substance p has been researched along with Allodynia in 245 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (0.82) | 18.7374 |
| 1990's | 60 (24.49) | 18.2507 |
| 2000's | 93 (37.96) | 29.6817 |
| 2010's | 77 (31.43) | 24.3611 |
| 2020's | 13 (5.31) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, S; Mao, M; Wang, J; Wang, X; Zhang, S; Zhou, F | 1 |
| Chang, S; Chen, Z; Jing, B; Li, X; Shi, H; Zhang, D; Zhao, G; Zheng, Y | 1 |
| Huyhn, R; Jung, T; Kim, B; McKemy, DD; Yamaki, S; Yang, C | 1 |
| Guo, C; Hu, H; Huang, AJW; Jiang, H; Li, F; Liu, Q; Yang, W | 1 |
| Luo, F; Niu, SN; Wang, JA | 1 |
| Ahlström, FHG; Blomqvist, KJ; Jokinen, V; Kalso, EA; Lilius, TO; Rauhala, PV; Sidorova, YA; Suleymanova, I; Viisanen, H | 1 |
| Fukushige, R; Hisaoka-Nakashima, K; Kishida, Y; Morioka, N; Nakamura, Y; Nakata, Y; Watanabe, K | 2 |
| Chang, S; Kim, DH; Kim, HY; Kim, SC; Ryu, Y; Yi, YJ | 1 |
| Chen, W; Ennes, HS; Marvizon, JC; McRoberts, JA | 1 |
| Choi, JG; Choi, SR; Kang, DW; Kim, HW; Kim, J; Park, JB | 1 |
| Brown, S; Clark, A; Duarte, FCK; Hurtig, M; Simpson, J; Srbely, J | 1 |
| Chang, CT; Chang, KV; Chen, CC; Chu, YC; Han, DS; Lee, CH; Li, MH; Lin, SH; Shieh, YD; Wang, JL | 1 |
| Fransson, R; Gaugaz, FZ; Hallberg, M; Lesniak, A; Lindeberg, G; Nyberg, F; Sandström, A; Skogh, A; Svensson, R | 2 |
| Demartini, C; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Tonsi, G; Zanaboni, AM | 1 |
| Kahn, LC; Mackinnon, SE; Yee, A | 1 |
| Chen, W; Gaveriaux-Ruff, C; Hakimian, JK; Kieffer, BL; Marvizón, JCG; Severino, A; Walwyn, W | 1 |
| Hallberg, M; Sandstrom, A | 1 |
| Demartini, C; Deseure, K; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Zanaboni, AM | 1 |
| Borbély, É; Gaszner, B; Gubányi, T; Hajna, Z; Helyes, Z; Hunyady, Á; Kemény, Á; Scheich, B | 1 |
| Chen, YW; Chiu, CC; Hung, CH; Lin, HT; Liu, CC; Wang, JJ | 1 |
| Buch, NS; Karlsson, P; Nikolajsen, L | 1 |
| Badolato, M; Brizzi, A; Caroleo, MC; Carullo, G; Cione, E; De Rosa, M; Gallelli, L; Pandey, A | 1 |
| Basbaum, AI; Eberhart, D; Meda, K; Rice, D; Solorzano, C; Urban, R; Wang, X; Yamanaka, H; Zhang, J | 1 |
| Berger, A; Borbély, E; Hajna, Z; Helyes, Z; Kereskai, L; Nagy, P; Paige, C; Pintér, E; Quinn, J; Sándor, K; Stewart, J; Szolcsányi, J; Tóth, I; Zimmer, A | 1 |
| Lai, QK; Lin, C; Liu, JH; Wu, B | 1 |
| Ericson, ME; Gupta, K; Gupta, M; Luk, K; Nguyen, J; Simone, DA; Vang, D; Vincent, L | 1 |
| Chun, J; Khan, S; Kim, YS; Shehzad, O | 1 |
| Ding, X; Fan, X; Ning, L; Wang, C; Wang, J; Wang, Y; Yue, S; Zhang, Y | 1 |
| Arora, V; Chopra, K | 1 |
| Chen, W; Corder, GF; Fu, W; Kuphal, KE; Marvizon, JC; McCarson, KE; Stiller, CO; Taylor, BK; Urban, JH; Winter, MK | 1 |
| Andersen, HH; Kullander, K; Lagerström, MC; Rogoz, K | 1 |
| Arizpe, HM; Clifford, JL; Fowler, M; Garza, TH; Loyd, DR; Novak, J; Petz, LN; Slater, TM | 1 |
| Dong, YB; Shang, JJ; Tang, RZ; Xie, JQ; Xu, H; Yuan, JY | 1 |
| Chen, W; Marvizón, JC; McRoberts, JA | 1 |
| Hamity, MV; Hammond, DL; Walder, RY | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Chen, YW; Hung, CH; Lin, MF; Tzeng, JI; Wang, JJ | 2 |
| Chen, CC; Chen, WN | 1 |
| Carlsson-Jonsson, A; Fransson, R; Gao, T; Hao, JX; Nyberg, F; Sandström, A; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Changeux, JP; Devesa, I; Ferrándiz-Huertas, C; Ferrer-Montiel, A; Luján, R; Mathivanan, S; Wolf, C | 1 |
| Gao, T; Hökfelt, T; Shi, T; Su, J; Svensson, CI; Wiesenfeld-Hallin, Z; Xiang, Q; Xu, X | 1 |
| Dai, GH; Deng, WT; Guo, XD; Huang, KB; Luo, GQ; Pan, SY; Peng, KR; Qian, NS; Wu, XN; Xiang, W; Yang, HJ; Zhang, T | 1 |
| Brolin, E; Fransson, R; Hallberg, M; Haramaki, Y; Jonsson, A; Nordvall, G; Nyberg, F; Sandström, A; Skogh, A; Watanabe, H | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Wei, T | 1 |
| Altier, C; Basso, L; Chapman, K; Dietrich, G; Flynn, R; Iftinca, MC; Lapointe, TK; Vergnolle, N | 1 |
| Chen, YJ; Li, Q; Liu, Y; Zhang, M; Zhao, YH; Zhao, YJ | 1 |
| Kras, JV; Pall, PS; Weisshaar, CL; Winkelstein, BA | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Sun, Y; Wei, T | 1 |
| Cho, SK; Hecht, AC; Iatridis, JC; Lai, A; Laudier, DM; Moon, A; Purmessur, D; Skovrlj, B; Winkelstein, BA | 1 |
| Abe, K; Chiba, T; Kambe, T; Kawakami, K; Koizumi, N; Oka, Y; Taguchi, K; Utsunomiya, I | 1 |
| Choi, JH; Chung, JY; Hwang, IK; Im, W; Kang, JY; Kim, M; Kim, SH; Lee, KY; Yoo, DY; Youn, HY | 1 |
| Hamity, MV; Hammond, DL; Li, Y; Maduka, UP; Walder, RY; White, SR | 1 |
| Taguchi, K | 1 |
| Dickenson, AH; Gustavsson, Y; Marino, MJ; Ramachandran, R; Sikandar, S; Sorkin, LS; Yaksh, TL | 1 |
| Borbély, É; Helyes, Z; Kemény, Á; Markovics, A; McDougall, JJ; Pintér, E; Quinn, JP; Sándor, K; Szolcsányi, J | 1 |
| Dyuizen, IV; Kasyanov, SP; Kipryushina, YO; Latyshev, NA; Manzhulo, IV; Ogurtsova, OS; Tyrtyshnaia, AA | 1 |
| Chen, H; Ding, M; Du, X; Fang, M; Fang, Y; Fu, X; Guo, F; Teng, W; Zhang, H | 1 |
| Crawley, B; Fitzsimmons, B; Hua, XY; Malkmus, S; Saito, O; Yaksh, TL | 1 |
| Choi, HW; Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Nam, JS; Park, SH; Seo, YJ; Suh, HW | 1 |
| Chen, CC; Hsieh, ST; Hsieh, YL; Tseng, TJ | 2 |
| Ikeda, T; Matsushima, O; Nakayama, T; Naono, R; Nishimori, T | 2 |
| Aloe, L; Manni, L | 1 |
| Baños, JE; Ruiz, G | 1 |
| Ko, MC; Naughton, NN | 1 |
| Lee, KE; Winkelstein, BA | 1 |
| Casals-Díaz, L; Navarro, X; Vivó, M | 1 |
| Chen, ZF; Drobish, JK; Gereau, RW; Gracias, NG; Sun, YG; Vasko, MR | 1 |
| Guo, J; Hu, XG; Meng, J; Shen, H; Xu, D; Yang, XB; Zhao, Y | 1 |
| Chikuma, T; Kato, T; Muramatsu, M; Takeda, K | 1 |
| Seybold, VS | 1 |
| Clark, DJ; Guo, TZ; Kingery, WS; Qiao, Y; Sahbaie, P; Shi, X; Yeomans, DC | 1 |
| Carlsson, A; Hallberg, M; Kamei, J; Nyberg, F; Ohsawa, M | 1 |
| Chabot-Doré, AJ; Fairbanks, CA; Kitto, KF; Overland, AC; Rothwell, PE; Stone, LS; Wilcox, GL | 1 |
| Bunnett, NW; Cattaruzza, F; Grady, EF; Miranda-Morales, M; Spreadbury, I; Vanner, S | 1 |
| Ikeda, T; Nakayama, T; Naono, R; Nishimori, T | 1 |
| Ikeda, T; Matsushima, O; Naono, R; Nishimori, T; Sakoda, S; Sunakawa, N | 1 |
| Oblinger, MM; Sarajari, S | 1 |
| Ericson, ME; Gupta, K; Gupta, P; Gupta, V; Hebbel, RP; Kehl, LJ; Khasabov, SG; Kohli, DR; Li, Y; Nguyen, J; Simone, DA | 1 |
| Harano, N; Hidaka, K; Inenaga, K; Kai, A; Nakanishi, O; Ono, K | 1 |
| Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S | 1 |
| Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 2 |
| Antal, M; Holló, K; Papp, I | 1 |
| Birklein, F; Fuchs, D; Reeh, PW; Sauer, SK | 1 |
| Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K | 1 |
| Dubois, D; Gendron, L | 1 |
| Fitzsimmons, B; Hua, XY; Newton, AC; O'Neill, A; Steinauer, J; Xu, Q; Yaksh, TL | 1 |
| Abrahamsen, B; Kullander, K; Lagerström, MC; Lind, AL; Mendez, JA; Olund, C; Rogoz, K; Smith, C; Wallén-Mackenzie, Å; Wood, JN | 1 |
| Aloe, L; Florenzano, F; Manni, L | 1 |
| Chen, JC; Lin, YT; Ro, LS; Wang, HL | 1 |
| Ikeda, T; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
| Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M | 1 |
| Aricò, G; Parenti, C; Ronsisvalle, G; Scoto, GM | 1 |
| Bian, ZX; Sung, JJ; Tsang, SW; Wu, J; Zhao, M | 1 |
| Amenta, PS; Awe, OO; Elliott, MB; Jallo, JI; Oshinsky, ML | 1 |
| De Felice, M; Melchiorri, P; Negri, L; Ossipov, MH; Porreca, F; Vanderah, TW | 1 |
| Abd El-Latif, MI; Izumi, M; Katayama, I; Matsui, S; Murota, H; Nishioka, M; Sano, S; Tani, M; Terao, M | 1 |
| Beaudry, F; Ferland, CE; Vachon, P | 1 |
| Ribeiro-da-Silva, A; Saeed, AW | 1 |
| Chichorro, JG; Martini, AC; Rae, GA; Teodoro, FC; Tronco Júnior, MF; Zampronio, AR | 1 |
| Baas, M; Duraku, LS; Holstege, JC; Hossaini, M; Ruigrok, TJ; Schüttenhelm, BN; Walbeehm, ET | 1 |
| Clark, JD; Li, X | 1 |
| Ghilardi, JR; Khasabov, SG; Mantyh, PW; Peters, CM; Rogers, SD; Simone, DA | 1 |
| Dickenson, AH; Hunt, SP; Morcuende, S; Suzuki, R; Webber, M | 1 |
| Lu, Y; Vera-Portocarrero, LP; Westlund, KN | 1 |
| Heinke, B; Ikeda, H; Ruscheweyh, R; Sandkühler, J | 1 |
| Boudah, A; Jasmin, L; Ohara, PT | 1 |
| Kline, RH; Vierck, CJ; Wiley, RG | 1 |
| Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL | 1 |
| Eisenach, JC; Ma, W | 1 |
| Gaus, S; Kawamoto, M; Moriwaki, K; Suyama, H; Yuge, O | 1 |
| Ai, J; Chen, XL; Li, QJ; Li, SQ; Li, WB; Sun, XC | 1 |
