donepezil has been researched along with Allodynia in 3 studies
Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study first examined the therapeutic actions of pilocarpine, which inhibits dry-eye and dry-mouth symptoms, using an experimental fibromyalgia-like chronic pain model produced by intermittent cold stress (ICS) in mice." | 7.81 | Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice. ( Mukae, T; Uchida, H; Ueda, H, 2015) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 7.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| " This study first examined the therapeutic actions of pilocarpine, which inhibits dry-eye and dry-mouth symptoms, using an experimental fibromyalgia-like chronic pain model produced by intermittent cold stress (ICS) in mice." | 3.81 | Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice. ( Mukae, T; Uchida, H; Ueda, H, 2015) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 3.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "Neuropathic pain is one of the most debilitating pain conditions, yet no therapeutic strategy has been really effective for its treatment." | 1.42 | Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception. ( Aissouni, Y; Balayssac, D; Bayet-Robert, M; Chalus, M; Dalmann, R; Daulhac, L; El Guerrab, A; Eschalier, A; Ferrier, J; Graveron-Demilly, D; Marchand, F; Pinguet, J; Richard, D, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mukae, T | 1 |
| Uchida, H | 1 |
| Ueda, H | 1 |
| Ferrier, J | 1 |
| Bayet-Robert, M | 1 |
| Dalmann, R | 1 |
| El Guerrab, A | 1 |
| Aissouni, Y | 1 |
| Graveron-Demilly, D | 1 |
| Chalus, M | 1 |
| Pinguet, J | 1 |
| Eschalier, A | 1 |
| Richard, D | 1 |
| Daulhac, L | 1 |
| Marchand, F | 1 |
| Balayssac, D | 1 |
| Hayashida, K | 1 |
| Parker, R | 1 |
| Eisenach, JC | 1 |
3 other studies available for donepezil and Allodynia
| Article | Year |
|---|---|
Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Donepezil; Fibromyalgia; Hyperalgesia; Indans; Injections | 2015 |
Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.
Topics: Analgesics; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Gene Expression; Hyperal | 2015 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic | 2007 |