diclofenac has been researched along with Allodynia in 67 studies
Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
diclofenac : A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs." | 9.10 | Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. ( Burian, M; Geisslinger, G; Seegel, M; Tegeder, I, 2003) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 7.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 7.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 7.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "Tactile-allodynia and Mechano-hyperalgesia were tested before the surgical procedure and at days 7, 8, and 9 postoperatively." | 5.48 | Effect of Pregabalin and Diclofenac on tactile allodynia, mechanical hyperalgesia and pro inflammatory cytokine levels (IL-6, IL-1β) induced by chronic constriction injury of the infraorbital nerve in rats. ( Eliav, E; Imamura, Y; Khan, J; Noboru, N, 2018) |
| "The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 5.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 5.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "Patients with knee OA (n = 35) were compared on QST responses to a demographically-matched pain-free control group (n = 39), after which patients completed a month-long treatment study of diclofenac sodium topical gel (1 %), applied up to 4 times daily." | 5.22 | Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis. ( Cornelius, M; Dolman, AJ; Edwards, RR; Finan, PH; Lazaridou, A; Martel, MO; Wasan, AD, 2016) |
| "To evaluate whether a diclofenac epolamine + heparin topical (plaster) is more effective than diclofenac plaster alone in reducing deep somatic hyperalgesia in subjects without spontaneous pain and whether the effect is linked to or independent of the anti-edematous action of heparin." | 5.20 | Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb. ( Affaitati, G; Costantini, R; Fabrizio, A; Frangione, V; Giamberardino, MA; Lanzarotti, A; Lapenna, D; Lopopolo, M; Tafuri, E, 2015) |
| "The aim of this study was to investigate the analgesic efficacy of Neodolpasse, a fixed-dose combination of orphenadrine and diclofenac, compared with those of its single active ingredients in a human pain model." | 5.11 | Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials fro ( Eggenreich, U; Gschanes, A; Reitmeir, P; Schaffler, K, 2005) |
| "This was a randomized, double-blind, placebo-controlled study designed to compare the antihyperalgesic efficacy of topical (65 mg) and oral (93 mg) diclofenac via estimates of mechanical pain thresholds obtained at the site of induced inflammation with von Frey hairs." | 5.10 | Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. ( Burian, M; Geisslinger, G; Seegel, M; Tegeder, I, 2003) |
| " The present study investigated under in vivo conditions whether systemic administration of quercetin attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with mechanical hyperalgesia and compared its effect to the non-steroidal anti-inflammatory drug, diclofenac." | 4.12 | Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs. ( Itou, H; Takeda, M; Toyota, R, 2022) |
| " Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels." | 3.88 | Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels. ( Gurtskaia, G; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2018) |