| Del Turco, D; Deller, T; Feil, R; Geisslinger, G; Hofmann, F; Ruth, P; Sausbier, M; Schmidtko, A; Tegeder, I | 1 |
| Ghilardi, JR; Mantyh, PW; Rogers, SD; Svensson, CI; Yaksh, TL | 1 |
| Jang, JH; Leem, JW; Nam, TS; Paik, KS | 1 |
| Amadesi, S; Bunnett, NW; Cottrell, GS; Davis, JB; Ennes, H; Geppetti, P; Grady, EF; Manni, C; Mayer, EA; McRoberts, JA; Nie, J; Trevisani, M; Vergnolle, N | 1 |
| Atweh, SF; Jabbur, SJ; Massaad, CA; Poole, S; Saadé, NE; Safieh-Garabedian, B | 1 |
| Ordeberg, G | 1 |
| Li, J; Sun, YG; Yang, BN; Yu, LC | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Kawasaki, Y; Kohno, T; Van Der Meer, C; Wang, H; Woolf, CJ; Zhuang, ZY | 1 |
| Gabra, BH; Sirois, P | 1 |
| Azizi, S; Fitzsimmons, B; Hua, XY; Powell, HC; Svensson, CI; Yaksh, TL | 1 |
| Berman, BM; Lao, L; Liu, B; Qiao, JT; Ren, K; Wang, L; Zhang, RX | 2 |
| Dennis, EA; Hua, XY; Lucas, KK; Powell, HC; Svensson, CI; Yaksh, TL | 1 |
| Bartfai, T; Fitzsimmons, B; Gu, G; Hua, XY; Kondo, I; Salgado, KF; Yaksh, TL | 1 |
| Gardell, LR; Hruby, VJ; Hunt, SP; King, T; Lai, J; Malan, PT; Ossipov, MH; Porreca, F; Vanderah, TW; Vardanyan, A; Wang, R | 1 |
| Bercik, P; Blennerhassett, P; Collins, SM; Huang, XX; Jackson, W; Mao, Y; Rochat, F; Verdú, EF; Verma-Gandhu, M; Wang, L | 1 |
| Dennis, EA; Fitzsimmons, B; Hadjipavlou-Litina, D; Hua, XY; Kokotos, CG; Kokotos, G; Stephens, D; Svensson, CI; Yaksh, TL | 1 |
| Kreider, RA; Rothman, SM; Winkelstein, BA | 1 |
| Clapp, DW; Hingtgen, CM; Roy, SL | 1 |
| Chen, WL; Zhang, YQ; Zhao, ZQ | 1 |
| Ambalavanar, R; Dessem, D; Gangula, P; Moritani, M; Moutanni, A; Yallampalli, C | 1 |
| Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F | 1 |
| Castro, AR; Lima, D; Pinto, M; Tavares, I | 1 |
| Dickenson, AH; Hunt, S; Rahman, W; Rygh, LJ; Sandhu, H; Suzuki, R; Vonsy, JL; Webber, M; Wong, Y | 1 |
| Asai, H; Mitsudo, K; Nagamine, K; Nishiguchi, H; Ozaki, N; Shinoda, M; Sugiura, Y; Tohnai, I; Ueda, M | 1 |
| Britto, LR; Cenac, N; Dale, CS; Giorgi, R; Juliano, L; Juliano, MA; Vergnolle, N | 1 |
| Hefferan, MP; Jones, TL; Marsala, M; Sorkin, LS | 1 |
| King, T; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW; Vera-Portocarrero, LP; Zhang, ET | 1 |
| Altier, C; Amadesi, S; Bautista-Cruz, F; Bunnett, NW; Cenac, N; Cottrell, GS; Geppetti, P; Grant, AD; Joseph, EK; Levine, JD; Liedtke, W; Lopez, CB; Materazzi, S; Nicoletti, P; Trevisani, M; Vanner, S; Vergnolle, N; Zamponi, GW | 1 |
| Cao, DY; Guo, Y; Tian, YL; Wang, HS; Yao, FR; Zhang, Q; Zhao, Y | 1 |
| Authier, N; Balayssac, D; Coudoré, F; Coudoré-Civiale, MA; Eschalier, A; Ling, B | 1 |
| Caudle, RM; Keller, J; Mannes, AJ; Neubert, JK; Perez, FM; Suckow, SK | 1 |
| Altier, C; Castiglioni, AJ; Chapman, K; Dale, CS; Dickenson, AH; Evans, RM; Kisilevsky, AE; Lipscombe, D; Matthews, EA; Vergnolle, N; Zamponi, GW | 1 |
| Bianchi, M; Ferrario, P; Franchi, S; Sacerdote, P; Sotgiu, ML | 1 |
| Finke, B; Gierer, P; Gradl, G; Mittlmeier, T; Schattner, S; Vollmar, B | 1 |
| Cang, CL; Ji, RR; Kawasaki, Y; Liang, LL; Zhang, H; Zhang, YQ; Zhao, ZQ | 1 |
| Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C | 1 |
| Chiang, H; Hsieh, ST; Hsieh, YL; Tseng, TJ | 1 |
| Asensio, E; Casals, L; Navarro, X; Puigdemasa, A; Udina, E; Vivó, M | 1 |
| Spaeth, M; Staud, R | 1 |
| Blömer, U; Held-Feindt, J; Juraschek, M; Knerlich-Lukoschus, F; Lucius, R; Mehdorn, HM | 1 |
| Beaudet, N; Dansereau, MA; Gosselin, RD; Kitabgi, P; Mauborgne, A; Mechighel, P; Melik-Parsadaniantz, S; Pohl, M; Pommier, B; Rostene, W; Sarret, P | 1 |
| Göres, E; Hilse, H; Morgenstern, E; Oehme, P | 1 |
| Galeazza, MT; Garry, MG; Hargreaves, KM; Seybold, VS; Strait, KA; Yost, HJ | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| Goettl, VM; Larson, AA | 3 |
| Björkman, R; Hallman, KM; Hedner, J; Hedner, T; Henning, M | 1 |
| Coderre, TJ; Yashpal, K | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP | 1 |
| Chatani, K; Gebhart, GF; Kawakami, M; Meller, ST; Weinstein, JN | 1 |
| Kuraishi, Y; Okano, K; Satoh, M | 2 |
| Kajander, KC; Xu, J | 1 |
| Bestetti, A; Clavenna, G; Daffonchio, L; Fedele, G; Ferrari, MP; Omini, C | 1 |
| Allchorne, A; Poole, S; Safieh-Garabedian, B; Winter, J; Woolf, CJ | 1 |
| Kato, T; Kream, RM; Marchand, JE; Shimonaka, H; Wurm, WH | 1 |
| Kuraishi, Y; Satoh, M | 1 |
| Asai, R; Kanai, Y; Murase, A; Nagahisa, A; Nakagaki, T; Shieh, TC; Taniguchi, K; Tsuchiya-Nakagaki, M | 1 |
| Courteix, C; Eschalier, A; Lavarenne, J | 1 |
| Henry, JL; Hui-Chan, CW; Radhakrishnan, V; Yashpal, K | 1 |
| Neugebauer, V; Rumenapp, P; Schaible, HG | 1 |
| Woolf, CJ | 1 |
| Canella, R; Leon, A; Marcolongo, G; Mazzari, S; Petrelli, L | 1 |
| Berti, F; Bianchi, M; Panerai, AE; Rossoni, G; Sacerdote, P | 1 |
| Henry, JL; Hui-Chan, CW; Yashpal, K | 1 |
| Davis, AJ; Perkins, MN | 1 |
| Traub, RJ | 1 |
| Carlton, SM; Coggeshall, RE; Zhou, S | 2 |
| Dirig, DM; Yaksh, TL | 1 |
| Bourdon, V; Damas, J; Liégeois, JF | 1 |
| Kitto, KF; Larson, AA | 1 |
| Allen, BJ; Daughters, RS; Ghilardi, JR; Honore, P; Lappi, DA; Li, J; Mantyh, PW; Rogers, SD; Simone, DA; Wiley, RG | 1 |
| Basbaum, AI; Chen, C; Malmberg, AB; Tonegawa, S | 1 |
| Bunnett, NW; Grady, EF; Martínez, V; Marvizón, JC; Mayer, EA | 1 |
| Cruwys, S; Garrett, NE; Malcangio, M; Tomlinson, DR | 1 |
| Caudle, RM; Iadarola, JM | 1 |
| Aloe, L; Angelucci, F; Fiore, M; Moroni, R | 1 |
| Chaplan, SR; Partridge, BJ; Sakamoto, E; Yaksh, TL | 1 |
| Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ | 1 |
| Nagy, I; Polgár, E; Szûcs, P; Urbán, L | 1 |
| Russell, IJ | 1 |
| Malcangio, M; Tomlinson, DR | 1 |
| Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA | 1 |
| Helme, RD; Khalil, Z; Liu, T | 1 |
| Benoliel, R; Caudle, RM; Eliav, E; Iadarola, MJ; Leeman, S; Mannes, AJ | 1 |
| Chen, P; Hua, XY; Marsala, M; Yaksh, TL | 1 |
| Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T | 1 |
| Elde, R; Hao, JX; Hökfelt, T; Wiesenfeld-Hallin, Z; Xu, XJ; Yu, W | 1 |
| Cuello, AC; Henry, JL; Julien, JP; McLeod, AL; Ribeiro-Da-Silva, A; Ritchie, J | 1 |
| Bueno, L; Fioramonti, J | 1 |
| Jia, YP; Linden, DR; Seybold, VS | 1 |
| Linden, DR; Seybold, VS | 1 |
| Castellote, JM; Kingery, WS; Maze, M | 1 |
| Katsuyama, S; Sakurada, C; Sakurada, S; Sakurada, T; Sasaki, J; Tan-No, K | 1 |
| De Felipe, C; Hunt, SP; O'Brien, JA; Palmer, JA | 1 |
| Angelici, O; Bonanno, G; Carità, F; Clarke, GD; Raiteri, M; Schmid, G; Zaratin, P | 1 |
| Herrero, JF; Laird, JM; López-García, JA | 1 |
| McGill, MM; Shehab, SA; Todd, AJ | 1 |
| Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C | 1 |
| Inoue, A; Morioka, N; Nakata, Y | 1 |
| Hua, XY; Wajima, Z; Yaksh, TL | 1 |
| Agashe, GS; Clark, JD; Davies, MF; Kingery, WS; Maze, M; Sawamura, S | 1 |
| Ebersberger, A; Malcangio, M; Mazario, J; Meyer-Tuve, A; Schaible, HG | 1 |
| Chen, J; Zheng, JH | 1 |
| Andrade-Gordon, P; Basbaum, AI; Brussee, V; Bunnett, NW; Cirino, G; Compton, SJ; Gerard, N; Grady, EF; Hollenberg, MD; Sharkey, KA; Vergnolle, N; Wallace, JL | 1 |
| Gillard, SE; Hammond, DL; Hurley, RW; Miller, RJ; Oh, SB; Tran, PB | 1 |
| Ackley, MA; Asghar, AU; King, AE; Worsley, MA | 1 |
| Conway, CM; Dirig, DM; Isakson, PC; Luo, ZD; Svensson, C; Yaksh, TL | 1 |
| Kastin, AJ; Martin-Schild, S; Smith, RR; Zadina, JE | 1 |
| Elde, R; Fairbanks, CA; Guo, A; Simone, DA; Stone, LS; Wang, J | 1 |
| de Weille, J; Lazdunski, M; Mamet, J; Voilley, N | 1 |
| Shu, YS; Zhang, YH; Zhao, ZQ | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Cahill, CM; Coderre, TJ | 1 |
| Kopp, S | 1 |
| Bueno, L; Coelho, AM; Fioramonti, J; Guiard, B; Vergnolle, N | 1 |
| Puskár, Z; Sakamoto, H; Spike, RC; Stewart, W; Todd, AJ; Watt, C | 1 |
| Willis, WD | 1 |
| Hylden, JL; Noguchi, K; Ruda, MA | 1 |
| Kawamura, M; Kuraishi, Y; Satoh, M | 1 |
| Malmberg, AB; Yaksh, TL | 1 |
| Gill, BK; Nakamura-Craig, M | 1 |
| Nakamura-Craig, M; Smith, TW | 1 |
| Diwakarla, S; Fransson, R; Gaugaz, FZ; Hallberg, M; Jonsson, A; Karlgren, M; Lesniak, A; Nyberg, F; Sandström, A; Skogh, A; Sköld, C; Svensson, R | 1 |
12 review(s) available for substance p and Allodynia
| Article | Year |
|---|---|
From the Anti-Nociceptive Substance P Metabolite Substance P (1-7) to Small Peptidomimetics.
