n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide has been researched along with Allodynia in 14 studies
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source
NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, 4 weeks following partial sciatic nerve ligation, a single intrathecal injection of the cyclooxygenase (COX)-1 preferring inhibitor ketorolac (50 microg) significantly attenuated tactile allodynia for 6 days." | 3.71 | Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. ( Du, W; Eisenach, JC; Ma, W, 2002) |
| "Its role as a mediator of hyperalgesia (clinically defined as an augmented sensitivity to painful stimuli) is not known." | 1.35 | Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. ( Cuzzocrea, S; Di Paola, R; Esposito, E; Matuschak, GM; Mazzon, E; Ndengele, MM; Salvemini, D, 2008) |
| "IL-1beta-induced hyperalgesia was blocked by pretreatment with IL-1 receptor antagonist." | 1.33 | Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. ( Ahn, DK; Bae, YC; Chae, JM; Choi, HS; Kwon, OW; Kyung, HM; Park, HS; Youn, DH, 2005) |
| "Inflammation is often accompanied with hyperalgesia." | 1.32 | Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia. ( Ibuki, T; Kobayashi, S; Matsumura, K; Nozaki, T; Tanaka, Y; Yamazaki, Y, 2003) |
| "This hyperalgesia was observed only in the period before the development of fever which started 120-135 min after the LPS injection." | 1.31 | Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats. ( Abe, M; Hori, T; Oka, T; Takahashi, S, 2001) |
| "Tactile allodynia was assessed 7 days after the surgery by measuring hindpaw withdrawal threshold to probing with von Frey filaments." | 1.30 | Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. ( Hunter, JC; Lashbrook, JM; Ossipov, MH; Porreca, F; Raffa, RB; Tallarida, RJ, 1999) |
| "Mechanical hyperalgesia induced by skin incision in rats is one of the animal models of postoperative incident pain." | 1.30 | The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat. ( Sakashita, Y; Yamamoto, T, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, Y | 2 |
| Connor, DT | 2 |
| Doubleday, R | 2 |
| Sorenson, RJ | 2 |
| Sercel, AD | 2 |
| Unangst, PC | 2 |
| Roth, BD | 2 |
| Gilbertsen, RB | 2 |
| Chan, K | 2 |
| Schrier, DJ | 2 |
| Guglietta, A | 2 |
| Bornemeier, DA | 2 |
| Dyer, RD | 2 |
| Beylin, VG | 1 |
| Cruz Duarte, P | 1 |
| St-Jacques, B | 1 |
| Ma, W | 2 |
| Ibuki, T | 1 |
| Matsumura, K | 1 |
| Yamazaki, Y | 1 |
| Nozaki, T | 1 |
| Tanaka, Y | 1 |
| Kobayashi, S | 1 |
| Lui, PW | 1 |
| Lee, CH | 1 |
| Ahn, DK | 1 |
| Chae, JM | 1 |
| Choi, HS | 1 |
| Kyung, HM | 1 |
| Kwon, OW | 1 |
| Park, HS | 1 |
| Youn, DH | 1 |
| Bae, YC | 1 |
| Piston, D | 1 |
| Wang, S | 1 |
| Feng, Y | 1 |
| Ye, YJ | 1 |
| Zhou, J | 1 |
| Jiang, KW | 1 |
| Xu, F | 1 |
| Zhao, Y | 1 |
| Cui, ZR | 1 |
| Ndengele, MM | 1 |
| Cuzzocrea, S | 1 |
| Esposito, E | 1 |
| Mazzon, E | 1 |
| Di Paola, R | 1 |
| Matuschak, GM | 1 |
| Salvemini, D | 1 |
| Yamamoto, T | 3 |
| Nozaki-Taguchi, N | 1 |
| Sakashita, Y | 2 |
| Lashbrook, JM | 1 |
| Ossipov, MH | 1 |
| Hunter, JC | 1 |
| Raffa, RB | 1 |
| Tallarida, RJ | 1 |
| Porreca, F | 1 |
| Abe, M | 1 |
| Oka, T | 1 |
| Hori, T | 1 |
| Takahashi, S | 1 |
| Du, W | 1 |
| Eisenach, JC | 1 |
14 other studies available for n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide and Allodynia
| Article | Year |
|---|---|
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Line; Cycl | 1999 |
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Carrageenan | 1999 |
Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model.
Topics: Animals; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclooxygenase Inhi | 2012 |
Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.
Topics: Animals; Brain; Carrageenan; Central Nervous System; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2003 |
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindli | 2004 |
Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats.
Topics: Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relation | 2005 |
The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats.
Topics: Acute Disease; Animals; Colitis; Cyclooxygenase 2; Hyperalgesia; Liver; Liver Diseases; Male; Morphi | 2007 |
Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity.
Topics: Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Synergism; | 2008 |
Role of spinal cyclooxygenase (COX)-2 on thermal hyperalgesia evoked by carageenan injection in the rat.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose | 1997 |
COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Cyclooxygen | 1998 |
Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase Inhibitors; Drug Synergism; Hyperalgesia; Injections, Sp | 1999 |
The role of the spinal opioid receptor like1 receptor, the NK-1 receptor, and cyclooxygenase-2 in maintaining postoperative pain in the rat.
Topics: Animals; Benzenesulfonates; Biphenyl Compounds; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 1999 |
Prostanoids in the preoptic hypothalamus mediate systemic lipopolysaccharide-induced hyperalgesia in rats.
Topics: Animals; Bacterial Infections; Body Temperature; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2001 |
Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibi | 2002 |