| "Mice subjected to chronic constriction injury (CCI) were tested for mechanical and cold allodynia after administration of the MAGL inhibitor, JZL184, or the non-selective COX inhibitor diclofenac." | 3.81 | Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Gujjar, R; Kinsey, SG; Leishman, E; Mahadevan, A, 2015) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| " In the present study, we compared the effects of crocin, safranal and diclofenac on local inflammation and its induced pain in rats." | 3.79 | Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. ( Eghdami, K; Erfanparast, A; Farshid, AA; Samadi, F; Tamaddonfard, E, 2013) |
| "The anti-edematous and anti-allodynic effects of JZL184 were compared to those of PF-3845, an inhibitor of fatty acid amide hydrolase (FAAH), and diclofenac, a non-selective cyclooxygenase inhibitor." | 3.79 | The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model. ( Chen, Y; Cravatt, BF; Ghosh, S; Gujjar, R; Lichtman, AH; Mahadevan, A; Wise, LE, 2013) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 3.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| "We compared the anti-hyperalgesic and anti-inflammatory effects of the α7 nACh receptor agonist compound B with the positive allosteric modulator (PAM) PNU-120596 and the standard non-steroidal anti-inflammatory drug (NSAID), diclofenac, in rats with hind paw inflammation induced by either formalin, carrageenan or complete Freund's adjuvant (CFA)." | 3.78 | The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. ( Christensen, J; Erichsen, H; Hansen, H; Hansen, R; Munro, G; Timmermann, D, 2012) |
| "We investigated the effects of exogenous phosphatidylcholine (PC) and non-steroidal diclofenac supplementation on polymorphonuclear cell influx in carrageenan-induced arthritis in rats." | 3.75 | Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats. ( Boros, M; Eros, G; Ghyczy, M; Gurabi, D; Hartmann, P; Horváth, G; Németh, I; Szabó, A, 2009) |
| " Efficacy of lumiracoxib in rat models of hyperalgesia, oedema, pyresis and arthritis was dose-dependent and similar to diclofenac." | 3.73 | Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. ( Berry, C; Dawson, J; Du, Z; Esser, R; Fox, A; Fujimoto, RA; Haston, W; Kimble, EF; Koehler, J; Marshall, PJ; Peppard, J; Quadros, E; Quintavalla, J; Toscano, K; Urban, L; van Duzer, J; Zhang, X; Zhou, S, 2005) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 3.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "Indomethacin, a typical cyclo-oxygenase inhibitor, acts as an analgesic by preventing the hyperalgesia induced by prostaglandins during inflammation." | 3.69 | Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. ( Ferreira, SH; Tonussi, CR, 1994) |
| "Punctate mechanical hyperalgesia surrounding the wound and presence of residual pain after 1 and 6 months were also assessed." | 2.73 | Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery. ( De Kock, MF; Lavand'homme, PM; Roelants, F; Waterloos, H, 2007) |
| "OBJECTIVE: Neuropathic pain is regulated by several metabolites of the kynurenine pathway (KYNA-kynurenic acid, and QA-quinolinic acid)." | 1.91 | Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation. ( Debbag, S; Saricaoglu, F; Yalcinkaya, A, 2023) |
