acetaldehyde has been researched along with Allodynia in 2 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Periorbital mechanical allodynia following systemic ethanol and acetaldehyde was investigated in mice after TRPA1 and TRPV1 pharmacological antagonism and global genetic deletion." | 8.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "We show in mice that intragastric ethanol administration evokes a sustained periorbital mechanical allodynia that is attenuated by systemic or local alcohol dehydrogenase inhibition, and TRPA1, but not TRPV1, global deletion, thus indicating the implication of acetaldehyde." | 8.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Results suggest that, in mice, periorbital mechanical allodynia, a response that mimics cutaneous allodynia reported during migraine attacks, is elicited by ethanol via the systemic production of acetaldehyde that, by releasing CGRP, engages the CGRP receptor in Schwann cells." | 8.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Periorbital mechanical allodynia following systemic ethanol and acetaldehyde was investigated in mice after TRPA1 and TRPV1 pharmacological antagonism and global genetic deletion." | 5.91 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Importantly, periorbital mechanical allodynia by both ethanol and acetaldehyde is abrogated by pretreatment with the CGRP receptor antagonist, olcegepant, and a selective silencing of RAMP1 in Schwann cells." | 5.91 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Periorbital mechanical allodynia following systemic ethanol and acetaldehyde was investigated in mice after TRPA1 and TRPV1 pharmacological antagonism and global genetic deletion." | 4.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "We show in mice that intragastric ethanol administration evokes a sustained periorbital mechanical allodynia that is attenuated by systemic or local alcohol dehydrogenase inhibition, and TRPA1, but not TRPV1, global deletion, thus indicating the implication of acetaldehyde." | 4.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Results suggest that, in mice, periorbital mechanical allodynia, a response that mimics cutaneous allodynia reported during migraine attacks, is elicited by ethanol via the systemic production of acetaldehyde that, by releasing CGRP, engages the CGRP receptor in Schwann cells." | 4.31 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Periorbital mechanical allodynia following systemic ethanol and acetaldehyde was investigated in mice after TRPA1 and TRPV1 pharmacological antagonism and global genetic deletion." | 1.91 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| "Importantly, periorbital mechanical allodynia by both ethanol and acetaldehyde is abrogated by pretreatment with the CGRP receptor antagonist, olcegepant, and a selective silencing of RAMP1 in Schwann cells." | 1.91 | Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine. ( Bellantoni, E; Chieca, M; De Logu, F; De Siena, G; Geppetti, P; Landini, L; Nassini, R; Souza Monteiro de Araujo, D, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Landini, L | 1 |
| Souza Monteiro de Araujo, D | 1 |
| Chieca, M | 1 |
| De Siena, G | 1 |
| Bellantoni, E | 1 |
| Geppetti, P | 1 |
| Nassini, R | 1 |
| De Logu, F | 1 |
| Zambelli, VO | 1 |
| Gross, ER | 1 |
| Chen, CH | 1 |
| Gutierrez, VP | 1 |
| Cury, Y | 1 |
| Mochly-Rosen, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oxidative Stress and Surgical Recovery[NCT04732000] | Phase 2 | 21 participants (Actual) | Interventional | 2021-07-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for acetaldehyde and Allodynia
| Article | Year |
|---|---|
Acetaldehyde via CGRP receptor and TRPA1 in Schwann cells mediates ethanol-evoked periorbital mechanical allodynia in mice: relevance for migraine.
Topics: Acetaldehyde; Animals; Ankyrins; Calcitonin Gene-Related Peptide; Ethanol; Hyperalgesia; Mice; Mice, | 2023 |
Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
Topics: Acetaldehyde; Acute Pain; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Be | 2014 |