acetic acid has been researched along with Allodynia in 78 studies
Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
acetic acid : A simple monocarboxylic acid containing two carbons.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 7.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Probucol reduced overt pain-like behavior, and carrageenan-induced mechanical and thermal hyperalgesia." | 7.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 7.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 7.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 7.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| "Our data indicate that duloxetine and ibuprofen have synergistic efficacy in a visceral and an inflammatory pain model in rodents, and suggest that duloxetine and ibuprofen in combination may provide a useful approach to the clinical treatment of persistent pain, particularly inflammation-related pain." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " Isobolographic analysis of the effects of duloxetine in combination with ibuprofen revealed a significant synergistic (greater than additive) interaction between duloxetine and ibuprofen both for reducing acetic acid-induced writhing and carrageenan-induced thermal hyperalgesia, but were additive for reversing mechanical allodynia." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 7.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 7.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "Mechanical and thermal hyperalgesia induced by carrageenan were determined using an electronic anesthesiometer and hot plate apparatus, respectively." | 5.46 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Stigmasterol is a common sterol found in plants, but the anti-nociceptive effect of this compound and its mechanism of action are not fully explored." | 5.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Furthermore, it markedly attenuated the mechanical allodynia caused by surgical incision (after acute treatment with stigmasterol, preventive and curative effects were observed) and partial sciatic nerve ligation (after acute treatment with stigmasterol) and complete Freund's adjuvant (after acute or repeated treatment with stigmasterol)." | 5.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Pentoxifylline (PTX) has strong antyinflamatory effects, decreases TNF-alpha and other proinflammatory cytokines production." | 5.38 | Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. ( Dobrogowski, J; Nowak, Ł; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "Pentoxifylline did not inhibit the nociceptive response in the hot plate test in mice." | 5.32 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "prevented BK and carrageenan-induced hyperalgesia (mean ID50 values of 6 nmol/kg and 13 nmol/kg), without affecting the hyperalgesia induced by des-Arg9-bradykinin (DABK) or by prostaglandin E2 (PGE2)." | 5.30 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| ") were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice." | 4.31 | Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves. ( Arena, AC; Cardoso, CAL; Euclides Silva-Filho, S; Heredia-Vieira, SC; Kassuya, CAL; Matos Leitão, M, 2023) |
| " The effect of the extract in three additional in vivo models were studied: intestinal motility and diarrhea induced by ricin oil, and visceral pain induced by intracolonic administration of capsaicin." | 4.02 | Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract. ( Bach, H; Carranza, A; Gorzalczany, SB; Rodríguez Basso, A; Zainutti, VM, 2021) |
| " The compound was tested on acute models of pain such as acetic acid-induced abdominal writhing, formalin-induced nociception and carrageenan-induced mechanical hyperalgesia." | 3.96 | Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound. ( Almeida, DS; Costa, EA; da Silva, DPB; Florentino, IF; Ghedini, PC; Lião, LM; Menegatti, R; Moreira, LKDS; Sanz, G; Vaz, BG, 2020) |
| " Acetic acid-induced abdominal writhing and CFA-induced mechanical hyperalgesia were performed to evaluate the antinociceptive activity, and the anti-oedematogenic activity was studied by CFA-induced paw oedema and croton oil-induced ear oedema." | 3.96 | Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM219. ( Cardoso, CS; Costa, EA; da Silva, ACG; da Silva, DPB; de S Gil, E; Florentino, IF; Galvão, GM; Leite, JA; Lião, LM; Menegatti, R; Sabino, JR; Sanz, G; Silva, ALP; Valadares, MC; Vaz, BG, 2020) |
