histamine has been researched along with Allodynia in 43 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)." | 7.85 | Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 7.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "We investigated the effects of tactile allodynia on the itch and mechanically evoked dysesthesiae produced by an intradermal injection of histamine in human volunteers." | 5.09 | Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. ( Atanassoff, PG; Brull, SJ; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| " We showed that decreasing intake of fermentable carbohydrates improved abdominal pain in patients with IBS, and this was accompanied by changes in the gut microbiota and decreased urinary histamine concentrations." | 4.12 | Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice. ( Baerg, L; Bai, X; Bercik, P; Beyak, M; Caminero, A; Collins, SM; De Palma, G; Jaramillo-Polanco, J; Jimenez-Vargas, N; Lomax, AE; Lopez-Lopez, C; Lu, J; Madsen, K; Manzar, A; Pigrau, M; Pinto-Sanchez, MI; Pujo, J; Rabbia, V; Reed, DE; Sessenwein, J; Shimbori, C; Surette, MG; Vanner, SJ; Verdu, EF; Yu, Y; Zhang, Y, 2022) |
| " After the capsaicin-induced pain subsided, the areas of allodynia and hyperalgesia were mapped and itch was provoked inside these areas by histamine (10 mg/mL) and cowhage (25-40 spicules)." | 3.85 | Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study. ( Andersen, HH; Arendt-Nielsen, L; Elberling, J; Gazerani, P; Hauberg, LE; Sharma, N, 2017) |
| " Moreover, similar to wild-type littermates, Nf1± mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia." | 3.79 | Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. ( Brenner, DS; Gereau, RW; Gutmann, DH; O'Brien, DE, 2013) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 3.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| ") inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice." | 3.73 | Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia. ( Costa, KA; Costa, MF; Henriques, MG; Penido, C; Pennaforte, RJ; Pereira, JF; Siani, AC, 2005) |
| " It produces edema on local administration due to the release of histamine and prostaglandins and is associated with hyperalgesia." | 3.73 | Calotropis procera latex-induced inflammatory hyperalgesia--effect of antiinflammatory drugs. ( Kumar, VL; Sehgal, R, 2005) |
| "Yet, hyperalgesia was typically accompanied by hyperknesis." | 2.76 | Sensory responses to injection and punctate application of capsaicin and histamine to the skin. ( Green, BG; LaMotte, RH; Shimada, SG; Sikand, P, 2011) |
| "Histamine 10 microl was injected into each bleb, and the resulting magnitude of itch estimated." | 2.69 | Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. ( Atanassoff, PG; Brull, SJ; Greenquist, K; Lamotte, RH; Silverman, DG; Zhang, J, 1999) |
| "However, in our patient with chronic migraine, the unilateral prick stimulation transiently (over 10 to 12 seconds) increased ipsilateral skin microcirculation at all 3 branches of the trigeminal nerve, with a slight expansion across the midline." | 1.56 | Quantification of Trigeminovascular Hypersensitivity Using Laser Speckle Contrast Analysis in a Patient With Chronic Migraine. ( Unal-Cevik, I; Yilmaz, E, 2020) |
| "In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density." | 1.51 | Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study. ( Agelopoulos, K; Conrad, H; Hatt, H; Hidding, J; Lotts, T; Osada, N; Pereira, MP; Pogatzki-Zahn, E; Schmelz, M; Ständer, S, 2019) |
