gamma-aminobutyric acid has been researched along with Allodynia in 318 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The intradermal capsaicin pain model has been used to evaluate analgesic effects of a variety of drugs." | 9.19 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "Using the Dixon sequential up-down method, the ED50 of pregabalin on intradermal capsaicin induced pain was successfully calculated (252 mg) using only 13 subjects." | 9.19 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "This study compared the effects of pregabalin (300 mg) and the tetracycline antibiotic and glial attenuator minocycline (400 mg) on capsaicin-induced spontaneous pain, flare, allodynia and hyperalgesia in patients with unilateral sciatica on both their affected and unaffected leg." | 9.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "Patients with unilateral sciatica have heightened responses to intradermal capsaicin compared to pain-free volunteers." | 9.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "It cannot be concluded that minocycline is unsuitable for further evaluation as an anti-neuropathic pain drug as pregabalin, our positive control, failed to reduce capsaicin-induced neuropathic pain." | 9.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster." | 9.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Compared to an earlier study of gabapentin 900 mg for acute zoster pain and allodynia that followed a nearly identical protocol, pregabalin had a similar effect on pain and was well tolerated, with no difference from placebo on sleepiness." | 9.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "The effect of pregabalin on acute herpes zoster pain has not been previously evaluated." | 9.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Over 6 hours of observation, pain decreased by a mean of 33% with pregabalin and 14% with placebo (p < 0." | 9.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Intradermal (ID) capsaicin injection in humans induces spontaneous pain, flare, primary hyperalgesia, secondary hyperalgesia, and allodynia." | 9.13 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| "This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster." | 9.11 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 7.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "(1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1." | 7.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 7.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 7.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| "In the present work, we investigated the antinociceptive effect of gabapentin in a chronic myositis model and its interference in spinal glial cells." | 7.85 | Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 7.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 7.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 7.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| "The objective of this study was to develop a pharmacokinetic-pharmacodynamic (PK-PD) model of the static allodynia response to pregabalin with and without sildenafil in a chronic constriction injury model of neuropathic pain." | 7.76 | Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain. ( Bender, G; Bies, RR; Bramwell, S; Danhof, M; DeJongh, J; Field, MJ; Florian, JA; Marshall, S; Tan, KK, 2010) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Pregabalin is used for treatment of neuropathic pain conditions." | 7.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "This study shows that pregabalin reduces both cutaneous and muscle hyperalgesia in inflammatory and noninflammatory models of muscle pain." | 7.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 7.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 7.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 7.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s." | 7.73 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "To systematically establish the pain relieving efficacies of venlafaxine and gabapentin alone and in combination." | 7.73 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "The effects of systemic and local injections of gabapentin, a novel anticonvulsant agent, were tested on nociceptive behaviors in mice with acute herpetic pain." | 7.71 | Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection. ( Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I, 2001) |
| " Dosing was set by the Dixon sequential up-down method; that is, a greater or less than 30% reduction in capsaicin pain decreased or increased the dose, respectively, by a fixed interval for the next subject." | 6.79 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "Secondary outcome measures included secondary hyperalgesia and tactile and thermal allodynia, and their respective areas (cm(2))." | 6.79 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "Effects on allodynia and SF-MPQ were not significant." | 6.76 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Secondary hyperalgesia and allodynia are a reflection of central sensitization." | 6.73 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| "Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin." | 6.71 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist." | 5.