Page last updated: 2024-08-18

pyrroles and Allodynia

pyrroles has been researched along with Allodynia in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (5.26)18.2507
2000's12 (31.58)29.6817
2010's22 (57.89)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Banerjee, P; Behravesh, S; Dodick, DW; Navratilova, E; Oyarzo, J; Porreca, F1
Ding, X; Fan, X; Han, J; Ning, L; Tang, S; Wang, C1
Butt, RP; Dua, P; Gore, K; Gorman, D; Groeneveld, GJ; Hay, JL; Loudon, P; Siebenga, P; van Amerongen, G1
Leánez, S; Pol, O; Redondo, A; Riego, G1
Alves, VS; Costa, R; Dias, FC; Figueiredo, CP; Matias, DO; Miranda, ALP; Passos, GF1
Choi, HY; Jang, C; Lee, JY; Lee, KT; Park, CS; Youn, I; Yune, TY1
Bowen, CA; Fang, X; Heffernan, ML; Hopkins, SC; Large, TH; Spanswick, DC; Spear, KL; Varney, MA; Wei, H; Zhao, FY1
Antunes, F; Barreiro, EJ; Fraga, CA; Mendes, TC; Nascimento, NM; Sudo, RT; Trachez, MM; Zapata-Sudo, G1
Bonanno, G; Di Cesare Mannelli, L; Fariello, RG; Farina, C; Ghelardini, C; Milanese, M; Misiano, P; Pittaluga, A1
Balaganur, V; Kant, V; Kumar, D; Latief, N; Lingaraju, MC; More, AS; Pathak, NN; Tandan, SK1
Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Takeda, K; Watanabe, C1
Abogadie, FC; Bunnett, NW; Darby, B; Grace, MS; Lieu, T; McIntyre, P; Veldhuis, N1
Di Cesare Mannelli, L; Farina, C; Ghelardini, C; Maresca, M; Scherz, MW1
Carcolé, M; Castany, S; Leánez, S; Pol, O1
Anzini, M; Biava, M; Brindisi, M; Brogi, S; Cappelli, A; Di Capua, A; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Pace, S; Poce, G; Rossi, A; Sautebin, L; Sticozzi, C; Valacchi, G1
Crestani, F; Knabl, J; Rudolph, U; Zeilhofer, HU; Zeilhofer, UB1
Almqvist, PM; Finnerup, NB; Gormsen, L; Jensen, TS1
Barreiro, EJ; Fraga, CA; Mendes, TC; Nascimento-Junior, NM; Raimundo, JM; Sudo, RT; Zapata-Sudo, G1
Kumar, VL; Wahane, VD1
Cummons, T; Harrison, JE; Hummel, M; Kennedy, JD; Lu, P; Mark, L; Whiteside, GT1
Guruprasad, B; Kumar, VL; Wahane, VD1
Chen, Y; Wang, ZJ; Yang, C1
Alfonso, S; Anzellotti, P; Anzini, M; Battilocchio, C; Biava, M; Bruno, A; Calderone, V; Di Cesare Mannelli, L; Ghelardini, C; Giordani, A; Giorgi, G; Martelli, A; Papa, G; Patrignani, P; Poce, G; Porretta, GC; Rossi, A; Rovini, M; Sautebin, L; Testai, L; Valenti, S1
Benemei, S; Creminon, C; Fusi, C; Geppetti, P; Materazzi, S; Nassini, R; Nilius, B; Patacchini, R; Pedretti, P; Prenen, J1
Borrelli, G; Borsini, F; Brindisi, M; Butini, S; Cabri, W; Campiani, G; Caprioli, A; Di Serio, S; Fezza, F; Gallo, G; Gemma, S; Maccarrone, M; Maramai, S; Minetti, P; Ros, S; Stasi, MA; Talamonti, E; Vincenti, S1
Dulin, JN; Grill, RJ; Karoly, ED; Strobel, HW; Wang, Y1
Aoki, K; Kimura, T; Nakajima-Yamada, T; Shimozato, T; Tsuchida, J; Ushiyama, S; Wada, Y; Yamada, K; Yasumoto, T1
Barsante, MM; Castro, MS; Pinho, V; Roffê, E; Souza, DG; Tafuri, WL; Teixeira, MM; Yokoro, CM1
Abe, T; Imagawa, N; Ito, M; Matsushita, M; Sagawa, S; Sakoda, K; Sasase, T; Tanaka, M; Yamada, H1
Kulkarni, SK; Patil, CS; Singh, VP1
Cunha, FQ; Cunha, TM; Ferreira, SH; Parada, CA; Poole, S; Santodomingo-Garzón, T; Valério, DA; Verri, WA1
Martinez, V; Taché, Y1
Miranda, A; Nordstrom, E; Sengupta, JN; Smith, C1
Ahmadiani, A; Esmaeili-Mahani, S; Javan, M; Koibuchi, N; Maghsoudi, N; Motamedi, F; Shimokawa, N1
Bradesi, S; Larauche, M; Mayer, EA; McLean, P; McRoberts, JA; Million, M; Taché, Y1
Arban, R; Belardetti, F; Bettelini, L; Carignani, C; Corsi, M; Dal Forno, G; Di Fabio, R; Maraia, G; Mugnaini, M; Quartaroli, M; Ratti, E; Reggiani, A; Trist, DG; Ugolini, A1
Kamei, J; Ohsawa, M1