Topics: Analgesics; Animals; Binding Sites; Dipeptides; Humans; Hyperalgesia; Neuralgia; Oligopeptides; Peptide Fragments; Peptidomimetics; Protein Conformation; Structure-Activity Relationship; Substance P | 2018 |
[Role of Transient Receptor Potential Channels in Paclitaxel- and Oxaliplatin-induced Peripheral Neuropathy].
Topics: Acute Disease; Animals; Antineoplastic Agents; Calcium Channels; Ganglia, Spinal; Gene Expression; Humans; Hyperalgesia; Molecular Targeted Therapy; Nerve Tissue Proteins; Organoplatinum Compounds; Oxaliplatin; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels; Up-Regulation | 2016 |
The role of peptides in central sensitization.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Chronic Disease; Gene Expression Regulation; Humans; Hyperalgesia; Ligands; Neurons; Pain; Pain Threshold; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Transcription Factors | 2009 |
Characterization of joint pain in human OA.
Topics: Arthralgia; Humans; Hyperalgesia; Nociceptors; Osteoarthritis; Pain Threshold; Peripheral Nervous System Diseases; Substance P | 2004 |
Psychophysical and neurochemical abnormalities of pain processing in fibromyalgia.
Topics: Afferent Pathways; Brain; Fibromyalgia; Humans; Hyperalgesia; Hypothalamo-Hypophyseal System; Nerve Fibers, Unmyelinated; Nerve Growth Factor; Neuronal Plasticity; Neurotransmitter Agents; Pain Threshold; Peripheral Nerves; Pituitary-Adrenal System; Recruitment, Neurophysiological; Serotonin; Substance P | 2008 |
Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain.
Topics: Animals; Ganglia, Spinal; Humans; Hyperalgesia; Inflammation; Models, Neurological; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Phenotype; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Nerve Growth Factor; Substance P | 1996 |
Advances in fibromyalgia: possible role for central neurochemicals.
Topics: Analgesia; Animals; Calcitonin Gene-Related Peptide; Dynorphins; Fibromyalgia; Humans; Hyperalgesia; Neurotransmitter Agents; Serotonin; Substance P | 1998 |
Effects of inflammatory mediators on gut sensitivity.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcitonin Gene-Related Peptide; Colonic Diseases, Functional; Humans; Hyperalgesia; Inflammation Mediators; Intestines; Serotonin; Substance P | 1999 |
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Topics: Afferent Pathways; Analgesics; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Humans; Hyperalgesia; Inflammation; Ion Transport; Models, Neurological; Morphine; Nerve Fibers; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Neurons, Afferent; Neuropeptides; Nociceptors; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Reflex; Spinal Cord; Substance P; Synaptic Transmission; Viscera | 2000 |
[Neural-immune interactions in dorsal root ganglia].
Topics: Animals; Cyclooxygenase 2; Ganglia; Humans; Hyperalgesia; Inflammation; Interleukin-1; Isoenzymes; Membrane Proteins; Neuroimmunomodulation; Neuropeptides; Prostaglandin-Endoperoxide Synthases; Spinal Nerve Roots; Substance P | 2000 |
Neuroendocrine, immune, and local responses related to temporomandibular disorders.
Topics: Arthritis; Calcitonin Gene-Related Peptide; Dinoprostone; Facial Pain; Fibromyalgia; Humans; Hyperalgesia; Inflammation Mediators; Interleukin-1; Leukotriene B4; Masseter Muscle; Neuroimmunomodulation; Neuropeptide Y; Neuropeptides; Neurosecretory Systems; Open Bite; Serotonin; Substance P; Synovial Fluid; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2001 |
Role of neurotransmitters in sensitization of pain responses.
Topics: Animals; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Agonists; Haplorhini; Hot Temperature; Humans; Hyperalgesia; Injections, Intradermal; Long-Term Potentiation; Mechanoreceptors; Microdialysis; Models, Animal; Models, Neurological; Neurons, Afferent; Neurotransmitter Agents; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Protein Processing, Post-Translational; Rats; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Signal Transduction; Spinothalamic Tracts; Substance P | 2001 |
233 other study(ies) available for substance p and Allodynia
| Article | Year |
|---|---|
Participation of transient receptor potential vanilloid 1 in the analgesic effect of duloxetine for paclitaxel induced peripheral neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin Gene-Related Peptide; Duloxetine Hydrochloride; Ganglia, Spinal; Hyperalgesia; Neuralgia; Paclitaxel; Pain; Peripheral Nervous System Diseases; Rats; Spinal Cord Dorsal Horn; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2022 |
Ferulic acid alleviates sciatica by inhibiting peripheral sensitization through the RhoA/p38MAPK signalling pathway.
Topics: Animals; Anti-Inflammatory Agents; Coumaric Acids; Cyclooxygenase 2; Dinoprostone; Guanosine Triphosphate; Hyperalgesia; Interleukin-6; Lipopolysaccharides; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatica; Substance P; Tumor Necrosis Factor-alpha | 2022 |
Endogenous Inflammatory Mediators Produced by Injury Activate TRPV1 and TRPA1 Nociceptors to Induce Sexually Dimorphic Cold Pain That Is Dependent on TRPM8 and GFRα3.
Topics: Animals; Calcitonin Gene-Related Peptide; Cold Temperature; Female; Glial Cell Line-Derived Neurotrophic Factor; Hyperalgesia; Male; Mice; Neurogenic Inflammation; Nociceptors; Pain; Sensory Receptor Cells; Substance P; Toll-Like Receptor 4; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels | 2023 |
TRPV1 activity and substance P release are required for corneal cold nociception.
Topics: Animals; Cold Temperature; Cornea; Dry Eye Syndromes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Sensory Receptor Cells; Substance P; Tamoxifen; Thermosensing; TRPV Cation Channels | 2019 |
Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model.
Topics: Animals; Constriction, Pathologic; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pulsed Radiofrequency Treatment; Rats; Rats, Sprague-Dawley; Substance P | 2020 |
Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression.
Topics: Animals; Central Nervous System Stimulants; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Humans; Hyperalgesia; Injections, Spinal; Male; Morphine; Morphine Derivatives; Nociception; Pain Measurement; Rats; Spinal Cord; Substance P | 2020 |
Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors.
Topics: Animals; Chronic Pain; Corpus Striatum; Hyperalgesia; Male; Neuralgia; Nociception; Pain Measurement; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Neurokinin-1; Sciatic Nerve; Sciatic Neuropathy; Substance P | 2020 |
Continuous infusion of substance P inhibits acute, but not subacute, inflammatory pain induced by complete Freund's adjuvant.
Topics: Acute Disease; Analgesics; Animals; Corpus Striatum; Edema; Freund's Adjuvant; Hyperalgesia; Inflammation; Infusions, Parenteral; Male; Pain; Pain Threshold; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 2020 |
Electroacupuncture at Neurogenic Spots in Referred Pain Areas Attenuates Hepatic Damages in Bile Duct-Ligated Rats.
Topics: Animals; Bile Ducts; Calcitonin Gene-Related Peptide; Electric Conductivity; Electroacupuncture; Hyperalgesia; Ligation; Liver; Neurogenic Inflammation; Pain, Referred; Rats, Sprague-Dawley; Skin; Substance P | 2021 |
cAMP signaling through protein kinase A and Epac2 induces substance P release in the rat spinal cord.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanine Nucleotide Exchange Factors; Hyperalgesia; Male; Organ Culture Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P | 2021 |
Inhibition of angiotensin converting enzyme induces mechanical allodynia through increasing substance P expression in mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Ganglia, Spinal; Gene Expression; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Peptidyl-Dipeptidase A; Spinal Cord Dorsal Horn; Substance P | 2021 |
Experimentally induced spine osteoarthritis in rats leads to neurogenic inflammation within neurosegmentally linked myotomes.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Neurogenic Inflammation; Osteoarthritis, Spine; Rats; Rats, Sprague-Dawley; Substance P | 2021 |
A role for substance P and acid-sensing ion channel 1a in prolotherapy with dextrose-mediated analgesia in a mouse model of chronic muscle pain.
Topics: Acid Sensing Ion Channels; Analgesia; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Fibromyalgia; Glucose; Hyperalgesia; Mice; Myalgia; Prolotherapy; Substance P | 2022 |
Importance of N- and C-terminal residues of substance P 1-7 for alleviating allodynia in mice after peripheral administration.
Topics: Analgesics; Animals; Caco-2 Cells; Humans; Hyperalgesia; Male; Mice; Neuralgia; Peptide Fragments; Permeability; Protein Stability; Sciatic Nerve; Structure-Activity Relationship; Substance P | 2017 |
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Caudal Nucleus; Trigeminal Ganglion; TRPA1 Cation Channel | 2017 |
Impact of N-methylation of the substance P 1-7 amide on anti-allodynic effect in mice after peripheral administration.
Topics: Analgesics; Animals; Caco-2 Cells; Humans; Hyperalgesia; Intestinal Absorption; Male; Methylation; Mice; Neuralgia; Peptide Fragments; Substance P | 2017 |
Important Details in Performing and Interpreting the Scratch Collapse Test.
Topics: Humans; Hyperalgesia; Neurologic Examination; Peripheral Nerve Injuries; Reproducibility of Results; Substance P | 2018 |
Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Chronic Pain; Hyperalgesia; Male; Mice; Mice, Transgenic; Neurons, Afferent; Pain Measurement; Receptors, Opioid, mu; Substance P | 2018 |
Antagonism of Transient Receptor Potential Ankyrin Type-1 Channels as a Potential Target for the Treatment of Trigeminal Neuropathic Pain: Study in an Animal Model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Immunohistochemistry; Male; Pain; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Substance P; Trigeminal Nerve Diseases; TRPA1 Cation Channel; TRPV Cation Channels | 2018 |
Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociception; Pain; Protein Precursors; Receptors, Neurokinin-1; Sciatic Nerve; Spinal Cord Dorsal Horn; Substance P; Tachykinins | 2019 |
Ultrasound therapy reduces persistent post-thoracotomy tactile allodynia and spinal substance P expression in rats.