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Neuropathic pain has proven to be a difficult condition to treat, so investigational therapy has been sought that may prove useful, such as the use of sigma-1 antagonists." | 5.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Chronic pain, neuropathic pain, inflammatory pain, ozone therapy, interventional therapy, gabapentin, spared nerve injury, bee venom, complete Freud's adjuvant." | 5.46 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Gabapentin (GBP) is an effective analgesic for neuropathic pain conditions but its clinical efficacy in cisplatin-induced neuropathic pain (CINP) is limited, in addition to generating unwanted side-effects." | 5.46 | Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. ( Ahmad, N; Islam, NU; Rahman, FU; Sewell, RDE; Shahid, M; Subhan, F, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Chronic myositis was induced by injection of Complete Freund Adjuvant (CFA) into the right gastrocnemius (GS) muscle of rats and tests for evaluating mechanical hyperalgesia, thermal hyperalgesia and tactile allodynia were performed." | 5.46 | Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017) |
| "Both phases display robust tactile allodynia." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "After onset of inflammation and allodynia, we assessed effects of i." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 5.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Mechanical allodynia was assessed using von Frey hairs." | 5.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 5.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 5.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Bortezomib (0." | 5.40 | Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. ( Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H, 2014) |
| "Morphine was less potent in neuroma pain than in mechanical allodynia." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "After TNT injury, mechanical allodynia and neuroma pain are observed." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The static allodynia endpoint was modeled by using three population PD approaches: 1) the behavior of the injured paw using a three-category ordinal logistic regression model; 2) paw withdrawal threshold (PWT) (g) between the injured and uninjured paw using the Hill equation with a baseline function; and 3) the baseline normalized difference in PWT between the injured and uninjured paw." | 5.36 | Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain. ( Bender, G; Bies, RR; Bramwell, S; Danhof, M; DeJongh, J; Field, MJ; Florian, JA; Marshall, S; Tan, KK, 2010) |
| "Muscle hyperalgesia (withdrawal threshold to compression of the muscle) and cutaneous hyperalgesia of the paw (withdrawal threshold to von Frey filaments) were measured before and after induction of hyperalgesia and after treatment with pregabalin (saline, 10 to 100 mg/kg i." | 5.34 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult." | 5.34 | Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "A complete reversal of hyperalgesia was seen with lacosamide at 30mg/kg." | 5.34 | Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "Secondary mechanical allodynia and hyperalgesia were measured at 5 and 15 min after capsaicin injection, respectively." | 5.33 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "Neuropathic pain is associated with a number of disease states of diverse aetiology that can share common pathophysiological mechanisms." | 5.33 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s." | 5.33 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "The intradermal capsaicin pain model has been used to evaluate analgesic effects of a variety of drugs." | 5.19 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "Using the Dixon sequential up-down method, the ED50 of pregabalin on intradermal capsaicin induced pain was successfully calculated (252 mg) using only 13 subjects." | 5.19 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "This study compared the effects of pregabalin (300 mg) and the tetracycline antibiotic and glial attenuator minocycline (400 mg) on capsaicin-induced spontaneous pain, flare, allodynia and hyperalgesia in patients with unilateral sciatica on both their affected and unaffected leg." | 5.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "Patients with unilateral sciatica have heightened responses to intradermal capsaicin compared to pain-free volunteers." | 5.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "It cannot be concluded that minocycline is unsuitable for further evaluation as an anti-neuropathic pain drug as pregabalin, our positive control, failed to reduce capsaicin-induced neuropathic pain." | 5.16 | The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica. ( Briggs, N; Gentgall, M; Hutchinson, MR; Rolan, P; Sumracki, NM; Williams, DB, 2012) |
