Page last updated: 2024-10-22

am 251 and Allodynia

am 251 has been researched along with Allodynia in 31 studies

AM 251: an analog of SR141716A; structure given in first source
AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.

Research Excerpts

ExcerptRelevanceReference
"Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization."7.78Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. ( Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV, 2012)
") suppressed the maintenance of mechanical and cold allodynia in the cisplatin and paclitaxel models."7.78The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. ( Deng, L; Guindon, J; Hohmann, AG; Makriyannis, A; Thakur, GA; Vemuri, VK; White, FA, 2012)
"Seven days of treatment with CBD reduced mechanical allodynia, decreased anxiety-like behavior, and normalized 5-HT activity."5.51Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. ( Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L, 2019)
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents."5.34New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007)
"The pharmacological inhibition of anandamide (AEA) hydrolysis by fatty acid amide hydrolase (FAAH) attenuates pain in animal models of osteoarthritis (OA) but has failed in clinical trials."3.81A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis. ( Binkowski, M; Czaja, M; Di Marzo, V; Kolosowska, N; Makuch, W; Malek, N; Morera, E; Mrugala, M; Przewlocka, B; Starowicz, K, 2015)
"Spinal glial activation has been implicated in sustained morphine-mediated paradoxical pain sensitization."3.78Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist. ( Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV, 2012)
") suppressed the maintenance of mechanical and cold allodynia in the cisplatin and paclitaxel models."3.78The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. ( Deng, L; Guindon, J; Hohmann, AG; Makriyannis, A; Thakur, GA; Vemuri, VK; White, FA, 2012)
"This study shows that electroacupuncture increases the anandamide level in inflammatory skin tissues, and CB2 receptors contribute to the analgesic effect of electroacupuncture in a rat model of inflammatory pain."3.75Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats. ( Chen, L; Li, F; Li, M; Li, YH; Pan, HL; Qiu, Y; Shi, J; Wang, L; Zhang, J, 2009)
"AM404 attenuated mechanical and cold hyperalgesia with minimal effects on motor coordination."1.62Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model. ( Hara, K; Haranishi, Y; Terada, T, 2021)
"Pain is a prevalent PD's non-motor symptom with a higher prevalence of analgesic drugs prescription for patients."1.56Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease. ( Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS, 2020)
"Seven days of treatment with CBD reduced mechanical allodynia, decreased anxiety-like behavior, and normalized 5-HT activity."1.51Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. ( Aboud, M; Comai, S; De Gregorio, D; Enns, J; Gobbi, G; Lopez-Canul, M; Maione, S; McLaughlin, RJ; Ochoa-Sanchez, R; Posa, L, 2019)
"Paclitaxel produced mechanical and cold allodynia without altering nestlet shredding or marble burying behaviors."1.48Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit. ( Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK, 2018)
"MCS reversed mechanical hyperalgesia, inhibited astrocyte and microglial activity, decreased proinflammatory cytokine staining, enhanced CB2 staining, and downregulated P2X4 receptors in the DHSC ipsilateral to sciatic injury."1.42The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain? ( Fonoff, ET; Lopes, PS; Pagano, RL; Silva, GD, 2015)
