clomipramine has been researched along with Allodynia in 6 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory hyperalgesia, and to use this model to investigate the antinociceptive effects of clomipramine and tramadol, two drugs used for the treatment of neuropathic pain." | 3.77 | Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice. ( Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T, 2011) |
| "Abolition of mechanical hyperalgesia was observed in mononeuropathic rats after five injections of clomipramine (5 mg·kg(-1) , s." | 1.37 | Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain? ( Courteix, C; Eschalier, A; Fialip, J; Libert, F; Loiodice, S; Privat, AM; Wattiez, AS, 2011) |
| "Its antihyperalgesic effect on mechanical hyperalgesia (paw pressure test) in rats induced by chronic constriction injury of the sciatic nerve was assessed after repeated administrations (five injections every half-life, a regimen close to clinical use)." | 1.32 | Evidence for an involvement of supraspinal delta- and spinal mu-opioid receptors in the antihyperalgesic effect of chronically administered clomipramine in mononeuropathic rats. ( Alloui, A; Ardid, D; Chapuy, E; Eschalier, A; Jourdan, D; Marchand, F, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suehiro, K | 1 |
| Funao, T | 1 |
| Fujimoto, Y | 1 |
| Yamada, T | 1 |
| Mori, T | 1 |
| Nishikawa, K | 1 |
| Kundermann, B | 1 |
| Hemmeter-Spernal, J | 1 |
| Strate, P | 1 |
| Gebhardt, S | 1 |
| Huber, MT | 1 |
| Krieg, JC | 1 |
| Lautenbacher, S | 1 |
| Wattiez, AS | 1 |
| Libert, F | 1 |
| Privat, AM | 1 |
| Loiodice, S | 1 |
| Fialip, J | 1 |
| Eschalier, A | 2 |
| Courteix, C | 1 |
| Alvarez, P | 1 |
| Brun, A | 1 |
| Labertrandie, A | 1 |
| Lopez, J | 1 |
| Correa, A | 1 |
| Constandil, L | 1 |
| Hernández, A | 1 |
| Pelissier, T | 1 |
| Marchand, F | 1 |
| Ardid, D | 1 |
| Chapuy, E | 1 |
| Alloui, A | 1 |
| Jourdan, D | 1 |
| Bianchi, M | 1 |
| Sacerdote, P | 1 |
| Panerai, AE | 1 |
1 trial available for clomipramine and Allodynia
| Article | Year |
|---|---|
Pain sensitivity in major depression and its relationship to central serotoninergic function as reflected by the neuroendocrine response to clomipramine.
Topics: Antidepressive Agents, Tricyclic; Area Under Curve; Chi-Square Distribution; Clomipramine; Depressiv | 2009 |
5 other studies available for clomipramine and Allodynia
| Article | Year |
|---|---|
Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.
Topics: Adrenergic Neurons; Analgesics; Animals; Clomipramine; Diabetes Mellitus, Experimental; Diabetic Neu | 2013 |
Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?
Topics: Analgesics; Animals; Antidepressive Agents; Clomipramine; Cyclopropanes; Diabetes Mellitus, Experime | 2011 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; | 2011 |
Evidence for an involvement of supraspinal delta- and spinal mu-opioid receptors in the antihyperalgesic effect of chronically administered clomipramine in mononeuropathic rats.
Topics: Animals; Clomipramine; Dose-Response Relationship, Drug; Drug Interactions; Hyperalgesia; Male; Mono | 2003 |
Chlomipramine differently affects inflammatory edema and pain in the rat.
Topics: Adrenalectomy; Animals; Clomipramine; Dose-Response Relationship, Drug; Edema; Hyperalgesia; Male; P | 1994 |