| "Overt pain-like behaviors were determined by the number of abdominal writhings induced by phenyl-p-benzoquinone and acetic acid." | 3.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Probucol reduced overt pain-like behavior, and carrageenan-induced mechanical and thermal hyperalgesia." | 3.85 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| " Intraperitoneal injection with EOCO (5 or 10mg/kg), aspirin (positive control, 300mg/kg), or DMSO (negative control) was performed 1h before the nociception tests: acetic acid-induced writhing response, formalin test, and hot plate test in mice, and acidic saline-induced allodynia in rats." | 3.81 | Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice. ( Cho, CS; Jung, SM; Kim, WU; Park, BJ; Park, Y; Woo, JM; Yoo, SA; Yoon, CH, 2015) |
| " Compound 1 inhibited carrageenan-induced paw edema and acetic acid-induced abdominal writhing, which are its only known anti-inflammatory activities." | 3.80 | Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway. ( Ambrosio, SR; Arakawa, NS; Carvalho, TT; Casagrande, R; de Souza, AR; Ferraz, CR; Hayashida, TH; Hohmann, MS; Mizokami, SS; Possebon, MI; Staurengo-Ferrari, L; Verri, WA; Zarpelon, AC, 2014) |
| " We investigated the antinociceptive effect of botulinum toxin type A (BTX-A) in male Wistar rats in two models of visceral pain: peritonitis induced by intraperitoneal injection of 1% acetic acid and colitis induced by intracolonic instillation of 0." | 3.80 | Antinociceptive effect of botulinum toxin type A on experimental abdominal pain. ( Babić, A; Bach-Rojecky, L; Drinovac, V; Lacković, Z, 2014) |
| " In particular, the glycine derivative proved to be extremely active in suppressing hyperalgesia and edema." | 3.80 | Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 3.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| " In addition, MEA (100 and 200mg/kg/IP) inhibited important events related to the inflammatory response induced by carrageenan or arachidonic acid, namely local edema and increase in tissue interleukin-1β levels." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| "The antinociceptive and antiinflammatory activities of MEA were evaluated using the writhing, formalin, and tail-flick tests, carrageenan-induced paw edema and arachidonic acid-induced ear edema." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| "The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain." | 3.76 | Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents. ( Bosković, B; Prostran, MS; Stepanović-Petrović, RM; Tomić, MA; Ugresić, ND; Vucković, SM, 2010) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "Our data indicate that duloxetine and ibuprofen have synergistic efficacy in a visceral and an inflammatory pain model in rodents, and suggest that duloxetine and ibuprofen in combination may provide a useful approach to the clinical treatment of persistent pain, particularly inflammation-related pain." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " Isobolographic analysis of the effects of duloxetine in combination with ibuprofen revealed a significant synergistic (greater than additive) interaction between duloxetine and ibuprofen both for reducing acetic acid-induced writhing and carrageenan-induced thermal hyperalgesia, but were additive for reversing mechanical allodynia." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " The number of writhing induced by acetic acid was reduced and the pain threshold of mice was increased by Bailian Caogen granule." | 3.73 | [Experimental study of Bailian Caogen granule on pharmacodynamics]. ( Chen, KM; Hao, W; Li, DM; Zhao, LN; Zhao, RY; Zhou, YX, 2006) |
| " The analgesic effect of the drug was studied with pain model of mice induced by acetic acid and hot plate, The severity of oedema in inflamed animal was observed to study the anti-inflammatory effects of Bailian Caogen granule." | 3.73 | [Experimental study of Bailian Caogen granule on pharmacodynamics]. ( Chen, KM; Hao, W; Li, DM; Zhao, LN; Zhao, RY; Zhou, YX, 2006) |
| "Systemic injections of TTX diminished pain behaviour in a dose-dependent manner in models of inflammatory, visceral and neuropathic pain without causing adverse events, whereas morphine analgesia was associated with heavy sedation." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "5% formalin injection into the hind paw, acetic acid administration intraperitoneally or neuropathic pain testing consisting of mechanical allodynia (von Frey filament) and thermal hyperalgesia (Plantar test)." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| "The antihyperalgesic effect of pentoxifylline was investigated in three experimental pain models." | 3.72 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| ") decreased thermal hyperalgesia observed in carrageenan-induced inflammatory hypersensitivity without affecting paw edema, abolished acetic acid-induced writhing activity in mice, and was shown to reduce mechanical allodynia and thermal hyperalgesia observed in a model of post-operative hypersensitivity and formalin-induced spontaneous pain." | 3.72 | Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. ( Decker, MW; Gauvin, DM; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL; Wilson, SG; Wismer, CT; Zhu, CZ, 2004) |