| "In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster." | 5.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Compared to an earlier study of gabapentin 900 mg for acute zoster pain and allodynia that followed a nearly identical protocol, pregabalin had a similar effect on pain and was well tolerated, with no difference from placebo on sleepiness." | 5.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "The effect of pregabalin on acute herpes zoster pain has not been previously evaluated." | 5.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Over 6 hours of observation, pain decreased by a mean of 33% with pregabalin and 14% with placebo (p < 0." | 5.15 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Intradermal (ID) capsaicin injection in humans induces spontaneous pain, flare, primary hyperalgesia, secondary hyperalgesia, and allodynia." | 5.13 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| " The analgesic activity of CHF3381 was investigated in the heat-capsaicin human pain model and compared with those of gabapentin." | 5.12 | CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model. ( Dahl, JB; Fabbri, L; Hilsted, KL; Imbimbo, BP; Mathiesen, O, 2006) |
| "Pregabalin significantly reduced the areas of punctate mechanical hyperalgesia and dynamic touch allodynia vs placebo (both P < 0." | 5.12 | Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. ( Chizh, BA; Göhring, M; Koppert, W; Quartey, GK; Schmelz, M; Tröster, A, 2007) |
| "Gabapentin significantly reduced the area of brush allodynia compared with placebo (P | 5.11 | Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia. ( Bach, FW; Brown, J; Chizh, BA; Gottrup, H; Jensen, TS; Juhl, G; Kristensen, AD; Lai, R, 2004) |
| "This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster." | 5.11 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| " Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | 3.88 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 3.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "(1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1." | 3.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "The combination of low-dose KML29:gabapentin additively attenuated mechanical allodynia and synergistically reduced cold allodynia." | 3.85 | The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017) |
| "Gabapentin is commonly prescribed for nerve pain but may also cause dizziness, sedation and gait disturbances." | 3.85 | The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 3.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 3.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| "In the present work, we investigated the antinociceptive effect of gabapentin in a chronic myositis model and its interference in spinal glial cells." | 3.85 | Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017) |
| " Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 3.85 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 3.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| " Sleep disruption-induced hypersensitivity was pharmacologically characterized with drugs relevant for pain treatment, including gabapentin (30 mg/kg and 50 mg/kg), Ica-6p (Kv7." | 3.81 | Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. ( Gilmour, G; Kennedy, JD; Schuh-Hofer, S; Treede, RD; Wafford, KA; Wodarski, R; Yurek, DA, 2015) |
| " Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia." | 3.81 | Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015) |
| " Here, we aim to reveal the risk factors of migraine with allodynia and to illustrate the effects of pregabalin on alleviating allodynia." | 3.81 | Effects of pregabalin on central sensitization in patients with migraine. ( Chen, CF; Yu, FY; Zhang, N, 2015) |
| "To evaluate the antinociceptive and hypnotic effects of pregabalin, we established a neuropathic pain-like model in mice using partial sciatic nerve ligation (PSNL), and examined thermal hyperalgesia, mechanical allodynia, electroencephalogram, rota-rod testing, and c-Fos expression in the anterior cingulate cortex." | 3.81 | Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015) |
| "Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)." | 3.81 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "The results demonstrated that oral AQU-118 attenuates mechanical allodynia in both neuropathic pain models and with efficacies that mirror gabapentin at the 40 mg/kg dose used in the CCI-IoN model but without effect on basal sensitivity to mechanical stimulation/locomotive activity." | 3.81 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "In OXPT-treated mice LPP1 and pregabalin dose-dependently reduced tactile allodynia (41-106% and 6-122%, respectively, p<0." | 3.80 | Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice. ( Cios, A; Filipek, B; Malawska, B; Mogilski, S; Sałat, K; Sałat, R; Więckowski, K; Wyska, E, 2014) |
| "This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine." | 3.80 | Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| " Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
| "Pregabalin was a very efficacious antiallodynic and analgesic drug capable of increasing the pain thresholds for tactile allodynia and thermal hyperalgesia in diabetic mice." | 3.79 | Evaluation of analgesic, antioxidant, cytotoxic and metabolic effects of pregabalin for the use in neuropathic pain. ( Gluch-Lutwin, M; Librowski, T; Nawiesniak, B; Sałat, K, 2013) |