| "PmV also induced hyperalgesia in both mice and rats, evaluated through electronic von Frey and rat paw pressure test, respectively." | 1.48 | Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents. ( Barbaro, KC; Kimura, LF; Picolo, G; Santos-Neto, M, 2018) |
| "Ongoing neuropathic pain and its attenuation by histamine was assessed using conditioned place-preference test." | 1.43 | Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy. ( Pertovaara, A; Viisanen, H; Wei, H; You, HJ, 2016) |
| "T1AM-induced hyperalgesia (1." | 1.42 | In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine. ( Chiellini, G; De Siena, G; Landucci, E; Laurino, A; Raimondi, L; Saba, A; Zucchi, R, 2015) |
| "Migraine is a neurovascular disorder that induces debilitating headaches associated with multiple symptoms including facial allodynia, characterized by heightened responsivity to normally innocuous mechanical stimuli." | 1.36 | A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats. ( Brown, K; Ellis, A; Mahoney, J; Maier, SF; McFadden, A; Rezvani, N; Sprunger, D; Watkins, LR; Wieseler, J, 2010) |
| "The DHEAS-induced hyperalgesia was abolished by diphenhydramine (DPH), a H(1) histamine (His) receptor antagonist, as well as the hyperalgesia induced by His or compound 48/80, a mast cell degranulating agent." | 1.32 | Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical. ( Mizuno, K; Uchida, H; Ueda, H; Yoshida, A, 2003) |
| "The ability of allergens to induce hyperalgesia in immunoglobulin E (IgE)-sensitized rats was investigated." | 1.32 | Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats. ( Calixto, JB; Cordeiro, RS; e Silva, PM; Lavich, TR; Martins, MA, 2003) |
| "In rats 20 mg kg-1, i." | 1.29 | Role of histamine in rodent antinociception. ( Bartolini, A; Ghelardini, C; Giotti, A; Lamberti, C; Malmberg-Aiello, P, 1994) |
| "Treatment with histamine (0." | 1.29 | Evidence for an inhibitory role of central histamine on carrageenin-induced hyperalgesia. ( Braga, PC; Guidobono, F; Netti, C; Pecile, A; Sibilia, V; Villani, P, 1994) |
| "We assessed hyperalgesia, by measuring tail flick latency following tail immersion in water at 49 degrees C, immediately after releasing the tourniquet and then at 30 min intervals for 2 h." | 1.27 | Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats. ( Butkow, N; Gelgor, L; Mitchell, D; Phillips, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.30) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 10 (23.26) | 29.6817 |
| 2010's | 17 (39.53) | 24.3611 |
| 2020's | 6 (13.95) | 2.80 |
| Authors | Studies |
|---|---|
| De Palma, G | 1 |
| Shimbori, C | 1 |
| Reed, DE | 1 |
| Yu, Y | 1 |
| Rabbia, V | 1 |
| Lu, J | 1 |
| Jimenez-Vargas, N | 1 |
| Sessenwein, J | 1 |
| Lopez-Lopez, C | 1 |
| Pigrau, M | 1 |
| Jaramillo-Polanco, J | 1 |
| Zhang, Y | 1 |
| Baerg, L | 1 |
| Manzar, A | 1 |
| Pujo, J | 1 |
| Bai, X | 1 |
| Pinto-Sanchez, MI | 1 |
| Caminero, A | 1 |
| Madsen, K | 1 |
| Surette, MG | 1 |
| Beyak, M | 1 |
| Lomax, AE | 1 |
| Verdu, EF | 1 |
| Collins, SM | 1 |
| Vanner, SJ | 1 |
| Bercik, P | 1 |
| Unal-Cevik, I | 1 |
| Yilmaz, E | 1 |
| Grundy, L | 1 |
| Caldwell, A | 1 |
| Garcia Caraballo, S | 1 |
| Erickson, A | 1 |
| Schober, G | 1 |
| Castro, J | 2 |
| Harrington, AM | 2 |
| Brierley, SM | 2 |
| Xu, S | 1 |
| Wang, X | 1 |
| Zhao, J | 1 |
| Yang, S | 1 |
| Dong, L | 1 |
| Qin, B | 1 |
| Tsagareli, MG | 1 |
| Nozadze, I | 1 |
