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indeloxazine and Allodynia

indeloxazine has been researched along with Allodynia in 3 studies

indeloxazine: RN given refers to parent cpd without isomeric designation

Research Excerpts

ExcerptRelevanceReference
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain."7.81Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015)
" Here, we investigated the relationship between SERT occupancies and the analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine, which are both 5-HT and NE reuptake inhibitors (SNRIs), on muscular pain in reserpine-induced myalgia (RIM) rats, an animal model of FM-like chronic pain."3.81Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats. ( Aoki, T; Fushiki, H; Honda, S; Irie, M; Iwashita, A; Murai, N; Murakami, Y; Nagakura, Y; Tamura, S, 2015)
" The results of this study indicate that the analgesic effect of repeated dosing of AS1069562 but not duloxetine is persistent even after a 1-week drug discontinuation in STZ-induced diabetic rats."1.40AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy. ( Aoki, T; Hamakawa, N; Matsuoka, N; Murai, N; Tamura, S; Yamamoto, H, 2014)
"In the PGE2-induced allodynia model, AS1069562 and duloxetine significantly suppressed allodynia, whereas amitriptyline did not."1.40Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline. ( Aoki, T; Matsuoka, N; Murai, N; Tamura, S; Tsukamoto, M, 2014)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Murai, N3
Aoki, T3
Tamura, S3
Yamamoto, H1
Hamakawa, N1
Matsuoka, N2
Tsukamoto, M1
Fushiki, H1
Honda, S1
Murakami, Y1
Iwashita, A1
Irie, M1
Nagakura, Y1

Other Studies

3 other studies available for indeloxazine and Allodynia

ArticleYear
AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy.
    Neuropharmacology, 2014, Volume: 79

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Duloxetine Hydrochlorid

2014
Antinociceptive effects of AS1069562, the (+)-isomer of indeloxazine, on spinal hypersensitivity induced by intrathecal injection of prostaglandin in mice: comparison with duloxetine and amitriptyline.
    European journal of pharmacology, 2014, Jun-15, Volume: 733

    Topics: Amitriptyline; Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Rel

2014
Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.
    Neuroscience, 2015, Mar-19, Volume: 289

    Topics: Analgesics; Animals; Brain; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Drug;

2015