Reviews

1 review(s) available for pyrroles and Allodynia

ArticleYear
CRF1 receptors as a therapeutic target for irritable bowel syndrome.
    Current pharmaceutical design, 2006, Volume: 12, Issue:31

    Topics: Animals; Brain; Corticotropin-Releasing Hormone; Gastrointestinal Motility; Gastrointestinal Tract; Hormone Antagonists; Humans; Hyperalgesia; Intestinal Mucosa; Irritable Bowel Syndrome; Peptide Fragments; Pyrimidines; Pyrroles; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Urocortins

2006

Trials

2 trial(s) available for pyrroles and Allodynia

ArticleYear
Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:2

    Topics: Adolescent; Adult; Analgesics; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Healthy Volunteers; Humans; Hyperalgesia; Male; Membrane Glycoproteins; Middle Aged; Pain Threshold; Pyrimidines; Pyrroles; Receptor, trkA; Receptor, trkB; Receptor, trkC; Young Adult

2018
The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:4

    Topics: Adult; Aged; Analgesia; Anesthetics, Local; Chronic Disease; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Hyperalgesia; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Pyrroles; Receptors, AMPA; Receptors, Kainic Acid; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Young Adult

2009

Other Studies

35 other study(ies) available for pyrroles and Allodynia

ArticleYear
Ubrogepant does not induce latent sensitization in a preclinical model of medication overuse headache.
    Cephalalgia : an international journal of headache, 2020, Volume: 40, Issue:9

    Topics: Analgesics; Animals; Central Nervous System Sensitization; Disease Models, Animal; Female; Headache Disorders, Secondary; Hyperalgesia; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Sumatriptan

2020
Role of TRPV4-P2X7 Pathway in Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion.
    Neurochemical research, 2021, Volume: 46, Issue:8

    Topics: Animals; Ganglia, Spinal; Hyperalgesia; Leucine; Male; Morpholines; Nerve Compression Syndromes; Neuralgia; Purinergic P2X Receptor Antagonists; Pyrroles; Rats, Wistar; Receptors, Purinergic P2X7; Rosaniline Dyes; Signal Transduction; Sulfonamides; TRPV Cation Channels

2021
Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain.
    Biochemical pharmacology, 2018, Volume: 148