| " Tests of other neurogenic inflammatory stimuli in NK1 -/- mice revealed impaired behavioural responses to cyclophosphamide cystitis and no acute reflex responses or primary hyperalgesia to intracolonic acetic acid." | 3.70 | Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. ( Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C, 2000) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 3.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9." | 1.56 | Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia. ( Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H, 2020) |
| "The poncirin (30 mg/kg) treatment considerably inhibited the mechanical hyperalgesia and allodynia as well as thermal hyperalgesia and cold allodynia." | 1.51 | Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice. ( Afridi, R; Khalid, S; Khan, AU; Khan, S; Kim, YS; Rasheed, H; Shal, B; Shehzad, O; Ullah, MZ, 2019) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| "Chronic neuropathic pain is a burden to millions of patients every day." | 1.51 | Neuropathic insult increases the responsiveness to acetic acid in mice. ( Bagdas, D; Damaj, MI; Gurdap, CO; Markwalter, PS; Neddenriep, B, 2019) |
| "Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve of C57BL/6J male mice and examined in assays of acetic acid (AA)-induced stretching or conditioned place aversion to assess nociceptive and aversive behaviors." | 1.51 | Neuropathic insult increases the responsiveness to acetic acid in mice. ( Bagdas, D; Damaj, MI; Gurdap, CO; Markwalter, PS; Neddenriep, B, 2019) |
| "Mechanical and thermal hyperalgesia induced by carrageenan were determined using an electronic anesthesiometer and hot plate apparatus, respectively." | 1.46 | Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects. ( Alves-Filho, JC; Antunes, MM; Casagrande, R; Cunha, FQ; Cunha, TM; Manchope, MF; Menezes, GB; Staurengo-Ferrari, L; Verri, WA; Zucoloto, AZ, 2017) |
| "Stigmasterol is a common sterol found in plants, but the anti-nociceptive effect of this compound and its mechanism of action are not fully explored." | 1.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "Furthermore, it markedly attenuated the mechanical allodynia caused by surgical incision (after acute treatment with stigmasterol, preventive and curative effects were observed) and partial sciatic nerve ligation (after acute treatment with stigmasterol) and complete Freund's adjuvant (after acute or repeated treatment with stigmasterol)." | 1.46 | Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. ( da Silva Brum, E; Ferreira, J; Oliveira, SM; Rossato, MF; Tonello, R; Trevisan, G; Walker, CIB, 2017) |
| "We report herein the development, synthesis, physicochemical and pharmacological characterization of a novel class of pharmacodynamic hybrids that selectively inhibit cyclooxygenase-2 (COX-2) isoform and present suitable nitric oxide releasing properties." | 1.40 | Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors. ( Alfonso, S; Anzini, M; Battilocchio, C; Biava, M; Calderone, V; Colovic, M; Consalvi, S; Di Capua, A; Di Cesare Mannelli, L; Dovizio, M; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Persiani, S; Poce, G; Rossi, A; Sautebin, L; Testai, L, 2014) |
| "TRR469 was anti-allodynic in the neuropathic pain model and did not display locomotor or cataleptic side effects." | 1.40 | TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. ( Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Targa, M; Varani, K; Vincenzi, F, 2014) |
| "Rotarod and catalepsy tests were used to identify potential side effects, while the functional effect of TRR469 was studied using [(3)H]-d-aspartate release from synaptosomes." | 1.40 | TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice. ( Baraldi, PG; Borea, PA; Gessi, S; Merighi, S; Romagnoli, R; Targa, M; Varani, K; Vincenzi, F, 2014) |
| "Twenty-eight gastric hyperalgesia rats and 20 control rats were used." | 1.39 | Desvenlafaxine succinate ameliorates visceral hypersensitivity but delays solid gastric emptying in rats. ( Chen, JD; Dai, F; Lei, Y; Li, S; Song, G, 2013) |
