A glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q06210]
EC 2.6.1.16;
D-fructose-6-phosphate amidotransferase 1;
Glutamine:fructose-6-phosphate amidotransferase 1;
GFAT 1;
GFAT1;
Hexosephosphate aminotransferase 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| aaptamine | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| n(3)-(4-methoxyfumaroyl)-2,3-diaminopropionic acid | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | molecular function | Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. [EC:2.6.1.16, RHEA:13237] |
| carbohydrate derivative binding | molecular function | Binding to a carbohydrate derivative. [GOC:pr] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| UDP-N-acetylglucosamine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai] |
| energy reserve metabolic process | biological process | The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. [GOC:mah] |
| glutamine metabolic process | biological process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. [GOC:ai] |
| circadian regulation of gene expression | biological process | Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. [GOC:mah] |
| UDP-N-acetylglucosamine metabolic process | biological process | The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai] |
| fructose 6-phosphate metabolic process | biological process | The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism. [ISBN:0198506732] |
| protein N-linked glycosylation | biological process | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] |