| "Tactile-allodynia and Mechano-hyperalgesia were tested before the surgical procedure and at days 7, 8, and 9 postoperatively." | 1.48 | Effect of Pregabalin and Diclofenac on tactile allodynia, mechanical hyperalgesia and pro inflammatory cytokine levels (IL-6, IL-1β) induced by chronic constriction injury of the infraorbital nerve in rats. ( Eliav, E; Imamura, Y; Khan, J; Noboru, N, 2018) |
| "The prevention of this hyperalgesia by diclofenac (1-10μg), the inhibitors of COX-1 SC-560 (0." | 1.46 | Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice. ( Álvarez, MG; Baamonde, A; Cernuda-Cernuda, R; Fernández-García, MT; Folgueras, AR; García-Domínguez, M; González-Rodríguez, S; Hidalgo, A; Lastra, A; Menéndez, L, 2017) |
| "The mechanical hyperalgesia was assessed by the Randall Selitto paw pressure test, which determines the paw withdrawal thresholds." | 1.43 | Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation. ( Almeida, FR; Cunha, FV; Lopes, EM; Macedo, EM; Oliveira, FA; Piauilino, CA; Santos, WC; Sousa, BP; Sousa, DP, 2016) |
| "Attenuation of hyperalgesia of inflamed TMJ by NSAIDs might be associated with their role in blocking upregulation of trigeminal ganglionic Nav1." | 1.43 | Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats. ( Bi, RY; Ding, Y; Gan, YH, 2016) |
| "A major concern in the treatment of acute pain/inflammation is the potential for drug-drug interactions resulting from P-gp induction by therapeutic agents co-administered with opioids." | 1.40 | P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac. ( Davis, TP; DeMarco, KM; Laracuente, ML; Ronaldson, PT; Sanchez-Covarrubias, L; Slosky, LM; Thompson, BJ; Zhang, Y, 2014) |
| "Cancer pain is one of the most severe types of chronic pain, and the most common cancer pain is bone cancer pain." | 1.38 | Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. ( Duan, KZ; Mei, YA; Xu, Q; Zhang, XM; Zhang, YQ; Zhao, ZQ, 2012) |
| "Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group." | 1.38 | Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012) |
| " Importance of aceclofenac as a new generational NSAID has inspired the development of topical dosage forms." | 1.36 | Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats. ( Dua, K; Pabreja, K; Padi, SS, 2010) |
| "However, lumiracoxib only produced anti-hyperalgesia." | 1.36 | Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity? ( Bakhle, YS; de Francischi, JN; dos Reis, WG; Ferreira-Alves, DL; Gassani, BC; Paiva-Lima, P; Rezende, RM, 2010) |
| " Importance of aceclofenac as a NSAID has inspired development of topical dosage forms." | 1.36 | Aceclofenac topical dosage forms: in vitro and in vivo characterization. ( Dua, K; Pabreja, K; Ramana, MV, 2010) |
| " A first-order model, including lag time and decreased relative bioavailability as a function of the dose, described the absorption process." | 1.36 | Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats. ( Castañeda-Hernández, G; Ortiz, MI; Salazar-Morales, UE; Trocóniz, IF; Vásquez-Bahena, DA, 2010) |
| "Thermal hyperalgesia was also decreased by intraplantar treatment with morphine (10 microg) or diclofenac (100 microg)." | 1.35 | Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat. ( Bölcskei, K; Füredi, R; Petho, G; Szolcsányi, J, 2009) |
