aspirin has been researched along with Allodynia in 29 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3 nmol) of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after surgery." | 7.78 | Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. ( Hu, S; Huang, YL; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, J; Wang, XW; Wang, YQ; Wang, ZF; Wu, GC, 2012) |
| "Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy." | 6.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "Also, areas of secondary hyperalgesia to light touch and pin-prick were diminished." | 6.68 | Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia. ( Kress, M; Schmelz, M, 1996) |
| " However, long-term use of these drugs causes unwanted side effects, which limits their implication." | 5.42 | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. ( Chen, L; Han, WJ; Hu, SJ; Liu, XZ; Luo, C; Sun, XL; Wang, HB, 2015) |
| "This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level." | 5.34 | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. ( Serhan, CN; Svensson, CI; Zattoni, M, 2007) |
| "Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin." | 5.31 | Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 5.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Norepinephrine did enhance spontaneous pain and mechanical and thermal hyperalgesia in capsaicin treated skin." | 5.12 | Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia. ( Baron, R; Binder, A; Hedderich, J; Schattschneider, J; Wasner, G; Zum Buttel, I, 2007) |
| " Intraperitoneal injection with EOCO (5 or 10mg/kg), aspirin (positive control, 300mg/kg), or DMSO (negative control) was performed 1h before the nociception tests: acetic acid-induced writhing response, formalin test, and hot plate test in mice, and acidic saline-induced allodynia in rats." | 3.81 | Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice. ( Cho, CS; Jung, SM; Kim, WU; Park, BJ; Park, Y; Woo, JM; Yoo, SA; Yoon, CH, 2015) |
| "3 nmol) of lipoxin A4 (LXA4), lipoxin B4 (LXB4) or aspirin-triggered-15-epi-lipoxin A4 (ATL) could alleviate the mechanical allodynia in CIBP on day 7 after surgery." | 3.78 | Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines. ( Hu, S; Huang, YL; Jiang, JW; Mao-Ying, QL; Mi, WL; Wang, J; Wang, XW; Wang, YQ; Wang, ZF; Wu, GC, 2012) |
| "Dipyrone blocked carrageenin-induced oedema and hyperalgesia in a dose-dependent manner." | 3.67 | Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia. ( Ferreira, SH; Lorenzetti, BB, 1985) |
| "Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy." | 2.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "Eighteen patients suffering from migraine without aura were analysed." | 2.71 | Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack. ( de Tommaso, M; Di Fruscolo, O; Guido, M; Lamberti, P; Libro, G; Livrea, P; Losito, L; Sardaro, M; Sciruicchio, V, 2005) |
| "Two forms of mechanical hyperalgesia were examined: phasic mechanical stimuli by using a custom-made impact stimulator for the determination of individual pain thresholds, tonic mechanical stimuli were applied using a pinch-device." | 2.69 | Patterns of hyperalgesia in complex regional pain syndrome. ( Birklein, F; Handwerker, HO; Neundörfer, B; Riedl, B; Sieweke, N, 1999) |
| "Also, areas of secondary hyperalgesia to light touch and pin-prick were diminished." | 2.68 | Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia. ( Kress, M; Schmelz, M, 1996) |
| "2 Aspirin-like drugs inhibit prostaglandins I2 and E2, synthesis, which explains their anti-algic effect." | 2.36 | Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists. ( Ferreira, SH, 1980) |
| "Efficacy of acute OTC medications for migraine varies greatly." | 1.91 | Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine. ( Ezzati, A; Fanning, KM; Lipton, RB; Reed, ML, 2023) |
| " However, long-term use of these drugs causes unwanted side effects, which limits their implication." | 1.42 | A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. ( Chen, L; Han, WJ; Hu, SJ; Liu, XZ; Luo, C; Sun, XL; Wang, HB, 2015) |
| "Remarkably, hyperalgesia evoked by Bjv or carrageenan was completely blocked in animals treated with ARPI or busulfan, or pre-treated with aspirin or clopidogrel." | 1.37 | Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom. ( Cirillo, MC; Giorgi, R; Gonçalves, LR; Nogueira, TO; Sano-Martins, IS; Santoro, ML; Senise, LV; Yamashita, KM, 2011) |
