2-amino-5-phosphonovalerate has been researched along with Allodynia in 49 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 7.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 3.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| " We found that intrathecal application of bicuculline, a GABA(A) receptor antagonist, to remove the inhibition readily elicited mechanical allodynia in naive mice, which could be dose-dependently attenuated by NMDARs antagonist D-APV." | 3.77 | GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn. ( Cao, J; Hu, XD; Li, S; Liu, YN; Shi, L; Suo, ZW; Yang, HB; Yang, X; Zheng, CR, 2011) |
| "We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons." | 1.48 | Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain. ( Gu, K; Jiang, B; Li, Y; Ma, P; Ma, X; Song, T; Wang, C; Yang, Y; Zhao, J, 2018) |
| "These results suggest that IL-1β-induced mechanical allodynia is mediated by sensitized peripheral NMDA/AMPA receptors through PKA-mediated signaling in the large-diameter primary afferent nerve fibers, whereas IL-1β-induced thermal hyperalgesia is mediated by sensitized peripheral TRPV1 receptors through PKC-mediated signaling in the small-diameter primary afferent nerve fibers." | 1.40 | Differential regulation of peripheral IL-1β-induced mechanical allodynia and thermal hyperalgesia in rats. ( Ahn, DK; Bae, YC; Kim, HJ; Kim, MJ; Kim, YJ; Lee, SY; Nam, SH; Yang, KY, 2014) |
| "Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood." | 1.38 | Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. ( Barres, B; Boroujerdi, A; Corpe, M; Deng, P; Eroglu, C; Kim, DS; Lee, J; Li, KW; Luo, ZD; Park, J; Peter Yu, Y; Sharp, K; Steward, O; Xu, ZC; Zaucke, F; Zhang, X; Zhou, CY, 2012) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "In PTX-treated rats, thermal hyperalgesia was observed, and the PKCgamma content of both the synaptosomal membrane and cytosolic fractions was significantly increased." | 1.32 | D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation. ( Chang, YC; Guo, YW; Wen, ZH; Wong, CS, 2003) |
| "We examined thermal hyperalgesia, excitability of dorsal root ganglion (DRG) neurons, and antinociceptive effects of N-methyl-d-aspartate (NMDA) receptor antagonists in rats with injury to different regions of DRG neurons." | 1.32 | Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. ( Rupert, RL; Song, XJ; Vizcarra, C; Wong, ZN; Xu, DS, 2003) |
| "Since hyperalgesia is a behavioral consequence of central sensitization, it should be attenuated at the level of the dorsal horn with NMDA receptor antagonists." | 1.32 | Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats. ( Hama, A; Sagen, J; Woon Lee, J, 2003) |
| "Magnesium (Mg)-deficient rats develop a mechanical hyperalgesia which is reversed by a N-Methyl-D-Aspartate (NMDA) receptor antagonist." | 1.31 | Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. ( Begon, S; Dubray, C; Eschalier, A; Mazur, A; Pickering, G; Rayssiguier, Y, 2001) |
| "Pretreatment with naloxone, an opioid receptor antagonist (1." | 1.31 | Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. ( Moriyama, T; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Watanabe, C, 2002) |
| "PGE2-induced, but not zymosan-induced, thermal hyperalgesia is mediated in part by activation of NMDA, AMPA/kainate and metabotropic glutamate receptors." | 1.31 | The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat. ( Randich, A; Turnbach, ME, 2002) |
| " At early time points, NMDA receptor and NGC activation enhance descending facilitation; as time progresses, the dose-response curve of NMDA shifts to the left and descending inhibition dominates and masks any descending facilitation." | 1.31 | The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation. ( Dubner, R; Ren, K; Terayama, R, 2002) |
