lamotrigine has been researched along with Allodynia in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Continuously administered intrathecal lamotrigine blocked the development of mechanical allodynia induced by SNL with suppression of microglial and astrocytic activation." | 7.79 | Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation. ( Choi, YS; Jun, IG; Kim, SH; Park, JY, 2013) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin." | 6.71 | A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003) |
| "Pain associated with hyperalgesia of the affected area occurs in a number of conditions." | 5.30 | Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997) |
| "Continuously administered intrathecal lamotrigine blocked the development of mechanical allodynia induced by SNL with suppression of microglial and astrocytic activation." | 3.79 | Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation. ( Choi, YS; Jun, IG; Kim, SH; Park, JY, 2013) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| " Oxcarbazepine and carbamazepine (3-100 mg x kg(-1)) did not affect mechanical hyperalgesia or tactile allodynia induced by partial sciatic nerve ligation in the rat following oral administration." | 3.72 | Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "Lamotrigine was generally well tolerated." | 2.73 | Double-blind, placebo-controlled trial of lamotrigine in combination with other medications for neuropathic pain. ( Blum, D; Grainger, J; Hammer, AE; Quessy, S; Silver, M, 2007) |
| "Outcome measures were the areas of secondary hyperalgesia to brush and von Frey hair stimulation and the painfulness of noxious thermal stimulation in nonsensitized skin." | 2.71 | A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. ( Dahl, JB; Hoke, F; Maloney, A; Petersen, KL; Rowbotham, MC, 2003) |
| " Subjects were then dosed with either lamotrigine (300 mg), 4030W92 (100 mg), or placebo, followed 2 h later by capsaicin (100 microg) injected intradermally on the volar aspect of the left forearm." | 2.71 | Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model. ( Quessy, S; Schulteis, G; Wallace, MS, 2004) |
| "Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system." | 1.37 | Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones. ( Arjun, M; Menon, N; Semwal, A; Sriram, D; Yogeeswari, P, 2011) |
| "Pain associated with hyperalgesia of the affected area occurs in a number of conditions." | 1.30 | Lamotrigine for pain with hyperalgesia. ( Dennehy, F; Harbison, J; Keating, D, 1997) |
| "Lamotrigine is a sodium channel blocker that inhibits the neuronal release of glutamate." | 1.30 | Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats. ( Klamt, JG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yogeeswari, P | 2 |
| Ragavendran, JV | 1 |
| Sriram, D | 2 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Menon, N | 1 |
| Semwal, A | 1 |
| Arjun, M | 1 |
| Choi, YS | 1 |
| Jun, IG | 1 |
| Kim, SH | 1 |
| Park, JY | 1 |
| Fox, A | 1 |
| Gentry, C | 1 |
| Patel, S | 1 |
| Kesingland, A | 1 |
| Bevan, S | 1 |
| Petersen, KL | 1 |
| Maloney, A | 1 |
| Hoke, F | 1 |
| Dahl, JB | 1 |
| Rowbotham, MC | 1 |
| Wallace, MS | 1 |
| Quessy, S | 2 |
| Schulteis, G | 1 |
| Ilyin, VI | 1 |
| Pomonis, JD | 1 |
| Whiteside, GT | 1 |
| Harrison, JE | 1 |
| Pearson, MS | 1 |
| Mark, L | 1 |
| Turchin, PI | 1 |
| Gottshall, S | 1 |
| Carter, RB | 1 |
| Nguyen, P | 1 |
| Hogenkamp, DJ | 1 |
| Olanrewaju, S | 1 |
| Benjamin, E | 1 |
| Woodward, RM | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Silver, M | 1 |
| Blum, D | 1 |
| Grainger, J | 1 |
| Hammer, AE | 1 |
| Nakamura-Craig, M | 1 |
| Follenfant, RL | 1 |
| Harbison, J | 1 |
| Dennehy, F | 1 |
| Keating, D | 1 |
| Klamt, JG | 1 |
| Boyce, S | 1 |
| Wyatt, A | 1 |
| Webb, JK | 1 |
| O'Donnell, R | 1 |
| Mason, G | 1 |
| Rigby, M | 1 |
| Sirinathsinghji, D | 1 |
| Hill, RG | 1 |
| Rupniak, NM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI[NCT00243152] | 6 participants (Actual) | Interventional | 2005-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