| "Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice." | 1.39 | Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). ( Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J, 2013) |
| "In addition, TFC reduced CFA-induced tactile hyperalgesia in a dose-dependent manner and the LD50 of TFC was determined to be 400 mg/kg." | 1.38 | Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus. ( Guo, JY; Han, CC; Liu, ZQ; Ren, J; Shi, JL, 2012) |
| "Pentoxifylline (PTX) has strong antyinflamatory effects, decreases TNF-alpha and other proinflammatory cytokines production." | 1.38 | Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models. ( Dobrogowski, J; Nowak, Ł; Thor, PJ; Wordliczek, J; Zurowski, D, 2012) |
| "In rat carrageenan-induced tactile allodynia, single administration of nefopam or ketoprofen only partially reduced allodynia." | 1.35 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Morphine was also effective in relieving pain in all three tests but with signs of considerable sedation." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Tetrodotoxin (TTX) is a powerful sodium channel blocker extracted from the puffer fish." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "It also diminished mechanical allodynia and thermal hyperalgesia with an ED(50) of 1." | 1.33 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "The effect on carrageenan-induced mechanical hyperalgesia, and acetic acid-induced vascular permeability was also determined." | 1.33 | Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Pain is commonly associated with inflammation." | 1.33 | Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats. ( Kulkarni, SK; Patil, CS; Singh, VP, 2005) |
| "Pentoxifylline did not inhibit the nociceptive response in the hot plate test in mice." | 1.32 | Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain. ( Benevides, VM; Brito, GA; Cunha, FQ; da Rocha, FA; Ferreira, SH; Poole, S; Ribeiro, RA; Sachs, D; Vale, ML, 2004) |
| "Because NMDA activity mediates hyperalgesia, we tested the hypothesis that PAR-1 receptors also regulate pain processing." | 1.32 | Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin. ( Fang, M; Fisher, LL; Kovács, KJ; Larson, AA, 2003) |
| "Hyperalgesia was induced by morphine withdrawal in mice treated with morphine for 15 days and then made hyperalgic by morphine substitution with water." | 1.31 | Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002) |
| "In a second model, hyperalgesia was induced by the i." | 1.31 | Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. ( Galeotti, N; Ghelardini, C; Grazioli, I; Uslenghi, C, 2002) |
| "We propose that two separate hyperalgesia pathways exist, one of which is NK1 receptor dependent, whereas the other does not require intact substance P/NK1 signalling." | 1.31 | Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. ( Cervero, F; De Felipe, C; Hunt, SP; Laird, JM; Olivar, T; Roza, C, 2000) |
| "However, the HE did not affect the hyperalgesia induced by carrageenan or PGE2." | 1.30 | Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). ( Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA, 1998) |
| "prevented BK and carrageenan-induced hyperalgesia (mean ID50 values of 6 nmol/kg and 13 nmol/kg), without affecting the hyperalgesia induced by des-Arg9-bradykinin (DABK) or by prostaglandin E2 (PGE2)." | 1.30 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (5.13) | 18.2507 |
| 2000's | 31 (39.74) | 29.6817 |
| 2010's | 34 (43.59) | 24.3611 |
| 2020's | 9 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Matos Leitão, M | 2 |
| Euclides Silva-Filho, S | 2 |
| Arena, AC | 2 |
| Heredia-Vieira, SC | 2 |
| Cardoso, CAL | 2 |
| Kassuya, CAL | 2 |
| Afridi, R | 1 |
| Khan, AU | 1 |
| Khalid, S | 1 |
| Shal, B | 1 |
| Rasheed, H | 1 |
| Ullah, MZ | 1 |
| Shehzad, O | 1 |
| Kim, YS | 1 |
| Khan, S | 1 |
| Osmakov, DI | 2 |
| Koshelev, SG | 2 |
| Palikov, VA | 2 |
| Palikova, YA | 2 |
| Shaykhutdinova, ER | 1 |
| Dyachenko, IA | 2 |
| Andreev, YA | 2 |
| Kozlov, SA | 2 |
| Kumari, P | 1 |
| Kaur, S | 1 |
| Kaur, J | 1 |
| Bhatti, R | 1 |
| Singh, P | 1 |
| Zhang, R | 1 |
| Xu, B | 1 |
| Zhang, Q | 1 |
| Chen, D | 1 |
| Zhang, M | 1 |
| Zhao, G | 1 |
| Xu, K | 1 |
| Xiao, J | 1 |
| Zhu, H | 1 |
| Niu, J | 1 |
| Li, N | 1 |
| Fang, Q | 1 |
| Almeida, DS | 1 |
| da Silva, DPB | 2 |
| Moreira, LKDS | 1 |
| Menegatti, R | 2 |
| Lião, LM | 2 |
| Sanz, G | 2 |
| Vaz, BG | 2 |
| Ghedini, PC | 1 |
| Costa, EA | 2 |
| Florentino, IF | 2 |
| Galvão, GM | 1 |
| Sabino, JR | 1 |
| Cardoso, CS | 1 |
| Silva, ALP | 1 |
