Page last updated: 2024-10-19

nitrites and Allodynia

nitrites has been researched along with Allodynia in 26 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

ExcerptRelevanceReference
" In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema."3.80Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014)
"More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression."3.79Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013)
"Tactile allodynia and sciatic, tibial, and peroneal functional indices were assessed before the knee joint immobilization, 24 hours after the knee cast removal, and 24 hours after 3 weeks of lumbar therapy with the Activator Adjusting Instrument, model 4 (AAI 4)."1.51Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization. ( Belló-Klein, A; Duarte, FCK; Kolberg, C; Partata, WA; Riffel, APK; Souza, JA, 2019)
"Nitroxyl (HNO) has become a nitrogen oxide of significant interest due to its pharmacological endpoints that are potentially favorable for treating varied diseases."1.46The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus-induced septic arthritis in mice. ( Bordignon, J; Casagrande, R; Domiciano, TP; Fattori, V; Figueiredo, F; Miranda, KM; Mizokami, SS; Pelayo, JS; Pinho-Ribeiro, FA; Ruiz-Miyazawa, KW; Staurengo-Ferrari, L; Verri, WA, 2017)
"Stavudine (50 mg/kg) was administered intravenously via tail vein in rats to induce neuropathic pain."1.43Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain. ( Bansal, Y; Kuhad, A; Marwaha, L; Saroj, P; Singh, R; Sodhi, RK, 2016)
"Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture."1.39The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats. ( Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Marchesi, M; Miranda, KM; Pinge-Filho, P; Schivo, IR; Souza, GR; Verri, WA; Zarpelon, AC, 2013)
"Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively."1.38Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012)
"Diabetic neuropathic pain is amongst the most difficult types of pain to treat mainly due to the lack of understanding of its etiology and inadequate relief with available drug therapy."1.37Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade. ( Chopra, K; Kuhad, A; Tiwari, V, 2011)
"CCD rats showed thermal hyperalgesia and increased nitrite production."1.36Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. ( Ding, XL; Ge, HY; Jiang, H; Ning, LP; Wang, R; Wang, YH; Yue, SW; Zhang, Y, 2010)
"Naproxen was administered daily 45 min before PTZ or vehicle."1.33Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2005)
"Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose and decreased body weights as compared with control mice."1.33Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. ( Agrewala, JN; Chopra, K; Kulkarni, SK; Sharma, S, 2006)
"Allodynia was also intensified by SNAP (5% or 30%) in rats pretreated with intraplantar 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 4 microg), a guanylate cyclase inhibitor."1.31Dual effect of local application of nitric oxide donors in a model of incision pain in rats. ( Cunha, FQ; Prado, WA; Schiavon, VF, 2002)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (7.69)18.2507
2000's9 (34.62)29.6817
2010's14 (53.85)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Pușcașu, C1
Ungurianu, A1
Șeremet, OC1
Andrei, C1
Mihai, DP1
Negreș, S1
Staurengo-Ferrari, L1
Ruiz-Miyazawa, KW1
Pinho-Ribeiro, FA1
Domiciano, TP1
Fattori, V1
Mizokami, SS1
Pelayo, JS1
Bordignon, J1
Figueiredo, F1
Casagrande, R2
Miranda, KM2
Verri, WA2
Evangelista, AF1
Vannier-Santos, MA1
de Assis Silva, GS1
Silva, DN1
Juiz, PJL1
Nonaka, CKV1
Dos Santos, RR1
Soares, MBP1
Villarreal, CF1
Duarte, FCK1
Kolberg, C1
Riffel, APK1
Souza, JA1
Belló-Klein, A1
Partata, WA1
Zarpelon, AC1
Souza, GR1
Cunha, TM1
Schivo, IR1
Marchesi, M1
Pinge-Filho, P1
Cunha, FQ2
Ferreira, SH1
Khan, S1
Shehzad, O1
Chun, J1
Kim, YS1
Arora, V1
Chopra, K4
Biava, M1
Battilocchio, C1
Poce, G1
Alfonso, S1
Consalvi, S1
Di Capua, A1
Calderone, V1
Martelli, A1
Testai, L1
Sautebin, L1
Rossi, A1
Ghelardini, C1
Di Cesare Mannelli, L1
Giordani, A1
Persiani, S1
Colovic, M1
Dovizio, M1
Patrignani, P1
Anzini, M1
Grace, PM1
Fabisiak, TJ1
Green-Fulgham, SM1
Anderson, ND1
Strand, KA1
Kwilasz, AJ1
Galer, EL1
Walker, FR1
Greenwood, BN1
Maier, SF1
Fleshner, M1
Watkins, LR1
Marwaha, L1
Bansal, Y1
Singh, R1
Saroj, P1
Sodhi, RK1
Kuhad, A3
Sachdeva, AK1
Tiwari, V2
Ding, XL1
Wang, YH1
Ning, LP1
Zhang, Y1
Ge, HY1
Jiang, H1
Wang, R1
Yue, SW1
Taliyan, R1
Sharma, PL1
Kandhare, AD1
Raygude, KS1
Ghosh, P1
Ghule, AE1
Bodhankar, SL1
Santana, DG1
Santos, CA1
Santos, AD1
Nogueira, PC1
Thomazzi, SM1
Estevam, CS1
Antoniolli, AR1
Camargo, EA1
Dhir, A2
Naidu, PS2
Kulkarni, SK3
Naik, AK1
Tandan, SK1
Kumar, D1
Dudhgaonkar, SP1
Padi, SS1
Sharma, S1
Agrewala, JN1
Costa, B1
Siniscalco, D1
Trovato, AE1
Comelli, F1
Sotgiu, ML1
Colleoni, M1
Maione, S1
Rossi, F1
Giagnoni, G1
Menéndez, L1
Juárez, L1
García, V1
Hidalgo, A1
Baamonde, A1
Wu, J2
Lin, Q2
McAdoo, DJ1
Willis, WD2
Palecek, J1
Palecková, V1
Peng, YB1
Cui, M1
Omote, K1
Hazama, K1
Kawamata, T1
Kawamata, M1
Nakayaka, Y1
Toriyabe, M1
Namiki, A1
Prado, WA1
Schiavon, VF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838]Phase 240 participants (Anticipated)Interventional2009-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

