spironolactone has been researched along with Allodynia in 4 studies
Spironolactone: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
spironolactone : A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute stress induced transient visceral hyperalgesia, which was absent 24 h after WAS and independent of GR and MR." | 1.38 | Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress. ( Greenwood-Van Meerveld, B; Myers, B, 2012) |
| "Tail flick latency, an index of hyperalgesia, was assessed by analgesiometer." | 1.35 | Ameliorative potential of spironolactone in diabetes induced hyperalgesia in mice. ( Bakshi, KS; Jaggi, AS; Khan, N; Singh, N, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, N | 1 |
| Bakshi, KS | 1 |
| Jaggi, AS | 2 |
| Singh, N | 2 |
| Myers, B | 2 |
| Greenwood-Van Meerveld, B | 2 |
4 other studies available for spironolactone and Allodynia
| Article | Year |
|---|---|
Ameliorative potential of spironolactone in diabetes induced hyperalgesia in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Hyperalgesia; Male; Mice; Nitric Oxide; Spironolac | 2009 |
Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats.
Topics: Animals; Constriction; Female; Foot Deformities; Hyperalgesia; Male; Neuralgia; Rats; Rats, Wistar; | 2010 |
Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress.
Topics: Amygdala; Animals; Colon; Hormone Antagonists; Hyperalgesia; Irritable Bowel Syndrome; Male; Mifepri | 2012 |
Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Catheterization; Colon; Drug Implants; Hormone Antagon | 2007 |