| da Silva, ACG | 1 |
| Valadares, MC | 1 |
| Leite, JA | 1 |
| de S Gil, E | 1 |
| Rodríguez Basso, A | 1 |
| Carranza, A | 1 |
| Zainutti, VM | 1 |
| Bach, H | 1 |
| Gorzalczany, SB | 1 |
| Khlifi, A | 1 |
| Pecio, Ł | 1 |
| Lobo, JC | 1 |
| Melo, D | 1 |
| Ben Ayache, S | 1 |
| Flamini, G | 1 |
| Oliveira, MBPP | 1 |
| Oleszek, W | 1 |
| Achour, L | 1 |
| Símaro, GV | 1 |
| Lemos, M | 1 |
| Mangabeira da Silva, JJ | 1 |
| Ribeiro, VP | 1 |
| Arruda, C | 1 |
| Schneider, AH | 1 |
| Wagner de Souza Wanderley, C | 1 |
| Carneiro, LJ | 1 |
| Mariano, RL | 1 |
| Ambrósio, SR | 2 |
| Faloni de Andrade, S | 1 |
| Banderó-Filho, VC | 1 |
| Sasse, A | 1 |
| Sheridan, H | 1 |
| Andrade E Silva, ML | 1 |
| Bastos, JK | 1 |
| Wei, S | 1 |
| Qiu, CY | 1 |
| Jin, Y | 1 |
| Liu, TT | 1 |
| Hu, WP | 1 |
| Zucoloto, AZ | 1 |
| Manchope, MF | 1 |
| Staurengo-Ferrari, L | 2 |
| Alves-Filho, JC | 2 |
| Cunha, TM | 2 |
| Antunes, MM | 1 |
| Menezes, GB | 1 |
| Cunha, FQ | 4 |
| Casagrande, R | 3 |
| Verri, WA | 3 |
| Yu, X | 1 |
| Wang, XP | 1 |
| Yan, XJ | 1 |
| Jiang, JF | 1 |
| Lei, F | 1 |
| Xing, DM | 1 |
| Guo, YY | 1 |
| Du, LJ | 1 |
| Walker, CIB | 1 |
| Oliveira, SM | 1 |
| Tonello, R | 1 |
| Rossato, MF | 1 |
| da Silva Brum, E | 1 |
| Ferreira, J | 3 |
| Trevisan, G | 1 |
| Qi, DB | 1 |
| Zhang, SH | 1 |
| Zhang, YH | 1 |
| Wu, SQ | 1 |
| Li, WM | 1 |
| Yu, JW | 1 |
| Huang, JH | 1 |
| Lü, KL | 1 |
| Zhou, MK | 1 |
| Feng, X | 1 |
| Tian, K | 1 |
| Zhuang, JT | 1 |
| Zhou, WL | 1 |
| Deng, CH | 1 |
| Tu, XA | 1 |
| Maleeva, EE | 1 |
| Logashina, YA | 1 |
| Tansley, SN | 1 |
| Macintyre, LC | 1 |
| Diamond, L | 1 |
| Sotocinal, SG | 1 |
| George, N | 1 |
| Meluban, L | 1 |
| Austin, JS | 1 |
| Coderre, TJ | 1 |
| Martin, LJ | 1 |
| Mogil, JS | 1 |
| Gurdap, CO | 1 |
| Markwalter, PS | 1 |
| Neddenriep, B | 1 |
| Bagdas, D | 1 |
| Damaj, MI | 1 |
| Qu, R | 1 |
| Tao, J | 1 |
| Wang, Y | 2 |
| Zhou, Y | 1 |
| Wu, G | 1 |
| Xiao, Y | 1 |
| Hu, CY | 1 |
| Jiang, X | 1 |
| Xu, GY | 4 |
| Patel, RB | 1 |
| Pawar, VD | 1 |
| Prajapati, KD | 1 |
| Sonara, BM | 1 |
| Deshpande, SS | 1 |
| Shah, GB | 1 |
| Jain, MR | 1 |
| Nowak, Ł | 1 |
| Zurowski, D | 1 |
| Dobrogowski, J | 1 |
| Wordliczek, J | 1 |
| Thor, PJ | 1 |
| Dai, F | 1 |
| Lei, Y | 1 |
| Li, S | 1 |
| Song, G | 1 |
| Chen, JD | 3 |
| Tang, QL | 1 |
| Lai, ML | 1 |
| Zhong, YF | 1 |
| Wang, AM | 1 |
| Su, JK | 1 |
| Zhang, MQ | 1 |
| Magro, DA | 1 |
| Hohmann, MS | 2 |
| Mizokami, SS | 2 |
| Ferreira, SH | 3 |
| Liew, FY | 1 |
| Biava, M | 1 |
| Battilocchio, C | 1 |
| Poce, G | 1 |
| Alfonso, S | 1 |
| Consalvi, S | 1 |
| Di Capua, A | 1 |
| Calderone, V | 1 |
| Martelli, A | 1 |
| Testai, L | 1 |
| Sautebin, L | 1 |
| Rossi, A | 1 |
| Ghelardini, C | 2 |
| Di Cesare Mannelli, L | 1 |
| Giordani, A | 1 |
| Persiani, S | 1 |
| Colovic, M | 1 |
| Dovizio, M | 1 |
| Patrignani, P | 1 |
| Anzini, M | 1 |
| Vincenzi, F | 1 |
| Targa, M | 1 |
| Romagnoli, R | 1 |
| Merighi, S | 1 |
| Gessi, S | 1 |
| Baraldi, PG | 1 |
| Borea, PA | 1 |
| Varani, K | 1 |
| Abdelazeem, AH | 1 |
| Abdelatef, SA | 1 |
| El-Saadi, MT | 1 |
| Omar, HA | 1 |
| Khan, SI | 1 |
| McCurdy, CR | 1 |
| El-Moghazy, SM | 1 |
| Yang, Y | 2 |
| Cui, X | 1 |
| Chen, Y | 1 |
| Li, X | 1 |
| Lin, L | 2 |
| Zhang, H | 1 |
| Lewis, ND | 1 |
| Muthukumarana, A | 1 |
| Fogal, SE | 1 |
| Corradini, L | 1 |
| Stefanopoulos, DE | 1 |
| Adusumalli, P | 1 |
| Pelletier, J | 1 |
| Panzenbeck, M | 1 |
| Berg, K | 1 |
| Canfield, M | 1 |
| Cook, BN | 1 |
| Razavi, H | 1 |
| Kuzmich, D | 1 |
| Anderson, S | 1 |
| Allard, D | 1 |
| Harrison, P | 1 |
| Grimaldi, C | 1 |
| Souza, D | 1 |
| Harcken, C | 1 |
| Fryer, RM | 1 |
| Modis, LK | 1 |
| Brown, ML | 1 |
| Cui, XF | 1 |
| Zhou, WM | 1 |
| Zhou, J | 1 |
| Li, XL | 1 |
| Zhang, HJ | 1 |
| Possebon, MI | 1 |
| Carvalho, TT | 1 |
| Zarpelon, AC | 1 |
| Ferraz, CR | 1 |
| Hayashida, TH | 1 |
| de Souza, AR | 1 |
| Arakawa, NS | 1 |
| Drinovac, V | 1 |
| Bach-Rojecky, L | 1 |
| Babić, A | 1 |
| Lacković, Z | 1 |
| Park, Y | 1 |
| Jung, SM | 1 |
| Yoo, SA | 1 |
| Kim, WU | 1 |
| Cho, CS | 1 |
| Park, BJ | 1 |
| Woo, JM | 1 |
| Yoon, CH | 1 |
| Russo, R | 1 |
| De Caro, C | 1 |
| Avagliano, C | 1 |
| Cristiano, C | 1 |
| La Rana, G | 1 |
| Mattace Raso, G | 1 |
| Berni Canani, R | 1 |
| Meli, R | 1 |
| Calignano, A | 1 |
| Gonçalves, GM | 1 |
| Capim, SL | 1 |
| Vasconcellos, ML | 1 |
| Marinho, BG | 1 |
| Nikai, T | 1 |
| Basbaum, AI | 1 |
| Ahn, AH | 1 |
| Lin, Y | 1 |
| Tian, G | 1 |
| Roman, K | 1 |
| Handy, C | 1 |
| Travers, JB | 1 |
| Lin, CL | 1 |
| Stephens, RL | 1 |
| Winston, JH | 3 |
| Marcon, R | 1 |
