induced burning and hyperalgesia. Acta dermato-venereologica, 1999, Volume: 79, Issue:2 Topics: Administration, Cutaneous; Adult; Anesthetics, Local; Capsaicin; Female; Humans; Hyperalgesia; Lidoc	1999
Effects of single and repeated applications of a eutectic mixture of local anaesthetics (EMLA) cream on spontaneous and evoked pain in post-herpetic neuralgia. Pain, 1999, Volume: 81, Issue:1-2 Topics: Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Female; Herpesviridae Infections	1999
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. Pain, 2000, Volume: 85, Issue:1-2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Axons; Capsaicin; Double-Blind Method; Female; Hu	2000
Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans. British journal of anaesthesia, 2000, Volume: 84, Issue:2 Topics: Analgesics; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Method; Hot Temperature;	2000
The effect of systemic lidocaine on pain and secondary hyperalgesia associated with the heat/capsaicin sensitization model in healthy volunteers. Anesthesia and analgesia, 2000, Volume: 91, Issue:4 Topics: Adult; Anesthetics, Local; Capsaicin; Cross-Over Studies; Dizziness; Double-Blind Method; Hot Temper	2000
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans. British journal of anaesthesia, 2000, Volume: 85, Issue:4 Topics: Analgesics; Analysis of Variance; Anesthetics, Local; Capsaicin; Cross-Over Studies; Double-Blind Me	2000
Effect of pre- or post-traumatically applied i.v. lidocaine on primary and secondary hyperalgesia after experimental heat trauma in humans. Pain, 2000, Dec-01, Volume: 88, Issue:3 Topics: Adult; Analysis of Variance; Anesthetics, Local; Burns; Cross-Over Studies; Double-Blind Method; Hot	2000
A new model of electrically evoked pain and hyperalgesia in human skin: the effects of intravenous alfentanil, S(+)-ketamine, and lidocaine. Anesthesiology, 2001, Volume: 95, Issue:2 Topics: Adult; Alfentanil; Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Local; Ax	2001

Article	Year
Nerve injury induces transient locus coeruleus activation over time: role of the locus coeruleus-dorsal reticular nucleus pathway. Pain, 2022, 05-01, Volume: 163, Issue:5 Topics: Animals; Chronic Pain; Hyperalgesia; Lidocaine; Locus Coeruleus; Male; Neuralgia; Rats; Rats, Spragu	2022
Trigeminal neuropathic pain reduces 50-kHz ultrasonic vocalizations in rats, which are restored by analgesic drugs. European journal of pharmacology, 2022, May-05, Volume: 922 Topics: Analgesics; Animals; Carbamazepine; Hyperalgesia; Lidocaine; Male; Midazolam; Neuralgia; Rats; Trige	2022
Somatosensory profile of a patient with mixed connective tissue disease and Sjögren syndrome. Journal of the American Dental Association (1939), 2020, Volume: 151, Issue:2 Topics: Adult; Female; Humans; Hyperalgesia; Lidocaine; Mixed Connective Tissue Disease; Pain Threshold; Sjo	2020
Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:7 Topics: Anesthetics, Local; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Models,	2017
Revisiting Mechanisms of Extraterritorial Allodynia. Current pain and headache reports, 2017, Volume: 21, Issue:5 Topics: Adenocarcinoma; Humans; Hyperalgesia; Lidocaine; Male; Middle Aged; Pain; Pain Threshold; Spinal Cor	2017
Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na Marine drugs, 2017, Aug-30, Volume: 15, Issue:9 Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Ciguatera Poisoning; Ciguatoxins; Enzyme-Linked I	2017
Efficacy and safety of 5% lidocaine-medicated plasters in localized pain with neuropathic and/or inflammatory characteristics: an observational, real-world study. European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:18 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Hyperalgesia; Lidoca	2017
Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. Pain, 2018, Volume: 159, Issue:2 Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Derm	2018
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. Pain, 2018, Volume: 159, Issue:4 Topics: Adenocarcinoma; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Bone Neoplasms; Bufan	2018
Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity. The Journal of physiology, 2018, 05-01, Volume: 596, Issue:9 Topics: Anesthetics, Local; Animals; Capsaicin; Cats; Female; Hyperalgesia; Lidocaine; Male; Nerve Net; Noci	2018
Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. Pain, 2018, Volume: 159, Issue:6 Topics: Adult; Aged; Algorithms; Capsaicin; Female; Healthy Volunteers; Humans; Hyperalgesia; Lidocaine; Mal	2018
Metabotropic glutamate receptor subtype 7 in the dorsal striatum oppositely modulates pain in sham and neuropathic rats. Neuropharmacology, 2018, Volume: 135 Topics: Animals; Benzhydryl Compounds; Benzoxazoles; Corpus Striatum; Glutamic Acid; Hyperalgesia; Lidocaine	2018
Thoracic paravertebral catheterization for more than one year: A report of mastodynia. Journal of clinical anesthesia, 2018, Volume: 47 Topics: Analgesics; Anesthetics, Local; Catheterization; Clonidine; Electric Injuries; Epidural Space; Femal	2018
Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. Neuroscience, 2018, 06-15, Volume: 381 Topics: Analgesics, Opioid; Animals; Brain; Central Nervous System Sensitization; Chronic Pain; Corticotropi	2018
The left central nucleus of the amygdala contributes to mechanical allodynia and hyperalgesia following right-sided peripheral nerve injury. Neuroscience letters, 2018, 09-25, Volume: 684 Topics: Anesthetics, Local; Animals; Central Amygdaloid Nucleus; Functional Laterality; Hyperalgesia; Lidoca	2018
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:5 Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Anim	2019
Neuropeptide Y release in the rat spinal cord measured with Y1 receptor internalization is increased after nerve injury. Neuropharmacology, 2019, 11-01, Volume: 158 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium Channel Blockers; Capsaicin; Cyclic	2019
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats. The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5 Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications;	2013
Descending facilitation maintains long-term spontaneous neuropathic pain. The journal of pain, 2013, Volume: 14, Issue:8 Topics: Afferent Pathways; Anesthetics, Local; Animals; Benzodiazepines; Conditioning, Operant; Disease Mode	2013
Differential effects of a 5% lidocaine medicated patch in peripheral nerve injury. Muscle & nerve, 2013, Volume: 48, Issue:2 Topics: Adult; Anesthetics, Local; Evoked Potentials; Female; Humans; Hyperalgesia; Lidocaine; Male; Middle	2013
Capturing the aversive state of cephalic pain preclinically. Annals of neurology, 2013, Volume: 74, Issue:2 Topics: Animals; Behavior, Animal; Gyrus Cinguli; Headache; Hyperalgesia; Lidocaine; Male; Microinjections;	2013
Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus. Neuroscience, 2013, Dec-03, Volume: 253 Topics: Action Potentials; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists;	2013
Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology, 2014, Volume: 120, Issue:4 Topics: Anesthetics, Combined; Anesthetics, Local; Animals; Behavior, Animal; Capsaicin; Disease Models, Ani	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Primary afferent input critical for maintaining spontaneous pain in peripheral neuropathy. Pain, 2014, Volume: 155, Issue:7 Topics: Adolescent; Adult; Afferent Pathways; Aged; Aged, 80 and over; Anesthetics, Local; Central Nervous S	2014
Descending mechanisms activated by the anterior pretectal nucleus initiate but do not maintain neuropathic pain in rats. European journal of pain (London, England), 2015, Volume: 19, Issue:8 Topics: Anesthetics, Local; Animals; Constriction, Pathologic; Hyperalgesia; Lidocaine; Male; Methysergide;	2015
CaMKII Phosphorylation in Primary Somatosensory Cortical Neurons is Involved in the Inhibition of Remifentanil-induced Hyperalgesia by Lidocaine in Male Sprague-Dawley Rats. Journal of neurosurgical anesthesiology, 2016, Volume: 28, Issue:1 Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2;	2016
Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide. Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:11 Topics: Anesthetics, Local; Animals; Cells, Cultured; Cytokines; Delayed-Action Preparations; Graphite; Huma	2015
Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nature medicine, 2015, Volume: 21, Issue:11 Topics: Adult; Aged; Anesthetics, Local; Animals; Antineoplastic Agents; Capsaicin; Diabetic Neuropathies; F	2015
Targeting Toll-like receptors to treat chronic pain. Nature medicine, 2015, Volume: 21, Issue:11 Topics: Anesthetics, Local; Animals; Chronic Pain; Flagellin; Humans; Hyperalgesia; Lidocaine; Mice; Nerve F	2015
Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. PloS one, 2015, Volume: 10, Issue:11 Topics: Animals; Arthritis; Behavior, Animal; Disease Models, Animal; Electrophysiology; Galanin; Glutamic A	2015
Pain: TLR5 opens the door to neuropathic-pain treatment. Nature reviews. Drug discovery, 2015, Volume: 14, Issue:12 Topics: Anesthetics, Local; Animals; Female; Flagellin; Ganglia, Spinal; Humans; Hyperalgesia; Lidocaine; Ma	2015
Distinct TRPV1- and TRPA1-based mechanisms underlying enhancement of oral ulcerative mucositis-induced pain by 5-fluorouracil. Pain, 2016, Volume: 157, Issue:5 Topics: Acetanilides; Anesthetics, Local; Animals; Anti-Bacterial Agents; Antimetabolites; Carcinosarcoma; C	2016
Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer. Neuroscience letters, 2016, Apr-21, Volume: 619 Topics: Analgesics; Animals; Anti-Anxiety Agents; Anxiety; Cell Line, Tumor; Facial Neoplasms; Hot Temperatu	2016
Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia. Brain, behavior, and immunity, 2016, Volume: 56 Topics: Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors; D	2016
Functional characterization of a mouse model for central post-stroke pain. Molecular pain, 2016, Volume: 12 Topics: Animals; Collagenases; Disease Models, Animal; Hyperalgesia; Kainic Acid; Lidocaine; Mice, Inbred C5	2016
Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 08-17, Volume: 36, Issue:33 Topics: Anesthetics, Local; Animals; Cytokines; Disease Models, Animal; Female; Ganglia, Spinal; Homeostasis	2016
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. Pain, 2016, Volume: 157, Issue:12 Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein	2016
Surgical incision can alter capsaicin-induced central sensitization in rat brainstem nociceptive neurons. Neuroscience, 2008, Oct-15, Volume: 156, Issue:3 Topics: Action Potentials; Analysis of Variance; Anesthetics, Local; Animals; Capsaicin; Hyperalgesia; Lidoc	2008
Lidocaine injection into the rat dorsal root ganglion causes neuroinflammation. Anesthesia and analgesia, 2009, Volume: 108, Issue:3 Topics: Anesthetics, Local; Animals; CD11b Antigen; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Hypera	2009
Lidocaine prevents referred hyperalgesia associated with cystitis. Neurourology and urodynamics, 2009, Volume: 28, Issue:5 Topics: Administration, Intravesical; Anesthetics, Local; Animals; Cystitis; Disease Models, Animal; Female;	2009
Is Intrathecal lidocaine administration risk-free in rats with neuropathic pain? Reply to [Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain 13 (2009) 130-137]. European journal of pain (London, England), 2009, Volume: 13, Issue:8 Topics: Anesthetics, Local; Animals; Constriction, Pathologic; Cytokines; Dinoprostone; Hyperalgesia; Inject	2009
Persistent deep mechanical hyperalgesia induced by repeated cold stress in rats. European journal of pain (London, England), 2010, Volume: 14, Issue:3 Topics: Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Cold Temperature; Disease Models	2010
Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury. Pain, 2010, Volume: 148, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Astrocytes; Citrates; Clonidine; Disease Models, Animal; Dizocil	2010
Systemic lidocaine inhibits remifentanil-induced hyperalgesia via the inhibition of cPKCgamma membrane translocation in spinal dorsal horn of rats. Journal of neurosurgical anesthesiology, 2009, Volume: 21, Issue:4 Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Local; Animals; Behavior, Animal; Cell Membrane; Dose-R	2009
Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats. Pain, 2010, Volume: 149, Issue:1 Topics: Anesthetics, Local; Animals; Female; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; Injections; Lid	2010
Luminal serotonin time-dependently modulates vagal afferent driven antinociception in response to colorectal distention in rats. Neurogastroenterology and motility, 2011, Volume: 23, Issue:1 Topics: Afferent Pathways; Analgesics; Animals; Capsaicin; Colon; Dilatation, Pathologic; Food Hypersensitiv	2011
Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus. European journal of pain (London, England), 2011, Volume: 15, Issue:4 Topics: Anesthetics, Local; Animals; Behavior, Animal; Blotting, Western; Constriction, Pathologic; Dose-Res	2011
Trigeminal nerve injuries in relation to the local anaesthesia in mandibular injections. British dental journal, 2010, Volume: 209, Issue:9 Topics: Adult; Aged; Anesthesia, Local; Anesthetics, Local; Chin; Cranial Nerve Injuries; Female; Gingiva; H	2010
The role of N-methyl-D-aspartate receptor subunits in the rat thalamic mediodorsal nucleus during central sensitization. Brain research, 2011, Jan-31, Volume: 1371 Topics: Afferent Pathways; Anesthetics, Local; Animals; Dental Pulp; Dizocilpine Maleate; Dorsomedial Hypoth	2011
Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain, 2011, Volume: 152, Issue:4 Topics: Aminopyridines; Analgesics; Analysis of Variance; Anesthetics, Local; Animals; Chronic Disease; Dise	2011
Lidocaine attenuates the development of diabetic-induced tactile allodynia by inhibiting microglial activation. Anesthesia and analgesia, 2011, Volume: 113, Issue:4 Topics: Anesthetics, Local; Animals; Behavior, Animal; Cells, Cultured; Chemokine CCL2; Chemotaxis; Diabetes	2011
Nitrous oxide (N(2)O) reduces postoperative opioid-induced hyperalgesia after remifentanil-propofol anaesthesia in humans. British journal of anaesthesia, 2011, Volume: 107, Issue:6 Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Female; Humans; Hyperalgesia; Lidoc	2011
Comparison of actions of systemically and locally administrated local anaesthetics in diabetic rats with painful neuropathy. Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:2 Topics: Anesthetics, Local; Animals; Bupivacaine; Diabetes Mellitus, Experimental; Disease Models, Animal; F	2013
Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans. European journal of pain (London, England), 2012, Volume: 16, Issue:4 Topics: Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Hot Temperature; Humans; Hyperalgesia;	2012
Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: an fMRI study in mice. Pain, 2012, Volume: 153, Issue:7 Topics: Anesthetics, Local; Animals; Cannabinoids; Disease Models, Animal; Female; Hyperalgesia; Lidocaine;	2012
[Transient segmental hyperalgesia following epidural analgesia]. Ugeskrift for laeger, 2012, May-21, Volume: 174, Issue:21 Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Catheterization; Di	2012
Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats. Anesthesiology, 2012, Volume: 117, Issue:2 Topics: Anesthetics, Local; Animals; Antipruritics; Capsaicin; Disease Models, Animal; Drug Administration R	2012
Expression of TRPV1 channels after nerve injury provides an essential delivery tool for neuropathic pain attenuation. PloS one, 2012, Volume: 7, Issue:9 Topics: Anesthetics, Local; Animals; Capsaicin; Gene Expression; Hyperalgesia; Lidocaine; Male; Mandibular N	2012
Antinociceptive activities of lidocaine and the nav1.8 blocker a803467 in diabetic rats. Journal of the American Association for Laboratory Animal Science : JAALAS, 2012, Volume: 51, Issue:5 Topics: Analgesics; Aniline Compounds; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fema	2012
Persistent secondary hyperalgesia after gastrocnemius incision in the rat. European journal of pain (London, England), 2002, Volume: 6, Issue:4 Topics: Anesthetics, Local; Animals; Bupivacaine; Hindlimb; Hot Temperature; Hyperalgesia; Lidocaine; Male;	2002
