menthol has been researched along with Allodynia in 27 studies
Menthol: A monoterpene cyclohexanol produced from mint oils.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical high-concentration L-menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia." | 8.90 | A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia. ( Andersen, HH; Arendt-Nielsen, L; Eskelund, PW; Gazerani, P; Møller, HG; Olsen, RV, 2014) |
| "Topical high-concentration L-menthol is the only established human experimental pain model to study mechanisms underlying cold hyperalgesia." | 7.81 | Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model. ( Andersen, HH; Arendt-Nielsen, L; Gazerani, P; Nikbakht, A; Poulsen, JN; Uchida, Y, 2015) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 5.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| "Menthol has previously been suggested as a model for hypersensitivity, but it has not yet been investigated if different levels of neuropathic pain may influence the effects of menthol or if topical application of menthol may act as a model for hypersensitivity in patients with phantom limb pain." | 5.39 | The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain. ( Arendt-Nielsen, L; Jensen, TS; Nikolajsen, L; Svensson, P; Vase, L, 2013) |
| "Both treatments resulted in cold and mechanical allodynia." | 5.38 | Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. ( Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "Cold hyperalgesia is 1 of the characteristic signs in neuropathic pain." | 5.37 | Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model. ( Baron, R; Binder, A; Klebe, O; Stengel, M; Wasner, G, 2011) |
| "Topical high-concentration L-menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia." | 4.90 | A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia. ( Andersen, HH; Arendt-Nielsen, L; Eskelund, PW; Gazerani, P; Møller, HG; Olsen, RV, 2014) |
| " Potent analgesic activity was observed in models of neuropathic pain, and the compound blocked capsaicin induced allodynia, showing dermal accumulation with little transdermal absorption." | 3.96 | Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. ( Ann, J; Blumberg, PM; Choi, K; Esch, TE; Ha, HJ; Hwang, SW; Kim, H; Kim, HS; Kim, M; Kim, YH; Lee, J; Pearce, LV; Thorat, SA; Turcios, NA, 2020) |
| "Topical high-concentration L-menthol is the only established human experimental pain model to study mechanisms underlying cold hyperalgesia." | 3.81 | Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model. ( Andersen, HH; Arendt-Nielsen, L; Gazerani, P; Nikbakht, A; Poulsen, JN; Uchida, Y, 2015) |
| "The cold- and menthol-sensitive receptor TRPM8 (transient receptor potential melastatin 8) has been suggested to play a role in cold allodynia, an intractable pain seen clinically." | 3.74 | TRPM8 mechanism of cold allodynia after chronic nerve injury. ( Chen, M; Gu, JG; Ling, J; Tan, W; Xing, H, 2007) |
| "Hyperalgesia was induced by capsaicin and cinnamaldehyde on heat pain thresholds and by menthol on cold pain thresholds (Cohen d=2." | 2.90 | TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers. ( Lötsch, J; Weyer-Menkhoff, I, 2019) |
| "The area size of mechanical hyperalgesia was not reliably reproducible." | 2.79 | Topical high-concentration menthol: reproducibility of a human surrogate pain model. ( Baron, R; Binder, A; Hüllemann, P; Mahn, F; Wasner, G, 2014) |
| "Menthol therefore has selective effects on noxious cold processing." | 2.72 | Psychophysical study of the effects of topical application of menthol in healthy volunteers. ( Attal, N; Bouhassira, D; Hatem, S; Willer, JC, 2006) |
