ketoprofen has been researched along with Allodynia in 24 studies
Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
ketoprofen : An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics." | 7.96 | Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020) |
| " The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 7.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 5.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "Managing severe acute nociceptive pain in buprenorphine-maintained individuals for opioid use disorder management is challenging owing to the high affinity and very slow dissociation of buprenorphine from μ-opioid receptors that hinders the use of full agonist opioid analgesics." | 3.96 | Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia. ( Bounes, V; Coutens, B; Derreumaux, C; Frances, B; Guiard, BP; Labaste, F; Minville, V; Moulédous, L; Roussin, A, 2020) |
| " The aim of this study was to compare the effects of bupivacaine via sciatic block with a systemic NSAID on oedema and hyperalgesia and on indices of systemic inflammation as measured by cytokines and prostaglandin E2 production in a model of peripheral inflammation in rats." | 3.76 | Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats. ( Beloeil, H; Benhamou, D; Combettes, E; Mazoit, JX, 2010) |
| "Ketoprofen is a potent non-steroidal anti-inflammatory drug has been used in the treatment of various kinds of pains, inflammation and arthritis." | 3.76 | Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion. ( Azmin, MN; Elrashid, SM; Munavvar, AS; Sakeena, MH; Yam, MF, 2010) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0." | 1.62 | Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 1.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "Pretreatment with ketoprofen or meloxicam prevented hyperalgesia and elevation of spinal PGE2, increasing the escape behavior time during forced swimming 95% respect to saline-treated rats." | 1.42 | Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia. ( Cardenas, R; Fernandez, AC; Guevara, C; Suarez-Roca, H, 2015) |
| "Ketoprofen levels were measured by HPLC." | 1.40 | Relationship between blood levels and the anti-hyperalgesic effect of ketoprofen in the rat. ( Aguilar-Carrasco, JC; Carrasco-Portugal, Mdel C; Flores-Murrieta, FJ; Jiménez-Andrade, JM; Rodríguez-Silverio, J, 2014) |
| "The effect of ketoprofen on the postoperative pain was also assessed immunohistochemically by assessing microglial activation in the spinal cord with anti-OX-42 and phosphorylated p38 mitogen-activated protein kinase antibodies." | 1.38 | Novel strategy for the control of postoperative pain: long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain. ( Araki, Y; Ito, S; Kaibori, M; Kwon, AH; Matsumura, S, 2012) |
| "Morphine treatment acutely suppressed the mechanical allodynia, but tolerance to this effect rapidly developed." | 1.35 | Sciatic nerve cuffing in mice: a model of sustained neuropathic pain. ( Barrot, M; Benbouzid, M; Doridot, S; Freund-Mercier, MJ; Pallage, V; Poisbeau, P; Rajalu, M; Waltisperger, E, 2008) |
| "Buprenorphine was associated with adverse effects for as long as 72 h after surgery." | 1.33 | Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic. ( Cooper, DM; Hoffman, W; Lee, HY; Wheat, N, 2005) |
| "Muscle hyperalgesia (post-operative decrease in threshold with respect to pre-stone implantation) was significantly reduced in extent and duration in ketoprofen with respect to saline-injected animals but no difference was found between the pre- and post-operative treatment." | 1.31 | Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period. ( Affaitati, G; Giamberardino, MA; Lerza, R; Vecchiet, L, 2000) |
| "Ketoprofen treatment compared to placebo significantly reduced the size of the cysts and both ureteral and uterine pain behaviors post-stone implantation." | 1.31 | Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats. ( Affaitati, G; Berkley, KJ; Centurione, L; Giamberardino, MA; Lapenna, D; Lerza, R; Vecchiet, L, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 10 (41.67) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bonacorso, HG | 1 |
| Rosa, WC | 1 |
| Oliveira, SM | 1 |
| Brusco, I | 1 |
| Brum, ES | 1 |
| Rodrigues, MB | 1 |
| Frizzo, CP | 1 |
| Zanatta, N | 1 |
| Chłoń-Rzepa, G | 1 |
| Ślusarczyk, M | 1 |
| Jankowska, A | 1 |
| Gawalska, A | 1 |
| Bucki, A | 1 |
| Kołaczkowski, M | 1 |
| Świerczek, A | 1 |
| Pociecha, K | 1 |
| Wyska, E | 1 |
| Zygmunt, M | 1 |
| Kazek, G | 1 |
| Sałat, K | 1 |
| Pawłowski, M | 1 |
| Coutens, B | 1 |
| Derreumaux, C | 1 |
| Labaste, F | 1 |
| Minville, V | 1 |
| Guiard, BP | 1 |
| Moulédous, L | 1 |
| Bounes, V | 1 |
| Roussin, A | 1 |
| Frances, B | 1 |
| Craft, RM | 1 |
| Hewitt, KA | 1 |
| Britch, SC | 1 |
| Aguilar-Carrasco, JC | 1 |
| Rodríguez-Silverio, J | 1 |
| Jiménez-Andrade, JM | 1 |
| Carrasco-Portugal, Mdel C | 1 |
| Flores-Murrieta, FJ | 1 |
| Guevara, C | 1 |
| Fernandez, AC | 1 |
| Cardenas, R | 1 |
| Suarez-Roca, H | 1 |
| Leitl, MD | 1 |
| Negus, SS | 1 |
| Romero-Alejo, E | 1 |
| Puig, MM | 1 |
| Romero, A | 1 |
| Drake, RA | 1 |
| Leith, JL | 1 |
| Almahasneh, F | 1 |
| Martindale, J | 1 |
| Wilson, AW | 1 |
| Lumb, B | 1 |
| Donaldson, LF | 1 |
| Spofford, CM | 1 |
| Ashmawi, H | 1 |
| Subieta, A | 1 |
| Buevich, F | 1 |
| Moses, A | 1 |
| Baker, M | 1 |
| Brennan, TJ | 1 |
| Combettes, E | 1 |
| Benhamou, D | 1 |