26 other studies available for nitrites and Allodynia

ArticleYear
The Influence of Sildenafil-Metformin Combination on Hyperalgesia and Biochemical Markers in Diabetic Neuropathy in Mice.
    Medicina (Kaunas, Lithuania), 2023, Jul-27, Volume: 59, Issue:8

    Topics: Animals; Biomarkers; Diabetes Mellitus; Diabetic Neuropathies; Hyperalgesia; Hypoglycemic Agents; In

2023
The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus-induced septic arthritis in mice.
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Animals; Antioxidants; Arthritis, Infectious; Hyperalgesia; Inflammation; Lung; Male; Mice; NF-kappa

2017
Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades.
    Journal of neuroinflammation, 2018, Jun-22, Volume: 15, Issue:1

    Topics: Animals; Bone Marrow Transplantation; Calcium-Binding Proteins; Culture Media, Conditioned; Cytokine

2018
Spinal Manipulation Therapy Improves Tactile Allodynia and Peripheral Nerve Functionality and Modulates Blood Oxidative Stress Markers in Rats Exposed to Knee-Joint Immobilization.
    Journal of manipulative and physiological therapeutics, 2019, Volume: 42, Issue:6

    Topics: Animals; Biomarkers; Catalase; Glutathione Peroxidase; Hyperalgesia; Immobilization; Lipid Peroxides

2019
The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats.
    Neuropharmacology, 2013, Volume: 71

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokin

2013
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP R

2013
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
    Journal of affective disorders, 2013, Volume: 151, Issue:3

    Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc

2013
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
    Bioorganic & medicinal chemistry, 2014, Jan-15, Volume: 22, Issue:2

    Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy

2014
Prior voluntary wheel running attenuates neuropathic pain.
    Pain, 2016, Volume: 157, Issue:9

    Topics: Activating Transcription Factor 3; Animals; Calcium-Binding Proteins; Constriction, Pathologic; Cyto

2016
Niflumic acid, a TRPV1 channel modulator, ameliorates stavudine-induced neuropathic pain.
    Inflammopharmacology, 2016, Volume: 24, Issue:6

    Topics: Analgesics; Animals; Biomarkers; Dose-Response Relationship, Drug; Hyperalgesia; Interleukin-1beta;

2016
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence.
    Behavioural brain research, 2009, Dec-28, Volume: 205, Issue:2

    Topics: Animals; Antioxidants; Brucella abortus; Catalase; Catechin; Disease Models, Animal; Fatigue Syndrom

2009
Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Animals; Behavior, Animal; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enz

2010
Emblica officinalis corrects functional, biochemical and molecular deficits in experimental diabetic neuropathy by targeting the oxido-nitrosative stress mediated inflammatory cascade.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Cytokines; Diabetes M

2011
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
    Inflammopharmacology, 2012, Volume: 20, Issue:2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe

2012
Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals.
    Neuroscience letters, 2012, Mar-05, Volume: 511, Issue:1

    Topics: Alcoholic Neuropathy; Animals; Calcium; Curcumin; DNA Fragmentation; Hyperalgesia; Interleukin-1beta

2012
Beneficial effects of the ethanol extract of Caesalpinia pyramidalis on the inflammatory response and abdominal hyperalgesia in rats with acute pancreatitis.
    Journal of ethnopharmacology, 2012, Jul-13, Volume: 142, Issue:2

    Topics: Abdominal Pain; Acute Disease; Amylases; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Caes

2012
Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:7

    Topics: Animals; Behavior, Animal; Brain; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Femal

2005
Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
    European journal of pharmacology, 2006, Jan-13, Volume: 530, Issue:1-2

    Topics: Animals; Arginine; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Disease Models, Ani

2006
Protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) on immobilization stress-induced behavioral and biochemical alterations in mice.
    European journal of pharmacology, 2006, Mar-27, Volume: 535, Issue:1-3

    Topics: Adrenal Glands; Analysis of Variance; Animals; Anxiety; Ascorbic Acid; Behavior, Animal; Biomarkers;

2006
Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
    European journal of pharmacology, 2006, May-01, Volume: 536, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Brain; Cur

2006
AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain.
    British journal of pharmacology, 2006, Volume: 148, Issue:7

    Topics: Analgesics; Animals; Apoptosis; Arachidonic Acids; bcl-2-Associated X Protein; Behavior, Animal; Blo

2006
Involvement of nitric oxide in the inhibition of bone cancer-induced hyperalgesia through the activation of peripheral opioid receptors in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Bone Neoplasms; Carbazoles; Dose-Response Relationship, Drug; Drug Ad

2007
Nitric oxide contributes to central sensitization following intradermal injection of capsaicin.
    Neuroreport, 1998, Mar-09, Volume: 9, Issue:4

    Topics: Analysis of Variance; Animals; Capsaicin; Hindlimb; Hyperalgesia; Injections, Intradermal; Male; NG-

1998
Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons.
    Journal of neurophysiology, 1999, Volume: 81, Issue:3

    Topics: Animals; Capsaicin; Enzyme Inhibitors; Hyperalgesia; Injections, Subcutaneous; Macaca fascicularis;

1999
Peripheral nitric oxide in carrageenan-induced inflammation.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Carrageenan; Drug Interactions; Edema; Enzyme Inhibitors; Guanidines; Hyperalgesia; Inflamm

2001
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
    European journal of pharmacology, 2002, Apr-19, Volume: 441, Issue:1-2

    Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibi

2002