| "Carrageenan induced significant mechanical allodynia, thermal hyperalgesia and paw oedema at 6 h post-carrageenan, while paw incision surgery induced significant mechanical allodynia and thermal hyperalgesia at 6 and 24 h post-surgery." | 1.34 | Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain. ( Biddlestone, L; Corbett, AD; Dolan, S, 2007) |
| "Thermal hyperalgesia was induced by mild heat injury (51 degrees C water for 20 s) which led to a 7-8 degrees C decrease of the noxious heat threshold." | 1.34 | Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model. ( Bölcskei, K; Horváth, D; Petho, G; Szolcsányi, J, 2007) |
| "Mechanical hyperalgesia, measured as the reduction in weight-bearing of the ipsilateral limb, and the development of static and dynamic allodynia were significantly inhibited by repeated lumaricoxib administration." | 1.32 | Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. ( Bevan, S; Courade, JP; Dawson, J; Fox, A; Glatt, M; Gonzalez, I; Medhurst, S; Urban, L, 2004) |
| "This blockade of PGE2 mechanical hyperalgesia induced by diclofenac (100 microg/paw) was antagonized in a dose-dependent manner by intraplantar administration of the sulphonylureas glibenclamide (40, 80 and 160 microg) and tolbutamide (80, 160 and 320 microg), specific blockers of ATP-sensitive K+ channels, and it was observed even when the hyperalgesic agent used was carrageenin, while the antinociceptive action of indomethacin (200 microg/paw), a typical cyclo-oxygenase inhibitor, over carrageenin-induced hyperalgesia was not affected by this treatment." | 1.32 | Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation. ( Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA, 2004) |
| "Thus diclofenac pretreatment partially prevented the insult-induced increase in total and regional neuronal c-fos-LI." | 1.31 | The effect of diclofenac on the expression of spinal cord c-fos-like immunoreactivity after ischemia-reperfusion-induced acute hyperalgesia in the rat tail. ( Cousins, MJ; Lin, Y; Mather, LE; Power, I, 2000) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "This hyperalgesia was observed only in the period before the development of fever which started 120-135 min after the LPS injection." | 1.31 | Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. ( Abe, M; Hori, T; Oka, T; Takahashi, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.49) | 18.7374 |
| 1990's | 3 (4.48) | 18.2507 |
| 2000's | 24 (35.82) | 29.6817 |
| 2010's | 35 (52.24) | 24.3611 |
| 2020's | 4 (5.97) | 2.80 |
| Authors | Studies |
|---|---|
| Barth, M | 1 |
| Bondoux, M | 1 |
| Luccarini, JM | 1 |
| Peyrou, V | 1 |
| Dodey, P | 1 |
| Pruneau, D | 1 |
| Massardier, C | 1 |
| Paquet, JL | 1 |
| Singh, P | 2 |
| Prasher, P | 1 |
| Dhillon, P | 1 |
| Bhatti, R | 2 |
| Muthukaman, N | 1 |
| Tambe, M | 1 |
| Shaikh, M | 1 |
| Pisal, D | 1 |
| Deshmukh, S | 1 |
| Tondlekar, S | 1 |
| Sarode, N | 1 |
| Narayana, L | 1 |
| Gajera, JM | 1 |
| Kattige, VG | 1 |
| Honnegowda, S | 1 |
| Karande, V | 1 |
| Kulkarni, A | 1 |
| Behera, D | 1 |
| Jadhav, SB | 1 |
| Gudi, GS | 1 |
| Khairatkar-Joshi, N | 1 |
| Gharat, LA | 1 |
| Kumari, P | 1 |
| Kaur, S | 1 |
| Kaur, J | 1 |
| Itou, H | 1 |
| Toyota, R | 1 |
| Takeda, M | 1 |
| Debbag, S | 1 |
| Yalcinkaya, A | 1 |
| Saricaoglu, F | 1 |
| Dos Santos Haupenthal, DP | 1 |
| Zortea, D | 1 |
| Zaccaron, RP | 1 |
| de Bem Silveira, G | 1 |
| Corrêa, MEAB | 1 |
| Mendes, C | 1 |
| de Roch Casagrande, L | 1 |
| Duarte, MB | 1 |
| Pinho, RA | 1 |
