Page last updated: 2024-11-13

cerebellin

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Description

cerebellin: cerebellum-specific hexadecapeptide marker for Purkinje cells [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25078121
MeSH IDM0135420

Synonyms (6)

Synonym
cerebellin
94071-26-8
nh2-ser-gly-ser-ala-lys-val-ala-phe-ser-ala-ile-arg-ser-thr-asn-his-oh
cerebellin (rat)
cerebellin(rat)(9ci)
DTXSID10240379

Research Excerpts

Overview

Cerebellin (CER) is a neuromodulatory hexadecapeptide that originates from the precursor protein precerebellin. Cerebellin is a 16-amino acid peptide, originally isolated from rat cerebellum.

ExcerptReferenceRelevance
"The cerebellins (Cblns) are a family of secreted proteins that are widely expressed throughout the nervous system, but whose functions have been studied only in the cerebellum and striatum. "( Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
Cagle, MC; Honig, MG, 2014
)
1.31
"Cerebellin (CER) is a neuromodulatory hexadecapeptide that originates from the precursor protein precerebellin (Cbln1). "( Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats.
Domin, D; Kaczmarek, P; Malendowicz, LK; Mergler, S; Nowak, KW; Rucinski, M; Skrzypski, M; Strowski, MZ; Szczepankiewicz, D; Szkudelski, T; Szwajkowski, P; Wiedenmann, B; Wojciechowicz, T, 2009
)
2.09
"Cerebellin (CER) is a regulatory peptide, originally isolated from rat cerebellum, which derives from the cleavage of precerebellin (Cbln), three types of which (Cbln1-3) have been identified in humans and rats. "( Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells.
Albertin, G; Malendowicz, LK; Nussdorfer, GG; Rucinski, M; Spinazzi, R; Ziolkowska, A, 2005
)
3.21
"Cerebellin is a 16-amino acid peptide, originally isolated from rat cerebellum, whose presence has been recently demonstrated in the human adrenal glands and especially in medullary chromaffin cells. "( Cerebellin enhances in vitro secretory activity of human adrenal gland.
Andreis, PG; Aragona, F; De Caro, R; Gottardo, L; Mazzocchi, G; Nussdorfer, GG, 1999
)
3.19
"Cerebellin is a 16-aminoacid peptide widely distributed in the central nervous system, where it exerts neuromodulatory functions. "( Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies.
Albertin, G; Macchi, C; Malendowicz, LK; Markowska, A; Nussdorfer, GG, 2000
)
3.19
"Cerebellin is a 16-amino acid peptide, that has been previously found to acutely stimulate steroid secretion from rat adrenal cortex in vivo and in vitro. "( Prolonged cerebellin administration inhibits the growth, but enhances steroidogenic capacity of rat adrenal cortex.
Hochól, A; Majchrzak, M; Malendowicz, LK; Neri, G; Nussdorfer, GG; Ziolkowska, A,
)
1.98
"Cerebellin is a hexadecapeptide that has been biochemically characterized and localized to cerebellar Purkinje cells and certain neurons of the dorsal cochlear nucleus (DCoN) of rat. "( Cerebellin is a postsynaptic neuropeptide.
Dahl, AL; Morgan, JI; Mugnaini, E, 1988
)
3.16
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (50)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (14.00)18.7374
1990's9 (18.00)18.2507
2000's9 (18.00)29.6817
2010's13 (26.00)24.3611
2020's12 (24.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.61 (24.57)
Research Supply Index3.95 (2.92)
Research Growth Index4.89 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (7.84%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (92.16%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]