A dissociative change in the efficacy of supraspinal versus spinal morphine in the neuropathic rat. Pain, 2003, Volume: 101, Issue:3 Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Respons	2003
Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions. Pain, 2003, Volume: 103, Issue:1-2 Topics: Anesthetics, Local; Animals; Behavior, Animal; Functional Laterality; Hyperalgesia; Infusions, Intra	2003
Involvement of the anterior pretectal nucleus in the control of persistent pain: a behavioral and c-Fos expression study in the rat. Pain, 2003, Volume: 103, Issue:1-2 Topics: Anesthetics, Local; Animals; Bupivacaine; Carrageenan; Disease Models, Animal; Dose-Response Relatio	2003
Central origin of secondary mechanical hyperalgesia. Journal of neurophysiology, 2003, Volume: 90, Issue:1 Topics: Adult; Anesthetics, Local; Central Nervous System; Electric Stimulation; Female; Forearm; Humans; Hy	2003
Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat. Neuroscience, 2003, Volume: 120, Issue:4 Topics: Adrenergic Agents; Anesthetics, Local; Animals; Cold Temperature; Disease Models, Animal; Electricit	2003
Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients. Pain, 2003, Volume: 105, Issue:1-2 Topics: Administration, Rectal; Adult; Anesthesia, Local; Anesthetics, Local; Case-Control Studies; Catheter	2003
Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. Anesthesia and analgesia, 2004, Volume: 98, Issue:1 Topics: Amiodarone; Anesthetics, Local; Animals; Cold Temperature; Hot Temperature; Hyperalgesia; Injections	2004
Characterization of a method for measuring primary hyperalgesia of deep somatic tissue. The journal of pain, 2005, Volume: 6, Issue:1 Topics: Animals; Arthralgia; Carrageenan; Disease Models, Animal; Functional Laterality; Hyperalgesia; Infla	2005
Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. The journal of pain, 2005, Volume: 6, Issue:10 Topics: Administration, Topical; Afferent Pathways; Anesthetics, Local; Animals; Arthralgia; Carrageenan; Hy	2005
Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. The journal of pain, 2005, Volume: 6, Issue:10 Topics: Administration, Topical; Afferent Pathways; Anesthetics, Local; Animals; Arthralgia; Carrageenan; Hy	2005
Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. The journal of pain, 2005, Volume: 6, Issue:10 Topics: Administration, Topical; Afferent Pathways; Anesthetics, Local; Animals; Arthralgia; Carrageenan; Hy	2005
Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. The journal of pain, 2005, Volume: 6, Issue:10 Topics: Administration, Topical; Afferent Pathways; Anesthetics, Local; Animals; Arthralgia; Carrageenan; Hy	2005
Transient attenuation of neuropathic manifestations in rats following lesion or reversible block of the lateral thalamic somatosensory nuclei. Experimental neurology, 2006, Volume: 197, Issue:1 Topics: Anesthetics, Local; Animals; Behavior, Animal; Cold Temperature; Excitatory Amino Acid Agonists; Fem	2006
Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat. Pain, 2006, Volume: 122, Issue:1-2 Topics: Action Potentials; Anesthetics, Local; Animals; Denervation; Dose-Response Relationship, Drug; Hyper	2006
Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats. Spine, 2006, Aug-15, Volume: 31, Issue:18 Topics: Acid Sensing Ion Channels; Animals; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Intervert	2006
Effectiveness of lidocaine patch 5% in patients with or without allodynia. CNS spectrums, 2006, Volume: 11, Issue:12 Topics: Administration, Cutaneous; Anesthetics, Local; Diabetic Neuropathies; Humans; Hyperalgesia; Lidocain	2006
A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report. Pain, 2007, Volume: 131, Issue:1-2 Topics: Administration, Topical; Afferent Pathways; Capsaicin; Humans; Hyperalgesia; Lidocaine; Male; Middle	2007
Inactivation of the periaqueductal gray attenuates antinociception elicited by stimulation of the rat medial preoptic area. Neuroscience letters, 2007, Dec-18, Volume: 429, Issue:2-3 Topics: Analgesia; Anesthetics, Local; Animals; Homocysteine; Hyperalgesia; Lidocaine; Male; Microinjections	2007
