Compounds > no 711
Page last updated: 2024-09-20

no 711

Cross-References

ID SourceID
PubMed CID4515
CHEMBL ID473104
CHEBI ID92744
SCHEMBL ID5969062
MeSH IDM0211110

Synonyms (40)

Synonym
BRD-K42221274-001-01-4
BIOMOL-NT_000271
NCGC00015712-01
tocris-1779
lopac-n-142
NCGC00025293-01
LOPAC0_000880
BPBIO1_000948
nnc-711
NCGC00025293-03
no-711
NCGC00025293-02
NCGC00015712-05
bdbm50080344
1-(2-benzhydrylideneaminooxy-ethyl)-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid; hydrochloride
CHEMBL473104 ,
1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2h-pyridine-5-carboxylic acid
CCG-204962
NCGC00015712-02
NCGC00015712-04
NCGC00015712-03
159094-94-7
3-pyridinecarboxylic acid, 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-
bgu9mz2g30 ,
unii-bgu9mz2g30
1-(2-{[(diphenylmethylidene)amino]oxy}ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid
gtpl4669
bdbm50426075
SCHEMBL5969062
DTXSID30166582
CHEBI:92744
1,2,5,6-tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid
Q27891706
BRD-K42221274-003-02-8
SDCCGSBI-0050855.P002
NCGC00015712-08
1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylicacid
1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid
9BC ,
3-pyridinecarboxylic acid, 1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-1,2,5,6-tetrahydro-

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thioredoxin reductaseRattus norvegicus (Norway rat)Potency10.00000.100020.879379.4328AID588453
arylsulfatase AHomo sapiens (human)Potency0.05361.069113.955137.9330AID720538
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency14.12540.035520.977089.1251AID504332
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency0.00630.00207.533739.8107AID891
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency0.19950.316212.443531.6228AID902
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency6.30961.000012.232631.6228AID1452
cytochrome P450 2C19 precursorHomo sapiens (human)Potency17.55950.00255.840031.6228AID899
cytochrome P450 2C9 precursorHomo sapiens (human)Potency35.71680.00636.904339.8107AID883
chromobox protein homolog 1Homo sapiens (human)Potency0.02380.006026.168889.1251AID488953
mitogen-activated protein kinase 1Homo sapiens (human)Potency0.15850.039816.784239.8107AID995
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency25.11890.00106.000935.4813AID943
lethal factor (plasmid)Bacillus anthracis str. A2012Potency28.37090.020010.786931.6228AID912
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency35.71680.00638.235039.8107AID883
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.16940.060110.745337.9330AID485368
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)IC50 (µMol)0.18090.03712.19228.5114AID1272002; AID1736160; AID370903; AID722623; AID722624
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)IC50 (µMol)623.61331.41255.26838.1283AID1272004; AID1736159; AID370905
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)IC50 (µMol)735.53971.54883.67618.1283AID1272005; AID1736158; AID1736188; AID370906
Sodium- and chloride-dependent betaine transporterMus musculus (house mouse)IC50 (µMol)815.47850.18003.188010.0000AID1272003; AID370904
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)Kd0.02650.02650.02650.0265AID1544946
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (41)

Assay IDTitleYearJournalArticle
AID1602655Inhibition of GAT-1 in rat brain homogenate assessed as decrease in [3H]GABA uptake preincubated for 8 mins followed by [3H]GABA addition and measured after 8 mins by scintillation counting analysis2019Bioorganic & medicinal chemistry, 04-01, Volume: 27, Issue:7
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
AID1272005Inhibition of mouse GAT3 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.
AID751641Displacement of [3H]GABA from GABA transporter in Wistar rat cerebral cortex after 20 mins2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
AID1736158Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation method2020European journal of medicinal chemistry, Feb-15, Volume: 188Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
AID1272004Inhibition of mouse GAT2 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.
AID722623Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysis2013Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
AID751706Displacement of [3H]GABA from GABA transporter in Wistar rat cerebral cortex at 10 uM after 20 mins relative to control2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
AID1736160Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation method2020European journal of medicinal chemistry, Feb-15, Volume: 188Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
AID370903Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK cells2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
AID722622Binding affinity to mouse GAT1 expressed in HEK293 cells membranes assessed as remaining [2H10]NO711 binding level at 10 uM using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay2013Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
AID1272002Inhibition of mouse GAT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.