| Luiz, AP | 1 |
| Werner, MF | 1 |
| Freitas, CS | 1 |
| Baggio, CH | 1 |
| Nascimento, FP | 1 |
| Soldi, C | 1 |
| Pizzolatti, MG | 1 |
| Santos, AR | 5 |
| Shenoy, M | 3 |
| Zhou, S | 1 |
| Pasricha, PJ | 3 |
| Tomić, MA | 1 |
| Vucković, SM | 1 |
| Stepanović-Petrović, RM | 1 |
| Ugresić, ND | 1 |
| Prostran, MS | 1 |
| Bosković, B | 1 |
| Nonato, FR | 1 |
| Nogueira, TM | 1 |
| Barros, TA | 1 |
| Lucchese, AM | 1 |
| Oliveira, CE | 1 |
| Santos, RR | 1 |
| Soares, MB | 1 |
| Villarreal, CF | 1 |
| Mori, LS | 1 |
| Boller, S | 1 |
| Kassuya, CA | 1 |
| Stefanello, MÉ | 1 |
| Zampronio, AR | 1 |
| Imanishi, J | 1 |
| Morita, Y | 1 |
| Yoshimi, E | 1 |
| Kuroda, K | 1 |
| Masunaga, T | 1 |
| Yamagami, K | 1 |
| Kuno, M | 1 |
| Hamachi, E | 1 |
| Aoki, S | 1 |
| Takahashi, F | 1 |
| Nakamura, K | 1 |
| Miyata, S | 1 |
| Ohkubo, Y | 1 |
| Mutoh, S | 1 |
| Liu, M | 1 |
| Shen, J | 1 |
| Liu, H | 1 |
| Xu, Y | 1 |
| Su, YP | 1 |
| Yang, J | 1 |
| Yu, CX | 1 |
| Ren, J | 1 |
| Shi, JL | 1 |
| Han, CC | 1 |
| Liu, ZQ | 1 |
| Guo, JY | 1 |
| Moreira, J | 1 |
| Klein-Júnior, LC | 1 |
| Cechinel Filho, V | 2 |
| de Campos Buzzi, F | 1 |
| Ozaki, N | 3 |
| Bielefeldt, K | 4 |
| Sengupta, JN | 1 |
| Gebhart, GF | 4 |
| Galeotti, N | 1 |
| Grazioli, I | 1 |
| Uslenghi, C | 1 |
| Fang, M | 1 |
| Kovács, KJ | 1 |
| Fisher, LL | 1 |
| Larson, AA | 1 |
| Lamb, K | 1 |
| Kang, YM | 1 |
| Tordjman, C | 1 |
| Andre, N | 1 |
| Bresson, Y | 1 |
| Bellot, I | 1 |
| Deschamps, C | 1 |
| Pastoureau, P | 1 |
| Wierzbicki, M | 1 |
| Patil, CS | 3 |
| Jain, NK | 3 |
| Singh, VP | 2 |
| Kulkarni, SK | 4 |
| Padi, SS | 1 |
| Singh, S | 1 |
| Vale, ML | 1 |
| Benevides, VM | 1 |
| Sachs, D | 1 |
| Brito, GA | 1 |
| da Rocha, FA | 1 |
| Poole, S | 2 |
| Ribeiro, RA | 1 |
| Zhu, CZ | 1 |
| Wilson, SG | 1 |
| Mikusa, JP | 1 |
| Wismer, CT | 1 |
| Gauvin, DM | 1 |
| Lynch, JJ | 1 |
| Wade, CL | 1 |
| Decker, MW | 1 |
| Honore, P | 1 |
| Gadotti, VM | 1 |
| Schmeling, LO | 1 |
| Machado, C | 1 |
| Liz, FH | 1 |
| Filho, VC | 1 |
| Meyre-Silva, C | 1 |
| Jones, CK | 1 |
| Peters, SC | 1 |
| Shannon, HE | 1 |
| Marcil, J | 1 |
| Walczak, JS | 1 |
| Guindon, J | 1 |
| Ngoc, AH | 1 |
| Lu, S | 1 |
| Beaulieu, P | 1 |
| Zhao, RY | 1 |
| Zhao, LN | 1 |
| Zhou, YX | 1 |
| Li, DM | 1 |
| Hao, W | 1 |
| Chen, KM | 1 |
| Winston, J | 1 |
| Medley, D | 1 |
| Naniwadekar, A | 1 |
| Meotti, FC | 1 |
| Carqueja, CL | 1 |
| Gadotti, Vde M | 1 |
| Tasca, CI | 1 |
| Walz, R | 1 |
| Szabó, G | 1 |
| Fischer, J | 1 |
| Kis-Varga, A | 1 |
| Gyires, K | 1 |
| Mittal, S | 1 |
| Girard, P | 1 |
| Verniers, D | 1 |
| Coppé, MC | 1 |
| Pansart, Y | 1 |
| Gillardin, JM | 1 |
| Mendes, GL | 1 |
| Campos, MM | 1 |
| Tratsk, KS | 1 |
| Yunes, RA | 1 |
| Calixto, JB | 3 |
| de Campos, RO | 1 |
| Alves, RV | 1 |
| Kyle, DJ | 1 |
| Chakravarty, S | 1 |
| Mavunkel, BJ | 1 |
| Khasar, SG | 1 |
| Lin, YH | 1 |
| Martin, A | 1 |
| Dadgar, J | 1 |
| McMahon, T | 1 |
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| Roza, C | 1 |
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| Hunt, SP | 1 |
| Cervero, F | 1 |
| Cunha, JM | 1 |
| Saegusa, H | 1 |
| Kurihara, T | 1 |
| Zong, S | 1 |
| Kazuno , A | 1 |
| Matsuda, Y | 1 |
| Nonaka, T | 1 |
| Han, W | 1 |
| Toriyama, H | 1 |
| Tanabe, T | 1 |
| Singh, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
78 other studies available for acetic acid and Allodynia
| Article | Year |
|---|---|
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hypera | 2023 |
Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Pain; Disease Mo | 2019 |
Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Animals; Anti-Inflammator | 2019 |
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 In | 2020 |
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Drug Tolerance; Fascia; Formaldehyde; Hot Temperature; Hyp | 2020 |
Investigation of anti-inflammatory potential of 5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione compound.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Edema; Hyperal | 2020 |
Anti-inflammatory and antinociceptive activity profile of a new lead compound - LQFM219.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; BALB 3T3 Cells; Carrageena | 2020 |
Pharmacologycal activity of peperina (Minthostachys verticillata) on gastrointestinal tract.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capsaicin; Castor Oil; Colitis, Ul | 2021 |
Leaves of Cleome amblyocarpa Barr. And Murb. And Cleome arabica L.: Assessment of nutritional composition and chemical profile (LC-ESI-MS/MS), anti-inflammatory and analgesic effects of their extracts.