| "Cisplatintreated mice display allodynia and an activation of DRG activated transcription factor 3, which is paralleled by its effects on behavior in the CPP system, wherein gabapentin, but not ketorolac, in the presence of the cisplatin polyneuropathy, is positively rewarding, confirming that this neuropathy is an aversive (painful) state that is ameliorated by gabapentin." | 3.79 | Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. ( Park, HJ; Pirie, E; Shtaerman, Y; Skahen, J; Stokes, JA; Yaksh, TL, 2013) |
| "The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH." | 3.78 | Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 3.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 3.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| " A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA)-induced monoarthritis (MA)." | 3.78 | Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. ( Deng, XM; Li, SS; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ, 2012) |
| "We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia." | 3.77 | Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011) |
| " We investigated pregabalin, indicated for neuropathic pain, and ondansetron, a drug that disrupts descending serotonergic processing in the central nervous system, on spinal neuronal hyperexcitability and visceral hypersensitivity in a rat model of opioid-induced hyperalgesia." | 3.77 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| " After recovery, rats received injections of lidocaine, GABA and glycine agonists or antagonists and their effects were assessed on behavioral tests of allodynia and hyperalgesia." | 3.76 | Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats. ( Al Amin, H; Atweh, SF; Jabbur, SJ; Saadé, NE; Tchachaghian, S, 2010) |
| "The objective of this study was to develop a pharmacokinetic-pharmacodynamic (PK-PD) model of the static allodynia response to pregabalin with and without sildenafil in a chronic constriction injury model of neuropathic pain." | 3.76 | Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain. ( Bender, G; Bies, RR; Bramwell, S; Danhof, M; DeJongh, J; Field, MJ; Florian, JA; Marshall, S; Tan, KK, 2010) |
| "The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation." | 3.75 | Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. ( Deng, XM; Sun, S; Xu, B; Xu, H; Zhang, WS; Zhang, YQ, 2009) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Pregabalin is used for treatment of neuropathic pain conditions." | 3.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "This study shows that pregabalin reduces both cutaneous and muscle hyperalgesia in inflammatory and noninflammatory models of muscle pain." | 3.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 3.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "A comparison of total body doses that cause allodynia following spinal or systemic administration indicated that NMDA induces allodynia in the spinal cord while sulprostone and phenylephrine act through a peripheral mechanism." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 3.74 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| "Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats." | 3.73 | Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 3.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Here, we have examined the effect of the novel antinociceptive agent CHF3381 on the development of nocifensive behaviour as well as secondary mechanical allodynia and hyperalgesia induced by intraplantar injection of capsaicin in rats." | 3.73 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s." | 3.73 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "To systematically establish the pain relieving efficacies of venlafaxine and gabapentin alone and in combination." | 3.73 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "Intrathecal gabapentin (30, 100, 200 microg) dose-dependently reduced incision-induced allodynia." | 3.72 | Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain. ( Chen, CC; Cheng, CR; Cheng, JK; Chiou, LC; Lai, YJ, 2003) |
| "GABA and glycine are inhibitory neurotransmitters used by many neurons in the spinal dorsal horn, and intrathecal administration of GABA(A) and glycine receptor antagonists produces behavioural signs of allodynia, suggesting that these transmitters have an important role in spinal pain mechanisms." | 3.72 | Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain. ( Hughes, DI; Maxwell, DJ; Polgár, E; Puskár, Z; Riddell, JS; Todd, AJ, 2003) |
| " Oxcarbazepine and carbamazepine (3-100 mg x kg(-1)) did not affect mechanical hyperalgesia or tactile allodynia induced by partial sciatic nerve ligation in the rat following oral administration." | 3.72 | Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "The present study investigated whether mechanical allodynia following contusive spinal cord injury (SCI) of the thoracic segments 12 and 13 of the rat was associated with a reduction in gamma-aminobutyric acid (GABA)ergic inhibition adjacent to the site of injury." | 3.72 | Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. ( Drew, GM; Duggan, AW; Siddall, PJ, 2004) |
| "The effects of systemic and local injections of gabapentin, a novel anticonvulsant agent, were tested on nociceptive behaviors in mice with acute herpetic pain." | 3.71 | Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection. ( Andoh, T; Kuraishi, Y; Nojima, H; Shiraki, K; Takasaki, I, 2001) |