fMRI scans acquired Stimuli Type: Brush Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness fMRI scans acquired Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** fMRI scans acquired Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face (V2) Right and Left Sides Rating: Pain/ unpleasantness **Extra time allotted for probe repositioning** Cortical, subcortical, and brain stem sensory regions Z-scores Increase or decrease in activation as affected by the drug (NCT00243152)
Timeframe: Week 10 during scanning session
| Intervention | Z-statistic (Number) | ||||||
|---|---|---|---|---|---|---|---|
| Heat Affected Thalamus (10,-14,8) | Heat Affected Post-Central (-56,-12,28) | Cold Affected Post-Central (68, -8, 32) | Cold Affected Thalamus (-4, -8, 0) | Brush Affected Post-Central (66,-16,14) | Brush Affected Thalamus (-14,-22, 4) | Brush Affected Spinal Trigeminal Nucles(2,-48,-68) | |
| Lamotrigine vs Placebo | -2.9294 | -2.7323 | -2.5114 | -3.033 | 3.905 | -3.791 | 2.9058 |
"Quantitative Sensory Testing (QST)~Stimuli Type: Heat, Cold, Brush Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Cold, threshold -1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness Stimuli Type: Heat, threshold +1°C Stimulation Regions: Face Affected and contralateral Unaffected mirror area Rating: Pain/ unpleasantness~Ratings on a likert scale of 0-10 with 0 being defined as no pain and 10 being defined as worst possible pain" (NCT00243152)
Timeframe: week 10 (during the scan)
| Intervention | scores on a pain scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Heat Affected | Heat Unaffected | Cold Affected | Cold Unaffected | Brush Affected | Brush Unaffected | |
| Lamotrigine | 3.2 | 3 | 2.1 | 2.2 | 2.8 | 1.2 |
| Placebo | 5.5 | 4 | 2.5 | 1.1 | 3.9 | .4 |
3 trials available for lamotrigine and Allodynia
| Article | Year |
|---|---|
A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Capsaicin; Double-Blind Method; Drug Therapy, Combinatio | 2003 |
Lack of effect of two oral sodium channel antagonists, lamotrigine and 4030W92, on intradermal capsaicin-induced hyperalgesia model.
Topics: Administration, Oral; Adult; Analysis of Variance; Capsaicin; Cold Temperature; Cross-Over Studies; | 2004 |
Double-blind, placebo-controlled trial of lamotrigine in combination with other medications for neuropathic pain.
Topics: Analgesics; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperalgesia; Lamotrigin | 2007 |
10 other studies available for lamotrigine and Allodynia
| Article | Year |
|---|---|
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Discovery of molecules for the treatment of neuropathic pain: synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Discovery; Female; Furans; Humans; Hydrazones; Hyp | 2011 |
Intrathecal lamotrigine attenuates mechanical allodynia and suppresses microglial and astrocytic activation in a rat model of spinal nerve ligation.
Topics: Animals; Astrocytes; Disease Models, Animal; Hyperalgesia; Infusions, Spinal; Lamotrigine; Ligation; | 2013 |
Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Gabapentin; | 2003 |
Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states.
Topics: Animals; Carbamazepine; Humans; Hyperalgesia; Lamotrigine; Male; Motor Activity; Pain; Pyrimidines; | 2006 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Effect of lamotrigine in the acute and chronic hyperalgesia induced by PGE2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes.
Topics: Acute Disease; Analgesics; Animals; Anticonvulsants; Chronic Disease; Diabetes Mellitus, Experimenta | 1995 |
Lamotrigine for pain with hyperalgesia.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Hyperalgesia; Lamotrigine; Male; Pain; Tri | 1997 |
Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats.
Topics: Analgesics; Animals; Diabetic Neuropathies; Dinoprostone; Disease Models, Animal; Dose-Response Rela | 1998 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excita | 1999 |