    Topics: Animals; Carbon Monoxide; Central Nervous System; Gene Expression Regulation; Heme Oxygenase-1; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Neuralgia; Organometallic Compounds; Pyrazines; Pyrroles; Sciatic Nerve; Signal Transduction

2018
The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice.
    European journal of pharmacology, 2019, Aug-05, Volume: 856

    Topics: Animals; Body Temperature; Body Weight; Diabetic Neuropathies; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Locomotion; Male; Mice; Morpholines; Psychomotor Performance; Pyrroles; Sciatic Nerve; TRPV Cation Channels

2019
Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats.
    International immunopharmacology, 2019, Volume: 75

    Topics: Animals; Cauda Equina; Celecoxib; Chronic Pain; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Hyperalgesia; Lumbar Vertebrae; Macrophages; Male; Neuralgia; Pyrroles; Rats, Sprague-Dawley; Spinal Stenosis

2019
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 345, Issue:3

    Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarboxylic Acids; D-Amino-Acid Oxidase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Freund's Adjuvant; Furans; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Ligation; Male; Neuralgia; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Spinal Nerves

2013
Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats.
    Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:7

    Topics: Analgesics; Animals; Hyperalgesia; Male; Muscarinic Agonists; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Pyrazoles; Pyridines; Pyrroles; Rats; Rats, Wistar; Receptor, Muscarinic M2; Spinal Nerves

2013
Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain.
    Neuropharmacology, 2014, Volume: 81

    Topics: Analysis of Variance; Animals; Anti-Retroviral Agents; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Hyperalgesia; Imidazoles; Male; Neuralgia; Osteoarthritis, Knee; Paclitaxel; Pain Measurement; Pain Threshold; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Vincristine; Weight-Bearing

2014
Atorvastatin attenuates neuropathic pain in rat neuropathy model by down-regulating oxidative damage at peripheral, spinal and supraspinal levels.
    Neurochemistry international, 2014, Volume: 68

    Topics: Animals; Antioxidants; Atorvastatin; Down-Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Male; Neuralgia; Oxidative Stress; Pyrroles; Rats, Wistar; Sciatic Nerve; Spinal Cord

2014
Potential involvement of μ-opioid receptor dysregulation on the reduced antinociception of morphine in the inflammatory pain state in mice.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:2

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Indoles; Inflammation; Injections, Subcutaneous; Male; Mice; Mice, Inbred Strains; Morphine; Pain; Phosphorylation; Protein Kinase C-alpha; Pyrroles; Receptors, Opioid, mu; Spinal Cord

2014
The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo.
    British journal of pharmacology, 2014, Volume: 171, Issue:16

    Topics: Animals; HEK293 Cells; Humans; Hyperalgesia; Leucine; Male; Mice, Inbred C57BL; Morpholines; Oligopeptides; Pain; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Receptor, PAR-2; Sulfonamides; TRPV Cation Channels; Trypsin

2014
A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam.
    Neurotoxicology, 2015, Volume: 50

    Topics: Analgesics; Analysis of Variance; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Male; Neuralgia; Niacinamide; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pyrroles; Rats; Rats, Sprague-Dawley; Reaction Time; Sorafenib; Time Factors

2015
The antinociceptive effects of a δ-opioid receptor agonist in mice with painful diabetic neuropathy: Involvement of heme oxygenase 1.
    Neuroscience letters, 2016, Feb-12, Volume: 614

    Topics: Analgesics, Opioid; Animals; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Induction; Heme Oxygenase-1; Hyperalgesia; Injections, Subcutaneous; Male; Mice, Inbred C57BL; Organometallic Compounds; Physical Stimulation; Pyrazines; Pyrroles; Receptors, Opioid, delta; Ruthenium

2016
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Adult; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Edema; Halogenation; Humans; Hyperalgesia; Models, Molecular; Pyrroles; Rats; Skin; Skin Neoplasms