Topics: Animals; Gene Expression; Hyperalgesia; Male; Pain Measurement; Pain, Postoperative; Random Allocation; Rats; Rats, Sprague-Dawley; Substance P; Thoracotomy; Ultrasonic Therapy | 2019 |
Possible inflammatory pain biomarkers in postamputation pain.
Topics: Adult; Aged; Amputees; Biomarkers; Calcitonin Gene-Related Peptide; Chronic Pain; Humans; Hyperalgesia; Middle Aged; Pain Measurement; Phantom Limb; Substance P | 2019 |
Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity.
Topics: Animals; Anticonvulsants; Hyperalgesia; Mice; Neuralgia; Peptidomimetics; Rats; Substance P | 2020 |
Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch.
Topics: Animals; Cell Death; Cognition Disorders; Disease Models, Animal; Glutamate Decarboxylase; Green Fluorescent Proteins; Hyperalgesia; Interneurons; Lectins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins v-fos; Pain; Pain Threshold; Phosphopyruvate Hydratase; Pruritus; Reaction Time; Receptors, Steroid; Receptors, Thyroid Hormone; Spinal Nerve Roots; Substance P | 2013 |
Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Topics: Animals; Arthritis, Experimental; Edema; Freund's Adjuvant; Gene Expression Regulation; Hyperalgesia; Inflammation; Interleukin-1beta; Joints; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Plethysmography; Protein Precursors; Receptors, Neurokinin-1; Signal Transduction; Substance P; Tachykinins; Tarsus, Animal | 2013 |
[Effect of food allergy early in life on visceral hyperalgesia in the developing rats and role of substance P abnormal expression in colon].
Topics: Animals; Colonic Diseases, Functional; Disease Models, Animal; Electrophysiology; Female; Food Hypersensitivity; Hyperalgesia; Intestinal Mucosa; Mast Cells; Ovalbumin; Pain Threshold; Rats; Rats, Sprague-Dawley; Stress, Psychological; Substance P | 2013 |
Mast cell activation contributes to sickle cell pathobiology and pain in mice.
Topics: Anemia, Sickle Cell; Animals; Benzamides; Cells, Cultured; Cytokines; Ganglia, Spinal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hyperalgesia; Hypoxia; Imatinib Mesylate; Leukocyte Count; Mast Cells; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neurogenic Inflammation; Nociceptors; Pain; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Skin; Substance P | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Liver; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pain; Signal Transduction; Substance P; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion.
Topics: Animals; Calcium; Cell Survival; Colchicine; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Microtubules; Nerve Compression Syndromes; Neuralgia; Radiculopathy; Random Allocation; Rats; Rats, Wistar; Substance P; Touch; TRPV Cation Channels; Tubulin Modulators | 2014 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippocampus; Hyperalgesia; Interleukin-1beta; Male; NF-kappa B; Nitrites; Nociception; Norepinephrine; Oxidative Stress; Pain; Rats, Wistar; Reserpine; Serotonin; Signal Transduction; Substance P; Superoxide Dismutase | 2013 |
Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons.
Topics: Animals; Freund's Adjuvant; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; In Vitro Techniques; Inflammation; Male; Neurons, Afferent; Neuropeptide Y; Pain Measurement; Pain Threshold; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neuropeptide Y; Signal Transduction; Spinal Cord; Spinal Nerve Roots; Substance P; Sulfur Isotopes | 2014 |
Glutamate, substance P, and calcitonin gene-related peptide cooperate in inflammation-induced heat hyperalgesia.
Topics: Androstanes; Animals; Benzimidazoles; Calcitonin Gene-Related Peptide; Female; Glutamic Acid; Hot Temperature; Hyperalgesia; Inflammation; Male; Mice; Nerve Growth Factor; Neurons, Afferent; Piperazines; Quinazolines; Substance P; TRPV Cation Channels; Vesicular Glutamate Transport Protein 2 | 2014 |
A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Morphine; Nociception; Nociceptive Pain; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tramadol | 2014 |
Shugan-decoction relieves visceral hyperalgesia and reduces TRPV1 and SP colon expression.
Topics: Analgesics; Animals; Behavior, Animal; Colon; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Hyperalgesia; Male; Pain Threshold; Rats; Rats, Wistar; Reflex; RNA, Messenger; Stress, Psychological; Substance P; TRPV Cation Channels; Visceral Afferents | 2013 |
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Opioid, mu; Sciatic Nerve; Sciatica; Spinal Cord; Substance P | 2014 |
Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Freund's Adjuvant; Glial Fibrillary Acidic Protein; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Neurons; Peripheral Nerve Injuries; Phosphopyruvate Hydratase; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Forced treadmill running suppresses postincisional pain and inhibits upregulation of substance P and cytokines in rat dorsal root ganglion.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Exercise Test; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Interleukin-1beta; Interleukin-6; Male; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Substance P; Time Factors | 2014 |
Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain.
Topics: Acid Sensing Ion Channels; Acids; Animals; Capsaicin; Chronic Pain; Cnidarian Venoms; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Pain Measurement; Signal Transduction; Substance P; TRPV Cation Channels | 2014 |
N-terminal truncations of substance P 1-7 amide affect its action on spinal cord injury-induced mechanical allodynia in rats.
Topics: Amides; Amino Acid Sequence; Animals; Female; Hyperalgesia; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Structure-Activity Relationship; Substance P | 2014 |
Transcutaneous electrical nerve stimulation attenuates postsurgical allodynia and suppresses spinal substance P and proinflammatory cytokine release in rats.
Topics: Animals; Cytokines; Hyperalgesia; Male; Models, Animal; Pain, Postoperative; Rats, Sprague-Dawley; Spinal Cord; Substance P; Transcutaneous Electric Nerve Stimulation; Up-Regulation | 2015 |
αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors.
Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Exocytosis; Gene Silencing; Hyperalgesia; Mice, Inbred C57BL; Nociceptors; Peptides; Rats; Rats, Wistar; Substance P; TRPV Cation Channels | 2014 |
Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model.
Topics: Activating Transcription Factor 3; Animals; Antibodies; Arthritis; Calcium Channels; Collagen; Disease Models, Animal; Galanin; Ganglia, Spinal; Hyperalgesia; Lectins; Lipopolysaccharides; Male; Mice; Mice, Inbred CBA; Nerve Tissue Proteins; Neuropeptide Y; Spinal Cord; Substance P; Time Factors | 2015 |
Antinociceptive effects of endomorphin-2: suppression of substance P release in the inflammatory pain model rat.
Topics: Animals; Arthritis, Experimental; Chronic Pain; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Male; Microdialysis; Microscopy, Electron; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociception; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Receptors, Presynaptic; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Mechanical; Substance P; Tryptophan | 2015 |
Small constrained SP1-7 analogs bind to a unique site and promote anti-allodynic effects following systemic injection in mice.
Topics: Analgesics; Animals; Area Under Curve; Binding Sites; Disease Models, Animal; Hyperalgesia; Male; Mice; Neuralgia; Pain Measurement; Pain Threshold; Peptide Fragments; Protein Binding; Statistics, Nonparametric; Substance P; Time Factors | 2015 |
Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization.
Topics: Animals; Body Temperature; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Neuropeptides; Pain; Pain Measurement; Peptide Fragments; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Up-Regulation | 2015 |
TRPV1 sensitization mediates postinflammatory visceral pain following acute colitis.
Topics: Abdominal Pain; Acute Disease; Animals; Behavior, Animal; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Ganglia, Spinal; HEK293 Cells; Humans; Hyperalgesia; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Pain Measurement; Pain Threshold; Signal Transduction; Substance P; Time Factors; Transfection; TRPV Cation Channels; Visceral Pain | 2015 |
Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats.
Topics: Animals; Hyperalgesia; Interleukin-1beta; Male; Masseter Muscle; Neurons; Physical Stimulation; Rats, Sprague-Dawley; Receptors, Interleukin-1; Restraint, Physical; Satellite Cells, Perineuronal; Stress, Psychological; Substance P; Time Factors; Touch; Trigeminal Ganglion | 2015 |
Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents.
Topics: Action Potentials; Animals; Behavior, Animal; Hyperalgesia; Lectins; Male; Nerve Growth Factor; Neurons, Afferent; Neuropeptides; Pain Threshold; Physical Stimulation; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord Dorsal Horn; Substance P; Zygapophyseal Joint | 2015 |
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Minocycline; Neuroglia; Nociception; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord; Substance P; Tibial Fractures; Time Factors | 2015 |
Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.
Topics: Animals; Annulus Fibrosus; Behavior, Animal; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Injections; Intervertebral Disc; Intervertebral Disc Degeneration; Lumbar Vertebrae; Male; Nerve Growth Factor; Pain; Punctures; Random Allocation; Rats; Rats, Sprague-Dawley; Substance P; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Paclitaxel-induced peripheral neuropathy increases substance P release in rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Gene Expression Regulation; Hyperalgesia; Male; Paclitaxel; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Spinal Cord; Substance P | 2016 |
SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy.
Topics: Animals; Calcitonin Gene-Related Peptide; Dogs; Ganglia, Spinal; Genetic Therapy; H-Reflex; Hyperalgesia; Nerve Growth Factor; Neuralgia; Neurons; Pain Measurement; Pyridoxine; Recombinant Proteins; Substance P | 2016 |
Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat.
Topics: Actin Cytoskeleton; Animals; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 6; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins | 2016 |
Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Carrageenan; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Nociception; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-fos; Receptors, AMPA; Spinal Cord Dorsal Horn; Substance P | 2016 |
Role of capsaicin-sensitive nerves and tachykinins in mast cell tryptase-induced inflammation of murine knees.
Topics: Animals; Arthritis; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Edema; Hyperalgesia; Knee Joint; Male; Mice, Inbred C57BL; Mice, Knockout; Neurogenic Inflammation; Pain; Protein Precursors; Receptor, PAR-2; Receptors, Neurokinin-1; Substance P; Tachykinins; Touch; TRPV Cation Channels; Tryptases | 2016 |
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Diclofenac; Disease Models, Animal; Docosahexaenoic Acids; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; Mice; Phosphopyruvate Hydratase; Rats; Rats, Wistar; Sciatica; Spinal Cord Dorsal Horn; Substance P; Time Factors; Weight-Bearing | 2016 |
Expression and distribution of SP and its NK1 receptor in the brain-gut axis in neonatal maternally separated rat model with visceral hypersensitivity.
Topics: Animals; Colon; Hyperalgesia; Irritable Bowel Syndrome; Male; Maternal Deprivation; Muscle, Smooth; Myenteric Plexus; Organ Specificity; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord Dorsal Horn; Substance P | 2016 |
Acetaminophen prevents hyperalgesia in central pain cascade.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Animals; Dinoprostone; Hyperalgesia; Injections, Spinal; Male; Neurotransmitter Agents; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2008 |
The differential effects of acetaminophen on lipopolysaccharide induced hyperalgesia in various mouse pain models.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Pain Measurement; Substance P | 2008 |
Influences of surgical decompression on the dorsal horn after chronic constriction injury: changes in peptidergic and delta-opioid receptor (+) nerve terminals.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Decompression, Surgical; Disease Models, Animal; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Sciatic Neuropathy; Substance P; Time Factors | 2008 |
Effect of the carboxyl-terminal of endokinins on SP-induced pain-related behavior.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Hot Temperature; Hyperalgesia; Male; Pain; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins | 2009 |
Low-frequency electro-acupuncture reduces the nociceptive response and the pain mediator enhancement induced by nerve growth factor.
