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ketoprofen and Allodynia

ketoprofen has been researched along with Allodynia in 24 studies

Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."7.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats."7.76Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010)
"Drug effects on formalin-induced mechanical allodynia were evaluated for comparison."5.43Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016)
"Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics."3.96Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020)
" The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats."3.76Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010)
"Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis."3.76Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. ( Azmin, MN; Elrashid, SM; Munavvar, AS; Sakeena, MH; Yam, MF, 2010)
" Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)."3.74Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008)
"Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0."1.62Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021)
"Drug effects on formalin-induced mechanical allodynia were evaluated for comparison."1.43Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016)
"Pretreatment with ketoprofen or meloxicam prevented hyperalgesia and elevation of spinal PGE2, increasing the escape behavior time during forced swimming 95% respect to saline-treated rats."1.42Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia. ( Cardenas, R; Fernandez, AC; Guevara, C; Suarez-Roca, H, 2015)
"Ketoprofen levels were measured by HPLC."1.40Relationship between blood levels and the anti-hyperalgesic effect of ketoprofen in the rat. ( Aguilar-Carrasco, JC; Carrasco-Portugal, Mdel C; Flores-Murrieta, FJ; Jiménez-Andrade, JM; Rodríguez-Silverio, J, 2014)
"The effect of ketoprofen on the postoperative pain was also assessed immunohistochemically by assessing microglial activation in the spinal cord with anti-OX-42 and phosphorylated p38 mitogen-activated protein kinase antibodies."1.38Novel strategy for the control of postoperative pain: long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain. ( Araki, Y; Ito, S; Kaibori, M; Kwon, AH; Matsumura, S, 2012)
"Morphine treatment acutely suppressed the mechanical allodynia, but tolerance to this effect rapidly developed."1.35Sciatic nerve cuffing in mice: a model of sustained neuropathic pain. ( Barrot, M; Benbouzid, M; Doridot, S; Freund-Mercier, MJ; Pallage, V; Poisbeau, P; Rajalu, M; Waltisperger, E, 2008)
"Buprenorphine was associated with adverse effects for as long as 72 h after surgery."1.33Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic. ( Cooper, DM; Hoffman, W; Lee, HY; Wheat, N, 2005)
"Muscle hyperalgesia (post-operative decrease in threshold with respect to pre-stone implantation) was significantly reduced in extent and duration in ketoprofen with respect to saline-injected animals but no difference was found between the pre- and post-operative treatment."1.31Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period. ( Affaitati, G; Giamberardino, MA; Lerza, R; Vecchiet, L, 2000)
"Ketoprofen treatment compared to placebo significantly reduced the size of the cysts and both ureteral and uterine pain behaviors post-stone implantation."1.31Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. ( Affaitati, G; Berkley, KJ; Centurione, L; Giamberardino, MA; Lapenna, D; Lerza, R; Vecchiet, L, 2002)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (16.67)18.2507
2000's8 (33.33)29.6817
2010's10 (41.67)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Bonacorso, HG1
Rosa, WC1
Oliveira, SM1
Brusco, I1
Brum, ES1
Rodrigues, MB1
Frizzo, CP1
Zanatta, N1
Chłoń-Rzepa, G1
Ślusarczyk, M1
Jankowska, A1
Gawalska, A1
Bucki, A1
Kołaczkowski, M1
Świerczek, A1
Pociecha, K1
Wyska, E1
Zygmunt, M1
Kazek, G1
Sałat, K1
Pawłowski, M1
Coutens, B1
Derreumaux, C1
Labaste, F1
Minville, V1
Guiard, BP1
Moulédous, L1
Bounes, V1
Roussin, A1
Frances, B1
Craft, RM1
Hewitt, KA1
Britch, SC1
Aguilar-Carrasco, JC1
Rodríguez-Silverio, J1
Jiménez-Andrade, JM1
Carrasco-Portugal, Mdel C1
Flores-Murrieta, FJ1
Guevara, C1
Fernandez, AC1
Cardenas, R1
Suarez-Roca, H1
Leitl, MD1
Negus, SS1
Romero-Alejo, E1
Puig, MM1
Romero, A1
Drake, RA1
Leith, JL1
Almahasneh, F1
Martindale, J1
Wilson, AW1
Lumb, B1
Donaldson, LF1
Spofford, CM1
Ashmawi, H1
Subieta, A1
Buevich, F1
Moses, A1
Baker, M1
Brennan, TJ1
Combettes, E1
Benhamou, D1
Mazoit, JX1
Beloeil, H1
Sakeena, MH1
Yam, MF1
Elrashid, SM1
Munavvar, AS1
Azmin, MN1
Araki, Y1
Kaibori, M1
Matsumura, S1
Kwon, AH1
Ito, S1
Cooper, DM1
Hoffman, W1
Wheat, N1
Lee, HY1
Whay, HR1
Webster, AJ1
Waterman-Pearson, AE1
Benbouzid, M1
Pallage, V1
Rajalu, M1
Waltisperger, E1
Doridot, S1
Poisbeau, P1
Freund-Mercier, MJ1
Barrot, M1
Girard, P1
Verniers, D1
Coppé, MC1
Pansart, Y1
Gillardin, JM1
Daffonchio, L1
Bestetti, A1
Clavenna, G1
Fedele, G1
Ferrari, MP1
Omini, C1
Giamberardino, MA3
Valente, R1
De Bigontina, P1
Iezzi, S1
Vecchiet, L3
Kido, H1
Murakami, N1
Ito, A1
Kimura, K1
Kodera, N1
Doi, T1
Naruse, T1
Ghezzi, P1
Melillo, G1
Meazza, C1
Sacco, S1
Pellegrini, L1
Asti, C1
Porzio, S1
Marullo, A1
Sabbatini, V1
Caselli, G1
Bertini, R1
Affaitati, G2
Lerza, R2
Shannon, HE1
Jones, CK1
Li, DL1
Peters, SC1
Simmons, RMA1
Iyengar, S1
Berkley, KJ1
Centurione, L1
Lapenna, D1