| "This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury." | 3.71 | Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. ( Malan, TP; Mata, HP; Porreca, F, 2002) |
| "Only gabapentin suppressed the secondary mechanical hyperalgesia-evoked neural response in a region of the brainstem's descending pain modulatory system (right nucleus cuneiformis) and left (contralateral) posterior insular cortex and secondary somatosensory cortex." | 2.82 | Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development. ( Andersson, J; Kong, Y; Mezue, M; Tracey, I; Wanigasekera, V, 2016) |
| " Dosing was set by the Dixon sequential up-down method; that is, a greater or less than 30% reduction in capsaicin pain decreased or increased the dose, respectively, by a fixed interval for the next subject." | 2.79 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "Secondary outcome measures included secondary hyperalgesia and tactile and thermal allodynia, and their respective areas (cm(2))." | 2.79 | Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method. ( Wallace, MS; Wong, W, 2014) |
| "The area of hyperalgesia for punctuate mechanical stimuli around the incision was measured 48 h after the operation with a hand-held von Frey filament." | 2.77 | Preoperative pregabalin administration significantly reduces postoperative opioid consumption and mechanical hyperalgesia after transperitoneal nephrectomy. ( Archan, S; Bornemann-Cimenti, H; Kern-Pirsch, C; Lederer, AJ; Michaeli, K; Rumpold-Seitlinger, G; Sandner-Kiesling, A; Wejbora, M; Zigeuner, R, 2012) |
| "Effects on allodynia and SF-MPQ were not significant." | 2.76 | Effect of a single dose of pregabalin on herpes zoster pain. ( Jensen-Dahm, C; Petersen, KL; Reda, H; Rowbotham, MC, 2011) |
| "Interestingly, opioids induce hyperalgesia via many of the same neuro-inflammatory and central sensitization processes that occur with the development of neuropathic pain." | 2.75 | Gabapentin improves cold-pressor pain responses in methadone-maintained patients. ( Compton, P; Kehoe, P; Ling, W; Sinha, K; Torrington, MA, 2010) |
| "Secondary hyperalgesia and allodynia are a reflection of central sensitization." | 2.73 | Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects. ( Baxendale, J; Bolognese, J; Calder, N; Connell, J; Cummings, C; Herman, G; Kehler, A; Wang, H, 2008) |
| "The electrical hyperalgesia model invokes central sensitization by repetitive stimulation of the skin." | 2.73 | Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. ( Chizh, BA; Göhring, M; Koppert, W; Quartey, GK; Schmelz, M; Tröster, A, 2007) |
| "Gabapentin was administered orally and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold to paw pressure was measured." | 2.73 | Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007) |
| "Gabapentin has been reported to inhibit various acute and chronic pain conditions in animals and humans." | 2.73 | Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007) |
| "Gabapentin pre-treatment reduced sensitivity to electrical induction of skin pain by 14%, p=0." | 2.72 | Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006) |
| "Gabapentin is an established therapy in neuropathic pain and reduces cutaneous pain in healthy volunteers." | 2.72 | Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006) |
| " In conclusion, single or repeated dosing of gabapentin reduced cutaneous but not muscle pain in healthy volunteers." | 2.72 | Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006) |
| "Spontaneous pain (VAS 0-10), areas of secondary hyperalgesia to pinprick (cm2) and mechanical pain threshold (g) within this area were assessed." | 2.72 | Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006) |
| "Secondary hyperalgesia was induced, but areas were reduced after pre-treatment, p<0." | 2.72 | Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers. ( Segerdahl, M, 2006) |
| "Further, large areas of mechanical hyperalgesia to pinprick adjacent to the erythema spots developed in all subjects." | 2.71 | The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers. ( Felouzis, E; Gustorff, B; Hoechtl, K; Kress, HG; Lehr, S; Sycha, T, 2004) |
| " This study examined the effects of gabapentin on signs of central sensitization (brush and pinprick hyperalgesia) in a human model of capsaicin-evoked pain, using a gabapentin dosing regimen similar to that used in the clinic." | 2.71 | Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia. ( Bach, FW; Brown, J; Chizh, BA; Gottrup, H; Jensen, TS; Juhl, G; Kristensen, AD; Lai, R, 2004) |
| "Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin." | 2.71 | A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster. ( Berry, JD; Petersen, KL, 2005) |
| "Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain." | 2.71 | Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. ( Buchanan, TJ; Huggins, JP; Iannetti, GD; Smart, TS; Tracey, I; Vennart, W; Wise, RG; Zambreanu, L, 2005) |
| "Pain is a hallmark of almost all bodily ailments and can be modulated by agents, including analgesics and anesthetics that suppress pain signals in the central nervous system." | 2.52 | Therapeutic Basis of Clinical Pain Modulation. ( Agrawal, DK; Hambsch, ZJ; Kerfeld, MJ; Kirkpatrick, DR; McEntire, DM; Reisbig, MD; Smith, TA; Youngblood, CF, 2015) |