"Mechanical allodynia and thermal hyperalgesia were evaluated in 436 male C57BL/6, cnr1KO and cnr2KO mice in the presence or absence of cannabinoid CB₁ (AM251) or CB₂ (AM630) receptor antagonists in a mouse model of neuropathic pain."1.40Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors. ( Beaulieu, P; Bouchard, JF; Charron, S; Desroches, J, 2014)
"Mechanical allodynia and thermal hyperalgesia were tested on ventral paw for 14 days."1.40Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. ( Iwasaki, H; Mao, J; Martyn, JA; Murata, E; Poon, KY; Ueda, M; Wang, S, 2014)
"To induce hyperalgesia, rat paws were treated with intraplantar prostaglandin E2 (PGE2, 2μg)."1.39Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors. ( Duarte, ID; Pacheco, Dda F; Romero, TR, 2013)
"However, RVM inactivation blocked the hyperalgesia produced upon removal from the EPM."1.38Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia. ( Cornélio, AM; Morgan, MM; Nunes-de-Souza, RL, 2012)
"The effects of NADA and EM on thermal hyperalgesia were evaluated in rats with a unilateral hind paw carrageenan-induced inflammation."1.37The antinociceptive potency of N-arachidonoyl-dopamine (NADA) and its interaction with endomorphin-1 at the spinal level. ( Benedek, G; Farkas, I; Horvath, G; Tuboly, G, 2011)
"Thermal hyperalgesia was significantly ameliorated in a dose-dependent manner with systemically administered WIN."1.36Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain. ( Ahmed, MM; Allcock, B; Gerovac, TA; McChesney, S; Miranpuri, GS; Patel, AU; Rajpal, S; Resnick, DK; Sweeney, C; Tilghman, JI, 2010)
"The NAGly induced anti-allodynia was dose dependent and, unlike HU-210, was unaffected by the cannabinoid CB(1) and CB(2) receptor antagonists, AM251 and SR144528 (30 nmol)."1.35Actions of N-arachidonyl-glycine in a rat neuropathic pain model. ( Mitchell, VA; Vaughan, CW; Vuong, LA, 2008)
"N-arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential vanilloid-type 1 (TRPV1) channels and is analgesic in rodents."1.34New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. ( Cascio, MG; de Novellis, V; De Petrocellis, L; Di Marzo, V; Maione, S; Morera, E; Nalli, M; Ortar, G; Rossi, F; Schiano-Moriello, A; Woodward, DF, 2007)
"Mechanical allodynia and thermal hyperalgesia were evaluated in 46 rats allocated to receive: (1) Vehicle (before surgery)-Vehicle (after surgery); (2) Vehicle-WIN55,212-2; (3) WIN55,212-2-Vehicle; (4) WIN55,212-2-WIN55,212-2; (5) AM251+vehicle; (6) AM251+WIN55,212-2; (7) AM630+vehicle; (8) AM630+WIN55,212-2; (9) Sham receiving vehicle; and (10) Sham receiving WIN55,212-2."1.34Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain. ( Beaulieu, P; Dani, M; Desroches, J; Guindon, J, 2007)
"Both mechanical allodynia and thermal hyperalgesia are seen both ipsilateral and contralateral to the side of nerve injury, but is significantly more severe ipsilaterally."1.34The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain. ( Hsu, KS; Huang, CC; Liang, YC, 2007)
"Paracetamol dose-dependently decreased mechanical allodynia and lowered nociceptive scores associated with hyperalgesia testing."1.34The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. ( Beaulieu, P; Dani, M; Guindon, J; Lambert, C, 2007)
"WIN 55,212-2 attenuated both heat and mechanical hyperalgesia dose-dependently."1.32Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury. ( Johanek, LM; Simone, DA, 2004)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (29.03)29.6817
2010's20 (64.52)24.3611
2020's2 (6.45)2.80