C-fiber spontaneous discharge evoked by chronic inflammation is suppressed by a long-term infusion of lidocaine yielding nanogram per milliliter plasma levels. Pain, 2008, Volume: 137, Issue:1 Topics: Animals; Chronic Disease; Hyperalgesia; Inflammation; Infusion Pumps; Lidocaine; Male; Nanostructure	2008
NK-1 receptors in the rostral ventromedial medulla contribute to hyperalgesia produced by intraplantar injection of capsaicin. Pain, 2008, Sep-30, Volume: 139, Issue:1 Topics: Animals; Capsaicin; Hindlimb; Hyperalgesia; Lidocaine; Male; Medulla Oblongata; Microinjections; Neu	2008
Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. European journal of pain (London, England), 2009, Volume: 13, Issue:2 Topics: Anesthetics, Local; Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Hot Temper	2009
Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy. Pain, 1995, Volume: 61, Issue:1 Topics: Animals; Disease Models, Animal; Hyperalgesia; Lidocaine; Ligation; Male; Peripheral Nervous System	1995
Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology, 1994, Volume: 80, Issue:2 Topics: Animals; Hyperalgesia; Injections, Intravenous; Lidocaine; Male; Pain Measurement; Rats; Rats, Sprag	1994
Skin blood flow abnormalities in a rat model of neuropathic pain: result of decreased sympathetic vasoconstrictor outflow? Journal of the autonomic nervous system, 1997, Mar-19, Volume: 63, Issue:1-2 Topics: Animals; Cold Temperature; Hindlimb; Hyperalgesia; Laser-Doppler Flowmetry; Lidocaine; Ligation; Mal	1997
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain, 1996, Volume: 68, Issue:2-3 Topics: Aldehyde Reductase; Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dia	1996
Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. Anesthesiology, 1998, Volume: 88, Issue:1 Topics: Animals; Hyperalgesia; Inflammation; Lidocaine; Male; Nerve Block; Rats; Rats, Sprague-Dawley; Time	1998
Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve. Anesthesia and analgesia, 1999, Volume: 89, Issue:6 Topics: Anesthetics, Local; Animals; Hindlimb; Hyperalgesia; Lidocaine; Male; Nerve Block; Neurons, Afferent	1999
Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats. Pain, 2000, Volume: 86, Issue:1-2 Topics: Anesthetics, Local; Animals; Antibodies, Blocking; Dizocilpine Maleate; Dynorphins; Excitatory Amino	2000
Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat. Journal of neurophysiology, 2000, Volume: 84, Issue:2 Topics: Anesthetics, Local; Animals; Ganglia, Spinal; Hyperalgesia; Infusion Pumps, Implantable; Lidocaine;	2000
Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain, 2000, Volume: 87, Issue:3 Topics: Anesthetics, Local; Animals; Benzodiazepinones; Cholecystokinin; Hot Temperature; Hyperalgesia; Lido	2000
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur	2001
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur	2001
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur	2001
Tonic descending facilitation from the rostral ventromedial medulla mediates opioid-induced abnormal pain and antinociceptive tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-01, Volume: 21, Issue:1 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Hot Temperatur	2001
Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections. Pain, 2001, Feb-01, Volume: 90, Issue:1-2 Topics: Anesthetics, Local; Animals; Hot Temperature; Hyperalgesia; Lidocaine; Male; Neurons, Afferent; Pain	2001
Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain, 2002, Volume: 97, Issue:3 Topics: Anesthetics, Local; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Dr	2002
II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. Prostaglandins, 1979, Volume: 18, Issue:2 Topics: Analgesics; Animals; Barium; Bucladesine; Endorphins; Enkephalins; Hyperalgesia; Hyperesthesia; Iono	1979
Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat. Pain, 1987, Volume: 28, Issue:1 Topics: Animals; Carrageenan; Hyperalgesia; Inflammation; Lidocaine; Male; Nociceptors; Rats; Rats, Inbred S	1987

lidocaine and Allodynia