Page last updated: 2024-11-12

neoline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

neoline: Aconitum jaluense; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

neoline : A diterpene alkaloid with formula C24H39NO6 that is isolated from several Aconitum species. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Flora	Rank	Flora Definition	Family	Family Definition
Aconitum	genus	A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH]	Ranunculaceae	The buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH]

Cross-References

ID Source	ID
PubMed CID	95371629
MeSH ID	M0468288

Synonyms (5)

Synonym
neoline
466-26-2
(1alpha,6alpha,14alpha,16beta)-n-ethyl-6,16- dimethoxy-4-methoxymethylaconitane-1,8,14-triol
neolinebullatine b
neoline, bullatine b

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" Beagle dogs were orally or intravenously administered with neoline for pharmacokinetic and absolute bioavailability study."	( Pharmacokinetics and bioavailability study of neoline in Beagle dogs. Gong, XH; Li, Y; Li, YX; Peng, C; Xiong, L; Yuan, A; Zhao, MJ, 2015)	0.42

Bioavailability

Excerpt	Reference	Relevance
" Low absolute bioavailability of Fuziline (1."	( Development and Validation of an UPLC-Q-TOF-MS Method for Quantification of Fuziline in Beagle Dog After Intragastric and Intravenous Administration. Gong, XH; Li, Y; Li, YX; Peng, C; Yuan, A; Zeng, DW; Zhang, RQ; Zhao, MJ, 2016)	0.43
"This paper is aim to investigate the pharmacokinetics and absolute bioavailability of neoline in Beagle dogs, and provide a theoretical basis for further study."	( Pharmacokinetics and bioavailability study of neoline in Beagle dogs. Gong, XH; Li, Y; Li, YX; Peng, C; Xiong, L; Yuan, A; Zhao, MJ, 2015)	0.42

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (8.33)	29.6817
2010's	8 (66.67)	24.3611
2020's	3 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.17	1	dialdehyde	biomarker
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.21	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.17	1	D-glucopyranose	epitope; mouse metabolite
liquiritigenin liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.	2.17	1	4',7-dihydroxyflavanone	hormone agonist; plant metabolite
sweroside [no description available]	2.21	1	glycoside
gingerol gingerol: an active ingredient in GINGER along with SHOGAOL. a nonvolatile methoxy phenyl decanone. gingerol : A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.	2.17	1	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite
chalcone trans-chalcone : The trans-isomer of chalcone.	2.17	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
napelline napelline: RN given for (1alpha,12alpha,15beta)-isomer; structure in first source	2.76	3	kaurane diterpenoid
neoisoliquiritin neoisoliquiritin: inhibits angiogenesis; isolated from licorice root; isoliquiritin is the (E)-isomer; structure in first source; isoliquiritin is also available	2.17	1	flavonoids; glycoside
songorine songorine: RN given refers to parent cpd; diterpene alkaloid from Aconitum karakolicum Rap.	8.14	4
hypaconitine hypaconitine: RN given refers to the (1alpha,6alpha,14alpha,15alpha,16beta)-isomer	2.47	2
benzoylaconine benzoylaconine: alkaloid isolated from Aconitum carmichaeli. benzoylaconine : A diterpene alkaloid with formula C32H45NO10 that is isolated from several Aconitum species.	2.94	3	benzoate ester; bridged compound; diterpene alkaloid; organic heteropolycyclic compound; polyether; secondary alcohol; tertiary alcohol; tertiary amino compound; tetrol	phytotoxin; plant metabolite
benzoylmesaconine benzoylmesaconine: structure in first source. benzoylmesaconine : A diterpene alkaloid with formula C31H43NO10 that is isolated from several Aconitum species.	2.72	2	benzoate ester; bridged compound; diterpene alkaloid; organic heteropolycyclic compound; polyether; secondary alcohol; tertiary alcohol; tertiary amino compound; tetrol	analgesic; antiinfective agent; plant metabolite
denudatine [no description available]	2.17	1
tridihexethyl mesaconitine: RN given refers to parent cpd(1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-isomer	2.8	3
talatisamine talatisamine: diterpenoid alkaloids found in folk medicine caowu; RN given refers to ((1alpha,14alpha,16beta)-isomer); RN for cpd without isomeric designation not avail 8/91	2.17	1
aconitine Aconitine: A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.. aconitine : A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.	9.01	12
isotalatizidine isotalatizidine: structure in first source. isotalatizidine : A diterpene alkaloid that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methoxymethyl, and methoxy groups, respectively.	2.87	3

Condition	Relationship Strength	Studies
Alloxan Diabetes [description not available]	2.25	1
Asymmetric Diabetic Proximal Motor Neuropathy [description not available]	2.25	1
Allodynia [description not available]	2.88	3
Diabetic Neuropathies Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)	2.25	1
Acute Confusional Senile Dementia [description not available]	2.31	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.63	2
Age-Related Memory Disorders [description not available]	2.31	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.31	1
Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.	2.31	1
Heart Disease, Ischemic [description not available]	2.17	1
Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).	2.17	1
Peripheral Nerve Injury [description not available]	2.21	1
Nerve Pain [description not available]	2.21	1
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.21	1
Peripheral Nerve Injuries Injuries to the PERIPHERAL NERVES.	2.21	1
Peripheral Nerve Diseases [description not available]	2.13	1
Peripheral Nervous System Diseases Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.	2.13	1

chemdatabank.com