Topics: Animals; Disease Models, Animal; Electroacupuncture; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Male; Mice; Nerve Growth Factor; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Skin; Substance P; TRPV Cation Channels | 2009 |
Heat hyperalgesia induced by endoneurial nerve growth factor and the expression of substance P in primary sensory neurons.
Topics: Afferent Pathways; Animals; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; Male; Nerve Growth Factor; Nociceptors; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Substance P | 2009 |
Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; Hyperalgesia; Injections, Spinal; Macaca mulatta; Male; Morphine; Nociceptin; Opioid Peptides; Pain Measurement; Pruritus; Receptors, Opioid; Substance P | 2009 |
Joint distraction magnitude is associated with different behavioral outcomes and substance P levels for cervical facet joint loading in the rat.
Topics: Animals; Behavior, Animal; Cervical Vertebrae; Enzyme-Linked Immunosorbent Assay; Forelimb; Ganglia, Spinal; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Shoulder; Spinal Cord; Substance P; Zygapophyseal Joint | 2009 |
Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Animals; Disease Models, Animal; Female; Gene Expression Regulation; Hyperalgesia; Lectins; Muscle, Skeletal; Nerve Fibers, Unmyelinated; Neural Conduction; Neuronal Plasticity; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatica; Spinal Cord; Substance P | 2009 |
The c-kit signaling pathway is involved in the development of persistent pain.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Constriction, Pathologic; Female; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Pain; Pain Measurement; Physical Stimulation; Point Mutation; Proto-Oncogene Proteins c-kit; Radioimmunoassay; Rhizotomy; Signal Transduction; Spinal Cord; Substance P | 2009 |
The alleviating pain effect of aqueous extract from tong-xie-yao-fang, on experimental visceral hypersensitivity and its mechanism.
Topics: Abdominal Pain; Animals; Animals, Newborn; Brain; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hyperalgesia; Irritable Bowel Syndrome; Maternal Deprivation; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin; Substance P; Viscera | 2009 |
Effect of memantine on the levels of neuropeptides and microglial cells in the brain regions of rats with neuropathic pain.
Topics: Analgesics; Animals; Brain; CD11 Antigens; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperalgesia; Hypothalamus; Male; Memantine; Microglia; Neuralgia; Neuropeptides; Periaqueductal Gray; Peripheral Nervous System Diseases; Rats; Rats, Wistar; Sciatic Neuropathy; Somatostatin; Substance P | 2009 |
Role of substance P signaling in enhanced nociceptive sensitization and local cytokine production after incision.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Pain, Postoperative; Piperidines; Protein Precursors; Signal Transduction; Substance P; Tachykinins; Time Factors | 2009 |
Substance P(1-7) induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Experimental; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Peptide Fragments; Receptors, sigma; Substance P; Temperature | 2010 |
Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Calcitonin Gene-Related Peptide; Clonidine; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Evoked Potentials; Excitatory Postsynaptic Potentials; Female; Hyperalgesia; In Vitro Techniques; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Oligopeptides; Patch-Clamp Techniques; Posterior Horn Cells; Potassium; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, delta; Signal Transduction; Spinal Cord; Substance P; Tetrodotoxin | 2009 |
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice.
Topics: Aldehydes; Animals; Calcitonin Gene-Related Peptide; Colitis; Colon; Cysteine Proteinase Inhibitors; Efferent Pathways; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Plant Oils; Pregnancy; Proto-Oncogene Proteins c-fos; Receptor, PAR-2; RNA, Messenger; Spinal Cord; Substance P; Transient Receptor Potential Channels; TRPA1 Cation Channel; Visceral Afferents | 2010 |
NMDA and AMPA receptors contribute to the maintenance of substance P-induced thermal hyperalgesia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance P | 2010 |
The amino-terminal region of hemokinin-1 regulates the induction of thermal hyperalgesia in rats.
Topics: Amino Acid Sequence; Animals; Arginine; Hyperalgesia; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Serine; Substance P; Tachykinins; Threonine | 2010 |
Estrogen effects on pain sensitivity and neuropeptide expression in rat sensory neurons.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Down-Regulation; Estrogen Replacement Therapy; Estrogens; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Ovariectomy; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger; Sciatic Neuropathy; Sensory Receptor Cells; Substance P | 2010 |
Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids.
Topics: Anemia, Sickle Cell; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Agonists; Cannabinoids; Cyclohexanols; Disease Models, Animal; Female; Hemoglobin, Sickle; Humans; Hyperalgesia; Male; Mice; Mice, Knockout; Mice, Transgenic; Morphine; Neuroglia; Pain; Receptors, Opioid, mu; Recombinant Proteins; Skin; Spinal Cord; Substance P | 2010 |
Differences between orofacial inflammation and cancer pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Carcinoma 256, Walker; Disease Models, Animal; Facial Neoplasms; Facial Pain; Galanin; Hot Temperature; Hyperalgesia; Indomethacin; Inflammation; Injections, Intraperitoneal; Male; Neuropeptides; Neurotransmitter Agents; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Substance P; Touch; Trigeminal Caudal Nucleus; Vibrissae | 2010 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fentanyl; Freund's Adjuvant; Histamine Agonists; Hyperalgesia; Inflammation; Male; Methylhistamines; Mice; Naloxone; Pain; Piperidines; Receptors, Histamine H3; Skin; Substance P | 2010 |
Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation.
Topics: Analgesics, Non-Narcotic; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Hindlimb; Hot Temperature; Humans; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peripheral Nervous System Agents; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins | 2010 |
Plasticity of hyperpolarization-activated and cyclic nucleotid-gated cation channel subunit 2 expression in the spinal dorsal horn in inflammatory pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Hyperalgesia; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; In Vitro Techniques; Inflammation; Ion Channels; Male; Microscopy, Confocal; Pain; Pain Measurement; Posterior Horn Cells; Potassium Channels; Presynaptic Terminals; Rats; Rats, Inbred WKY; Spinal Cord; Substance P | 2010 |
Sensitized peripheral nociception in experimental diabetes of the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Bradykinin; Calcitonin Gene-Related Peptide; Capsaicin; Diabetes Mellitus, Experimental; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; In Vitro Techniques; Male; Nerve Fibers; Nociceptors; Pain Measurement; Pain Threshold; Rats; Reaction Time; Sciatic Nerve; Skin; Streptozocin; Substance P | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Freund's Adjuvant; GABA Agents; Hyperalgesia; In Vitro Techniques; Inflammation; Male; Medulla Oblongata; Membrane Potentials; Microinjections; Muscimol; Ondansetron; Oxazines; Pain Measurement; Pain Threshold; Posterior Horn Cells; Pyridazines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Serotonin Antagonists; Spinal Cord; Substance P; Tryptophan; Up-Regulation | 2010 |
Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice.
Topics: Analgesia; Animals; Behavior, Animal; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Neurons; Oligopeptides; Pain; Pain Measurement; Protein Precursors; Receptors, Opioid, delta; Substance P; Tachykinins | 2010 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Formaldehyde; Gene Expression Regulation, Enzymologic; Hyperalgesia; Inflammation; Male; Nerve Tissue Proteins; Pain Measurement; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reaction Time; Signal Transduction; Sirolimus; Spinal Cord; Statistics, Nonparametric; Substance P; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2011 |
A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain.
Topics: Analysis of Variance; Animals; DNA Primers; Genotype; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Transgenic; Microscopy, Fluorescence; Models, Neurological; Pain; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Substance P; Vesicular Glutamate Transport Protein 2 | 2011 |
Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats.
Topics: Animals; Blotting, Western; Electroacupuncture; Female; Hyperalgesia; Nerve Growth Factor; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptor, trkA; Skin; Spinal Cord; Streptozocin; Substance P; TRPV Cation Channels | 2011 |
Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Cells, Cultured; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; MAP Kinase Signaling System; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, trkB; Sensory Receptor Cells; Substance P; TRPV Cation Channels; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Knockdown of the tachykinin neurokinin 1 receptor by intrathecal administration of small interfering RNA in rats.
Topics: Animals; Base Sequence; Behavior, Animal; Carrageenan; Formaldehyde; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Vectors; Hyperalgesia; Inflammation; Injections, Spinal; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Small Interfering; Sendai virus; Spinal Cord; Substance P | 2011 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde; Glycyrrhetinic Acid; Hot Temperature; Humans; Hyperalgesia; Inflammation; Ligation; Male; Neuralgia; Neurokinin A; Neurokinin B; Pain; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Sciatic Nerve; Substance P | 2011 |
Pharmacological characteristics of endokinin C/D-derived peptides in nociceptive and inflammatory processing in rats.
Topics: Amino Acid Sequence; Amino Acids; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Formaldehyde; Humans; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Male; Nociceptive Pain; Pain Measurement; Peptide Fragments; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substance P; Tachykinins; Time Factors; Tryptophan | 2011 |
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain.
Topics: Animals; Carrageenan; Dose-Response Relationship, Drug; Hyperalgesia; Infusions, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Nociception; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2012 |
Nerve growth factor-mediated neuronal plasticity in spinal cord contributes to neonatal maternal separation-induced visceral hypersensitivity in rats.
Topics: Animals; Animals, Newborn; Anxiety, Separation; Blotting, Western; Calcitonin Gene-Related Peptide; Carbazoles; Female; Fluorescent Antibody Technique; Gastrointestinal Diseases; Hyperalgesia; Indole Alkaloids; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Male; Maternal Deprivation; Nerve Growth Factor; Neuronal Plasticity; Pain Measurement; Pregnancy; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; Spinal Cord; Substance P | 2012 |
Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury.
Topics: Animals; Brain Injuries; Brain Stem; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Headache; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Nociception; Somatosensory Cortex; Substance P | 2012 |
Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.
Topics: Animals; Anisomycin; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Neuropeptides; Protein Synthesis Inhibitors; Puromycin; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors; Up-Regulation | 2012 |
Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis.
Topics: Animals; Cell Differentiation; Cell Proliferation; Dermatitis, Atopic; Female; Hot Temperature; Humans; Hyperalgesia; Hypersensitivity; Immunohistochemistry; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Nerve Tissue Proteins; Neurites; Pruritus; Sensory Thresholds; Skin; Substance P; TRPV Cation Channels | 2012 |
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins; Eugenol; Gait; Hyperalgesia; Iodoacetic Acid; Knee Joint; Male; Osteoarthritis; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2012 |
De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion.
Topics: Animals; Brachial Plexus; Brain Stem; Capsaicin; Cholera Toxin; Disease Models, Animal; Gene Expression Regulation; Hyperalgesia; Male; Microscopy, Confocal; Neural Pathways; Peripheral Nerve Injuries; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2013 |
Peripheral substance P and neurokinin-1 receptors have a role in inflammatory and neuropathic orofacial pain models.
Topics: Animals; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Facial Pain; Grooming; Hot Temperature; Hyperalgesia; Inflammation; Injections; Lip; Male; Neuralgia; Neurokinin-1 Receptor Antagonists; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Tropanes | 2013 |
Re-innervation patterns by peptidergic Substance-P, non-peptidergic P2X3, and myelinated NF-200 nerve fibers in epidermis and dermis of rats with neuropathic pain.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dermis; Disease Models, Animal; Epidermis; Hyperalgesia; Langerhans Cells; Male; Nerve Fibers, Myelinated; Neuralgia; Neurofilament Proteins; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, Purinergic P2X3; Substance P; Time Factors; Ubiquitin Thiolesterase | 2013 |
Hyperalgesia during opioid abstinence: mediation by glutamate and substance p.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Gene Expression; Genes, fos; Glutamic Acid; Histocytochemistry; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Morphine; Neurotransmitter Agents; Pain Measurement; Posterior Horn Cells; Reaction Time; Substance P; Substance Withdrawal Syndrome | 2002 |
Spinal neurons that possess the substance P receptor are required for the development of central sensitization.