AID370904Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK cells2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
AID1736159Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation method2020European journal of medicinal chemistry, Feb-15, Volume: 188Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
AID1573613Inhibition of human GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition and measured after 4 mins by liquid scintillation counting method2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries.
AID1272003Inhibition of mouse BGT1 mediated [3]GABA uptake expressed in HEK293 cells after 3 mins by scintillation counting2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.
AID370906Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK cells2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
AID1544946Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presence of NO711 by LC-ESI-MS/MS analysis relative to control2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1).
AID722624Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assay2013Journal of medicinal chemistry, Feb-14, Volume: 56, Issue:3
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward γ-aminobutyric acid transporter 1.
AID1736188Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation method2020European journal of medicinal chemistry, Feb-15, Volume: 188Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
AID370905Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK cells2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
AID1347050Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504836Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation2002The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
AID1347410qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library2019Cellular signalling, 08, Volume: 60A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347151Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347405qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347057CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID588378qHTS for Inhibitors of ATXN expression: Validation
AID588349qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay
AID1347049Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347058CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347059CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation2019PloS one, , Volume: 14, Issue:7
Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347045Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line2019Science translational medicine, 07-10, Volume: 11, Issue:500
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1346940Human GAT1 (GABA transporter subfamily)1994European journal of pharmacology, Oct-14, Volume: 269, Issue:2
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's2 (10.00)29.6817
2010's11 (55.00)24.3611
2020's6 (30.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
tiagabine[no description available]medium70beta-amino acid;
piperidinemonocarboxylic acid;
tertiary amino compound;
thiophenes		anticonvulsant;
GABA reuptake inhibitor
ci 966[no description available]medium10diarylmethane
guvacine[no description available]medium40alpha,beta-unsaturated monocarboxylic acid;
beta-amino acid;
pyridine alkaloid;
secondary amino compound;
tetrahydropyridine		GABA reuptake inhibitor;
plant metabolite
nipecotic acid[no description available]medium30beta-amino acid;
piperidinemonocarboxylic acid
n-(4,4-diphenyl-3-butenyl)nipecotic acid[no description available]medium30diarylmethane
nipecotic acid[no description available]medium20amino acid zwitterion;
nipecotic acid
nipecotic acid, (s)-isomer[no description available]medium20nipecotic acid
snap 5114[no description available]medium30
gamma-aminobutyric acid[no description available]medium50amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
melatonin[no description available]medium10acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
epibatidine[no description available]medium10alkaloid
astemizole[no description available]medium10benzimidazoles;
piperidines		anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist
desipramine[no description available]medium10dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
diazepam[no description available]medium101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
dibucaine[no description available]medium10aromatic ether;
monocarboxylic acid amide;
tertiary amino compound		topical anaesthetic
fluoxetine[no description available]medium10(trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound
glyburide[no description available]medium10monochlorobenzenes;
N-sulfonylurea		anti-arrhythmia drug;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor;
hypoglycemic agent
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
ketanserin[no description available]medium10aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist
nitrendipine[no description available]medium10C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent
prazosin[no description available]medium10aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
pyrilamine[no description available]medium10aromatic ether;
ethylenediamine derivative		H1-receptor antagonist