| Feuser, PE | 1 |
| Machado-de-Ávila, RA | 1 |
| Silveira, PCL | 1 |
| Khan, J | 1 |
| Noboru, N | 1 |
| Imamura, Y | 1 |
| Eliav, E | 1 |
| Tsagareli, MG | 1 |
| Nozadze, I | 1 |
| Tsiklauri, N | 1 |
| Gurtskaia, G | 1 |
| Larsen, IM | 1 |
| Drewes, AM | 1 |
| Olesen, AE | 1 |
| Andreev, YA | 1 |
| Osmakov, DI | 1 |
| Koshelev, SG | 1 |
| Maleeva, EE | 1 |
| Logashina, YA | 1 |
| Palikov, VA | 1 |
| Palikova, YA | 1 |
| Dyachenko, IA | 1 |
| Kozlov, SA | 1 |
| Zagorchev, PI | 1 |
| Apostolova, EG | 1 |
| Pilicheva, BA | 1 |
| Draganova-Filipova, MN | 1 |
| Kokova, VY | 1 |
| Lukanov, JB | 1 |
| Tamaddonfard, E | 1 |
| Farshid, AA | 1 |
| Eghdami, K | 1 |
| Samadi, F | 1 |
| Erfanparast, A | 1 |
| Affaitati, G | 1 |
| Fabrizio, A | 1 |
| Frangione, V | 1 |
| Lanzarotti, A | 1 |
| Lopopolo, M | 1 |
| Tafuri, E | 1 |
| Lapenna, D | 1 |
| Giamberardino, MA | 1 |
| Costantini, R | 1 |
| de Souza, AH | 1 |
| da Costa Lopes, AM | 1 |
| Castro, CJ | 1 |
| Pereira, EM | 1 |
| Klein, CP | 1 |
| da Silva, CA | 1 |
| da Silva, JF | 1 |
| Ferreira, J | 1 |
| Gomez, MV | 1 |
| Sanchez-Covarrubias, L | 1 |
| Slosky, LM | 1 |
| Thompson, BJ | 1 |
| Zhang, Y | 1 |
| Laracuente, ML | 1 |
| DeMarco, KM | 1 |
| Ronaldson, PT | 1 |
| Davis, TP | 1 |
| Crowe, MS | 1 |
| Leishman, E | 1 |
| Banks, ML | 1 |
| Gujjar, R | 2 |
| Mahadevan, A | 2 |
| Bradshaw, HB | 1 |
| Kinsey, SG | 1 |
| Guruprasad, B | 1 |
| Chaudhary, P | 2 |
| Choedon, T | 1 |
| Kumar, VL | 3 |
| Bi, RY | 1 |
| Ding, Y | 1 |
| Gan, YH | 1 |
| Silva, LC | 1 |
| Castor, MG | 1 |
| Navarro, LC | 1 |
| Romero, TR | 1 |
| Duarte, ID | 2 |
| Macedo, EM | 1 |
| Santos, WC | 1 |
| Sousa, BP | 1 |
| Lopes, EM | 1 |
| Piauilino, CA | 1 |
| Cunha, FV | 1 |
| Sousa, DP | 1 |
| Oliveira, FA | 1 |
| Almeida, FR | 1 |
| Edwards, RR | 1 |
| Dolman, AJ | 1 |
| Martel, MO | 1 |
| Finan, PH | 1 |
| Lazaridou, A | 1 |
| Cornelius, M | 1 |
| Wasan, AD | 1 |
| Manzhulo, IV | 1 |
| Ogurtsova, OS | 1 |
| Kipryushina, YO | 1 |
| Latyshev, NA | 1 |
| Kasyanov, SP | 1 |
| Dyuizen, IV | 1 |
| Tyrtyshnaia, AA | 1 |
| Krügel, U | 1 |
| Straub, I | 1 |
| Beckmann, H | 1 |
| Schaefer, M | 1 |
| González-Rodríguez, S | 1 |
| Álvarez, MG | 1 |
| García-Domínguez, M | 1 |
| Lastra, A | 1 |
| Cernuda-Cernuda, R | 1 |
| Folgueras, AR | 1 |
| Fernández-García, MT | 1 |
| Hidalgo, A | 1 |
| Baamonde, A | 1 |
| Menéndez, L | 1 |
| Buettner, C | 1 |
| Melo-Carrillo, A | 1 |
| Burstein, R | 1 |
| Füredi, R | 1 |
| Bölcskei, K | 2 |
| Szolcsányi, J | 2 |
| Petho, G | 2 |
| Acosta-Madrid, II | 1 |
| Castañeda-Hernández, G | 2 |
| Cilia-López, VG | 1 |
| Cariño-Cortés, R | 1 |
| Pérez-Hernández, N | 1 |
| Fernández-Martínez, E | 1 |
| Ortiz, MI | 2 |
| Dolan, S | 2 |
| Gunn, MD | 1 |
| Biddlestone, L | 2 |
| Nolan, AM | 1 |
| Hartmann, P | 1 |
| Szabó, A | 1 |
| Eros, G | 1 |
| Gurabi, D | 1 |
| Horváth, G | 1 |
| Németh, I | 1 |
| Ghyczy, M | 1 |
| Boros, M | 1 |
| Wahane, VD | 1 |
| Vásquez-Bahena, DA | 1 |
| Salazar-Morales, UE | 1 |
| Trocóniz, IF | 1 |
| Gassani, BC | 1 |
| Rezende, RM | 1 |
| Paiva-Lima, P | 1 |
| Ferreira-Alves, DL | 1 |
| dos Reis, WG | 1 |
| Bakhle, YS | 1 |
| de Francischi, JN | 1 |
| Pabreja, K | 2 |
| Dua, K | 2 |
| Padi, SS | 1 |
| Ramana, MV | 1 |
| Ramos, MV | 1 |
| Mohan, M | 1 |
| Matos, MP | 1 |
| Duan, KZ | 1 |
| Xu, Q | 1 |
| Zhang, XM | 1 |
| Zhao, ZQ | 1 |