Topics: Animals; Capsaicin; Cytotoxins; Hyperalgesia; Immunotoxins; Injections, Spinal; Male; N-Glycosyl Hydrolases; Neurons; Nociceptors; Pain Measurement; Physical Stimulation; Plant Proteins; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Stimulation, Chemical; Substance P | 2002 |
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways.
Topics: Animals; Brain Stem; Efferent Pathways; Hyperalgesia; Immunohistochemistry; Immunotoxins; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Pain Threshold; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin Antagonists; Substance P; Synaptic Transmission | 2002 |
Nociception in persistent pancreatitis in rats: effects of morphine and neuropeptide alterations.
Topics: Amylases; Analgesics, Opioid; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Immunohistochemistry; Lipase; Male; Morphine; Neuropeptides; Organotin Compounds; Pain; Pain Measurement; Pancreas; Pancreatitis; Physical Stimulation; Rats; Rats, Inbred Lew; Substance P | 2003 |
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, T-Type; Excitatory Postsynaptic Potentials; Hyperalgesia; Ion Channel Gating; Long-Term Potentiation; Membrane Potentials; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Nickel; Patch-Clamp Techniques; Posterior Horn Cells; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2003 |
Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception.
Topics: Analgesics, Opioid; Animals; Antibodies, Monoclonal; Behavior, Animal; Biphenyl Compounds; Central Nervous System; Denervation; Disease Models, Animal; Disease Progression; Female; Hyperalgesia; Immunohistochemistry; Immunotoxins; Injections, Intraventricular; Injections, Spinal; Lumbosacral Region; Male; Morphine; Norepinephrine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P; Time | 2003 |
Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Conditioning, Operant; Dose-Response Relationship, Drug; Escape Reaction; Female; Hot Temperature; Hyperalgesia; Immunotoxins; Injections, Spinal; Morphine; Pain Measurement; Rats; Rats, Long-Evans; Reaction Time; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Imidazoles; Inflammation; Injections, Spinal; Isoenzymes; Male; Microglia; Mitogen-Activated Protein Kinases; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2003 |
Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Carrageenan; Cell Count; Cyclooxygenase Inhibitors; Drug Interactions; Dynorphins; Functional Laterality; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Ketorolac; Male; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 2003 |
Capsaicin treatment inhibits osteopenia and heat hyperalgesia induced by chronic constriction injury to the sciatic nerve in rats.
Topics: Animals; Bone Density; Bone Diseases, Metabolic; Capsaicin; Hot Temperature; Hyperalgesia; Male; Nerve Endings; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Substance P | 2003 |
[Intrathecal injection of Sar9, Met(O2)11-substance P, neurokinin-1 receptor agonist, increases nitric oxide synthase expression and nitric oxide production in the rat spinal cord].
Topics: Animals; Female; Hyperalgesia; Injections, Spinal; Male; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain Threshold; Peptide Fragments; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2003 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Mice; Mice, Knockout; Neurons; Pain; Reaction Time; Substance P; Thionucleotides | 2004 |
Constitutive spinal cyclooxygenase-2 participates in the initiation of tissue injury-induced hyperalgesia.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Hindlimb; Hyperalgesia; Immunohistochemistry; Injections, Spinal; Isoenzymes; Lumbosacral Region; Male; N-Methylaspartate; Neuroglia; Neurons; Physical Stimulation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Up-Regulation | 2004 |
Involvement of peripherally released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model of the rat.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Functional Laterality; Hyperalgesia; Lumbosacral Region; Male; Pain Measurement; Pain Threshold; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord Injuries; Statistics, Nonparametric; Substance P; Time Factors | 2004 |
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Cells, Cultured; Enzyme Activators; Enzyme Inhibitors; Humans; Hyperalgesia; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Drug; RNA, Messenger; Spinal Cord; Substance P; Type C Phospholipases | 2004 |
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
Topics: Analgesics; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Antagonists; Hyperalgesia; Injections, Spinal; Nerve Growth Factor; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Time Factors; Up-Regulation | 2004 |
Antinociceptive effects of galanin in the rat tuberomammillary nucleus and the plasticity of galanin receptor 1 during hyperalgesia.
Topics: Analysis of Variance; Animals; Carrageenan; Dose-Response Relationship, Drug; Functional Laterality; Galanin; Hyperalgesia; Hypothalamic Area, Lateral; Immunohistochemistry; Male; Neuronal Plasticity; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Reaction Time; Receptors, Galanin; Sciatic Neuropathy; Substance P; Time Factors | 2004 |
Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Male; N-Methylaspartate; Nerve Fibers, Unmyelinated; Organ Culture Techniques; Pain Measurement; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; src-Family Kinases; Stimulation, Chemical; Substance P | 2004 |
Pathways for the bradykinin B1 receptor-mediated diabetic hyperalgesia in mice.
Topics: Animals; Bradykinin B1 Receptor Antagonists; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Receptor, Bradykinin B1; Signal Transduction; Streptozocin; Substance P | 2004 |
Spinal p38beta isoform mediates tissue injury-induced hyperalgesia and spinal sensitization.
Topics: Animals; Down-Regulation; Hyperalgesia; Injections, Spinal; Male; Microglia; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Oligoribonucleotides, Antisense; Pain; Pain Measurement; Posterior Horn Cells; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2005 |
Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Electroacupuncture; Freund's Adjuvant; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Lectins; Male; Pain Measurement; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 2005 |
Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2.
Topics: Animals; Blotting, Western; Carrageenan; Dialysis; Dinoprostone; Dose-Response Relationship, Drug; Functional Laterality; Gene Expression Regulation, Enzymologic; Group II Phospholipases A2; Hyperalgesia; Indoles; Inflammation; Inhibition, Psychological; Male; Pain Measurement; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Time Factors | 2005 |
Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.
Topics: Analysis of Variance; Animals; Blotting, Western; Electroacupuncture; Freund's Adjuvant; Hindlimb; Hyperalgesia; Immunohistochemistry; Inflammation; Lectins; Male; N-Glycosyl Hydrolases; Neurons; Opioid Peptides; Pain Measurement; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Skin; Spinal Cord; Substance P | 2005 |
Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization?
Topics: Animals; Carrageenan; Dinoprostone; Galanin; Hyperalgesia; Injections, Spinal; Male; Nociceptors; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2005 |
Role of NK-1 neurotransmission in opioid-induced hyperalgesia.
Topics: Animals; Cell Count; Drug Interactions; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mice; Mice, Knockout; Morphine; Narcotics; Neurokinin-1 Receptor Antagonists; Pain Measurement; Protein Transport; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Substance P; Synaptic Transmission; Time Factors; Touch; Tryptophan | 2005 |
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice.
Topics: Abdominal Pain; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Culture Media, Conditioned; Dexamethasone; Electromyography; Female; Hyperalgesia; Intestines; Irritable Bowel Syndrome; Mice; Mice, Inbred BALB C; Peroxidase; Physical Stimulation; Probiotics; Substance P | 2006 |
Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release.
Topics: Animals; Carrageenan; Chemical Phenomena; Chemistry, Physical; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Microdialysis; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Spinal Cord; Substance P | 2006 |
Spinal neuropeptide responses in persistent and transient pain following cervical nerve root injury.
Topics: Acute Disease; Animals; Calcitonin Gene-Related Peptide; Cervical Vertebrae; Chronic Disease; Hyperalgesia; Immunohistochemistry; Male; Neck Pain; Neuralgia; Radiculopathy; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Substance P | 2005 |
Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Ganglia, Spinal; Heterozygote; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Growth Factor; Neuralgia; Neurofibromatosis 1; Neurons, Afferent; Neuropeptides; Organ Culture Techniques; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins p21(ras); Substance P; Synaptic Transmission | 2006 |
Neurokinin-1 receptor in peripheral nerve terminals mediates thermal hyperalgesia.
Topics: Androstanes; Animals; Behavior, Animal; Benzimidazoles; Cell Degranulation; Edema; Hyperalgesia; Male; Mast Cells; Nerve Endings; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Sural Nerve | 2006 |
Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist.
Topics: Afferent Pathways; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Hyperalgesia; Male; Masseter Muscle; Myositis; Neurons, Afferent; Neuropeptides; Peptide Fragments; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome; Trigeminal Ganglion; Up-Regulation | 2006 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Male; Mexiletine; Motor Activity; Neuralgia; Nitriles; Pain; Pain Measurement; Piperidines; Rats; Rats, Wistar; Sodium Channel Blockers; Stress, Mechanical; Substance P; Veratridine | 2006 |
Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study.
Topics: Animals; Arthritis; Baclofen; Behavior, Animal; Drug Interactions; Freund's Adjuvant; GABA Agonists; Gene Expression; Hyperalgesia; Immunohistochemistry; Male; Pain Measurement; Pain Threshold; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Substance P | 2006 |
Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons.
Topics: Animals; Chronic Disease; Early Growth Response Protein 1; Efferent Pathways; Hot Temperature; Hyperalgesia; Long-Term Potentiation; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Oligonucleotides, Antisense; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; Synaptic Transmission | 2006 |
Mechanical allodynia and thermal hyperalgesia induced by experimental squamous cell carcinoma of the lower gingiva in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Carcinoma, Squamous Cell; Cell Line, Tumor; Disease Models, Animal; Gingiva; Hot Temperature; Hyperalgesia; Immunohistochemistry; Male; Mouth Mucosa; Mouth Neoplasms; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Inbred F344; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Substance P; Trigeminal Ganglion; Trigeminal Nerve; TRPV Cation Channels | 2006 |
The C-terminus of murine S100A9 protein inhibits hyperalgesia induced by the agonist peptide of protease-activated receptor 2 (PAR2).
Topics: Analgesics; Animals; Calcium; Calgranulin B; Cell Line; Early Growth Response Protein 1; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Nociceptors; Oligopeptides; Pain Measurement; Pain Threshold; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptor, PAR-2; Substance P; Transfection; Trypsin | 2006 |
Low-speed subcellular fractionation method for determining noxious stimulus-evoked spinal neurokinin-1 receptor internalization.
Topics: Animals; Cell Fractionation; Dose-Response Relationship, Drug; Functional Laterality; Hyperalgesia; Male; Protein Transport; Rats; Receptors, Neurokinin-1; Spinal Cord; Subcellular Fractions; Substance P | 2007 |
Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways.
Topics: Afferent Pathways; Animals; Drug Tolerance; Dynorphins; Hyperalgesia; Male; Morphine; Neurons; Ondansetron; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Spinal Cord; Substance P | 2007 |
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Signaling; Cell Line; Cells, Cultured; Epithelial Cells; Ganglia, Spinal; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nociceptors; Pain; Peptides; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Substance P; TRPV Cation Channels | 2007 |
Electrophysiological evidence for the interaction of substance P and glutamate on Adelta and C afferent fibre activity in rat hairy skin.
Topics: Animals; Electric Stimulation; Electrophysiology; Glutamic Acid; Hair; Hyperalgesia; Injections, Subcutaneous; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Conduction; Rats; Rats, Sprague-Dawley; Skin; Substance P | 2006 |
Effects of decompression on neuropathic pain behaviors and skin reinnervation in chronic constriction injury.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Decompression, Surgical; Disease Models, Animal; Foot; Functional Laterality; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Skin; Substance P; Time Factors; Ubiquitin Thiolesterase | 2007 |
Behavioral and immunohistological assessment of painful neuropathy induced by a single oxaliplatin injection in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Behavior, Animal; Calcitonin Gene-Related Peptide; Carbamazepine; Hyperalgesia; Immunohistochemistry; Magnesium; Male; Neurons, Afferent; Organoplatinum Compounds; Oxaliplatin; Pain; Pain Measurement; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P | 2007 |
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
Topics: Adenylyl Cyclases; Animals; CHO Cells; Cholera Toxin; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Drug Combinations; Hyperalgesia; Injections, Spinal; Male; Neurons, Afferent; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2007 |
Differential role of N-type calcium channel splice isoforms in pain.