| " Deletion or inhibition of the TRPM8 channel was found to prevent the cold hyperalgesia induced by chronic administration of morphine." | 1.56 | Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling. ( Altier, C; Basso, L; Defaye, M; Flynn, R; Hassan, A; Iftinca, M; Kwok, C; Ramachandran, R; Roland, C; Trang, T, 2020) |
| "Each menthol concentration was applied for 15 min and participants were asked to rate the sensation produced using a series of visual analogue scales and by selecting words from a descriptor list derived from the McGill pain questionnaire (MPQ)." | 1.51 | Development of a topical menthol stimulus to evaluate cold hyperalgesia. ( Benson, HAE; Moss, P; Wright, A, 2019) |
| "Menthol inhibited phototoxicity-evoked APs and reduced pain behavior when applied topically to mice." | 1.48 | Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. ( Baptista-Hon, D; Bull, F; Dalgaty, F; Gallacher, M; Hales, TG; Ibbotson, SH; Wright, L, 2018) |
| "Cold allodynia and significant recovery from spared-nerve injury-induced mechanical hypersensitivity are two novel phenotypes which characterize the global CB1R-/- mice." | 1.43 | Cannabinoid 1 receptor knockout mice display cold allodynia, but enhanced recovery from spared-nerve injury-induced mechanical hypersensitivity. ( Blanck, T; Norcini, M; Piskoun, B; Recio-Pinto, E; Russo, L; Sideris, A, 2016) |
| " AMG2850 is potent in vitro at rat TRPM8 (IC90 against icilin activation of 204 ± 28 nM), highly selective (>100-fold IC90 over TRPV1 and TRPA1 channels), and orally bioavailable (F po > 40 %)." | 1.42 | AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. ( Davis, C; Gavva, NR; Kerstein, PC; Lehto, SG; Stucky, CL; Wang, J; Wang, W; Weyer, AD; Wild, KD; Youngblood, BD; Zhang, M, 2015) |
| "However, the role of TRPM8 in visceral hyperalgesia is poorly understood in pathological states such as inflammatory bowel disease." | 1.40 | TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice. ( Fujino, H; Horie, S; Hosoya, T; Matsumoto, K; Murayama, T; Nakamura, H; Tashima, K, 2014) |
| "Menthol was applied topically to the hind paws of naive and spinal nerve-ligated (SNL) rats." | 1.40 | Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol. ( Brice, NL; Dickenson, AH; Gonçalves, L; Hendrick, A; Leveridge, M; Mack, SR; Patel, R, 2014) |
| "When menthol was administered to ION-CCI rats, total contact time was further reduced and total contact number increased at the cooling temperatures." | 1.39 | Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine. ( Gu, JG; Ling, JX; Xu, GY; Zuo, X, 2013) |
| "Menthol has previously been suggested as a model for hypersensitivity, but it has not yet been investigated if different levels of neuropathic pain may influence the effects of menthol or if topical application of menthol may act as a model for hypersensitivity in patients with phantom limb pain." | 1.39 | The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain. ( Arendt-Nielsen, L; Jensen, TS; Nikolajsen, L; Svensson, P; Vase, L, 2013) |
| "Both treatments resulted in cold and mechanical allodynia." | 1.38 | Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. ( Aoki, M; Ishii, K; Mori, A; Nakahara, T; Sakamoto, K, 2012) |
| "Cold hyperalgesia is 1 of the characteristic signs in neuropathic pain." | 1.37 | Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model. ( Baron, R; Binder, A; Klebe, O; Stengel, M; Wasner, G, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 18 (66.67) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ann, J | 1 |
| Kim, HS | 1 |
| Thorat, SA | 1 |
| Kim, H | 1 |
| Ha, HJ | 1 |
| Choi, K | 1 |
| Kim, YH | 1 |
| Kim, M | 1 |
| Hwang, SW | 1 |
| Pearce, LV | 1 |
| Esch, TE | 1 |
| Turcios, NA | 1 |
| Blumberg, PM | 1 |
| Lee, J | 1 |