Other Studies

24 other studies available for ketoprofen and Allodynia

ArticleYear
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
    Bioorganic & medicinal chemistry letters, 2017, 04-01, Volume: 27, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Co

2017
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
    European journal of medicinal chemistry, 2018, Oct-05, Volume: 158

    Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho

2018
Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
    European journal of pharmacology, 2020, May-15, Volume: 875

    Topics: Acute Pain; Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Comb

2020
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
    Behavioural pharmacology, 2021, 04-01, Volume: 32, Issue:2&3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos

2021
Relationship between blood levels and the anti-hyperalgesic effect of ketoprofen in the rat.
    Drug development research, 2014, Volume: 75, Issue:3

    Topics: Analgesics; Animals; Carrageenan; Female; Hot Temperature; Hyperalgesia; Ketoprofen; Rats, Wistar

2014
Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.
    Neuroscience letters, 2015, Mar-30, Volume: 591

    Topics: Animals; Biomarkers; Corticosterone; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors;

2015
Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats.
    Behavioural pharmacology, 2016, Volume: 27, Issue:4

    Topics: Analgesics; Analgesics, Opioid; Animals; Bupropion; Depression; Disease Models, Animal; Dose-Respons

2016
Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation.
    The Journal of pharmacy and pharmacology, 2016, Volume: 68, Issue:8

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, An

2016
Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 08-31, Volume: 36, Issue:35

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arthritis; Disease Models, Anima

2016
Ketoprofen produces modality-specific inhibition of pain behaviors in rats after plantar incision.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Delayed-Action Preparations; Dos

2009
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:7

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Dinoprostone; Dis

2010
Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion.
    Journal of oleo science, 2010, Volume: 59, Issue:12

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Emulsions; Esters;

2010
Novel strategy for the control of postoperative pain: long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Implants; Hydrogels;

2012
Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic.
    Comparative medicine, 2005, Volume: 55, Issue:4

    Topics: Abdomen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Buprenor

2005
Role of ketoprofen in the modulation of hyperalgesia associated with lameness in dairy cattle.
    The Veterinary record, 2005, Dec-03, Volume: 157, Issue:23

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cattle Diseases; Female; Foot Diseases; Hy

2005
Sciatic nerve cuffing in mice: a model of sustained neuropathic pain.
    European journal of pain (London, England), 2008, Volume: 12, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety Disorders; Constriction; Drug Tolerance; E

2008
Nefopam and ketoprofen synergy in rodent models of antinociception.
    European journal of pharmacology, 2008, Apr-28, Volume: 584, Issue:2-3

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A

2008
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates;

1995
Effects of spasmolytic and/or non-steroidal antiinflammatory drugs on muscle hyperalgesia of ureteral origin in rats.
    European journal of pharmacology, 1995, May-15, Volume: 278, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butylscopolammonium Bromide; Electric Stimulation;

1995
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
    Japanese journal of pharmacology, 1998, Volume: 76, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1998
Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: role of cytokine modulation.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cytokines; Dinoprostone; Edema; Guine

1998
Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period.
    Brain research, 2000, Sep-29, Volume: 878, Issue:1-2

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Electric Stimulation; Female;

2000
Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats.
    Pain, 2001, Volume: 93, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Hyperalgesia; Ke

2001
Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats.
    Pain, 2002, Volume: 95, Issue:3

    Topics: Abdominal Muscles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Colic; Cysts;

2002