| "Opioid-induced hyperalgesia has recently been described as representing a challenge for physicians in the clinical setting." | 2.50 | Managing difficult pain conditions in the cancer patient. ( Mercadante, S, 2014) |
| "Whereas most pain due to cancer can be relieved with relatively simple methods using oral analgesics, as suggested by WHO guidelines, some patients may have difficult pain situations that require more complex approaches." | 2.50 | Managing difficult pain conditions in the cancer patient. ( Mercadante, S, 2014) |
| "Three types of hyperalgesia can occur during the postoperative period: primary hyperalgesia, which disappears with wound healing, secondary or central hyperalgesia, which can lead to chronic pain, and opiate-induced hyperalgesia." | 2.48 | [Prevention of postoperative hyperalgesia]. ( Mamie, C, 2012) |
| "Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters." | 2.47 | [Pregabalin and postoperative hyperalgesia. A review]. ( Bornemann-Cimenti, H; Kern-Pirsch, C; Lederer, AJ; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2011) |
| "Once established, postherpetic neuralgia is particularly difficult to treat, and is often resistant to conventional analgesics." | 2.47 | [Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia]. ( Takasaki, I, 2011) |
| "Gabapentin was designed as a lipophilic GABA analog and was first synthesized as a potential anticonvulsant and was launched in 1994 as add-on therapy for the treatment of epilepsy." | 2.40 | 3-substituted GABA analogs with central nervous system activity: a review. ( Bryans, JS; Wustrow, DJ, 1999) |
| "A cardinal, intractable symptom of neuropathic pain is mechanical allodynia, pain caused by innocuous stimuli via low-threshold mechanoreceptors such as Aβ fibers." | 1.62 | A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. ( Furue, H; Koga, K; Sekine, M; Tashima, R; Tozaki-Saitoh, H; Tsuda, M; Watanabe, M; Yasaka, T; Yoshikawa, Y, 2021) |
| "Sensory dysfunctions such as allodynia and hyperalgesia are only part of the symptoms associated with neuropathic pain that extend to memory and affectivity deficits." | 1.62 | 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors. ( Amodeo, P; Belardo, C; Boccella, S; Calignano, A; Cristiano, C; de Novellis, V; Di Marzo, V; Guida, F; Iannotta, M; Iannotti, FA; Infantino, R; Luongo, L; Maione, S; Marabese, I; Paino, S; Palazzo, E; Ricciardi, F; Vitale, RM, 2021) |
| "Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons." | 1.56 | Parabrachial nucleus circuit governs neuropathic pain-like behavior. ( Chen, Z; Duan, S; Guo, F; Li, KY; Li, XJ; Li, XY; Li, YY; Liu, R; Ma, XL; Sun, H; Sun, L; Wen, MQ; Wu, MY; Xu, CL; Yu, YQ; Zhu, ZG, 2020) |
| "A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA)." | 1.51 | Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats. ( Kato, D; Obata, H; Saito, S; Suto, T, 2019) |
| "MCS reversed the hyperalgesia induced by peripheral neuropathy in the rats with chronic sciatic nerve constriction and induced a significant increase in the glycine and GABA levels in the PAG in comparison with the naive and sham-treated rats." | 1.51 | Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain. ( Antunes, GF; Assis, DV; Auada, AVV; de Andrade, EM; Fonoff, ET; Gouveia, FV; Lebrun, I; Lopes, PSS; Martinez, RCR; Pagano, RL, 2019) |
| "Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "The brain regions relating SNL-induced neuropathic pain were as follows: the posterior association area of the parietal region, superior colliculus, inferior colliculus, primary somatosensory area, cingulate cortex, and cingulum bundle." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "SNL induced- neuropathic pain is transmitted to the primary somatosensory area and parietal region through the cingulum bundle and limbic system." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "Neuropathic pain was severely induced by SNL on the postoperative day 14, excepting the sham group." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "While S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin-induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw-pressure test." | 1.48 | Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. ( Ardid, D; Berrocoso, E; Bravo, L; Chalus, M; Chapuy, E; Chaumette, T; Eschalier, A; Llorca-Torralba, M; Marchand, F; Mico, JA; Sors, A, 2018) |
| "This effect of S 38093 in neuropathic pain could be partly mediated by α2 receptors desensitization in the locus coeruleus." | 1.48 | Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. ( Ardid, D; Berrocoso, E; Bravo, L; Chalus, M; Chapuy, E; Chaumette, T; Eschalier, A; Llorca-Torralba, M; Marchand, F; Mico, JA; Sors, A, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Neuropathic pain was induced by a chronic constriction injury of the sciatic nerve (CCI) and mechanical allodynia and the spatial memory was assessed using the Von Frey filaments and Morris water maze respectively." | 1.46 | In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain. ( Farahmandfar, M; Janzadeh, A; Naghdi, N; Nasirinezhad, F; Saffarpour, S; Shaabani, M, 2017) |