| Mei, YA | 1 |
| Zhang, YQ | 1 |
| Zhu, CZ | 1 |
| Mills, CD | 2 |
| Hsieh, GC | 1 |
| Zhong, C | 2 |
| Mikusa, J | 2 |
| Lewis, LG | 1 |
| Gauvin, D | 1 |
| Lee, CH | 1 |
| Decker, MW | 1 |
| Bannon, AW | 2 |
| Rueter, LE | 1 |
| Joshi, SK | 1 |
| Ito, S | 1 |
| Tajima, K | 1 |
| Nogawa, M | 1 |
| Inoue, N | 1 |
| Kyoi, T | 1 |
| Takahashi, Y | 1 |
| Sasagawa, T | 1 |
| Nakamura, A | 1 |
| Kotera, T | 1 |
| Ueda, M | 1 |
| Yamashita, Y | 1 |
| Banno, K | 1 |
| Narai, Y | 1 |
| Imamachi, N | 1 |
| Saito, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513] | 66 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis[NCT01383954] | Phase 4 | 52 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Transversus Abdominis Plane (TAP) Block for Cesarean Section[NCT01015807] | 90 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| Efficacy of a Single-shot Wound Infiltration With Bupivacaine/Adrenalin During Cesarean Section in Reducing Postoperative Pain. A Randomized Prospective Controlled Trial[NCT03395912] | 288 participants (Actual) | Interventional | 2018-01-25 | Completed | |||
| Efficacy of Continuous Infusion of Levobupivacaine to the Surgical Wound Following Cesarean[NCT01458431] | Phase 3 | 70 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants assessed their knee pain using a visual analog scale (VAS) where 0=no pain and 100=worst possible pain. Pain scores were recorded in an electronic diary prior to and 4 hours after the first daily application of diclofenac gel for breakthrough pain. The daily percent change in pain scores over the 7 days prior to Week 1 were averaged. Percent change from Baseline (average pain score 7 days prior to first treatment) was calculated as (value at baseline - value at post-baseline visit) / (value at baseline) x 100. A positive change from Baseline indicates improvement. (NCT01383954)
Timeframe: Baseline and Week 1
| Intervention | percent change (Mean) |
|---|---|
| Diclofenac Gel | 33.3 |
Participants assessed their knee pain using a visual analog scale (VAS) where 0=no pain and 100=worst possible pain. Pain scores were recorded in an electronic diary prior to and 4 hours after the first daily application of diclofenac gel for breakthrough pain. The daily percent change in pain scores over the 7 days prior to Week 2 were averaged. Percent change from baseline (average pain score 7 days prior to first treatment) was calculated as (value at baseline - value at post-baseline visit)/ (value at baseline) x 100. A positive change from baseline indicates improvement. (NCT01383954)
Timeframe: Baseline and Week 2
| Intervention | percent change (Mean) |
|---|---|
| Diclofenac Gel | 33.3 |
Determine which of three different TAP formulations (Placebo, TAP, Clo-TAP) has the most beneficial effect on the postoperative area of hyperalgesia 48hrs after the start of the cesarean section. The smaller the area of WHA, assessed in cm2, the better the outcome. Area sizes may range from 0 to any size. (NCT01015807)
Timeframe: 48hrs after CS
| Intervention | cm^2 (Mean) |
|---|---|
| Placebo | 1.07 |
| TAP (Bupi) | 1.27 |
| Clo-TAP (Bupi + Clon) | 0.74 |
7 trials available for diclofenac and Allodynia
| Article | Year |
|---|---|
The Effect of a Combination of Diclofenac and Methadone Applied as Gel in a Human Experimental Pain Model - A Randomized, Placebo-controlled Trial.