rolipram[no description available]medium10pyrrolidin-2-onesantidepressant;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
spiperone[no description available]medium10aromatic ketone;
azaspiro compound;
organofluorine compound;
piperidines;
tertiary amino compound		alpha-adrenergic antagonist;
antipsychotic agent;
dopaminergic antagonist;
psychotropic drug;
serotonergic antagonist
triiodothyronine[no description available]medium102-halophenol;
amino acid zwitterion;
iodophenol;
iodothyronine		human metabolite;
mouse metabolite;
thyroid hormone
yohimbine[no description available]medium10methyl 17-hydroxy-20xi-yohimban-16-carboxylatealpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
metergoline[no description available]medium10carbamate ester;
ergoline alkaloid		dopamine agonist;
geroprotector;
serotonergic antagonist
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
diltiazem[no description available]medium105-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetateantihypertensive agent;
calcium channel blocker;
vasodilator agent
tiotidine[no description available]medium10thiazoles
idazoxan[no description available]medium10benzodioxine;
imidazolines		alpha-adrenergic antagonist
alpha,beta-methyleneadenosine 5'-triphosphate[no description available]medium10nucleoside triphosphate analogue
phenylisopropyladenosine[no description available]medium10aromatic amine;
benzenes;
hydrocarbyladenosine;
purine nucleoside;
secondary amino compound		adenosine A1 receptor agonist;
neuroprotective agent
1-hexadecyl-2-acetyl-glycero-3-phosphocholine[no description available]medium102-acetyl-1-alkyl-sn-glycero-3-phosphocholineantihypertensive agent;
beta-adrenergic antagonist;
bronchoconstrictor agent;
hematologic agent;
vasodilator agent
kallidin, des-arg(10)-[no description available]medium10
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine[no description available]medium10adenosines;
monocarboxylic acid amide;
organoiodine compound		adenosine A3 receptor agonist
alpha-methylhistamine[no description available]medium10aralkylamino compound;
imidazoles		H3-receptor agonist
bradykinin[no description available]medium10oligopeptidehuman blood serum metabolite;
vasodilator agent
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
bemesetron[no description available]medium10
4-diphenylacetoxy-n-methylpiperidine methiodide[no description available]medium10iodide salt;
quaternary ammonium salt		cholinergic antagonist;
muscarinic antagonist
sch 23390[no description available]medium10benzazepine
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
leukotriene d4[no description available]medium10dipeptide;
leukotriene;
organic sulfide		bronchoconstrictor agent;
human metabolite;
mouse metabolite
(3r)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone[no description available]medium10morpholines;
naphthyl ketone;
organic heterotricyclic compound;
synthetic cannabinoid		analgesic;
apoptosis inhibitor;
neuroprotective agent
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium10peptide
naltrindole[no description available]medium10isoquinolines
mdl 105519[no description available]medium10
endothelins[no description available]medium10
4-nitrobenzaldehyde[no description available]medium30benzaldehydes;
C-nitro compound
furaldehyde[no description available]medium20aldehyde;
furans		Maillard reaction product;
metabolite
thiophene-2-carboxaldehyde[no description available]medium20aldehyde;
thiophenes		metabolite
syringaldehyde[no description available]medium20dimethoxybenzene;
hydroxybenzaldehyde		hypoglycemic agent;
plant metabolite
2-Methoxybenzaldehyde[no description available]medium30carbonyl compound
pyrrole-2-carboxaldehyde[no description available]medium201,3-thiazole-2-carbaldehyde;
pyrroles
4-anisaldehyde[no description available]medium30benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
3-phenoxybenzaldehyde[no description available]medium30
quinoline-4-carbaldehyde[no description available]medium30
2-quinolinecarboxaldehyde[no description available]medium30
4-hydroxybenzaldehyde[no description available]medium20hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
benzaldehyde[no description available]medium20benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
1-naphthaldehyde[no description available]medium20naphthaldehydemouse metabolite
2-naphthaldehyde[no description available]medium20naphthaldehydemouse metabolite
3-nitrobenzaldehyde[no description available]medium20
3-pyridinaldehyde[no description available]medium20pyridinecarbaldehyde
2-nitrobenzaldehyde[no description available]medium20benzaldehydes;
C-nitro compound
diphenylacetaldehyde[no description available]medium20
pyridine-2-carboxaldehyde[no description available]medium20pyridinecarbaldehyde
9-anthraldehyde[no description available]medium20
4-methoxy-1-naphthalaldehyde[no description available]medium20
2-benzyloxybenzaldehyde[no description available]medium20
phenylacetaldehyde[no description available]medium10alpha-CH2-containing aldehyde;
phenylacetaldehydes		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
2-chlorobenzaldehyde[no description available]medium10
salicylaldehyde[no description available]medium10hydroxybenzaldehydenematicide;
plant metabolite
hydratropic aldehyde[no description available]medium10phenylacetaldehydes