| Tsiklauri, N | 1 |
| Carstens, MI | 2 |
| Gurtskaia, G | 1 |
| Carstens, E | 2 |
| Brizuela, M | 1 |
| Andersen, HH | 2 |
| Lo Vecchio, S | 1 |
| Elberling, J | 2 |
| Yosipovitch, G | 1 |
| Arendt-Nielsen, L | 2 |
| Kimura, LF | 1 |
| Santos-Neto, M | 1 |
| Barbaro, KC | 1 |
| Picolo, G | 1 |
| Hidding, J | 1 |
| Agelopoulos, K | 1 |
| Pereira, MP | 1 |
| Conrad, H | 1 |
| Hatt, H | 1 |
| Lotts, T | 1 |
| Osada, N | 1 |
| Pogatzki-Zahn, E | 1 |
| Schmelz, M | 2 |
| Ständer, S | 1 |
| O'Brien, DE | 1 |
| Brenner, DS | 1 |
| Gutmann, DH | 1 |
| Gereau, RW | 1 |
| Akiyama, T | 1 |
| Nagamine, M | 1 |
| Yue, JX | 1 |
| Wang, RR | 1 |
| Yu, J | 1 |
| Tang, YY | 1 |
| Hou, WW | 1 |
| Lou, GD | 1 |
| Zhang, SH | 1 |
| Chen, Z | 1 |
| Wei, H | 2 |
| Jin, CY | 1 |
| Viisanen, H | 2 |
| You, HJ | 2 |
| Pertovaara, A | 2 |
| Laurino, A | 1 |
| De Siena, G | 1 |
| Saba, A | 1 |
| Chiellini, G | 1 |
| Landucci, E | 1 |
| Zucchi, R | 1 |
| Raimondi, L | 1 |
| Pall, PS | 1 |
| Hurwitz, OE | 1 |
| King, BA | 1 |
| LaMotte, RH | 5 |
| Sharma, N | 1 |
| Hauberg, LE | 1 |
| Gazerani, P | 1 |
| Wieseler, J | 1 |
| Ellis, A | 1 |
| Sprunger, D | 1 |
| Brown, K | 1 |
| McFadden, A | 1 |
| Mahoney, J | 1 |
| Rezvani, N | 1 |
| Maier, SF | 1 |
| Watkins, LR | 1 |
| Cenac, N | 1 |
| Altier, C | 1 |
| Motta, JP | 1 |
| d'Aldebert, E | 1 |
| Galeano, S | 1 |
| Zamponi, GW | 1 |
| Vergnolle, N | 1 |
| Mobarakeh, JI | 2 |
| Torkaman-Boutorabi, A | 1 |
| Rahimi, AA | 1 |
| Ghasri, S | 1 |
| Nezhad, RM | 1 |
| Hamzely, A | 1 |
| Khoshkholgh Sima, B | 1 |
| Takahashi, K | 1 |
| Nunoki, K | 1 |
| Yanai, K | 2 |
| Sikand, P | 1 |
| Shimada, SG | 1 |
| Green, BG | 1 |
| Steinhoff, M | 1 |
| Ikoma, A | 1 |
| Ibironke, GF | 1 |
| Mordi, NE | 1 |
| Uchida, H | 1 |
| Mizuno, K | 1 |
| Yoshida, A | 1 |
| Ueda, H | 1 |
| Lavich, TR | 1 |
| Cordeiro, RS | 1 |
| Calixto, JB | 1 |
| e Silva, PM | 1 |
| Martins, MA | 1 |
| SPECKMANN, K | 3 |
| GROSS, U | 1 |
| MOECKEL, W | 2 |
| Simone, DA | 1 |
| Zhang, X | 1 |
| Li, J | 1 |
| Zhang, JM | 1 |
| Honda, CN | 1 |
| Giesler, GJ | 1 |
| Galeotti, N | 1 |
| Malmberg-Aiello, P | 2 |
| Bartolini, A | 2 |
| Schunack, W | 1 |
| Ghelardini, C | 2 |
| Massaad, CA | 1 |
| Safieh-Garabedian, B | 1 |
| Poole, S | 1 |
| Atweh, SF | 1 |
| Jabbur, SJ | 1 |
| Saadé, NE | 1 |
| Schattschneider, J | 2 |
| Bode, A | 1 |
| Wasner, G | 2 |
| Binder, A | 1 |
| Deuschl, G | 1 |
| Baron, R | 2 |
| Penido, C | 1 |
| Costa, KA | 1 |
| Pennaforte, RJ | 1 |
| Costa, MF | 1 |
| Pereira, JF | 1 |
| Siani, AC | 1 |
| Henriques, MG | 1 |
| Sehgal, R | 1 |
| Kumar, VL | 1 |
| Mizumura, K | 1 |
| Minagawa, M | 1 |
| Koda, H | 1 |
| Kumazawa, T | 1 |
| Lamberti, C | 1 |
| Giotti, A | 1 |
| Netti, C | 1 |
| Sibilia, V | 1 |
| Guidobono, F | 1 |
| Villani, P | 1 |
| Pecile, A | 1 |
| Braga, PC | 1 |
| Koppert, W | 1 |
| Zeck, S | 1 |
| Sittl, R | 1 |
| Likar, R | 1 |
| Knoll, R | 1 |
| Atanassoff, PG | 2 |
| Brull, SJ | 2 |
| Zhang, J | 2 |
| Greenquist, K | 1 |
| Silverman, DG | 2 |
| Schwarz, K | 1 |
| Kleinert, A | 1 |
| Sakurada, S | 1 |
| Orito, T | 1 |
| Sakurada, C | 1 |
| Sato, T | 1 |
| Hayashi, T | 1 |
| Onodera, K | 1 |
| Watanabe, T | 1 |
| Sakurada, T | 1 |
| Gelgor, L | 1 |
| Phillips, S | 1 |
| Butkow, N | 1 |
| Mitchell, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for histamine and Allodynia
| Article | Year |
|---|---|
Pruritogenic mechanisms and gut sensation: putting the "irritant" into irritable bowel syndrome.
