nitrites has been researched along with Allodynia in 26 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema." | 3.80 | Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014) |
| "More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| "Tactile allodynia and sciatic, tibial, and peroneal functional indices were assessed before the knee joint immobilization, 24 hours after the knee cast removal, and 24 hours after 3 weeks of lumbar therapy with the Activator Adjusting Instrument, model 4 (AAI 4)." | 1.51 | Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization. ( Belló-Klein, A; Duarte, FCK; Kolberg, C; Partata, WA; Riffel, APK; Souza, JA, 2019) |
| "Nitroxyl (HNO) has become a nitrogen oxide of significant interest due to its pharmacological endpoints that are potentially favorable for treating varied diseases." | 1.46 | The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus-induced septic arthritis in mice. ( Bordignon, J; Casagrande, R; Domiciano, TP; Fattori, V; Figueiredo, F; Miranda, KM; Mizokami, SS; Pelayo, JS; Pinho-Ribeiro, FA; Ruiz-Miyazawa, KW; Staurengo-Ferrari, L; Verri, WA, 2017) |
| "Stavudine (50 mg/kg) was administered intravenously via tail vein in rats to induce neuropathic pain." | 1.43 | Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain. ( Bansal, Y; Kuhad, A; Marwaha, L; Saroj, P; Singh, R; Sodhi, RK, 2016) |
| "Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture." | 1.39 | The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats. ( Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Marchesi, M; Miranda, KM; Pinge-Filho, P; Schivo, IR; Souza, GR; Verri, WA; Zarpelon, AC, 2013) |
| "Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively." | 1.38 | Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012) |
| "Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy." | 1.37 | Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. ( Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "CCD rats showed thermal hyperalgesia and increased nitrite production." | 1.36 | Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. ( Ding, XL; Ge, HY; Jiang, H; Ning, LP; Wang, R; Wang, YH; Yue, SW; Zhang, Y, 2010) |
| "Naproxen was administered daily 45 min before PTZ or vehicle." | 1.33 | Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2005) |
| "Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose and decreased body weights as compared with control mice." | 1.33 | Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. ( Agrewala, JN; Chopra, K; Kulkarni, SK; Sharma, S, 2006) |
| "Allodynia was also intensified by SNAP (5% or 30%) in rats pretreated with intraplantar 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 4 microg), a guanylate cyclase inhibitor." | 1.31 | Dual effect of local application of nitric oxide donors in a model of incision pain in rats. ( Cunha, FQ; Prado, WA; Schiavon, VF, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 14 (53.85) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Pușcașu, C | 1 |
| Ungurianu, A | 1 |
| Șeremet, OC | 1 |
| Andrei, C | 1 |
| Mihai, DP | 1 |
| Negreș, S | 1 |
| Staurengo-Ferrari, L | 1 |
| Ruiz-Miyazawa, KW | 1 |
| Pinho-Ribeiro, FA | 1 |
| Domiciano, TP | 1 |
| Fattori, V | 1 |
| Mizokami, SS | 1 |
| Pelayo, JS | 1 |
| Bordignon, J | 1 |
| Figueiredo, F | 1 |
| Casagrande, R | 2 |
| Miranda, KM | 2 |
| Verri, WA | 2 |
| Evangelista, AF | 1 |
| Vannier-Santos, MA | 1 |
| de Assis Silva, GS | 1 |
| Silva, DN | 1 |
| Juiz, PJL | 1 |
| Nonaka, CKV | 1 |
| Dos Santos, RR | 1 |
| Soares, MBP | 1 |
| Villarreal, CF | 1 |
| Duarte, FCK | 1 |
| Kolberg, C | 1 |
| Riffel, APK | 1 |
| Souza, JA | 1 |
| Belló-Klein, A | 1 |
| Partata, WA | 1 |
| Zarpelon, AC | 1 |
| Souza, GR | 1 |
| Cunha, TM | 1 |
| Schivo, IR | 1 |
| Marchesi, M | 1 |
| Pinge-Filho, P | 1 |
| Cunha, FQ | 2 |
| Ferreira, SH | 1 |
| Khan, S | 1 |
| Shehzad, O | 1 |
| Chun, J | 1 |
| Kim, YS | 1 |
| Arora, V | 1 |
| Chopra, K | 4 |
| Biava, M | 1 |
| Battilocchio, C | 1 |
| Poce, G | 1 |
| Alfonso, S | 1 |
| Consalvi, S | 1 |
| Di Capua, A | 1 |
| Calderone, V | 1 |
| Martelli, A | 1 |
| Testai, L | 1 |
| Sautebin, L | 1 |
| Rossi, A | 1 |
| Ghelardini, C | 1 |
| Di Cesare Mannelli, L | 1 |
| Giordani, A | 1 |
| Persiani, S | 1 |
| Colovic, M | 1 |
| Dovizio, M | 1 |
| Patrignani, P | 1 |
| Anzini, M | 1 |
| Grace, PM | 1 |
| Fabisiak, TJ | 1 |
| Green-Fulgham, SM | 1 |
| Anderson, ND | 1 |
| Strand, KA | 1 |
| Kwilasz, AJ | 1 |
| Galer, EL | 1 |
| Walker, FR | 1 |
| Greenwood, BN | 1 |
| Maier, SF | 1 |
| Fleshner, M | 1 |
| Watkins, LR | 1 |
| Marwaha, L | 1 |
| Bansal, Y | 1 |
| Singh, R | 1 |
| Saroj, P | 1 |
| Sodhi, RK | 1 |
| Kuhad, A | 3 |
| Sachdeva, AK | 1 |
| Tiwari, V | 2 |
| Ding, XL | 1 |