Topics: Acetic Acid; Africa, Northern; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carr | 2021 |
Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Behavior, Anima | 2021 |
TNF-α acutely enhances acid-sensing ion channel currents in rat dorsal root ganglion neurons via a p38 MAPK pathway.
Topics: Acetic Acid; Acid Sensing Ion Channels; Action Potentials; Animals; Ganglia, Spinal; Hyperalgesia; M | 2021 |
Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Benzoquinones; Carrage | 2017 |
Anti-nociceptive effect of patchouli alcohol: Involving attenuation of cyclooxygenase 2 and modulation of mu-opioid receptor.
Topics: Acetic Acid; Analgesics; Animals; Calcium; Cell Line; Cyclooxygenase 2; Cytoplasm; Hyperalgesia; Inf | 2019 |
Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain.
Topics: Acetic Acid; Acetylcholinesterase; Acute Disease; Analgesics; Animals; Brain; Chronic Disease; Freun | 2017 |
A rat model for studying electroacupuncture analgesia on acute visceral hyperalgesia.
Topics: Acetic Acid; Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Elect | 2018 |
[Expressions of TRPV1 and TRPA1 in the dorsal root ganglion in the rat model of orchialgia].
Topics: Acetic Acid; Animals; Ganglia, Spinal; Hyperalgesia; Male; Membrane Glycoproteins; Oxidoreductases; | 2017 |
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds.
Topics: Acetic Acid; Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Analgesics; Animals; Biol | 2018 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Neuropathic insult increases the responsiveness to acetic acid in mice.
Topics: Acetic Acid; Animals; Conditioning, Classical; Disease Models, Animal; Hyperalgesia; Male; Mice; Mic | 2019 |
Neonatal colonic inflammation sensitizes voltage-gated Na(+) channels via upregulation of cystathionine β-synthetase expression in rat primary sensory neurons.
Topics: Acetic Acid; Aminooxyacetic Acid; Animals; Animals, Newborn; Carbocyanines; Colitis; Coloring Agents | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarat | 2013 |
Pentoxifylline modifies central and peripheral vagal mechanism in acute and chronic pain models.
Topics: Acetic Acid; Acute Pain; Animals; Anti-Inflammatory Agents; Chronic Pain; Cytokines; Hyperalgesia; I | 2012 |
Desvenlafaxine succinate ameliorates visceral hypersensitivity but delays solid gastric emptying in rats.
Topics: Acetic Acid; Administration, Oral; Adrenergic Uptake Inhibitors; Animals; Cyclohexanols; Desvenlafax | 2013 |
Antinociceptive effect of berberine on visceral hypersensitivity in rats.
Topics: Acetic Acid; Analgesics; Animals; Berberine; Colon; Defecation; Disease Models, Animal; Disease Prog | 2013 |
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice.
Topics: Acetic Acid; Animals; Benzoquinones; Homozygote; Hot Temperature; Hyperalgesia; Interleukin-1 Recept | 2013 |
Enhancing the pharmacodynamic profile of a class of selective COX-2 inhibiting nitric oxide donors.
Topics: Acetic Acid; Amides; Animals; Carrageenan; Cell Line; Constriction, Pathologic; Cyclooxygenase 2; Cy | 2014 |
TRR469, a potent A(1) adenosine receptor allosteric modulator, exhibits anti-nociceptive properties in acute and neuropathic pain models in mice.
Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Catalepsy; CHO Cells; Cricetinae; Cricetulu | 2014 |
Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Cell Line, Tumor | 2014 |
Exendin-4, an analogue of glucagon-like peptide-1, attenuates hyperalgesia through serotonergic pathways in rats with neonatal colonic sensitivity.
Topics: Acetic Acid; Animals; Colon; Exenatide; Hyperalgesia; Male; Peptides; Rats; Rats, Sprague-Dawley; Se | 2014 |
CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Bone Marrow Cells; Bone Marrow Transplantation; Cell | 2014 |
Epidermal growth factor upregulates serotonin transporter and its association with visceral hypersensitivity in irritable bowel syndrome.
Topics: Acetic Acid; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme In | 2014 |
Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Analgesics; Anti-Inflammatory Agents; Carrageenan; Cyclic GMP; Diterpenes; Edema; Freun | 2014 |
Antinociceptive effect of botulinum toxin type A on experimental abdominal pain.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Botulinum Toxins, Type A; Capsaicin; Colitis; Dise | 2014 |
Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Chamaecyparis; Cytokines; Hot T | 2015 |
Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice.