| "A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10." | 1.46 | Murine model and mechanisms of treatment-induced painful diabetic neuropathy. ( Anaya, CJ; Enriquez, C; Jolivalt, CG; Marquez, A; Nicodemus, JM, 2017) |
| "Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist." | 1.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Neuropathic pain has proven to be a difficult condition to treat, so investigational therapy has been sought that may prove useful, such as the use of sigma-1 antagonists." | 1.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Chronic pain, neuropathic pain, inflammatory pain, ozone therapy, interventional therapy, gabapentin, spared nerve injury, bee venom, complete Freud's adjuvant." | 1.46 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Gabapentin (GBP) is an effective analgesic for neuropathic pain conditions but its clinical efficacy in cisplatin-induced neuropathic pain (CINP) is limited, in addition to generating unwanted side-effects." | 1.46 | Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model. ( Ahmad, N; Islam, NU; Rahman, FU; Sewell, RDE; Shahid, M; Subhan, F, 2017) |
| "The rat model of neuropathic pain was successfully established." | 1.46 | [Effects of HCN2 in the development of peripheral neuropathic pain in rats]. ( Fu, B; Huang, T; Liu, SJ; Wang, B; Wang, J; Weng, XC, 2017) |
| "Treatment with gabapentin, but not amitriptyline, was associated with a complete attenuation of hind paw mechanical hypersensitivity observed with indinavir treatment." | 1.46 | A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017) |
| "It often presents with significant neuropathic pain and is associated with previous exposure to neurotoxic nucleoside reverse transcriptase inhibitors." | 1.46 | A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017) |
| "CFA-induced hyperalgesia and sensitivity to morphine (0." | 1.46 | Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter? ( Bjerrum, OJ; Heegaard, AM; Hestehave, S; Jeggo, RD; Kristensen, PJ; Munro, G, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Using 3 rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, we investigated the antihypersensitivity effect of acute and repeated agomelatine administration." | 1.46 | Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. ( Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E, 2017) |
| "Chronic myositis was induced by injection of Complete Freund Adjuvant (CFA) into the right gastrocnemius (GS) muscle of rats and tests for evaluating mechanical hyperalgesia, thermal hyperalgesia and tactile allodynia were performed." | 1.46 | Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis. ( Chacur, M; Freitas, MF; Rocha, IR; Rosa, AS, 2017) |
| "Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constriction injury (CCI) is induced by ligation of the infraorbital nerve (IoN)." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "However, studies on trigeminal neuropathic pain remain limited." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Both phases display robust tactile allodynia." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "After onset of inflammation and allodynia, we assessed effects of i." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Gabapentin was used for the treatment of term and preterm infants with suspected visceral hyperalgesia caused by a variety of neurologic and gastrointestinal morbidities." | 1.43 | Gabapentin Use in the Neonatal Intensive Care Unit. ( Bidegain, M; Cotten, CM; DeMeo, S; Edwards, L; Hauer, JM; Hornik, CD; Pizoli, C; Smith, PB, 2016) |
| "Gabapentin displays non-linear drug disposition, which complicates dosing for optimal therapeutic effect." | 1.43 | Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model. ( Holm, R; Keizer, R; Kreilgaard, M; Larsen, MS; Munro, G; Mørk, A; Savic, R, 2016) |
| "The plasma/brain ECF concentration-time profiles of gabapentin were adequately described with a two-compartment plasma model with saturable intestinal absorption rate (K m = 44." | 1.43 | Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model. ( Holm, R; Keizer, R; Kreilgaard, M; Larsen, MS; Munro, G; Mørk, A; Savic, R, 2016) |
| "In the nerve injury model of neuropathic pain, WNK1/HSN2 contributed to a maladaptive decrease in the activity of the K(+)-Cl(-)cotransporter KCC2 by increasing its inhibitory phosphorylation at Thr(906)and Thr(1007), resulting in an associated loss of GABA (γ-aminobutyric acid)-mediated inhibition of spinal pain-transmitting nerves." | 1.43 | Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. ( Andrews, N; Castonguay, G; Dion, PA; Duan, J; Gaudet, R; Hince, P; Inquimbert, P; Kahle, KT; Khanna, AR; Laganière, J; Latremoliere, A; Lavastre, V; Mapplebeck, JC; Mogil, JS; Omura, T; Rochefort, D; Rouleau, GA; Schmouth, JF; Sotocinal, SG; Ward, C; Woolf, CJ; Zhang, J, 2016) |
| "The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "The mechanical allodynia was significantly increased on day 3 after BCAO compared with that during the pre-BCAO assessment." | 1.43 | Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia. ( Harada, S; Matsuura, W; Tokuyama, S, 2016) |
| "After MPNL, mechanical allodynia was established, and mice quickly recovered from the surgery without any significant motor impairment." | 1.43 | Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016) |