4-(dimethylamino)benzaldehyde[no description available]medium10benzaldehydes;
substituted aniline;
tertiary amino compound		chromogenic compound
4-methylbenzaldehyde[no description available]medium10tolualdehydeplant metabolite
4-chlorobenzaldehyde[no description available]medium10
piperonal[no description available]medium10arenecarbaldehyde;
benzodioxoles		fragrance;
insect repellent;
plant metabolite
2-methylbenzaldehyde[no description available]medium10tolualdehydeplant metabolite
3-methoxybenzaldehyde[no description available]medium10benzaldehydes;
monomethoxybenzene		Brassica napus metabolite
3-methylbenzaldehyde[no description available]medium10tolualdehydeplant metabolite
4-cyanobenzaldehyde[no description available]medium10benzaldehydes
4-(trifluoromethyl)benzaldehyde[no description available]medium10benzaldehydes
4-fluorobenzaldehyde[no description available]medium10
2-bromobenzaldehyde[no description available]medium10
lilial[no description available]medium10
cinnamaldehyde[no description available]medium103-phenylprop-2-enal;
cinnamaldehydes		antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent
beta-proline[no description available]medium10
beta-alanine[no description available]medium10amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
2,3-diaminopropionic acid[no description available]medium10alanine derivative;
amino acid zwitterion;
beta-amino acid;
diamino acid;
non-proteinogenic alpha-amino acid		Escherichia coli metabolite
isoserine[no description available]medium10
b 844-39[no description available]low00diarylmethane
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
adiphenine[no description available]low00diarylmethane
3-(2'-aminobenzhydryloxy)tropane[no description available]low00diarylmethane
2,2-bis(4-glycidyloxyphenyl)propane[no description available]low00diarylmethane
benproperine[no description available]low00diarylmethane
cogentin[no description available]low00diarylmethane
bifemelane[no description available]low00diarylmethane
bisacodyl[no description available]low00diarylmethane
chlorcyclizine[no description available]low00diarylmethane
cifenline[no description available]low00diarylmethane
clidinium[no description available]low00diarylmethane
clofedanol[no description available]low00diarylmethane;
tertiary amino compound		antitussive
clofoctol[no description available]low00diarylmethane
cloperastine[no description available]low00diarylmethane
r 59022[no description available]low00diarylmethane
dichlorophen[no description available]low00bridged diphenyl fungicide;
diarylmethane
fendiline[no description available]low00diarylmethane
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine[no description available]low00diarylmethane
fluspirilene[no description available]low00diarylmethane
homochlorocyclizine[no description available]low00diarylmethane
isopropamide iodide[no description available]low00diarylmethane
lidoflazine[no description available]low00diarylmethane
lomerizine[no description available]low00diarylmethane
manidipine[no description available]low00diarylmethane
meclizine[no description available]low00diarylmethane
mepenzolate[no description available]low00diarylmethane
methadone[no description available]low00benzenes;
diarylmethane;
ketone;
tertiary amino compound
mitotane[no description available]low00diarylmethane
oxatomide[no description available]low00benzimidazoles;
diarylmethane;
N-alkylpiperazine		anti-allergic agent;
anti-inflammatory agent;
geroprotector;
H1-receptor antagonist;
serotonergic antagonist
pipenzolate[no description available]low00diarylmethane
piperidolate[no description available]low00diarylmethane
proadifen[no description available]low00diarylmethane
propiverine[no description available]low00diarylmethane
aurin[no description available]low00diarylmethane
dpi 201-106[no description available]low00diarylmethane
terfenadine[no description available]low00diarylmethane
mepenzolate bromide[no description available]low00diarylmethane
chlorphenoxamine[no description available]low00diarylmethaneanticoronaviral agent
chlorfenethol[no description available]low00diarylmethane
diphenadione[no description available]low00beta-triketone;
diarylmethane
phenyltoloxamine[no description available]low00diarylmethane
n,n,n',n'-tetramethyl-4,4'-methylenedianiline[no description available]low00diarylmethane
diphenan[no description available]low00diarylmethane
diphenylmethane[no description available]low00diarylmethane
2,2'-methylenebis(4-methyl-6-tert-butylphenol)[no description available]low00diarylmethane
piperidolate hydrochloride[no description available]low00diarylmethane
benactyzine[no description available]low00diarylmethane
prenylamine[no description available]low00diarylmethane
isomethadone[no description available]low00diarylmethane
pipradrol[no description available]low00diarylmethane
normethadone[no description available]low00diarylmethane
captodiamine[no description available]low00diarylmethane
methadyl acetate[no description available]low00diarylmethane
benzomethamine[no description available]low00diarylmethane
chlorobenzilate[no description available]low00diarylmethane
dimenhydrinate[no description available]low00diarylmethane
poldine[no description available]low00diarylmethane