| "SR 141716A evoked thermal hyperalgesia with an ED50 of 0." | 1.30 | Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia. ( Aanonsen, L; Hargreaves, KM; Richardson, JD, 1998) |
| "The effect of intrathecal L-NAME on mechanical hyperalgesia was also examined." | 1.30 | Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain. ( Brennan, TJ; Zahn, PK, 1998) |
| "However, this drug was unable to block hyperalgesia when already established." | 1.30 | Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol. ( Bianchi, M; Panerai, AE, 1997) |
| " The NMDA receptor antagonist D-AP5 reversed this effect, leaving the (1S,3R)-ACPD dose-response curve unchanged in naive animals." | 1.30 | mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia. ( Berthele, A; Boxall, SJ; Tölle, TR; Urban, L; Zieglgänsberger, W, 1998) |
| "This hyperalgesia was attenuated in a dose-dependent manner by the selective NMDA receptor antagonist APV (10-30 fmol, 1 microl) microinjected into the RVM." | 1.30 | Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia. ( Coutinho, VS; Gebhart, FG; Urban, OM, 1998) |
| "Prior work has shown that LPS induces hyperalgesia via activation of hepatic vagal afferents to the brain, thereby activating a centrifugal pain facilitory circuit." | 1.29 | Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade. ( Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP, 1994) |
| "Hyperalgesia is not mediated solely by circuitry intrinsic to the spinal cord, but rather involves activation of centrifugal pathways originating within the brain and descending to the spinal cord via pathway(s) outside of the dorsolateral funiculus." | 1.29 | Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade. ( Furness, LE; Horan, R; Maier, SF; Martinez, J; Watkins, LR; Wiertelak, EP, 1994) |
| "The spinally-induced PGE2 hyperalgesia was antagonized by intrathecal injections (9 micrograms) of AP5 (2-amino-5-phosphonopentanoate/2-amino-5) a selective NMDA receptor antagonist." | 1.29 | Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. ( Ferreira, SH; Lorenzetti, BB, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 20 (40.82) | 18.2507 |
| 2000's | 15 (30.61) | 29.6817 |
| 2010's | 14 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tolou-Dabbaghian, B | 1 |
| Delphi, L | 1 |
| Rezayof, A | 1 |
| Kim, MJ | 1 |
| Lee, SY | 1 |
| Yang, KY | 1 |
| Nam, SH | 1 |
| Kim, HJ | 1 |
| Kim, YJ | 1 |
| Bae, YC | 1 |
| Ahn, DK | 1 |
| Wong, H | 1 |
| Kang, I | 1 |
| Dong, XD | 1 |
| Christidis, N | 1 |
| Ernberg, M | 1 |
| Svensson, P | 1 |
| Cairns, BE | 1 |
| Ahmadi, S | 1 |
| Golbaghi, H | 1 |
| Azizbeigi, R | 1 |
| Esmailzadeh, N | 1 |
| Ferrari, LF | 1 |
| Lotufo, CM | 1 |
| Araldi, D | 1 |
| Rodrigues, MA | 1 |
| Macedo, LP | 1 |
| Ferreira, SH | 2 |
| Parada, CA | 1 |
| Kouvaras, E | 1 |
| Asprodini, EK | 1 |
| Asouchidou, I | 1 |
| Vasilaki, A | 1 |
| Kilindris, T | 1 |
| Michaloudis, D | 1 |
| Koukoutianou, I | 1 |
| Papatheodoropoulos, C | 1 |
| Kostopoulos, G | 1 |
| Wong, CS | 2 |
| Wu, GJ | 1 |
| Chen, WF | 1 |
| Jean, YH | 1 |
| Hung, CH | 1 |
| Lin, CS | 1 |
| Huang, SY | 1 |
| Wen, ZH | 2 |
| Cao, J | 1 |
| Yang, X | 1 |
| Liu, YN | 1 |
| Suo, ZW | 1 |
| Shi, L | 1 |
| Zheng, CR | 1 |
| Yang, HB | 1 |
| Li, S | 1 |
| Hu, XD | 1 |
| Heinl, C | 1 |
| Drdla-Schutting, R | 1 |
| Xanthos, DN | 1 |
| Sandkühler, J | 1 |
| Mutso, AA | 1 |
| Radzicki, D | 2 |
| Baliki, MN | 1 |
| Huang, L | 1 |
| Banisadr, G | 1 |
| Centeno, MV | 1 |
| Radulovic, J | 1 |