| Mazoit, JX | 1 |
| Beloeil, H | 1 |
| Sakeena, MH | 1 |
| Yam, MF | 1 |
| Elrashid, SM | 1 |
| Munavvar, AS | 1 |
| Azmin, MN | 1 |
| Araki, Y | 1 |
| Kaibori, M | 1 |
| Matsumura, S | 1 |
| Kwon, AH | 1 |
| Ito, S | 1 |
| Cooper, DM | 1 |
| Hoffman, W | 1 |
| Wheat, N | 1 |
| Lee, HY | 1 |
| Whay, HR | 1 |
| Webster, AJ | 1 |
| Waterman-Pearson, AE | 1 |
| Benbouzid, M | 1 |
| Pallage, V | 1 |
| Rajalu, M | 1 |
| Waltisperger, E | 1 |
| Doridot, S | 1 |
| Poisbeau, P | 1 |
| Freund-Mercier, MJ | 1 |
| Barrot, M | 1 |
| Girard, P | 1 |
| Verniers, D | 1 |
| Coppé, MC | 1 |
| Pansart, Y | 1 |
| Gillardin, JM | 1 |
| Daffonchio, L | 1 |
| Bestetti, A | 1 |
| Clavenna, G | 1 |
| Fedele, G | 1 |
| Ferrari, MP | 1 |
| Omini, C | 1 |
| Giamberardino, MA | 3 |
| Valente, R | 1 |
| De Bigontina, P | 1 |
| Iezzi, S | 1 |
| Vecchiet, L | 3 |
| Kido, H | 1 |
| Murakami, N | 1 |
| Ito, A | 1 |
| Kimura, K | 1 |
| Kodera, N | 1 |
| Doi, T | 1 |
| Naruse, T | 1 |
| Ghezzi, P | 1 |
| Melillo, G | 1 |
| Meazza, C | 1 |
| Sacco, S | 1 |
| Pellegrini, L | 1 |
| Asti, C | 1 |
| Porzio, S | 1 |
| Marullo, A | 1 |
| Sabbatini, V | 1 |
| Caselli, G | 1 |
| Bertini, R | 1 |
| Affaitati, G | 2 |
| Lerza, R | 2 |
| Shannon, HE | 1 |
| Jones, CK | 1 |
| Li, DL | 1 |
| Peters, SC | 1 |
| Simmons, RMA | 1 |
| Iyengar, S | 1 |
| Berkley, KJ | 1 |
| Centurione, L | 1 |
| Lapenna, D | 1 |
24 other studies available for ketoprofen and Allodynia
| Article | Year |
|---|---|
Synthesis of novel trifluoromethyl-substituted spiro-[chromeno[4,3-d]pyrimidine-5,1'-cycloalkanes], and evaluation of their analgesic effects in a mouse pain model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Benzopyrans; Capsaicin; Heterocyclic Co | 2017 |
Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain.
Topics: Amides; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phospho | 2018 |
Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
Topics: Acute Pain; Analgesics; Animals; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Comb | 2020 |
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos | 2021 |
Relationship between blood levels and the anti-hyperalgesic effect of ketoprofen in the rat.
Topics: Analgesics; Animals; Carrageenan; Female; Hot Temperature; Hyperalgesia; Ketoprofen; Rats, Wistar | 2014 |
Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.
Topics: Animals; Biomarkers; Corticosterone; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; | 2015 |
Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Bupropion; Depression; Disease Models, Animal; Dose-Respons | 2016 |
Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, An | 2016 |
Periaqueductal Grey EP3 Receptors Facilitate Spinal Nociception in Arthritic Secondary Hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arthritis; Disease Models, Anima | 2016 |
Ketoprofen produces modality-specific inhibition of pain behaviors in rats after plantar incision.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Delayed-Action Preparations; Dos | 2009 |
Comparison of a bupivacaine peripheral nerve block and systemic ketoprofen on peripheral inflammation and hyperalgesia in rats.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Dinoprostone; Dis | 2010 |
Anti-inflammatory and analgesic effects of ketoprofen in palm oil esters nanoemulsion.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Emulsions; Esters; | 2010 |
Novel strategy for the control of postoperative pain: long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Implants; Hydrogels; | 2012 |
Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic.
Topics: Abdomen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Buprenor | 2005 |
Role of ketoprofen in the modulation of hyperalgesia associated with lameness in dairy cattle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cattle Diseases; Female; Foot Diseases; Hy | 2005 |
Sciatic nerve cuffing in mice: a model of sustained neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety Disorders; Constriction; Drug Tolerance; E | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Effects of a new foam formulation of ketoprofen lysine salt in experimental models of inflammation and hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Exudates and Transudates; | 1995 |
Effects of spasmolytic and/or non-steroidal antiinflammatory drugs on muscle hyperalgesia of ureteral origin in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butylscopolammonium Bromide; Electric Stimulation; | 1995 |
Anti-inflammatory, analgesic and anti-pyretic effects of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a new non-steroidal anti-inflammatory drug, in rats and guinea pigs.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1998 |
Differential contribution of R and S isomers in ketoprofen anti-inflammatory activity: role of cytokine modulation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cytokines; Dinoprostone; Edema; Guine | 1998 |
Pre-emptive analgesia in rats with artificial ureteric calculosis. Effects on visceral pain behavior in the post-operative period.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Electric Stimulation; Female; | 2000 |
Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Hyperalgesia; Ke | 2001 |
Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats.
Topics: Abdominal Muscles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Colic; Cysts; | 2002 |