thiphenamil[no description available]low00diarylmethane
4-cumylphenol[no description available]low00diarylmethane
4,4'-bisphenol f[no description available]low00bisphenol;
diarylmethane		environmental food contaminant;
xenoestrogen
o,p'-ddt[no description available]low00diarylmethane
4,4'-methylene bis(2-methylaniline)[no description available]low00diarylmethane
dipipanone[no description available]low00diarylmethane
diphenamid[no description available]low00diarylmethane
paracymethadol[no description available]low00diarylmethane
bisphenol a-glycidyl methacrylate[no description available]low00diarylmethane
azacyclonol[no description available]low00diarylmethane
dimenoxadol[no description available]low00diarylmethane
amphenone b[no description available]low00diarylmethane
propinox[no description available]low00diarylmethane
embramine[no description available]low00diarylmethane
chlorophacinone[no description available]low00beta-triketone;
diarylmethane
aminopentamide[no description available]low00diarylmethane
octocrylene[no description available]low00diarylmethane
terodiline[no description available]low00diarylmethane
tofenacin[no description available]low00diarylmethane
pipoxolan[no description available]low00diarylmethane
penfluridol[no description available]low00diarylmethane
emepronium[no description available]low00diarylmethane
levomethadyl acetate hydrochloride[no description available]low00diarylmethane
flumecinol[no description available]low00diarylmethane
setastine[no description available]low00diarylmethane
progabide[no description available]low00diarylmethane
beclobrate[no description available]low00diarylmethane
cetirizine dihydrochloride[no description available]low00diarylmethane
niguldipine[no description available]low00diarylmethane
mandrax[no description available]low00diarylmethane
droprenylamine[no description available]low00diarylmethane
quifenadine[no description available]low00diarylmethane
carebastine[no description available]low00diarylmethane
lercanidipine[no description available]low00diarylmethane
diphenidol hydrochloride[no description available]low00diarylmethane
dioxadrol[no description available]low00diarylmethane
budipine[no description available]low00diarylmethane
epicainide[no description available]low00diarylmethane
butinoline[no description available]low00diarylmethane
denaverine[no description available]low00diarylmethane
lifarizine[no description available]low00diarylmethane
fenpiverinium[no description available]low00diarylmethane
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)[no description available]low00diarylmethane
amperozide[no description available]low00diarylmethane;
monofluorobenzenes;
N-alkylpiperazine;
secondary carboxamide;
ureas		anxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
2,2'-bisphenol f[no description available]low00diarylmethane
3-hydroxy-2,2-diphenylpropanoic acid[no description available]low00diarylmethane
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]low00diarylmethane
bisphenol f diglycidyl ether[no description available]low00aromatic ether;
diarylmethane;
epoxide
methylene bis(methylanthranilate)[no description available]low00diarylmethane
tesmilifene[no description available]low00diarylmethane
pd 123177[no description available]low00diarylmethane
bw 373u86[no description available]low00diarylmethane
gilutensin hydrochloride[no description available]low00diarylmethane
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide[no description available]low00diarylmethane
ae0047[no description available]low00diarylmethane
lercanidipine hydrochloride[no description available]low00diarylmethane
cloperastine hydrochloride[no description available]low00diarylmethane
1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane[no description available]low00diarylmethane
2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid[no description available]low00diarylmethane
Difeterol[no description available]low00diarylmethane
1,1-bis(4-hydroxyphenyl)cyclohexane[no description available]low00diarylmethane
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene[no description available]low00diarylmethane
N-[2-(dimethylamino)ethyl]-2,2-diphenylacetamide[no description available]low00diarylmethane
propiverine hydrochloride[no description available]low00diarylmethane
gw 3965[no description available]low00diarylmethane
1,1-Bis(4-hydroxyphenyl)ethane[no description available]low00diarylmethane
uk 78282[no description available]low00diarylmethane
r 59949[no description available]low00diarylmethane
4-[1-(4-hydroxyphenyl)ethenyl]phenol[no description available]low00diarylmethane
5-[4-(diphenylmethyl)-1-piperazinyl]-2-(2-methoxyphenyl)-4-oxazolecarbonitrile[no description available]low00diarylmethane
flunarizine[no description available]low00diarylmethane
N-[4-[oxo-[(1-oxo-2,2-diphenylethyl)hydrazo]methyl]phenyl]propanamide[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone[no description available]low00diarylmethane
benztropine[no description available]low00diarylmethane
3-[[[(1-oxo-2,2-diphenylethyl)amino]-sulfanylidenemethyl]amino]benzoic acid[no description available]low00diarylmethane
3-bromo-5-[[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-oxomethyl]-2-pyranone[no description available]low00diarylmethane
