Page last updated: 2024-11-03

probucol and Allodynia

probucol has been researched along with Allodynia in 4 studies

Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.

Research Excerpts

ExcerptRelevanceReference
"The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA)."7.91Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation. ( Badaro-Garcia, S; Borghi, SM; Camilios-Neto, D; Casagrande, R; Dos Santos, TS; Fattori, V; Manchope, MF; Verri, WA; Zucoloto, AZ, 2019)
"Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid."7.85Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017)
"The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA)."3.91Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation. ( Badaro-Garcia, S; Borghi, SM; Camilios-Neto, D; Casagrande, R; Dos Santos, TS; Fattori, V; Manchope, MF; Verri, WA; Zucoloto, AZ, 2019)
"Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid."3.85Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Derangula, K1
Javalgekar, M1
Kumar Arruri, V1
Gundu, C1
Kumar Kalvala, A1
Kumar, A1
Zucoloto, AZ3
Manchope, MF3
Staurengo-Ferrari, L2
Alves-Filho, JC2
Cunha, TM2
Antunes, MM1
Menezes, GB2
Cunha, FQ2
Casagrande, R3
Verri, WA3
Pinho-Ribeiro, FA1
Zarpelon, AC1
Saraiva, ALL1
Cecílio, NT1
Borghi, SM1
Dos Santos, TS1
Fattori, V1
Badaro-Garcia, S1
Camilios-Neto, D1

Other Studies

4 other studies available for probucol and Allodynia

ArticleYear
Probucol attenuates NF-κB/NLRP3 signalling and augments Nrf-2 mediated antioxidant defence in nerve injury induced neuropathic pain.
    International immunopharmacology, 2022, Volume: 102

    Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Neuralgia; NF-E2-Related Factor 2; NF

2022
Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2017, Volume: 66, Issue:7

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Benzoquinones; Carrage

2017
Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production.
    European journal of pharmacology, 2017, Aug-15, Volume: 809

    Topics: Animals; Cytokines; Hyperalgesia; Inflammation; Leukocytes; Lipopolysaccharides; Macrophages; Male;

2017
Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation.
    Inflammation, 2019, Volume: 42, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Freund's Adjuvant; Hyperalgesia; Inflammation; Mice

2019