| Journigan, VB | 1 |
| Feng, Z | 1 |
| Rahman, S | 1 |
| Wang, Y | 1 |
| Amin, ARMR | 1 |
| Heffner, CE | 1 |
| Bachtel, N | 1 |
| Wang, S | 1 |
| Gonzalez-Rodriguez, S | 1 |
| Fernández-Carvajal, A | 1 |
| Fernández-Ballester, G | 1 |
| Hilton, JK | 1 |
| Van Horn, WD | 1 |
| Ferrer-Montiel, A | 1 |
| Xie, XQ | 1 |
| Rahman, T | 1 |
| Iftinca, M | 1 |
| Basso, L | 1 |
| Flynn, R | 1 |
| Kwok, C | 1 |
| Roland, C | 1 |
| Hassan, A | 1 |
| Defaye, M | 1 |
| Ramachandran, R | 1 |
| Trang, T | 1 |
| Altier, C | 1 |
| Wright, L | 1 |
| Baptista-Hon, D | 1 |
| Bull, F | 1 |
| Dalgaty, F | 1 |
| Gallacher, M | 1 |
| Ibbotson, SH | 1 |
| Hales, TG | 1 |
| Weyer-Menkhoff, I | 1 |
| Lötsch, J | 3 |
| Wright, A | 1 |
| Benson, HAE | 1 |
| Moss, P | 1 |
| Zuo, X | 1 |
| Ling, JX | 1 |
| Xu, GY | 1 |
| Gu, JG | 3 |
| Andersen, HH | 2 |
| Olsen, RV | 1 |
| Møller, HG | 1 |
| Eskelund, PW | 1 |
| Gazerani, P | 2 |
| Arendt-Nielsen, L | 3 |
| Mahn, F | 1 |
| Hüllemann, P | 1 |
| Wasner, G | 2 |
| Baron, R | 2 |
| Binder, A | 2 |
| Hosoya, T | 1 |
| Matsumoto, K | 1 |
| Tashima, K | 1 |
| Nakamura, H | 1 |
| Fujino, H | 1 |
| Murayama, T | 1 |
| Horie, S | 1 |
| Patel, R | 1 |
| Gonçalves, L | 1 |
| Leveridge, M | 1 |
| Mack, SR | 1 |
| Hendrick, A | 1 |
| Brice, NL | 1 |
| Dickenson, AH | 1 |
| Naganawa, T | 1 |
| Baad-Hansen, L | 1 |
| Ando, T | 1 |
| Svensson, P | 2 |
| Lehto, SG | 1 |
| Weyer, AD | 1 |
| Zhang, M | 1 |
| Youngblood, BD | 1 |
| Wang, J | 1 |
| Wang, W | 1 |
| Kerstein, PC | 1 |
| Davis, C | 1 |
| Wild, KD | 1 |
| Stucky, CL | 1 |
| Gavva, NR | 1 |
| Poulsen, JN | 1 |
| Uchida, Y | 1 |
| Nikbakht, A | 1 |
| Alsharari, SD | 1 |
| King, JR | 1 |
| Nordman, JC | 1 |
| Muldoon, PP | 1 |
| Jackson, A | 1 |
| Zhu, AZ | 1 |
| Tyndale, RF | 1 |
| Kabbani, N | 1 |
| Damaj, MI | 1 |
| Sideris, A | 1 |
| Piskoun, B | 1 |
| Russo, L | 1 |
| Norcini, M | 1 |
| Blanck, T | 1 |
| Recio-Pinto, E | 1 |
| Flühr, K | 1 |
| Neddermeyer, TJ | 1 |
| Altis, K | 1 |
| Schmidtko, A | 1 |
| Angioni, C | 1 |
| Kuczka, K | 1 |
| Schmidt, H | 1 |
| Geisslinger, G | 1 |
| Tegeder, I | 1 |
| Gentry, C | 1 |
| Stoakley, N | 1 |
| Andersson, DA | 1 |
| Bevan, S | 1 |
| Stengel, M | 1 |
| Klebe, O | 1 |
| Zhao, M | 1 |
| Isami, K | 1 |
| Nakamura, S | 1 |
| Shirakawa, H | 1 |
| Nakagawa, T | 1 |
| Kaneko, S | 1 |
| Aoki, M | 1 |
| Mori, A | 1 |
| Nakahara, T | 1 |
| Sakamoto, K | 1 |
| Ishii, K | 1 |
| Vase, L | 1 |
| Nikolajsen, L | 1 |
| Jensen, TS | 1 |
| Namer, B | 1 |
| Seifert, F | 1 |
| Handwerker, HO | 1 |
| Maihöfner, C | 1 |
| Xing, H | 2 |
| Ling, J | 2 |
| Chen, M | 2 |
| Hatem, S | 1 |
| Attal, N | 1 |
| Willer, JC | 1 |
| Bouhassira, D | 1 |
| Tan, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High-concentration L-menthol as a Counter-irritant to TRPA1-induced Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde[NCT02653703] | 14 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for menthol and Allodynia
| Article | Year |
|---|---|
A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia.
Topics: Animals; Humans; Hyperalgesia; Menthol; Neuralgia; Pain Measurement; Pain Threshold; Translational R | 2014 |
6 trials available for menthol and Allodynia
| Article | Year |
|---|---|
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.
Topics: Acrolein; Adult; Capsaicin; Cold Temperature; Cross-Over Studies; Female; Healthy Volunteers; Hot Te | 2019 |
Topical high-concentration menthol: reproducibility of a human surrogate pain model.
Topics: Adult; Antipruritics; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Menthol; Middle Aged; | 2014 |
Capsaicin or menthol sensitization induces quantitative but no qualitative changes to thermal and mechanical pain thresholds.