Topics: Acetic Acid; Amides; Analgesics; Anilides; Animals; Butyric Acid; Formaldehyde; Hot Temperature; Hyp | 2016 |
Antihyperalgesic effect of [(±)-(2,4,6-cis)-4-chloro-6-(naphthalen-1-yl)-tetrahydro-2H-pyran-2-yl]methanol: participation of the NO/cGMP/KATP pathway and κ-opioid receptor.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Cyclic GMP; Disease Models, Animal; Dose-Res | 2016 |
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Carrageenan; Drug Evaluation, P | 2008 |
Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Ceftriaxone; Colon; Disease Models, Animal; Ethanol; Excitat | 2009 |
Electroacupuncture attenuates visceral hyperalgesia and inhibits the enhanced excitability of colon specific sensory neurons in a rat model of irritable bowel syndrome.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Animals, Newborn; Colon; Dilatation; Electroacupuncture; E | 2009 |
Evidence of TRPV1 receptor and PKC signaling pathway in the antinociceptive effect of amyrin octanoate.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; | 2009 |
The endogenous hydrogen sulfide producing enzyme cystathionine-beta synthase contributes to visceral hypersensitivity in a rat model of irritable bowel syndrome.
Topics: Acetic Acid; Animals; Blotting, Western; Colon; Cystathionine beta-Synthase; Fluorescent Antibody Te | 2009 |
Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.
Topics: Acetaminophen; Acetic Acid; Algorithms; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Carbamaz | 2010 |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Behavior, An | 2011 |
Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Carrageenan; Disease Models, | 2011 |
Pharmacological profile of FK881(ASP6537), a novel potent and selective cyclooxygenase-1 inhibitor.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; CHO Cells; Cricetinae; Cricetulus; Cyclo | 2011 |
Gelsenicine from Gelsemium elegans attenuates neuropathic and inflammatory pain in mice.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Behavior, Animal; Drugs, Chinese Herbal; Formaldehyde; | 2011 |
Isolation and biological activity of triglycerides of the fermented mushroom of Coprinus Comatus.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Biological | 2012 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Ac | 2013 |
Models of gastric hyperalgesia in the rat.
Topics: Acetic Acid; Animals; Avoidance Learning; Behavior, Animal; Catheterization; Disease Models, Animal; | 2002 |
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Dopamine Antagonists; Drug | 2002 |
Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin.
Topics: Acetic Acid; Amino Acid Chloromethyl Ketones; Animals; Behavior, Animal; Capillary Permeability; End | 2003 |
Nerve growth factor and gastric hyperalgesia in the rat.
Topics: Acetic Acid; Animals; Antibodies; Electromyography; Enzyme-Linked Immunosorbent Assay; Hyperalgesia; | 2003 |
General pharmacology of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
Topics: Acetic Acid; Air; Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, E | 2003 |
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic A | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
Topics: Acetic Acid; Animals; Arthritis, Experimental; Carrageenan; Hot Temperature; Hyperalgesia; Iloprost; | 2004 |
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
Topics: Acetic Acid; Animals; Carrageenan; Central Nervous System; Constriction, Pathologic; Edema; Formalde | 2004 |
Differential effect of zileuton, a 5-lipoxygenase inhibitor, against nociceptive paradigms in mice and rats.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Capillary Permeability; Carrageenan; Cyclopropanes; Dose | 2005 |
Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Animals; Bauhinia; Carrageenan; Constriction, Pathologic | 2005 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2007 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relation | 2006 |
[Experimental study of Bailian Caogen granule on pharmacodynamics].
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Body Temperature; Coptis; Drug Combinations; Drugs, | 2006 |
The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats.
Topics: Acetic Acid; Age Factors; Anilides; Animals; Animals, Newborn; Capsaicin; Catheterization; Cinnamate | 2007 |
Involvement of cellular prion protein in the nociceptive response in mice.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Edema; Freund's Adjuvant; Glutamic Aci | 2007 |
New celecoxib derivatives as anti-inflammatory agents.
Topics: Acetic Acid; Animals; Carrageenan; Celecoxib; Chronic Disease; Crystallization; Cyclooxygenase 1; Cy | 2008 |
P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity.
Topics: Acetic Acid; Adenosine Triphosphate; Animals; Chronic Disease; Colon; Disease Models, Animal; Hypera | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response R | 1998 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Anim | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Rec | 1999 |
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Carrageenan; Enzyme Inhibitors; Epinephrine; Hot Temper | 1999 |
A comparison of the anti-inflammatory and anti-nociceptive activity of nitroaspirin and aspirin.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca | 2000 |
Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene.
Topics: Acetic Acid; Animals; Behavior, Animal; Capsaicin; Colon; Cyclophosphamide; Cystitis; Female; Hypera | 2000 |
Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist.
Topics: Acetic Acid; Animals; Antibodies; Bradykinin; Carrageenan; Cytokines; Dinoprostone; Dopamine; Dose-R | 2000 |
Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.
Topics: Acetic Acid; Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Calcium Channel Blockers; Cal | 2001 |
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central | 2001 |
Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons.
Topics: Acetic Acid; Anesthetics, Local; Animals; Disease Models, Animal; Ganglia, Spinal; Gastritis; Hypera | 2002 |
Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat.
Topics: Acetic Acid; Animals; Hyperalgesia; Iodoacetamide; Models, Animal; Rats; Sensation; Sodium Channels; | 2002 |