| "This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level." | 1.34 | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing. ( Serhan, CN; Svensson, CI; Zattoni, M, 2007) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "Mechanical hyperalgesia was significantly reduced by the pre-treatment of 150 mg/kg, but not 50 mg/kg aspirin." | 1.31 | Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Aspirin-treated arthritic animals exhibited significantly less mechanical hyperalgesia and knee joint inflammation compared with vehicle treated arthritic animals." | 1.31 | A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis. ( Fuchs, PN; LaBuda, CJ, 2001) |
| "Prior work has shown that LPS induces hyperalgesia via activation of hepatic vagal afferents to the brain, thereby activating a centrifugal pain facilitory circuit." | 1.29 | Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade. ( Furness, LE; Maier, SF; Watkins, LR; Wiertelak, EP, 1994) |
| "We assessed hyperalgesia, by measuring tail flick latency following tail immersion in water at 49 degrees C, immediately after releasing the tourniquet and then at 30 min intervals for 2 h." | 1.27 | Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats. ( Butkow, N; Gelgor, L; Mitchell, D; Phillips, S, 1986) |
| "4." | 1.26 | Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. ( Ferreira, SH; Vargaftig, BB, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 7 (24.14) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Voilley, N | 1 |
| de Weille, J | 1 |
| Mamet, J | 1 |
| Lazdunski, M | 1 |
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Ezzati, A | 1 |
| Fanning, KM | 1 |
| Reed, ML | 1 |
| Lipton, RB | 1 |
| Lima, LM | 1 |
| da Silva, TF | 1 |
| da Silva Monteiro, CE | 1 |
| Aparecida-Silva, C | 1 |
| Bispo Júnior, W | 1 |
| de Queiroz, AC | 1 |
| Alexandre-Moreira, MS | 1 |
| Zapata-Sudo, G | 1 |
| Barreiro, EJ | 1 |
| Akerman, S | 1 |
| Karsan, N | 1 |
| Bose, P | 1 |
| Hoffmann, JR | 1 |
| Holland, PR | 1 |
| Romero-Reyes, M | 1 |
| Goadsby, PJ | 1 |
| Wang, ZF | 2 |
| Li, Q | 1 |
| Liu, SB | 1 |
| Mi, WL | 2 |
| Hu, S | 2 |
| Zhao, J | 1 |
| Tian, Y | 1 |
| Mao-Ying, QL | 2 |
| Jiang, JW | 2 |
| Ma, HJ | 1 |
| Wang, YQ | 2 |
| Wu, GC | 2 |
| Park, Y | 1 |
| Jung, SM | 1 |
| Yoo, SA | 1 |
| Kim, WU | 1 |
| Cho, CS | 1 |
| Park, BJ | 1 |
| Woo, JM | 1 |
| Yoon, CH | 1 |
| Han, WJ | 1 |
| Chen, L | 1 |
| Wang, HB | 1 |
| Liu, XZ | 1 |
| Hu, SJ | 1 |
| Sun, XL | 1 |
| Luo, C | 1 |
| Herrndobler, F | 1 |
| Koppert, W | 1 |
| Ringler, R | 1 |
| Maihöfner, C | 1 |
| Chattopadhyay, M | 1 |
| Velazquez, CA | 1 |
| Pruski, A | 1 |
| Nia, KV | 1 |
| Abdellatif, KR | 1 |
| Keefer, LK | 1 |
| Kashfi, K | 1 |
| Yamashita, KM | 1 |
| Nogueira, TO | 1 |
| Senise, LV | 1 |
| Cirillo, MC | 1 |
| Gonçalves, LR | 1 |
| Sano-Martins, IS | 1 |
| Giorgi, R | 1 |
| Santoro, ML | 1 |
| Wang, J | 1 |
| Wang, XW | 1 |
| Huang, YL | 1 |
| Millecamps, M | 1 |
| Etienne, M | 1 |
| Jourdan, D | 1 |
| Eschalier, A | 1 |
| Ardid, D | 1 |
| de Tommaso, M | 1 |
| Losito, L | 1 |
| Libro, G | 1 |
| Guido, M | 1 |
| Di Fruscolo, O | 1 |
| Sardaro, M | 1 |
| Sciruicchio, V | 1 |
| Lamberti, P | 1 |
| Livrea, P | 1 |
| Schattschneider, J | 1 |
| Zum Buttel, I | 1 |
| Binder, A | 1 |
| Wasner, G | 1 |
| Hedderich, J | 1 |
| Baron, R | 1 |
| Svensson, CI | 1 |
| Zattoni, M | 1 |
| Serhan, CN | 1 |
| Ferreira, SH | 3 |
| Vargaftig, BB | 1 |
| Higgs, GA | 1 |
| Towett, PK | 1 |
| Kanui, TI | 1 |
| Wiertelak, EP | 1 |
| Furness, LE | 1 |
| Watkins, LR | 1 |
| Maier, SF | 1 |
| Schmelz, M | 1 |
| Kress, M | 1 |
| Walpole, C | 1 |
| Ko, SY | 1 |
| Brown, M | 1 |
| Beattie, D | 1 |
| Campbell, E | 1 |
| Dickenson, F | 1 |
| Ewan, S | 1 |
| Hughes, GA | 1 |
| Lemaire, M | 1 |
| Lerpiniere, J | 1 |
| Patel, S | 1 |
| Urban, L | 1 |
| Sieweke, N | 1 |
| Birklein, F | 1 |
| Riedl, B | 1 |
| Neundörfer, B | 1 |
| Handwerker, HO | 1 |
| al-Swayeh, OA | 1 |
| Clifford, RH | 1 |
| del Soldato, P | 1 |
| Moore, PK | 1 |
| LaBuda, CJ | 2 |
| Fuchs, PN | 2 |
| Lorenzetti, BB | 1 |
| Gelgor, L | 1 |
| Phillips, S | 1 |
| Butkow, N | 1 |
| Mitchell, D | 1 |
2 reviews available for aspirin and Allodynia
| Article | Year |
|---|---|
Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists.