Topics: Adolescent; Adult; Antipruritics; Capsaicin; Female; Humans; Hyperalgesia; Male; Menthol; Middle Age | 2009 |
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Case-Control Studies; Cold Temperature; C | 2009 |
TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.
Topics: Acrolein; Adult; Axons; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Ion C | 2005 |
Psychophysical study of the effects of topical application of menthol in healthy volunteers.
Topics: Administration, Topical; Adult; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; H | 2006 |
20 other studies available for menthol and Allodynia
| Article | Year |
|---|---|
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Topics: Analgesics; Animals; Capsaicin; CHO Cells; Cricetulus; Drug Discovery; Hyperalgesia; Mice, Inbred IC | 2020 |
Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies.
Topics: Amides; Biphenyl Compounds; Calcium; HEK293 Cells; Humans; Hyperalgesia; Menthol; Patch-Clamp Techni | 2020 |
Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling.
Topics: Animals; Cells, Cultured; Enzyme Activation; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Ma | 2020 |
Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy.
Topics: Acrylamides; Animals; Animals, Newborn; Antipruritics; Bridged Bicyclo Compounds, Heterocyclic; Derm | 2018 |
Development of a topical menthol stimulus to evaluate cold hyperalgesia.
Topics: Adult; Aged; Female; Healthy Volunteers; Humans; Hyperalgesia; Male; Menthol; Middle Aged; Pain Meas | 2019 |
Operant behavioral responses to orofacial cold stimuli in rats with chronic constrictive trigeminal nerve injury: effects of menthol and capsazepine.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Conditioning, Operant; Facial Nerve; Facial | 2013 |
TRPM8 has a key role in experimental colitis-induced visceral hyperalgesia in mice.
Topics: Anilides; Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Hyperalgesia; Male; Ment | 2014 |
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: a comparison with topical menthol.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Male; Menthol; Morpholi | 2014 |
Influence of topical application of capsaicin, menthol and local anesthetics on intraoral somatosensory sensitivity in healthy subjects: temporal and spatial aspects.
Topics: Administration, Topical; Adult; Analysis of Variance; Anesthetics, Local; Antipruritics; Capsaicin; | 2015 |
AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia.
Topics: Action Potentials; Animals; Behavior, Animal; Blood Pressure; Brain; Calcium; CHO Cells; Cold Temper | 2015 |
Cold and L-menthol-induced sensitization in healthy volunteers--a cold hypersensitivity analogue to the heat/capsaicin model.
Topics: Administration, Topical; Adult; Capsaicin; Cold Temperature; Female; Hand; Hot Temperature; Humans; | 2015 |
Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.
Topics: Animals; Body Temperature; Brain; Female; Hyperalgesia; Hypothermia, Induced; Male; Maze Learning; M | 2015 |
Cannabinoid 1 receptor knockout mice display cold allodynia, but enhanced recovery from spared-nerve injury-induced mechanical hypersensitivity.
Topics: Animals; Cold Temperature; Ganglia, Spinal; Hyperalgesia; Male; Menthol; Mice, Knockout; Motor Activ | 2016 |
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.
Topics: Animals; Antipruritics; Cold Temperature; Dose-Response Relationship, Drug; Foot; Group VI Phospholi | 2010 |
Topical high-concentration (40%) menthol-somatosensory profile of a human surrogate pain model.
Topics: Administration, Topical; Adult; Antipruritics; Dose-Response Relationship, Drug; Hand; Humans; Hyper | 2011 |
Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.
Topics: Animals; Behavior, Animal; Calcium Channels; Capsaicin; Cisplatin; Cryopyrin-Associated Periodic Syn | 2012 |
Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin; Cold Temperature; Hyperalg | 2012 |
The effects of menthol on cold allodynia and wind-up-like pain in upper limb amputees with different levels of phantom limb pain.
Topics: Administration, Topical; Adult; Aged; Cold Temperature; Female; Humans; Hyperalgesia; Male; Menthol; | 2013 |
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Cold Temperature; Dose-Response Relationship, Drug; Hyperalgesi | 2006 |
TRPM8 mechanism of cold allodynia after chronic nerve injury.
Topics: Animals; Capsaicin; Cells, Cultured; Chronic Disease; Cold Temperature; Disease Models, Animal; Fema | 2007 |