Authors

AuthorsStudies
Ortar, G1
Cascio, MG1
De Petrocellis, L1
Morera, E2
Rossi, F1
Schiano-Moriello, A1
Nalli, M1
de Novellis, V1
Woodward, DF1
Maione, S2
Di Marzo, V2
Crivelaro do Nascimento, G1
Ferrari, DP1
Guimaraes, FS1
Del Bel, EA1
Bortolanza, M1
Ferreira-Junior, NC1
Haranishi, Y1
Hara, K1
Terada, T1
Segat, GC1
Manjavachi, MN1
Matias, DO1
Passos, GF1
Freitas, CS1
Costa, R1
Calixto, JB1
Giorno, TBS1
Moreira, IGDS1
Rezende, CM1
Fernandes, PD1
De Gregorio, D1
McLaughlin, RJ1
Posa, L1
Ochoa-Sanchez, R1
Enns, J1
Lopez-Canul, M1
Aboud, M1
Comai, S1
Gobbi, G1
Slivicki, RA2
Saberi, SA1
Iyer, V1
Vemuri, VK2
Makriyannis, A2
Hohmann, AG3
Freitas, RL1
Salgado-Rohner, CJ1
Hallak, JE1
Crippa, JA1
Coimbra, NC1
Duncan, M1
Galic, MA1
Wang, A1
Chambers, AP1
McCafferty, DM1
McKay, DM1
Sharkey, KA1
Pittman, QJ1
Desroches, J2
Charron, S1
Bouchard, JF1
Beaulieu, P3
Ueda, M1
Iwasaki, H1
Wang, S1
Murata, E1
Poon, KY1
Mao, J1
Martyn, JA1
Krustev, E1
Reid, A1
McDougall, JJ1
Silva, GD1
Lopes, PS1
Fonoff, ET1
Pagano, RL1
Malek, N1
Mrugala, M1
Makuch, W1
Kolosowska, N1
Przewlocka, B1
Binkowski, M1
Czaja, M1
Starowicz, K1
Parvathy, SS1
Masocha, W1
Carey, LM1
Leishman, E1
Cornett, B1
Mackie, K1
Bradshaw, H1
Chen, L1
Zhang, J1
Li, F1
Qiu, Y1
Wang, L1
Li, YH1
Shi, J1
Pan, HL1
Li, M1
Ahmed, MM1
Rajpal, S1
Sweeney, C1
Gerovac, TA1
Allcock, B1
McChesney, S1
Patel, AU1
Tilghman, JI1
Miranpuri, GS1
Resnick, DK1
Farkas, I1
Tuboly, G1
Benedek, G1
Horvath, G1
Tumati, S1
Largent-Milnes, TM1
Keresztes, A1
Ren, J1
Roeske, WR1
Vanderah, TW1
Varga, EV1
Escobar, W1
Ramirez, K1
Avila, C1
Limongi, R1
Vanegas, H1
Vazquez, E1
Cornélio, AM1
Nunes-de-Souza, RL1
Morgan, MM1
Deng, L1
Guindon, J3
Thakur, GA1
White, FA1
Romero, TR1
Pacheco, Dda F1
Duarte, ID2
Johanek, LM1
Simone, DA1
Liu, C1
Walker, JM1
Dani, M2
Liang, YC1
Huang, CC1
Hsu, KS1
Vuong, LA1
Mitchell, VA1
Vaughan, CW1
Lambert, C1
da Fonseca Pacheco, D1
Klein, A1
de Castro Perez, A1
da Fonseca Pacheco, CM1
de Francischi, JN1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Dose Controlled Diabetic Neuropathic Pain Study Using Non-Intoxicating Cannabidiol in a Rapidly Dissolvable Sublingual Tablet[NCT04088929]Phase 232 participants (Actual)Interventional2019-09-30Completed
A Randomized, Double-Blind, Placebo-Controlled Trial Using Cannabidiol for the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet[NCT04679545]Phase 250 participants (Anticipated)Interventional2020-12-10Recruiting
Cannabinoids and an Anti-inflammatory Diet for the Treatment of Neuropathic Pain After Spinal Cord Injury[NCT04057456]Phase 3140 participants (Anticipated)Interventional2023-03-01Recruiting
A Randomized, Double-Blind, Placebo-Controlled Trial Using Cannabidiol and Palmitoylethanolamide for the Treatment of Painful Diabetic Peripheral Neuropathy of the Feet[NCT05766969]Phase 1/Phase 252 participants (Anticipated)Interventional2023-06-05Not yet recruiting
Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269]Phase 230 participants (Anticipated)Interventional2020-04-20Recruiting
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms[NCT05142267]120 participants (Anticipated)Interventional2022-03-02Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

31 other studies available for am 251 and Allodynia

ArticleYear
New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain.
    Journal of medicinal chemistry, 2007, Dec-27, Volume: 50, Issue:26

    Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Biphenyl Compounds; Brain; Calcium; Carbama

2007
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
    Neuropharmacology, 2020, Volume: 163

    Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecox

2020
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:3

    Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyper

2021
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.
    Neuropharmacology, 2017, Volume: 125

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phyto

2017
New
    Scientific reports, 2018, 07-03, Volume: 8, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy

2018
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.
    Pain, 2019, Volume: 160, Issue:1

    Topics: Action Potentials; Animals; Anxiety; Cannabidiol; Capsaicin; Disease Models, Animal; Exploratory Beh

2019
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides;