Topics: Administration, Cutaneous; Adult; Capsaicin; Chronic Pain; Cross-Over Studies; Diclofenac; Dose-Resp | 2018 |
Effects of topical diclofenac plus heparin (DHEP+H plaster) on somatic pain sensitivity in healthy subjects with a latent algogenic condition of the lower limb.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Diclofenac; | 2015 |
Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; | 2016 |
Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; | 2016 |
Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; | 2016 |
Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; | 2016 |
Anti-hyperalgesic effects of nimesulide: studies in rats and humans.
Topics: Aged; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; | 2002 |
Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Central Nervous System; Cross-Over | 2003 |
Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials fro
Topics: Adult; Analgesics; Capsaicin; Cross-Over Studies; Diclofenac; Double-Blind Method; Drug Combinations | 2005 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
Postoperative analgesic effects of continuous wound infiltration with diclofenac after elective cesarean delivery.
Topics: Adult; Amides; Analgesia, Patient-Controlled; Anesthetics, Local; Anti-Inflammatory Agents, Non-Ster | 2007 |
60 other studies available for diclofenac and Allodynia
| Article | Year |
|---|---|
From bradykinin B2 receptor antagonists to orally active and selective bradykinin B1 receptor antagonists.
Topics: Administration, Oral; Analgesics; Animals; Binding, Competitive; Biological Availability; Bradykinin | 2012 |
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Topics: Animals; Anti-Inflammatory Agents; Catalytic Domain; Crystallography, X-Ray; Cyclooxygenase 2 Inhibi | 2015 |
Tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives as microsomal prostaglandin E
Topics: A549 Cells; Administration, Oral; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease | 2017 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Diclofenac; Hyperalgesia; Inflam | 2022 |
Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation.
Topics: Animals; Diclofenac; Hyperalgesia; Kynurenine; Neuralgia; Nociception; Rats; Rats, Sprague-Dawley; S | 2023 |
Effects of phonophoresis with diclofenac linked gold nanoparticles in model of traumatic muscle injury.
Topics: Animals; Catalase; Diclofenac; Disease Models, Animal; Glutathione; Gold; Hyperalgesia; Metal Nanopa | 2020 |
Effect of Pregabalin and Diclofenac on tactile allodynia, mechanical hyperalgesia and pro inflammatory cytokine levels (IL-6, IL-1β) induced by chronic constriction injury of the infraorbital nerve in rats.
Topics: Animals; Behavior, Animal; Constriction; Diclofenac; Hyperalgesia; Inflammation Mediators; Interleuk | 2018 |
Non-steroidal anti-inflammatory drugs attenuate agonist-evoked activation of transient receptor potential channels.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Diclofenac; Disease Models, | 2018 |
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Biol | 2018 |
In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations.
Topics: Acrylic Resins; Analgesics; Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibi | 2018 |
Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carotenoids; Carrageenan; Cyclohexenes; Diclofenac; D | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Mem | 2014 |
Combined inhibition of monoacylglycerol lipase and cyclooxygenases synergistically reduces neuropathic pain in mice.
Topics: Analgesics; Animals; Benzodioxoles; Cannabinoid Receptor Antagonists; Cyclooxygenase Inhibitors; Dic | 2015 |
Artesunate Ameliorates Functional Limitations in Freund's Complete Adjuvant-Induced Monoarthritis in Rat by Maintaining Oxidative Homeostasis and Inhibiting COX-2 Expression.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apoptosis; Artemisinins; Artesunate; Arthritis, Exper | 2015 |
Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; D | 2016 |
κ-Opioid receptor participates of NSAIDs peripheral antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dipyrone; Hindlimb; Hype | 2016 |
Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclohexane Monoterpe | 2016 |
Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Dicl | 2016 |
Primidone inhibits TRPM3 and attenuates thermal nociception in vivo.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; | 2017 |
Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemokine CCL5; Cyclooxygenase 2 Inhibi | 2017 |
Terminating Migraine-Associated Allodynia Using Oral Suspension Diclofenac: A Prospective Non-Randomized Drug Trial.