| Wang, YH | 1 |
| Ning, LP | 1 |
| Zhang, Y | 1 |
| Ge, HY | 1 |
| Jiang, H | 1 |
| Wang, R | 1 |
| Yue, SW | 1 |
| Taliyan, R | 1 |
| Sharma, PL | 1 |
| Kandhare, AD | 1 |
| Raygude, KS | 1 |
| Ghosh, P | 1 |
| Ghule, AE | 1 |
| Bodhankar, SL | 1 |
| Santana, DG | 1 |
| Santos, CA | 1 |
| Santos, AD | 1 |
| Nogueira, PC | 1 |
| Thomazzi, SM | 1 |
| Estevam, CS | 1 |
| Antoniolli, AR | 1 |
| Camargo, EA | 1 |
| Dhir, A | 2 |
| Naidu, PS | 2 |
| Kulkarni, SK | 3 |
| Naik, AK | 1 |
| Tandan, SK | 1 |
| Kumar, D | 1 |
| Dudhgaonkar, SP | 1 |
| Padi, SS | 1 |
| Sharma, S | 1 |
| Agrewala, JN | 1 |
| Costa, B | 1 |
| Siniscalco, D | 1 |
| Trovato, AE | 1 |
| Comelli, F | 1 |
| Sotgiu, ML | 1 |
| Colleoni, M | 1 |
| Maione, S | 1 |
| Rossi, F | 1 |
| Giagnoni, G | 1 |
| Menéndez, L | 1 |
| Juárez, L | 1 |
| García, V | 1 |
| Hidalgo, A | 1 |
| Baamonde, A | 1 |
| Wu, J | 2 |
| Lin, Q | 2 |
| McAdoo, DJ | 1 |
| Willis, WD | 2 |
| Palecek, J | 1 |
| Palecková, V | 1 |
| Peng, YB | 1 |
| Cui, M | 1 |
| Omote, K | 1 |
| Hazama, K | 1 |
| Kawamata, T | 1 |
| Kawamata, M | 1 |
| Nakayaka, Y | 1 |
| Toriyabe, M | 1 |
| Namiki, A | 1 |
| Prado, WA | 1 |
| Schiavon, VF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838] | Phase 2 | 40 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 other studies available for nitrites and Allodynia
| Article | Year |
|---|---|
The Influence of Sildenafil-Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice.
Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Neuropathies; Hyperalgesia; Hypoglycemic Agents; In | 2023 |
The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus-induced septic arthritis in mice.
Topics: Animals; Antioxidants; Arthritis, Infectious; Hyperalgesia; Inflammation; Lung; Male; Mice; NF-kappa | 2017 |
Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades.
Topics: Animals; Bone Marrow Transplantation; Calcium-Binding Proteins; Culture Media, Conditioned; Cytokine | 2018 |
Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization.
Topics: Animals; Biomarkers; Catalase; Glutathione Peroxidase; Hyperalgesia; Immobilization; Lipid Peroxides | 2019 |
The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokin | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP R | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy | 2014 |
Prior voluntary wheel running attenuates neuropathic pain.
Topics: Activating Transcription Factor 3; Animals; Calcium-Binding Proteins; Constriction, Pathologic; Cyto | 2016 |
Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain.
Topics: Analgesics; Animals; Biomarkers; Dose-Response Relationship, Drug; Hyperalgesia; Interleukin-1beta; | 2016 |
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence.
Topics: Animals; Antioxidants; Brucella abortus; Catalase; Catechin; Disease Models, Animal; Fatigue Syndrom | 2009 |
Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
Topics: Animals; Behavior, Animal; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enz | 2010 |
Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Cytokines; Diabetes M | 2011 |
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 2012 |
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.
Topics: Alcoholic Neuropathy; Animals; Calcium; Curcumin; DNA Fragmentation; Hyperalgesia; Interleukin-1beta | 2012 |
Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
Topics: Abdominal Pain; Acute Disease; Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Caes | 2012 |
Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice.
Topics: Animals; Behavior, Animal; Brain; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Femal | 2005 |
Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
Topics: Animals; Arginine; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Disease Models, Ani | 2006 |
Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.
Topics: Adrenal Glands; Analysis of Variance; Animals; Anxiety; Ascorbic Acid; Behavior, Animal; Biomarkers; | 2006 |
Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Brain; Cur | 2006 |
AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Apoptosis; Arachidonic Acids; bcl-2-Associated X Protein; Behavior, Animal; Blo | 2006 |
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad | 2007 |
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG- | 1998 |
Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons.
Topics: Animals; Capsaicin; Enzyme Inhibitors; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis; | 1999 |
Peripheral nitric oxide in carrageenan-induced inflammation.
Topics: Animals; Carrageenan; Drug Interactions; Edema; Enzyme Inhibitors; Guanidines; Hyperalgesia; Inflamm | 2001 |
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibi | 2002 |