2018
Involvement of prelimbic medial prefrontal cortex in panic-like elaborated defensive behaviour and innate fear-induced antinociception elicited by GABAA receptor blockade in the dorsomedial and ventromedial hypothalamic nuclei: role of the endocannabinoid
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:8

    Topics: Analysis of Variance; Animals; Bicuculline; Defense Mechanisms; Disease Models, Animal; Dose-Respons

2013
Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-01, Volume: 305, Issue:3

    Topics: Animals; Body Temperature; Cytokines; Data Interpretation, Statistical; Fever; Hyperalgesia; Immunit

2013
Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB₁ and CB₂ receptors.
    Neuropharmacology, 2014, Volume: 77

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Endocannabinoids; Glycerides; Hyperalgesia; Male; Mice

2014
Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.
    Anesthesiology, 2014, Volume: 121, Issue:6

    Topics: Aging; Analgesics, Non-Narcotic; Animals; Burns; Hyperalgesia; Injections, Spinal; Male; Neuroglia;

2014
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
    Arthritis research & therapy, 2014, Sep-27, Volume: 16, Issue:5

    Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannab

2014
The spinal anti-inflammatory mechanism of motor cortex stimulation: cause of success and refractoriness in neuropathic pain?
    Journal of neuroinflammation, 2015, Jan-20, Volume: 12

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cytokines; Deep B

2015
A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
    Pain, 2015, Volume: 156, Issue:5

    Topics: Activating Transcription Factor 3; Amidohydrolases; Anilides; Animals; Arachidonic Acids; Benzamides

2015
Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors.
    Scientific reports, 2015, Jun-18, Volume: 5

    Topics: Animals; Female; Hyperalgesia; Indomethacin; Male; Mice; Mice, Inbred BALB C; Minocycline; Paclitaxe

2015
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
    Molecular pain, 2016, Volume: 12

    Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heter

2016
Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats.
    The journal of pain, 2009, Volume: 10, Issue:7

    Topics: Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Electroacupuncture; Endocannabinoi

2009
Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain.
    The spine journal : official journal of the North American Spine Society, 2010, Volume: 10, Issue:12

    Topics: Analgesics; Analysis of Variance; Animals; Benzoxazines; Dose-Response Relationship, Drug; Hot Tempe

2010
The antinociceptive potency of N-arachidonoyl-dopamine (NADA) and its interaction with endomorphin-1 at the spinal level.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4

    Topics: Acrylamides; Analgesics; Animals; Arachidonic Acids; Area Under Curve; Bridged Bicyclo Compounds, He

2011
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
    Journal of neuroimmunology, 2012, Volume: 244, Issue:1-2

    Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoids; Hyperalgesia; Indoles; Inflammation; Interleu

2012
Metamizol, a non-opioid analgesic, acts via endocannabinoids in the PAG-RVM axis during inflammation in rats.
    European journal of pain (London, England), 2012, Volume: 16, Issue:5

    Topics: Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Modulators

2012
Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia.
    Brain research, 2012, Apr-23, Volume: 1450

    Topics: Animals; Anxiety; GABA-A Receptor Agonists; Hyperalgesia; Male; Medulla Oblongata; Muscimol; Pain Me

2012
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
    Molecular pain, 2012, Sep-22, Volume: 8

    Topics: Animals; Benzylamines; Chromones; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Cyclams; Disea

2012
Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors.
    Life sciences, 2013, May-02, Volume: 92, Issue:14-16

    Topics: Amides; Analysis of Variance; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Rece

2013
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Animals; Benzoxazines; Burns; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disea

2004
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.
    Journal of neurophysiology, 2006, Volume: 96, Issue:6

    Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Canna

2006
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain.
    European journal of pharmacology, 2007, Jul-30, Volume: 568, Issue:1-3

    Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Hyperalgesia; Indoles; Male; Morpholines; Naphthale

2007
The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Disease Models, Animal; Dose-

2007
Actions of N-arachidonyl-glycine in a rat neuropathic pain model.
    Neuropharmacology, 2008, Volume: 54, Issue:1

    Topics: Analgesics; Animals; Arachidonic Acids; Area Under Curve; Camphanes; Disease Models, Animal; Dose-Re

2008
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonist

2007
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Benzomorphans; Cannabin

2008