Topics: Alternative Splicing; Analysis of Variance; Animals; Animals, Newborn; Calcium Channels, N-Type; Cells, Cultured; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Membrane Potentials; Neuralgia; Neurons, Afferent; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Substance P | 2007 |
Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hexokinase; Hyperalgesia; Leucine; Male; Pain; Pain Measurement; Peptides; Physical Stimulation; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord; Substance P; Tachykinins | 2007 |
Effects of the bisphosphonate ibandronate on hyperalgesia, substance P, and cytokine levels in a rat model of persistent inflammatory pain.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cytokines; Dinoprostone; Diphosphonates; Drug Evaluation, Preclinical; Edema; Foot; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Ibandronic Acid; Inflammation; Interleukin-1beta; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Continuous intra-arterial application of substance P induces signs and symptoms of experimental complex regional pain syndrome (CRPS) such as edema, inflammation and mechanical pain but no thermal pain.
Topics: Animals; Chemotaxis, Leukocyte; Complex Regional Pain Syndromes; Disease Models, Animal; Edema; Endothelial Cells; Hyperalgesia; Hypesthesia; Infusion Pumps, Implantable; Injections, Intra-Arterial; Male; Microcirculation; Neurogenic Inflammation; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Substance P | 2007 |
Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Nerve Tissue Proteins; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Patch-Clamp Techniques; Peptide Fragments; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; TRPV Cation Channels | 2007 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Lumbosacral Region; Male; Nitroglycerin; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Substance P; Trigeminal Caudal Nucleus | 2008 |
Enhancement of cutaneous nerve regeneration by 4-methylcatechol in resiniferatoxin-induced neuropathy.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Catechols; Disease Models, Animal; Diterpenes; Drug Interactions; Ganglia, Spinal; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neural Conduction; Neuroprotective Agents; Peripheral Nervous System Diseases; Reaction Time; Skin; Substance P; Ubiquitin Thiolesterase | 2008 |
Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Hyperalgesia; Lectins; Nerve Regeneration; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; Reaction Time; Recovery of Function; Reflex; Sciatic Neuropathy; Spinal Cord; Substance P; Time Factors | 2008 |
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Topics: Animals; Calcitonin Gene-Related Peptide; Chemokine CCL2; Gene Expression; Hyperalgesia; Immunohistochemistry; Inflammation; Lumbosacral Region; Male; Motor Activity; Neuralgia; Pain Measurement; Rats; Rats, Inbred LEC; Receptors, CCR2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord Injuries; Substance P; Thoracic Vertebrae; Time; TRPV Cation Channels | 2008 |
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcium; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Male; Neurons, Afferent; Pain Threshold; Potassium Chloride; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, CCR2; Spinal Cord; Subcellular Fractions; Substance P; TRPV Cation Channels | 2008 |
Substance P: does it produce analgesia or hyperalgesia?
Topics: Acetates; Animals; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Hyperesthesia; Mice; Nociceptors; Pain; Perception; Receptors, Drug; Substance P | 1980 |
Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Ganglia, Spinal; Hyperalgesia; Male; Neuritis; Neuronal Plasticity; Neurons, Afferent; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin; Spinal Cord; Substance P; Tachykinins | 1995 |
Effects of colchicine applied to the peripheral nerve on the thermal hyperalgesia evoked with chronic nerve constriction.
Topics: Animals; Calcitonin Gene-Related Peptide; Colchicine; Hot Temperature; Hyperalgesia; Ligation; Pain Measurement; Peripheral Nerves; Rats; Reaction Time; Sciatic Nerve; Spinal Cord; Substance P; Vasoactive Intestinal Peptide | 1993 |
Activity at phencyclidine and mu opioid sites mediates the hyperalgesic and antinociceptive properties of the N-terminus of substance P in a model of visceral pain.
Topics: Animals; Biological Assay; Disease Models, Animal; Dizocilpine Maleate; Hyperalgesia; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Peptide Fragments; Phencyclidine; Receptors, Opioid, mu; Spinal Cord; Substance P | 1994 |
Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P.
Topics: Acetaminophen; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; N-Methylaspartate; Nociceptors; Rats; Rats, Sprague-Dawley; Spinal Cord Diseases; Substance P | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABAB receptor system.
Topics: Animals; Arthritis, Experimental; Bicuculline; Electric Stimulation; GABA-B Receptor Antagonists; Hyperalgesia; In Vitro Techniques; Male; Naloxone; Pain Measurement; Pain Threshold; Radioimmunoassay; Rats; Rats, Inbred Lew; Receptors, GABA-B; Spinal Cord; Substance P; Weight Loss | 1994 |
Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Cholecystokinin; Disease; Excitatory Amino Acids; Hyperalgesia; Injections, Spinal; Lipopolysaccharides; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Serotonin; Spinal Cord; Substance P | 1994 |
Characterization of thermal hyperalgesia, c-fos expression, and alterations in neuropeptides after mechanical irritation of the dorsal root ganglion.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Immunohistochemistry; Lumbar Vertebrae; Male; Neuropeptides; Proto-Oncogene Proteins c-fos; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatica; Substance P | 1995 |
Effects of intrathecally injected glutamate and substance P antagonists on repeated cold stress-induced hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Cold Temperature; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hyperalgesia; Hypnotics and Sedatives; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Substance P | 1995 |
Quantitative evaluation of calcitonin gene-related peptide and substance P levels in rat spinal cord following peripheral nerve injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Male; Peripheral Nerve Injuries; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Substance P | 1995 |
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates; Female; Gastric Mucosa; Gels; Hyperalgesia; Inflammation; Ketoprofen; Lysine; Male; Prostaglandins; Rats; Rats, Sprague-Dawley; Substance P | 1995 |
Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcitonin Gene-Related Peptide; Dexamethasone; Freund's Adjuvant; Humans; Hyperalgesia; Indomethacin; Inflammation; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Substance P; Up-Regulation | 1995 |
Substance P markedly potentiates the antinociceptive effects of morphine sulfate administered at the spinal level.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hyperalgesia; Injections, Spinal; Male; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 1993 |
Participation of spinal cord substance P in hyperalgesia induced by repeated cold stress.
Topics: Animals; Cold Temperature; Hyperalgesia; Male; Pain; Rats; Rats, Sprague-Dawley; Sensory Thresholds; Spinal Cord; Stress, Physiological; Substance P; Synapses; Synaptic Transmission | 1993 |
Non-specific activity of (+/-)CP-96,345 in models of pain and inflammation.
Topics: Animals; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Neurokinin-1 Receptor Antagonists; Pain; Rats; Stereoisomerism; Substance P; Time Factors; Verapamil | 1993 |
RP-67580, a specific tachykinin NK1 receptor antagonist, relieves chronic hyperalgesia in diabetic rats.
Topics: Analgesics; Analysis of Variance; Animals; Diabetic Neuropathies; Hyperalgesia; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P | 1993 |
Implication of a nitric oxide synthase mechanism in the action of substance P: L-NAME blocks thermal hyperalgesia induced by endogenous and exogenous substance P in the rat.
Topics: Animals; Arginine; Enzyme Inhibitors; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Stereoisomerism; Substance P | 1995 |
The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arthritis; Benzamides; Carrageenan; Hyperalgesia; Iontophoresis; Kaolin; Knee Joint; Male; Neurokinin A; Nociceptors; Pain; Piperidines; Pressure; Rats; Rats, Wistar; Receptors, Neurokinin-2; Spinal Cord; Substance P | 1996 |
N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation.
Topics: Amides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Degranulation; Dextrans; Ear, External; Edema; Endocannabinoids; Ethanolamines; Evans Blue; Excipients; Extravasation of Diagnostic and Therapeutic Materials; Female; Formaldehyde; Hyperalgesia; Male; Mast Cells; Mice; Mice, Inbred BALB C; Palmitic Acids; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Substance P | 1996 |
Carbamazepine exerts anti-inflammatory effects in the rat.
Topics: Animals; Anti-Inflammatory Agents; Carbamazepine; Dinoprostone; Dose-Response Relationship, Drug; Edema; Exudates and Transudates; Hyperalgesia; Inflammation; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P | 1995 |
SR 48968 specifically depresses neurokinin A- vs. substance P-induced hyperalgesia in a nociceptive withdrawal reflex.
Topics: Animals; Benzamides; Biphenyl Compounds; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Substance P and capsaicin-induced mechanical hyperalgesia in the rat knee joint; the involvement of bradykinin B1 and B2 receptors.
Topics: Animals; Capsaicin; Female; Hyperalgesia; Knee Joint; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Substance P | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Foot; Formaldehyde; Hot Temperature; Hyperalgesia; Inflammation; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1996 |
Localization and activation of substance P receptors in unmyelinated axons of rat glabrous skin.
Topics: Animals; Axons; Behavior, Animal; Foot; Hyperalgesia; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin; Staining and Labeling; Substance P; Tissue Distribution | 1996 |
Nitric oxide mediates long-term hyperalgesic and antinociceptive effects of the N-terminus of substance P in the formalin assay in mice.
Topics: Analgesics; Animals; Arginine; Enzyme Inhibitors; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Peptide Fragments; Stereoisomerism; Substance P; Time Factors | 1996 |
Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing.
Topics: Animals; Hot Temperature; Hyperalgesia; Male; Nociceptors; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1996 |
Involvement of 5-hydroxytryptamine and bradykinin in the hyperalgesia induced in rats by collagenase from Clostridium histolyticum.
Topics: Analgesics; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Bradykinin; Clostridium; Edema; Female; Hindlimb; Hyperalgesia; Indoles; Isoindoles; Kininogens; Lisinopril; Methysergide; Microbial Collagenase; Neurokinin-1 Receptor Antagonists; Ondansetron; Prostaglandins; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Substance P | 1997 |
Mutual antagonism between nerve growth factor and substance P N-terminal activity on nociceptive activity in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Nerve Growth Factors; Peptide Fragments; Substance P | 1997 |
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Topics: Animals; Capsaicin; Cell Membrane; Cells, Cultured; Fluorescent Antibody Technique; Hyperalgesia; Immunotoxins; Injections, Spinal; N-Glycosyl Hydrolases; Neurons; Pain; Pain Management; Pain Measurement; Plant Proteins; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.
Topics: Animals; Ganglia, Spinal; Gene Deletion; Hyperalgesia; Inflammation; Interneurons; Isoenzymes; Ligation; Mice; Mice, Knockout; Neuropeptide Y; Pain; Pain Management; Pain Threshold; Protein Kinase C; Receptors, Neurokinin-1; Sciatic Nerve; Signal Transduction; Spinal Cord; Substance P | 1997 |
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Capsaicin; Electric Stimulation; Endocytosis; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Long-Term Potentiation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1997 |
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cord.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Evoked Potentials; GABA Antagonists; GABA-B Receptor Antagonists; Hot Temperature; Hyperalgesia; Hypesthesia; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Nerve Growth Factors; Neurotrophin 3; Organophosphorus Compounds; Pain; Pain Threshold; Perfusion; Pressure; Rats; Rats, Wistar; Secretory Rate; Single-Blind Method; Spinal Cord; Substance P | 1997 |
Good pain, bad pain.