2016
The role of spinal thrombin through protease-activated receptor 1 in hyperalgesia after neural injury.
    Journal of neurosurgery. Spine, 2017, Volume: 26, Issue:4

    Topics: Animals; Antithrombins; Capillary Permeability; Central Nervous System Agents; Cervical Vertebrae; Disease Models, Animal; Fibrin; Hirudins; Hyperalgesia; Injections, Spinal; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrroles; Quinazolines; Radiculopathy; Rats, Sprague-Dawley; Receptor, PAR-1; Spinal Cord

2017
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
    Pain, 2009, Volume: 141, Issue:3

    Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Histidine; Hyperalgesia; Indoles; Male; Mice; Mice, Mutant Strains; Motor Activity; Physical Stimulation; Point Mutation; Protein Subunits; Pyrroles; Receptors, GABA-A

2009
Sedation and antinociception induced by a new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivative (LASSBio-873) is modulated by activation of muscarinic receptors.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1

    Topics: Adrenergic alpha-Antagonists; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; GABA Antagonists; Hot Temperature; Hyperalgesia; Hypnotics and Sedatives; Inflammation; Male; Mice; Motor Activity; Muscarinic Antagonists; Narcotic Antagonists; Pain; Pain Measurement; Pyrazoles; Pyridines; Pyrroles; Receptors, Muscarinic

2009
Atorvastatin ameliorates inflammatory hyperalgesia in rat model of monoarticular arthritis.
    Pharmacological research, 2010, Volume: 61, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Diclofenac; Female; Freund's Adjuvant; Heptanoic Acids; Hyperalgesia; Inflammation; Joints; Lower Extremity; Male; Motor Activity; Pyrroles; Rats; Rats, Wistar

2010
Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors.
    Neuropharmacology, 2010, Volume: 59, Issue:3

    Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Corticotropin-Releasing Hormone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Hyperalgesia; Indomethacin; Inflammation; Male; Mice; Pain; Pain Threshold; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Spinal Cord Injuries; Stomach Ulcer; Stress, Psychological

2010
Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis.
    Inflammopharmacology, 2010, Volume: 18, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis, Experimental; Atorvastatin; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Glutathione; Heptanoic Acids; Hyperalgesia; Injections, Intra-Articular; Joints; Male; Oxidative Stress; Pyrroles; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2010
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
    Neuroscience, 2011, Oct-13, Volume: 193

    Topics: Analysis of Variance; Anilides; Animals; Ankyrins; Antineoplastic Agents, Phytogenic; Capsaicin; Carbazoles; Central Nervous System; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Oligopeptides; Paclitaxel; Pain Measurement; Physical Stimulation; Protein Kinase C; Pyrroles; Pyrrolidinones; Receptor, PAR-2; Sulfonamides; Time Factors; TRPV Cation Channels; Tryptases; Type C Phospholipases

2011
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties.
    Journal of medicinal chemistry, 2011, Nov-24, Volume: 54, Issue:22

    Topics: Acetates; Animals; Cell Line; Constriction, Pathologic; Cyclooxygenase 2 Inhibitors; Edema; Esters; Humans; Hyperalgesia; In Vitro Techniques; Isoenzymes; Macrophages; Male; Mice; Models, Molecular; Nitric Oxide Donors; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents

2011
TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism.
    Pflugers Archiv : European journal of physiology, 2012, Volume: 463, Issue:4

    Topics: Acetanilides; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cold Temperature; Drug Hypersensitivity; Glutathione; Hyperalgesia; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Paclitaxel; Peripheral Nervous System Diseases; Purines; Pyrroles; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2012
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
    Journal of medicinal chemistry, 2012, Aug-09, Volume: 55, Issue:15

    Topics: Amidohydrolases; Analgesics; Animals; Brain; CHO Cells; Cricetinae; Cricetulus; Cyclohexanes; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Furans; Humans; Hyperalgesia; Maze Learning; Mice; Models, Molecular; Pain Threshold; Pyrroles; Rats; Recombinant Proteins; Stereotyped Behavior; Structure-Activity Relationship; Thiophenes