Topics: Colon; Histamine; Humans; Hyperalgesia; Irritable Bowel Syndrome; Mast Cells; Visceral Pain | 2021 |
4 trials available for histamine and Allodynia
| Article | Year |
|---|---|
Sensory responses to injection and punctate application of capsaicin and histamine to the skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Histamine Agonists; Humans; Hyperalgesia; Injections, Intr | 2011 |
Low-dose lidocaine suppresses experimentally induced hyperalgesia in humans.
Topics: Adult; Anesthetics, Local; Axons; Body Temperature; Double-Blind Method; Female; Histamine; Hot Temp | 1998 |
Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia.
Topics: Adult; Analysis of Variance; Anesthetics, Local; Double-Blind Method; Forearm; Histamine; Humans; Hy | 1999 |
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia.
Topics: Adult; Capsaicin; Forearm; Histamine; Humans; Hyperalgesia; Injections, Intradermal; Male; Middle Ag | 1999 |
38 other studies available for histamine and Allodynia
| Article | Year |
|---|---|
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice.
Topics: Abdominal Pain; Animals; Carbohydrates; Gastrointestinal Microbiome; Histamine; Hyperalgesia; Irrita | 2022 |
Quantification of Trigeminovascular Hypersensitivity Using Laser Speckle Contrast Analysis in a Patient With Chronic Migraine.
Topics: Adult; Chronic Disease; Female; Flunarizine; Histamine; Histamine H1 Antagonists; Humans; Hyperalges | 2020 |
Histamine induces peripheral and central hypersensitivity to bladder distension via the histamine H
Topics: Administration, Intravesical; Animals; Calcium Signaling; Cells, Cultured; Cystitis, Interstitial; F | 2020 |
GPER-mediated, oestrogen-dependent visceral hypersensitivity in stressed rats is associated with mast cell tryptase and histamine expression.
Topics: Abdominal Pain; Animals; Cell Degranulation; Colon; Disease Models, Animal; Estradiol; Female; Hista | 2020 |
Thermal Hyperalgesia and Mechanical Allodynia Elicited by Histamine and Non-histaminergic Itch Mediators: Respective Involvement of TRPV1 and TRPA1.
Topics: Animals; Histamine; Hyperalgesia; Male; Mice; Pruritus; Receptors, G-Protein-Coupled; Transient Rece | 2020 |
UVB- and NGF-induced cutaneous sensitization in humans selectively augments cowhage- and histamine-induced pain and evokes mechanical hyperknesis.
Topics: Adult; Female; Histamine; Humans; Hyperalgesia; Male; Mucuna; Nerve Growth Factor; Nociception; Pain | 2018 |
Potamotrygon motoro stingray venom induces both neurogenic and inflammatory pain behavior in rodents.
Topics: Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Fish Venoms; Histamine; Hyperalgesia; In | 2018 |
Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study.
Topics: Adult; Aged; Aged, 80 and over; Antipruritics; Capsaicin; Case-Control Studies; Chronic Disease; Fem | 2019 |
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1.
Topics: Animals; Capsaicin; Chloroquine; Constriction; Disease Models, Animal; Functional Laterality; Histam | 2013 |
Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlative responses of lumbar dorsal horn neurons in the mouse.
Topics: Action Potentials; Animals; Capsaicin; Disease Models, Animal; Electrophysiology; Hindlimb; Histamin | 2014 |
Histamine upregulates Nav1.8 expression in primary afferent neurons via H2 receptors: involvement in neuropathic pain.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Famotidine; Gang | 2014 |
Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Neurons; A | 2014 |
In the brain of mice, 3-iodothyronamine (T1AM) is converted into 3-iodothyroacetic acid (TA1) and it is included within the signaling network connecting thyroid hormone metabolites with histamine.
Topics: Animals; Avoidance Learning; Behavior, Animal; Biotransformation; Disease Models, Animal; Hippocampu | 2015 |
Psychophysical measurements of itch and nociceptive sensations in an experimental model of allergic contact dermatitis.