Topics: Analgesics; Animals; Aspirin; Calcium; Cyclic AMP; Epoprostenol; Hyperalgesia; Morphine; Narcotic An | 1980 |
Arachidonic acid metabolism, pain and hyperalgesia: the mode of action of non-steroid mild analgesics.
Topics: Analgesics; Arachidonic Acids; Aspirin; Epoprostenol; Humans; Hyperalgesia; Hyperesthesia; Pain; Pro | 1980 |
6 trials available for aspirin and Allodynia
| Article | Year |
|---|---|
Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity.
Topics: Adolescent; Adult; Aspirin; Double-Blind Method; Humans; Hyperalgesia; Middle Aged; Migraine Disorde | 2019 |
[Modulation of cortical pain processing by cyclooxygenase inhibition: a functional MRI study].
Topics: Acute Disease; Adult; Analgesics; Aspirin; Brain Mapping; Cerebral Cortex; Cyclooxygenase Inhibitors | 2009 |
Effects of symptomatic treatments on cutaneous hyperalgesia and laser evoked potentials during migraine attack.
Topics: Adult; Aspirin; Evoked Potentials; Female; Hot Temperature; Humans; Hyperalgesia; Indoles; Lasers; L | 2005 |
Mechanisms of adrenosensitivity in capsaicin induced hyperalgesia.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, | 2007 |
Topical acetylsalicylate attenuates capsaicin induced pain, flare and allodynia but not thermal hyperalgesia.
Topics: Administration, Topical; Aspirin; Capsaicin; Double-Blind Method; Hot Temperature; Humans; Hyperalge | 1996 |
Patterns of hyperalgesia in complex regional pain syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Hot Temperature; Humans; Hyperalgesia; Inf | 1999 |
21 other studies available for aspirin and Allodynia
| Article | Year |
|---|---|
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors.
Topics: Acid Sensing Ion Channels; Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; | 2001 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Predictors of treatment-response to caffeine combination products, acetaminophen, acetylsalicylic acid (aspirin), and nonsteroidal anti-inflammatory drugs in acute treatment of episodic migraine.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; Female | 2023 |
Design and Synthesis In Silico Drug-like Prediction and Pharmacological Evaluation of Cyclopolymethylenic Homologous of LASSBio-1514.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Caco-2 Cells; Computer Simulation; Drug Desi | 2021 |
Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Astrocytes; Constriction, Pathologic; Dis | 2014 |
Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Chamaecyparis; Cytokines; Hot T | 2015 |
A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Behavior, Animal; Cyclic N- | 2015 |
Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antipyretics; Aspirin; Dinoprostone; | 2010 |
Involvement of circulating platelets on the hyperalgesic response evoked by carrageenan and Bothrops jararaca snake venom.
Topics: Animals; Aspirin; Blood Platelets; Bothrops; Busulfan; Carrageenan; Clopidogrel; Crotalid Venoms; Cy | 2011 |
Lipoxins and aspirin-triggered lipoxin alleviate bone cancer pain in association with suppressing expression of spinal proinflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bone Neoplasms; Carcinoma 256, Walker; Di | 2012 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing.
Topics: Animals; Aspirin; Astrocytes; Blotting, Western; Carrageenan; Hyperalgesia; Immunohistochemistry; In | 2007 |
Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.
Topics: Animals; Aspirin; Carrageenan; Cyclooxygenase Inhibitors; Edema; Hyperalgesia; Indomethacin; Lysopho | 1981 |
Hyperalgesia following administration of morphine and pethidine in the root rat (Tachyoryctes splendens).
Topics: Animals; Aspirin; Behavior, Animal; Drug Interactions; Hot Temperature; Hydrocortisone; Hyperalgesia | 1995 |
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Aspirin; Binding, Competitive; Disease; Dizocilpine | 1994 |
2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models.
Topics: Analgesics; Animals; Aspirin; Binding, Competitive; Brain; Drug Design; Guinea Pigs; Humans; Hyperal | 1998 |
A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca | 2000 |
Low dose aspirin attenuates escape/avoidance behavior, but does not reduce mechanical hyperalgesia in a rodent model of inflammatory pain.
Topics: Animals; Aspirin; Avoidance Learning; Carrageenan; Dose-Response Relationship, Drug; Escape Reaction | 2001 |
A comparison of chronic aspartame exposure to aspirin on inflammation, hyperalgesia and open field activity following carrageenan-induced monoarthritis.
Topics: Animals; Arthritis, Experimental; Aspartame; Aspirin; Behavior, Animal; Carrageenan; Dose-Response R | 2001 |
Mode of analgesic action of dipyrone: direct antagonism of inflammatory hyperalgesia.
Topics: Acetaminophen; Aminopyrine; Analgesics; Animals; Aspirin; Bucladesine; Carrageenan; Dinoprostone; Di | 1985 |
Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats.
Topics: Aminopyridines; Animals; Aspirin; Histamine; Hyperalgesia; Hyperesthesia; Ischemia; Male; Prostaglan | 1986 |