probucol has been researched along with Allodynia in 4 studies
Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
probucol : A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high levels of cholesterol in blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA)." | 7.91 | Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation. ( Badaro-Garcia, S; Borghi, SM; Camilios-Neto, D; Casagrande, R; Dos Santos, TS; Fattori, V; Manchope, MF; Verri, WA; Zucoloto, AZ, 2019) |
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 7.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "The effect of the lipid-lowering agent probucol in inflammatory hyperalgesia and leukocyte recruitment was evaluated in a model of subacute inflammation by Complete Freund's adjuvant (CFA)." | 3.91 | Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation. ( Badaro-Garcia, S; Borghi, SM; Camilios-Neto, D; Casagrande, R; Dos Santos, TS; Fattori, V; Manchope, MF; Verri, WA; Zucoloto, AZ, 2019) |
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 3.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Derangula, K | 1 |
| Javalgekar, M | 1 |
| Kumar Arruri, V | 1 |
| Gundu, C | 1 |
| Kumar Kalvala, A | 1 |
| Kumar, A | 1 |
| Zucoloto, AZ | 3 |
| Manchope, MF | 3 |
| Staurengo-Ferrari, L | 2 |
| Alves-Filho, JC | 2 |
| Cunha, TM | 2 |
| Antunes, MM | 1 |
| Menezes, GB | 2 |
| Cunha, FQ | 2 |
| Casagrande, R | 3 |
| Verri, WA | 3 |
| Pinho-Ribeiro, FA | 1 |
| Zarpelon, AC | 1 |
| Saraiva, ALL | 1 |
| Cecílio, NT | 1 |
| Borghi, SM | 1 |
| Dos Santos, TS | 1 |
| Fattori, V | 1 |
| Badaro-Garcia, S | 1 |
| Camilios-Neto, D | 1 |
4 other studies available for probucol and Allodynia
| Article | Year |
|---|---|
Probucol attenuates NF-κB/NLRP3 signalling and augments Nrf-2 mediated antioxidant defence in nerve injury induced neuropathic pain.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Neuralgia; NF-E2-Related Factor 2; NF | 2022 |
Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Benzoquinones; Carrage | 2017 |
Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production.
Topics: Animals; Cytokines; Hyperalgesia; Inflammation; Leukocytes; Lipopolysaccharides; Macrophages; Male; | 2017 |
Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Freund's Adjuvant; Hyperalgesia; Inflammation; Mice | 2019 |