Topics: Adjuvants, Immunologic; Cyclobutanes; Dermatitis, Allergic Contact; Female; Histamine; Histamine Ago | 2015 |
Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Hyperalgesia; Ligation | 2016 |
Histaminergic and non-histaminergic elicited itch is attenuated in capsaicin-evoked areas of allodynia and hyperalgesia: A healthy volunteer study.
Topics: Adult; Capsaicin; Female; Healthy Volunteers; Histamine; Humans; Hyperalgesia; Male; Nociceptors; Pa | 2017 |
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Blood-Brain Barrier; Bradykinin; C | 2010 |
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity.
Topics: Animals; Calcium; Cells, Cultured; Colon; Electromyography; Ganglia, Spinal; Gene Silencing; Histami | 2010 |
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag | 2011 |
Dissecting itch and pain sensations in human skin.
Topics: Acute Pain; Capsaicin; Female; Histamine; Humans; Hyperalgesia; Male; Skin | 2011 |
Effect of restraint stress on nociceptive responses in rats: role of the histaminergic system.
Topics: Animals; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists | 2011 |
Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical.
Topics: Animals; Behavior, Animal; Capillary Permeability; Dehydroepiandrosterone Sulfate; Dichlorodiphenyl | 2003 |
Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.
Topics: Allergens; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyproheptadine; Dinitrophenols; Dos | 2003 |
[Effect of histamine and antihistamine on cutaneous wound-hyperalgesia; the problem of histaminergic nerves].
Topics: Anti-Allergic Agents; Histamine; Histamine Agents; Histamine H1 Antagonists; Humans; Hyperalgesia; H | 1953 |
[CONTRIBUTION TO THE QUESTION OF PAIN OR HYPERALGESIA RELEASING SUBSTANCES].
Topics: Anti-Allergic Agents; Contusions; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hy | 1963 |
[HISTAMINE AS THE ACTIVE AGENT IN HYPERALGESIAS OF THE SKIN].
Topics: Histamine; Humans; Hyperalgesia; Hyperesthesia; Pharmacology | 1965 |
Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli.
Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Electrophysiology; Evoked Potentials; H | 2004 |
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway.
Topics: Animals; Behavior, Animal; Calcium; Enzyme Inhibitors; Exploratory Behavior; Histamine; Histamine Ag | 2004 |
Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.
Topics: Analgesics; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Cytokines; Dose-R | 2004 |
Idiopathic restless legs syndrome: abnormalities in central somatosensory processing.
Topics: Blood Flow Velocity; Female; Histamine; Humans; Hyperalgesia; Male; Middle Aged; Nerve Fibers, Unmye | 2004 |
Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia.
Topics: Allergens; Animals; Anti-Allergic Agents; Bradykinin; Capillary Permeability; Dinoprostone; Dose-Res | 2005 |
Calotropis procera latex-induced inflammatory hyperalgesia--effect of antiinflammatory drugs.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Behavior, Animal; Calotropis; Dose-Response | 2005 |
Histamine-induced sensitization of the heat response of canine visceral polymodal receptors.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Histamine; Hot Temperature; Hyperalgesia; Male; Noc | 1994 |
Role of histamine in rodent antinociception.
Topics: Analgesics; Animals; Histamine; Histidine; Hyperalgesia; Male; Methylhistamines; Methylhistidines; M | 1994 |
Evidence for an inhibitory role of central histamine on carrageenin-induced hyperalgesia.
Topics: Animals; Carrageenan; Central Nervous System; Dimaprit; Histamine; Histamine Agonists; Hyperalgesia; | 1994 |
Histamine-induced itch converts into pain in neuropathic hyperalgesia.
Topics: Histamine; Hot Temperature; Humans; Hyperalgesia; Nociceptors; Pain; Pruritus | 2001 |
Possible involvement of tachykinin NK(1) and NMDA receptors in histamine-induced hyperalgesia in mice.
Topics: Animals; Excitatory Amino Acid Antagonists; Histamine; Histamine Antagonists; Hyperalgesia; Male; Mi | 2002 |
Injectable aspirin and mepyramine abolish post-ischaemic hyperalgesia in rats.
Topics: Aminopyridines; Animals; Aspirin; Histamine; Hyperalgesia; Hyperesthesia; Ischemia; Male; Prostaglan | 1986 |