Page last updated: 2024-11-03

proglumide and Allodynia

proglumide has been researched along with Allodynia in 4 studies

Proglumide: A drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
proglumide : A racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs.
N(2)-benzoyl-N,N-dipropyl-alpha-glutamine : A dicarboxylic acid monoamide obtained by formal condensation of the alpha-carboxy group of N-benzoylglutamic acid with dippropylamine.

Research Excerpts

ExcerptRelevanceReference
" Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)."3.83Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016)
" Both nocebo hyperalgesia and HPA hyperactivity were antagonized by the benzodiazepine diazepam, suggesting that anxiety played a major role in these effects."3.73The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. ( Amanzio, M; Asteggiano, G; Benedetti, F; Vighetti, S, 2006)
"In patients who reported mild postoperative pain, we evoked a nocebo response, a phenomenon equal but opposite to placebo."2.68Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. ( Amanzio, M; Benedetti, F; Casadio, C; Maggi, G; Oliaro, A, 1997)
"Mustard oil hyperalgesia was also inhibited in animals that had received electrolytic lesions in the rostral ventromedial medulla (RVM)."1.29Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil. ( Gebhart, GF; Jiang, MC; Urban, MO, 1996)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yin, K1
Deuis, JR1
Lewis, RJ1
Vetter, I1
Benedetti, F2
Amanzio, M2
Vighetti, S1
Asteggiano, G1
Urban, MO1
Jiang, MC1
Gebhart, GF1
Casadio, C1
Oliaro, A1
Maggi, G1

Trials

1 trial available for proglumide and Allodynia

ArticleYear
Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide.
    Pain, 1997, Volume: 71, Issue:2

    Topics: Analgesics, Non-Narcotic; Cholecystokinin; Double-Blind Method; Female; Humans; Hyperalgesia; Male;

1997

Other Studies

3 other studies available for proglumide and Allodynia

ArticleYear
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
    Molecular pain, 2016, Volume: 12

    Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai

2016
The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Nov-15, Volume: 26, Issue:46

    Topics: Adrenocorticotropic Hormone; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Anxiety; Cholecystokinin

2006
Participation of central descending nociceptive facilitatory systems in secondary hyperalgesia produced by mustard oil.
    Brain research, 1996, Oct-21, Volume: 737, Issue:1-2

    Topics: Animals; Anti-Ulcer Agents; Benzodiazepinones; Cholecystokinin; Denervation; Devazepide; Hormone Ant

1996