2-(5-bromo-3-nitro-1,2,4-triazol-1-yl)-N-(diphenylmethyl)acetamide[no description available]low00diarylmethane
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanol[no description available]low00diarylmethane
cinnarizine[no description available]low00diarylmethane;
N-alkylpiperazine;
olefinic compound		anti-allergic agent;
antiemetic;
calcium channel blocker;
geroprotector;
H1-receptor antagonist;
histamine antagonist;
muscarinic antagonist
levocetirizine[no description available]low00diarylmethane
amn082[no description available]low00benzenes;
diamine;
diarylmethane;
secondary amino compound		metabotropic glutamate receptor agonist;
neuroprotective agent
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide[no description available]low00diarylmethane
N-(4-fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester[no description available]low00diarylmethane
2,2-diphenylacetic acid (2,6-dimethylphenyl) ester[no description available]low00diarylmethane
1-ethyl-3-[(1-oxo-2,2-diphenylethyl)amino]thiourea[no description available]low00diarylmethane
2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester[no description available]low00diarylmethane
2-[2-[bis(4-methoxyphenyl)methylidene]hydrazinyl]benzoic acid[no description available]low00diarylmethane
N-[4-bromo-2-[[(2-hydrazinyl-2-oxoethyl)amino]-phenylmethyl]phenyl]-3-(4-morpholinyl)propanamide[no description available]low00diarylmethane
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamide[no description available]low00diarylmethane
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamide[no description available]low00diarylmethane
adrafinil[no description available]low00diarylmethane
zamifenacin[no description available]low00diarylmethane
2-(cyclohexylamino)-N-[(diphenylmethylene)amino]propanamide[no description available]low00diarylmethane
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one[no description available]low00diarylmethane
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
flunarizine hydrochloride[no description available]low00diarylmethane
(2-amino-5-chlorophenyl)(phenyl)methanone oxime[no description available]low00diarylmethane
imidafenacin[no description available]low00diarylmethane
2-(3,3-diphenylpropylamino)acetamide[no description available]low00diarylmethane
cgk 733[no description available]low00diarylmethane
dexniguldipine[no description available]low00diarylmethane
lu 208075[no description available]low00diarylmethane
fesoterodine[no description available]low00diarylmethane
3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione[no description available]low00diarylmethane
pnu 200577[no description available]low00diarylmethane
gc 1 compound[no description available]low00diarylmethane
tas 301[no description available]low00diarylmethane
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone[no description available]low00diarylmethane
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamine[no description available]low00diarylmethane
1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol[no description available]low00diarylmethane
(8R)-3-[3-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]phenyl]-7-(1-oxo-3,3-diphenylpropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide[no description available]low00diarylmethane
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone[no description available]low00diarylmethane
2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester[no description available]low00diarylmethane;
tert-butyl ester
pf 04971729[no description available]low00diarylmethane
ML-210[no description available]low00C-nitro compound;
diarylmethane;
isoxazoles;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
tertiary carboxamide		antineoplastic agent;
EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Allodynia0low10
Allodynia, Mechanical0low10
Allodynia, Tactile0low10
Allodynia, Thermal0low10
Alloxan Diabetes0low10
Anemia, Fanconi0low10
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Cancer of Breast0low10
Cancer of the Breast0low10
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Contact Dermatitis0low10
Dermatitis Venenata0low10
Dermatitis, Contact0low10
Diabetes Mellitus, Experimental0low10
Disease Models, Animal0low20
Eczema, Contact0low10
Experimental Diabetes Mellitus0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Fever, Zika0low10
Human Mammary Carcinoma0low10
Hyperalgesia0low10
Hyperalgesia, Mechanical0low10
Hyperalgesia, Primary0low10
Hyperalgesia, Secondary0low10
Hyperalgesia, Tactile0low10
Hyperalgesia, Thermal0low10
Hyperalgesic Sensations0low10
Hyperalgia0low10
Hyperalgia, Mechanical0low10
Hyperalgia, Primary0low10
Hyperalgia, Secondary0low10
Hypersensitivity, Contact0low10
Itching0low10
Malignant Neoplasm of Breast0low10
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Mechanical Allodynia0low10
Mechanical Hyperalgesia0low10
Neoplasms, Breast0low10
Nerve Pain0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neurodynia0low10
Neuropathic Pain0low10
Paroxysmal Nerve Pain0low10
Pruritis0low10
Pruritus0low10
Sensitivity, Contact0low10
Streptozocin Diabetes0low10
Streptozotocin Diabetes0low10
Tactile Allodynia0low10
Thermal Allodynia0low10
Tumors, Breast0low10
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10