Topics: Animals; Gene Expression Regulation; Humans; Hyperalgesia; Immunotoxins; Isoenzymes; Mice; Mutation; N-Glycosyl Hydrolases; Neuronal Plasticity; Neurons; Pain; Pain Management; Plant Proteins; Protein Kinase C; Rats; Receptors, Neurokinin-1; Ribosome Inactivating Proteins, Type 1; Saporins; Signal Transduction; Spinal Cord; Substance P | 1997 |
Role of TNF-alpha but not NGF in murine hyperalgesia induced by parasitic infection.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Degranulation; Female; Hyperalgesia; Indomethacin; Mast Cells; Mice; Nerve Growth Factors; Pain Measurement; Schistosomiasis mansoni; Substance P; Tumor Necrosis Factor-alpha | 1997 |
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Glutamate; Serine; Stereoisomerism; Substance P | 1998 |
An antagonist of substance P N-terminal fragments, D-substance P(1-7), reveals that both nociceptive and antinociceptive effects are induced by substance P N-terminal activity during noxious chemical stimulation.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Pain; Pain Measurement; Peptide Fragments; Stimulation, Chemical; Substance P | 1998 |
Involvement of spinal substance P and excitatory amino acids in inflammatory hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Carrageenan; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Substance P | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; Formaldehyde; Gene Targeting; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Mutagenesis; Neuritis; Pain; Pain Threshold; Physical Stimulation; Receptors, Neurokinin-1; Stress, Physiological; Substance P | 1998 |
Alterations of substance P immunoreactivity in lumbar and thoracic segments of rat spinal cord in ultraviolet irradiation induced hyperalgesia of the hindpaw.
Topics: Animals; Hindlimb; Hyperalgesia; Immunologic Techniques; Lumbosacral Region; Radiation Injuries, Experimental; Rats; Rats, Inbred WKY; Spinal Cord; Substance P; Thorax; Ultraviolet Rays | 1998 |
Evidence for the interaction of glutamate and NK1 receptors in the periphery.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Microscopy, Immunoelectron; Neurons, Afferent; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Skin; Substance P; Tail | 1998 |
A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats.
Topics: Animals; Baclofen; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dizocilpine Maleate; GABA Agonists; GABA-B Receptor Agonists; Hyperalgesia; Indoles; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Physical Stimulation; Pressure; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord; Substance P | 1998 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; Mice; Motor Activity; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Substance P; Zymosan | 1998 |
Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury.
Topics: Animals; Antioxidants; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Free Radicals; Hyperalgesia; Male; Peripheral Nerve Injuries; Pregnatrienes; Rats; Rats, Sprague-Dawley; Skin; Substance P; Superoxide Dismutase; Temperature; Vasodilation | 1999 |
Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Constriction, Pathologic; Diphtheria Toxin; Hyperalgesia; Immunohistochemistry; Inflammation; Injections, Spinal; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sciatic Nerve; Substance P | 1999 |
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1999 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Dinoprostone; Disease Models, Animal; Hyperalgesia; Indomethacin; Male; Neuralgia; Pain; Pain Threshold; Peripheral Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sciatic Nerve; Seminal Vesicles; Sheep; Substance P | 1999 |
Spinal cord ischemia reduces mu-opioid receptors in rats: correlation with morphine insensitivity.
Topics: Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Hyperalgesia; Immunohistochemistry; Ischemia; Linear Models; Morphine; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Spinal Cord; Stress, Mechanical; Substance P | 1999 |
Transgenic mice over-expressing substance P exhibit allodynia and hyperalgesia which are reversed by substance P and N-methyl-D-aspartate receptor antagonists.
Topics: Analgesics; Animals; Biphenyl Compounds; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Ketamine; Male; Mice; Mice, Transgenic; Myelin Basic Protein; Neurokinin-1 Receptor Antagonists; Nociceptors; Promoter Regions, Genetic; Reaction Time; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Spinal Cord; Stress, Mechanical; Substance P | 1999 |
Spinal neurokin3 receptors facilitate the nociceptive flexor reflex via a pathway involving nitric oxide.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Motor Neurons; Movement; Nitric Oxide; Nociceptors; Peptide Fragments; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Reflex; Spinal Cord; Substance P | 1999 |
Spinal neurokinin3 receptors mediate thermal but not mechanical hyperalgesia via nitric oxide.
Topics: Animals; Animals, Newborn; Body Temperature; Electric Stimulation; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Male; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Physical Stimulation; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Spinal Cord; Substance P | 1999 |
Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.
Topics: Animals; Anti-Inflammatory Agents; Axotomy; Dose-Response Relationship, Drug; Edema; Evans Blue; Glucocorticoids; Hindlimb; Hyperalgesia; Male; Methylprednisolone; Neurogenic Inflammation; Nociceptors; Pain Threshold; Rats; Rats, Sprague-Dawley; Reflex; Sciatic Nerve; Substance P | 1999 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neurokinin-1 Receptor Antagonists; Nociceptin; Opioid Peptides; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Reaction Time; Receptors, Neurokinin-1; Spinal Cord; Stereoisomerism; Substance P | 1999 |
Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation.
Topics: Animals; Dynorphins; Freund's Adjuvant; Gene Expression; Hyperalgesia; Mice; Mice, Knockout; Neuritis; Peripheral Nerves; Posterior Horn Cells; Protein Precursors; Receptors, Neurokinin-1; RNA, Messenger; Substance P; Tachykinins | 1999 |
NK3 receptor blockade prevents hyperalgesia and the associated spinal cord substance P release in monoarthritic rats.
Topics: Afferent Pathways; Animals; Arthritis, Experimental; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Peptide Fragments; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Neurokinin-3; Spinal Cord; Substance P | 2000 |
Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem.
Topics: Afferent Pathways; Animals; Axonal Transport; Brain Stem; Cholera Toxin; Hyperalgesia; Male; Microscopy, Confocal; Neurons, Afferent; Pain; Periaqueductal Gray; Posterior Horn Cells; Rats; Receptors, Neurokinin-1; Spinal Cord; Stereotaxic Techniques; Substance P | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Mustard Plant; Nociceptors; Pain; Physical Stimulation; Plant Extracts; Plant Oils; Receptors, Neurokinin-1; Substance P; Urinary Bladder; Visceral Afferents | 2000 |
Inhibition of spinal protein kinase C blocks substance P-mediated hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Injections, Spinal; Male; Maleimides; Nociceptors; Pain Measurement; Posterior Horn Cells; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission | 2000 |
Glucocorticoid inhibition of neuropathic hyperalgesia and spinal Fos expression.
Topics: Animals; Complex Regional Pain Syndromes; Hyperalgesia; Immunohistochemistry; Male; Methylprednisolone; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 2001 |
Effect of brain-derived neurotrophic factor on the release of substance P from rat spinal cord.
Topics: Animals; Arthritis; Brain-Derived Neurotrophic Factor; Electric Stimulation; Hyperalgesia; Knee Joint; Male; Posterior Horn Cells; Rats; Rats, Wistar; Spinal Cord; Substance P; Touch | 2001 |
Differential roles of spinal neurokinin 1/2 receptors in development of persistent spontaneous nociception and hyperalgesia induced by subcutaneous bee venom injection in the conscious rat.
Topics: Analgesics; Animals; Bee Venoms; Consciousness; Disease Models, Animal; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Threshold; Physical Stimulation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Spinal Cord; Substance P | 2001 |
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.
Topics: Animals; Gene Expression Regulation; Genes, fos; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Pain; Prostaglandins; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Thrombin; Spinal Cord; Substance P | 2001 |
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Chemokines; Fluorescent Dyes; Ganglia, Spinal; HIV Envelope Protein gp120; Hyperalgesia; Inflammation; Intracellular Fluid; Male; Neurons; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, CCR4; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Substance P | 2001 |
Peripheral inflammation reduces the response of spinal dorsal horn neurons to an NK3 receptor agonist.
Topics: Action Potentials; Animals; Carrageenan; Hyperalgesia; Inflammation; Lysine; Neurokinin B; Nociceptors; Pain; Peptide Fragments; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P | 2001 |
The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Ibuprofen; Injections, Intraperitoneal; Injections, Spinal; Isoenzymes; Male; Membrane Proteins; N-Methylaspartate; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 2001 |
Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury.
Topics: Animals; Calcitonin Gene-Related Peptide; Chronic Disease; Down-Regulation; Functional Laterality; Hyperalgesia; Immunohistochemistry; Ligation; Male; Mice; Mice, Inbred ICR; Nerve Crush; Neuralgia; Oligopeptides; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Posterior Horn Cells; Reaction Time; Sciatic Nerve; Substance P | 2001 |
Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons.
Topics: Afferent Pathways; Aging; Animals; Animals, Newborn; Binding Sites; Capsaicin; Drosophila Proteins; Fluorescent Antibody Technique; Ganglia, Spinal; Hyperalgesia; Lectins; Microscopy, Confocal; Pain Measurement; Pain Threshold; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases; Receptor, trkA; Receptors, Drug; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Skin; Substance P | 2001 |
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; COS Cells; Cyclooxygenase Inhibitors; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Lectins; Male; Membrane Proteins; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Patch-Clamp Techniques; Rats; Rats, Wistar; RNA, Messenger; Sodium Channel Blockers; Sodium Channels; Substance P; Transfection | 2001 |
Substance P potentiates thermal hyperalgesia induced by intrathecal administration of D-serine in rats.
Topics: Animals; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; N-Methylaspartate; Nociceptors; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Serine; Substance P | 2001 |
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation | 2002 |
Attenuation of hyperalgesia in a rat model of neuropathic pain after intrathecal pre- or post-treatment with a neurokinin-1 antagonist.
Topics: Animals; Cold Temperature; Disease Models, Animal; Hyperalgesia; Injections, Spinal; Male; Neurokinin-1 Receptor Antagonists; Nociceptors; Physical Stimulation; Rats; Rats, Long-Evans; Sciatica; Substance P; Tryptophan | 2002 |
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats.
Topics: Animals; Catheterization; Chelating Agents; Chromium Radioisotopes; Colitis; Colon; Compliance; Edetic Acid; Hyperalgesia; Injections, Intraperitoneal; Intestinal Absorption; Male; Neurons, Afferent; Oligopeptides; Prostaglandins; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Thrombin; Rectum; Signal Transduction; Spinal Cord; Substance P; Trypsin; Up-Regulation | 2002 |
MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli.
Topics: Afferent Pathways; Animals; Cell Communication; Female; Hot Temperature; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Oligopeptides; Pain; Posterior Horn Cells; Presynaptic Terminals; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 2002 |
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Effects of intrathecal antibodies to substance P, calcitonin gene-related peptide and galanin on repeated cold stress-induced hyperalgesia: comparison with carrageenan-induced hyperalgesia.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Carrageenan; Cold Temperature; Galanin; Hyperalgesia; Injections, Spinal; Male; Neuropeptides; Nociceptors; Pain; Peptides; Rats; Rats, Inbred Strains; Sensory Thresholds; Spinal Cord; Stress, Physiological; Substance P | 1992 |
Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hyperalgesia; Ibotenic Acid; Injections, Spinal; N-Methylaspartate; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Effect of neurokinin A, substance P and calcitonin gene related peptide in peripheral hyperalgesia in the rat paw.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Inflammation; Male; Neurokinin A; Nociceptors; Rats; Rats, Inbred Strains; Substance P | 1991 |
Substance P and peripheral inflammatory hyperalgesia.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Hyperesthesia; Inflammation; Male; Pain; Rats; Rats, Inbred Strains; Substance P | 1989 |
An imidazole based H-Phe-Phe-NH
Topics: Amides; Animals; Cell Death; Cell Survival; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Injections, Intraperitoneal; Mice; Molecular Structure; Peptidomimetics; Rats; Spinal Nerves | 2018 |