| Martina, M | 2 |
| Miller, RJ | 1 |
| Apkarian, AV | 1 |
| Guo, YW | 1 |
| Chang, YC | 1 |
| Song, XJ | 1 |
| Vizcarra, C | 1 |
| Xu, DS | 1 |
| Rupert, RL | 1 |
| Wong, ZN | 1 |
| Ro, JY | 1 |
| Nies, M | 1 |
| Zhang, Y | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 1 |
| Wu, X | 1 |
| Gao, J | 1 |
| Yan, J | 1 |
| Fan, J | 1 |
| Owyang, C | 1 |
| Li, Y | 2 |
| Okano, K | 2 |
| Kuraishi, Y | 3 |
| Satoh, M | 3 |
| Thompson, SW | 1 |
| Babbedge, R | 1 |
| Levers, T | 1 |
| Dray, A | 1 |
| Urban, L | 2 |
| Onogi, T | 1 |
| Kagawa, M | 1 |
| Minami, M | 1 |
| Wiertelak, EP | 2 |
| Furness, LE | 2 |
| Watkins, LR | 2 |
| Maier, SF | 2 |
| Horan, R | 1 |
| Martinez, J | 1 |
| Lorenzetti, BB | 1 |
| Chaplan, SR | 1 |
| Malmberg, AB | 1 |
| Yaksh, TL | 1 |
| Lawand, NB | 1 |
| Willis, WD | 1 |
| Westlund, KN | 1 |
| Kolhekar, R | 1 |
| Murphy, S | 1 |
| Gebhart, GF | 1 |
| Marvizón, JC | 1 |
| Martínez, V | 1 |
| Grady, EF | 1 |
| Bunnett, NW | 1 |
| Mayer, EA | 1 |
| Richardson, JD | 1 |
| Aanonsen, L | 1 |
| Hargreaves, KM | 1 |
| Zahn, PK | 1 |
| Brennan, TJ | 1 |
| Bianchi, M | 1 |
| Panerai, AE | 1 |
| Boxall, SJ | 1 |
| Berthele, A | 1 |
| Tölle, TR | 1 |
| Zieglgänsberger, W | 1 |
| Zhuo, M | 1 |
| Coutinho, VS | 1 |
| Urban, OM | 1 |
| Gebhart, FG | 1 |
| Sakurada, C | 2 |
| Sakurada, S | 2 |
| Katsuyama, S | 1 |
| Sasaki, J | 1 |
| Tan-No, K | 2 |
| Sakurada, T | 2 |
| Begon, S | 1 |
| Pickering, G | 1 |
| Eschalier, A | 1 |
| Mazur, A | 1 |
| Rayssiguier, Y | 1 |
| Dubray, C | 1 |
| Watanabe, C | 1 |
| Okuda, K | 1 |
| Sugiyama, A | 1 |
| Moriyama, T | 1 |
| Turnbach, ME | 1 |
| Randich, A | 1 |
| Terayama, R | 1 |
| Dubner, R | 2 |
| Ren, K | 2 |
| Skyba, DA | 1 |
| King, EW | 1 |
| Sluka, KA | 1 |
| Sher, GD | 1 |
| Cartmell, SM | 1 |
| Gelgor, L | 1 |
| Mitchell, D | 1 |
| Song, T | 1 |
| Ma, X | 1 |
| Ma, P | 1 |
| Gu, K | 1 |
| Zhao, J | 1 |
| Yang, Y | 1 |
| Jiang, B | 1 |
| Wang, C | 1 |
| Daou, I | 1 |
| Tuttle, AH | 1 |
| Longo, G | 1 |
| Wieskopf, JS | 1 |
| Bonin, RP | 1 |
| Ase, AR | 1 |
| Wood, JN | 1 |
| De Koninck, Y | 1 |
| Ribeiro-da-Silva, A | 1 |
| Mogil, JS | 1 |
| Séguéla, P | 1 |
| Pollema-Mays, SL | 1 |
| Sanz-Clemente, A | 1 |
| Honda, K | 1 |
| Noma, N | 1 |
| Shinoda, M | 1 |
| Miyamoto, M | 1 |
| Katagiri, A | 1 |
| Kita, D | 1 |
| Liu, MG | 1 |
| Sessle, BJ | 1 |
| Yasuda, M | 1 |
| Iwata, K | 1 |
| Kim, DS | 1 |
| Li, KW | 1 |
| Boroujerdi, A | 1 |
| Peter Yu, Y | 1 |
| Zhou, CY | 1 |
| Deng, P | 1 |
| Park, J | 1 |
| Zhang, X | 1 |
| Lee, J | 1 |
| Corpe, M | 1 |
| Sharp, K | 1 |
| Steward, O | 1 |
| Eroglu, C | 1 |
| Barres, B | 1 |
| Zaucke, F | 1 |
| Xu, ZC | 1 |
| Luo, ZD | 1 |
| Chen, S | 1 |
| Mohajerani, MH | 1 |
| Xie, Y | 1 |
| Murphy, TH | 1 |
| Hama, A | 1 |
| Woon Lee, J | 1 |
| Sagen, J | 1 |
| Fukuizumi, T | 1 |
| Ohkubo, T | 1 |
| Kitamura, K | 1 |
| Bennett, AD | 1 |
| Everhart, AW | 1 |
| Hulsebosch, CE | 1 |
| Williams, GM | 1 |
| Hylden, JL | 1 |
| Ruda, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Fentanyl on Expression of Main Opioid Receptor (OPRM1) on Human Granulosa Cells During Ultrasound-guided Transvaginal Oocyte Retrieval.[NCT03248076] | 30 participants (Anticipated) | Observational | 2017-04-01 | Recruiting | |||
| The Effect of Magnesium Sulfate Infusion on the Quality of Recovery of Ambulatory Patients[NCT01433081] | 50 participants (Actual) | Interventional | 2011-02-28 | Completed | |||
| Does Magnesium Sulfate as a Supplement in Adductor Canal Blocks Improve Pain Control After Total Knee Arthroplasty?[NCT02581683] | Phase 4 | 130 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Opioid consumption after discharge (NCT01433081)