Topics: Adolescent; Adult; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Hyperalgesia; Middle Aged; | 2017 |
Effects of analgesics on the plantar incision-induced drop of the noxious heat threshold measured with an increasing-temperature water bath in the rat.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Disease Models, An | 2009 |
Interaction between Heliopsis longipes extract and diclofenac on the thermal hyperalgesia test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asteraceae; Diclofenac; Dose-Response | 2009 |
The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat.
Topics: Allosteric Regulation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzhydryl Compounds; Carra | 2009 |
Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diclofenac; H | 2009 |
Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Diclofenac; Female; Freund | 2010 |
Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.
Topics: Administration, Oral; Analgesics; Animals; Biological Availability; Carrageenan; Cyclooxygenase 2 In | 2010 |
Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Topics: Acetazolamide; Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Diclofenac; Dose-Response Relationsh | 2010 |
Evaluation of extemporaneously manufactured topical gels containing aceclofenac on inflammation and hyperalgesia in rats.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrage | 2010 |
Aceclofenac topical dosage forms: in vitro and in vivo characterization.
Topics: Acrylic Resins; Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageen | 2010 |
Protective effect of proteins derived from the latex of Calotropis procera against inflammatory hyperalgesia in monoarthritic rats.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Calotropis; Carrageenan; Diclofenac; Edema; Female; Fr | 2011 |
Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model.
Topics: 4-Aminopyridine; Activating Transcription Factor 3; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Int | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo | 2012 |
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicycl | 2012 |
The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodioxoles; Carrageenan; Diclo | 2013 |
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; C | 2013 |
B vitamins increase the anti-hyperalgesic effect of diclofenac in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Diclofenac; Female; | 2002 |
Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bone Density; Bone Neoplasms; Cyclooxygenase 2; Cyc | 2004 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response | 2004 |
Anti-inflammatory, antinociceptive and ulcerogenic activity of a zinc-diclofenac complex in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Diclofenac; Drug Combinations; Drug Eval | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, D | 2004 |
Acid-induced pain and its modulation in humans.
Topics: Acid Sensing Ion Channels; Administration, Cutaneous; Adult; Amiloride; Analgesics; Anti-Inflammator | 2004 |
Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Availability; | 2005 |
Inhibition of chemokine expression in rat inflamed paws by systemic use of the antihyperalgesic oxidized ATP.
Topics: Adenosine Triphosphate; Administration, Cutaneous; Administration, Oral; Analgesics, Non-Narcotic; A | 2005 |
Antinociceptive effect of methyleugenol on formalin-induced hyperalgesia in mice.
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclooxygenase 1; C | 2006 |
Oral administration of Ginkgo biloba extract, EGb-761 inhibits thermal hyperalgesia in rodent models of inflammatory and post-surgical pain.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dis | 2007 |
Heat injury-induced drop of the noxious heat threshold measured with an increasing-temperature water bath: a novel rat thermal hyperalgesia model.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Diclofenac; Dose-Response Rela | 2007 |
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates; | 1995 |
Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization.
Topics: Analgesia; Animals; Arginine; Carrageenan; Diclofenac; Dinoprostone; Drug Interactions; Enzyme Activ | 1994 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
The effect of diclofenac on the expression of spinal cord c-fos-like immunoreactivity after ischemia-reperfusion-induced acute hyperalgesia in the rat tail.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Diclofenac; Hyperalgesi | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Br | 2001 |
A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds; Caproates; Diclofenac; | 2001 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
B-vitamins potentiate the antinociceptive effect of diclofenac in carrageenin-induced hyperalgesia in the rat tail pressure test.
Topics: Administration, Oral; Analgesics; Animals; Carrageenan; Diclofenac; Dose-Response Relationship, Drug | 1989 |