2012
Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-09, Volume: 33, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Leukotriene B4; Locomotion; Metabolomics; Oxidative Stress; Physical Stimulation; Pyrroles; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries

2013
R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models.
    European journal of pharmacology, 2005, Jan-04, Volume: 506, Issue:3

    Topics: Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hyperalgesia; Male; Mice; Mice, Inbred DBA; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrroles; Rats; Rats, Inbred Lew

2005
Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis.
    European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Atorvastatin; Chemokine CCL2; Chemokine CCL5; Chemokines, CC; Dose-Response Relationship, Drug; Edema; Female; Heptanoic Acids; Hindlimb; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Interleukin-1; Interleukin-10; Interleukin-6; Leukocytes; Neutrophils; Peroxidase; Pyrroles; Rats; Tarsal Joints; Time Factors; Tumor Necrosis Factor-alpha

2005
Novel protein kinase C-beta isoform selective inhibitor JTT-010 ameliorates both hyper- and hypoalgesia in streptozotocin- induced diabetic rats.
    Diabetes, obesity & metabolism, 2005, Volume: 7, Issue:5

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperalgesia; Hypesthesia; Indans; Male; Neural Conduction; Protein Kinase C; Protein Kinase C beta; Pyrroles; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2005
Anti-inflammatory effect of licofelone against various inflammatory challenges.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Female; Freund's Adjuvant; Granuloma; Hyperalgesia; Indomethacin; Lipoxygenase Inhibitors; Mice; Pain Measurement; Pain Threshold; Pyrroles; Rats; Rats, Wistar; Time Factors; Touch

2006
Atorvastatin inhibits inflammatory hypernociception.
    British journal of pharmacology, 2006, Volume: 149, Issue:1

    Topics: Animals; Atorvastatin; Bradykinin; Cholesterol; Cytokines; Dinoprostone; Enzyme Inhibitors; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperalgesia; Inflammation; Interleukin-1; Lipopolysaccharides; Male; Mice; Nitric Oxide Synthase; Pain Measurement; Pyrroles; Skin

2006
Neonatal gastric suctioning results in chronic visceral and somatic hyperalgesia: role of corticotropin releasing factor.
    Neurogastroenterology and motility, 2007, Volume: 19, Issue:8

    Topics: Abdominal Pain; Animals; Animals, Newborn; Catheterization; Chronic Disease; Corticotropin-Releasing Hormone; Gastric Mucosa; Hot Temperature; Hyperalgesia; Intubation, Gastrointestinal; Male; Manometry; Nociceptors; Pyrimidines; Pyrroles; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Suction

2007
Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.
    Journal of neuroscience research, 2008, Feb-01, Volume: 86, Issue:2

    Topics: Alkaloids; Analgesics, Opioid; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression; GTP-Binding Proteins; Hyperalgesia; Immunoblotting; Indoles; Male; Morphine; Nifedipine; Polymerase Chain Reaction; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Rats; Rats, Wistar; RNA, Messenger; Spinal Cord

2008
Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats.
    American journal of physiology. Gastrointestinal and liver physiology, 2008, Volume: 294, Issue:4

    Topics: Animals; Blood-Brain Barrier; Chronic Disease; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Hyperalgesia; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Mechanotransduction, Cellular; Peptide Fragments; Pressure; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Rectum; Stress, Psychological

2008
Potent antihyperalgesic activity without tolerance produced by glycine site antagonist of N-methyl-D-aspartate receptor GV196771A.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Drug Tolerance; Electrophysiology; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Hyperalgesia; In Vitro Techniques; Indoles; Male; Mice; Pain Measurement; Patch-Clamp Techniques; Pyrroles; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1999
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
    European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3

    Topics: Analysis of Variance; Animals; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Spinal Cord

1999