Timeframe: 24 hours
| Intervention | miligram morphine equivalents (Median) |
|---|---|
| Magnesium Sulfate Infusion | 10 |
| Placebo | 30 |
Quality of recovery scores post operative. Scored on a scale of 40 (poor recovery) to 200 (good recovery). (NCT01433081)
Timeframe: 24 hours post operative
| Intervention | units on scale 40 (low) - 200 (high) (Mean) |
|---|---|
| Magnesium Sulfate Infusion | 183 |
| Placebo | 159 |
49 other studies available for 2-amino-5-phosphonovalerate and Allodynia
| Article | Year |
|---|---|
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme | 2019 |
Differential regulation of peripheral IL-1β-induced mechanical allodynia and thermal hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Disease Models, Animal; Diterpenes; Dose-Response Relationship | 2014 |
NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Size; Excitatory Amino Acid Antagonists; Female; Humans; | 2014 |
N-methyl-D-aspartate receptors involved in morphine-induced hyperalgesia in sensitized mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Behavior, Animal; Hyperalgesia; Magnesium | 2014 |
Inflammatory sensitization of nociceptors depends on activation of NMDA receptors in DRG satellite cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dinoprostone; Ganglia, Spinal; Hyperalgesia; Nociceptors; Quin | 2014 |
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicu | 2008 |
N-Methyl-D-aspartate receptor antagonist d-AP5 prevents pertussis toxin-induced alterations in rat spinal cords by inhibiting increase in concentrations of spinal CSF excitatory amino acids and downregulation of glutamate transporters.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Excitato | 2009 |
GABAergic disinhibition induced pain hypersensitivity by upregulating NMDA receptor functions in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Diazepam; Drug Interactions; Excitatory Amino Aci | 2011 |
Distinct mechanisms underlying pronociceptive effects of opioids.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela | 2011 |
Abnormalities in hippocampal functioning with persistent pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Biophysics; Bromodeoxyuridine; Conditioning, | 2012 |
D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Cytosol; E | 2003 |
Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Dizocilpine Maleate; Electrophysiology; Excitatory Amin | 2003 |
The role of peripheral N-methyl-D-aspartate receptors in muscle hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bite Force; Disease Models, Animal; Dose-Response Relationship | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anaphylaxis; Animals; Cerebral Co | 2008 |
Effects of intrathecally injected glutamate and substance P antagonists on repeated cold stress-induced hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Cold | 1995 |
No evidence for contribution of nitric oxide to spinal reflex activity in the rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Electric Stimulation; Hyperalgesia; In Vitro Techniq | 1995 |
Intrathecal neuromedin C enhances mechanical nociception: possible involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Animals; Bom | 1994 |
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Aspirin; Binding, Competitive; Disease; Dizocilpine | 1994 |
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cordotomy; Formaldehyde; Hot Temperature; Hyperalges | 1994 |
Intrathecal administration of prostaglandin E2 causes sensitization of the primary afferent neuron via the spinal release of glutamate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dinoprostone; Glutamic Acid; Hyperalgesia; Injections, Spinal; | 1996 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Excitatory Amino Acid An | 1997 |
Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carrageenan; Excitatory Amino Acid Agonists; Hot Temperature; | 1997 |
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1997 |
Hypoactivity of the spinal cannabinoid system results in NMDA-dependent hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dizocilpine Maleate; | 1998 |
Lack of effect of intrathecally administered N-methyl-D-aspartate receptor antagonists in a rat model for postoperative pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hypera | 1998 |
Formalin injection in the tail facilitates hindpaw withdrawal reflexes induced by thermal stimulation in the rat: effect of paracetamol.
Topics: 2-Amino-5-phosphonovalerate; Acetaminophen; Analgesics, Non-Narcotic; Animals; Excitatory Amino Acid | 1997 |
Involvement of spinal substance P and excitatory amino acids in inflammatory hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anti-Inflammatory Agents | 1998 |
mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino | 1998 |
NMDA receptor-dependent long term hyperalgesia after tail amputation in mice.
Topics: 2-Amino-5-phosphonovalerate; Amputation, Surgical; Animals; Dizocilpine Maleate; Excitatory Amino Ac | 1998 |
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Colon; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; H | 1998 |
Involvement of tachykinin NK1 receptors in nociceptin-induced hyperalgesia in mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, D | 1999 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.
Topics: 2-Amino-5-phosphonovalerate; Alkaloids; Analgesics; Animals; Benzophenanthridines; Dizocilpine Malea | 2001 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Di | 2002 |
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hype | 2002 |
The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Electric Stimulation; Excitatory Amino Acid Agonis | 2002 |
Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline.
Topics: 2-Amino-5-phosphonovalerate; Acids; Animals; Drug Administration Schedule; Drug Combinations; Excita | 2002 |
Role of N-methyl-D-aspartate and opiate receptors in nociception during and after ischaemia in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hot Temperature; Hyperalgesia; Ischemia; Male; Meperidine; Mor | 1992 |
Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.
Topics: Analgesics; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists | 2018 |
Remote optogenetic activation and sensitization of pain pathways in freely moving mice.
Topics: Afferent Pathways; Animals; Avoidance Learning; Cells, Cultured; Channelrhodopsins; Female; Ganglia, | 2013 |
Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.
Topics: Acetylcholine; Action Potentials; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2017 |
Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Face; Flavonoids; Hyperalgesia; Male; MAP Kinase Kina | 2011 |
Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Antibodies; Disease Models, Ani | 2012 |
Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex.
Topics: Anesthetics, Local; Animals; Bacterial Proteins; Carrier Proteins; Channelrhodopsins; Disease Models | 2012 |
Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino A | 2003 |
Spinal sensitization mechanism in vincristine-induced hyperalgesia in mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Calcium Channels; Dose-Respons | 2003 |
Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino | 2000 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; C | 1992 |