| "Peripheral neuropathic pain is a consequence of an injury/disease of the peripheral nerves." | 1.43 | Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016) |
| "In the present study, we found that neuropathic pain induced by the chemotherapeutic drug paclitaxel or L5 ventral root transection significantly impaired the function of GABAergic synapses of spinal dorsal horn neurons via the reduction of the GAD67 expression." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| "Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the interactions between synaptic dysfunction and the genes that are involved in persistent pain remain elusive." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| "Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the underlying molecular mechanisms remain elusive." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 1.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Mechanical allodynia was assessed using von Frey hairs." | 1.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Neuropathic pain is a severe and unbearable condition which arises due to activation of peripheral nociceptors after tissue damage, neuropathic pain is caused from anomalous physiology of central or peripheral nervous system and it may not be related to the ongoing tissue damage or inflammation." | 1.43 | Potential Contribution of Antioxidant Mechanism in the Defensive Effect of Lycopene Against Partial Sciatic Nerve Ligation Induced Behavioral, Biochemical and Histopathological Modification in Wistar Rats. ( Goel, R; Tyagi, N, 2016) |
| "Neuropathic pain was induced in wistar rats by partial sciatic nerve ligation." | 1.43 | Potential Contribution of Antioxidant Mechanism in the Defensive Effect of Lycopene Against Partial Sciatic Nerve Ligation Induced Behavioral, Biochemical and Histopathological Modification in Wistar Rats. ( Goel, R; Tyagi, N, 2016) |
| "Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 1.43 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "Robust allodynia was observed in all three ligation groups." | 1.42 | Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015) |
| "Burst and tonic SCS both reduce allodynia." | 1.42 | Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy. ( Crosby, ND; Goodman-Keiser, MD; Smith, JR; Weisshaar, CL; Winkelstein, BA; Zeeman, ME, 2015) |
| "The cutaneous allodynia (CA) symptoms that occurred during headache attacks were examined with the Allodynia Symptom Checklist (ASC)." | 1.42 | Effects of pregabalin on central sensitization in patients with migraine. ( Chen, CF; Yu, FY; Zhang, N, 2015) |
| "Pregabalin was effective at relieving allodynia in migraine." | 1.42 | Effects of pregabalin on central sensitization in patients with migraine. ( Chen, CF; Yu, FY; Zhang, N, 2015) |
| "Gabapentin was effective in transiently reversing mechanical allodynia in those mice with lowered thresholds." | 1.42 | Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "Male WT mice develop a persistent tactile allodynia resulting from cisplatin administration." | 1.42 | Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "A hallmark of peripheral neuropathic pain (PNP) is chronic spontaneous pain and/or hypersensitivity to normally painful stimuli (hyperalgesia) or normally nonpainful stimuli (allodynia)." | 1.42 | Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats. ( Al Otaibi, M; Djouhri, L; Sathish, J; Smith, T, 2015) |
| "Adenosine is an inhibitory neuromodulator that was previously thought to mediate antinociception through the A1 and A2A receptor subtypes." | 1.42 | Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. ( Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW, 2015) |
| "Treatment with gabapentin achieved complete remission." | 1.42 | Pressure pain sensitivity map of multifocal nummular headache: a case report. ( Barón, J; Carreres, A; Cuadrado, ML; Fernández-de-Las-Peñas, C; Guerrero, AL; Herrero-Velázquez, S; Madeleine, P; Rodríguez, C; Rodríguez-Valencia, E; Ruiz, M, 2015) |
| "The map reflected 4 restricted areas of mechanical hyperalgesia confined just to the painful areas." | 1.42 | Pressure pain sensitivity map of multifocal nummular headache: a case report. ( Barón, J; Carreres, A; Cuadrado, ML; Fernández-de-Las-Peñas, C; Guerrero, AL; Herrero-Velázquez, S; Madeleine, P; Rodríguez, C; Rodríguez-Valencia, E; Ruiz, M, 2015) |
| " The intensity of tactile allodynia in STZ-induced diabetic mice was alleviated by the oral administration of PGN; however, the antiallodynic effect varied according to its dosing time." | 1.42 | Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice. ( Akamine, T; Hashimoto, H; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Taniguchi, M, 2015) |
| "The intensity of tactile allodynia in STZ-induced diabetic mice was alleviated by the oral administration of PGN; however, the antiallodynic effect varied according to its dosing time." | 1.42 | Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice. ( Akamine, T; Hashimoto, H; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Taniguchi, M, 2015) |
| "Intrathecal tianeptine reduces neuropathic pain." | 1.42 | Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. ( Heo, BH; Kim, WM; Kim, YC; Lin, H; Yoon, MH, 2015) |
| "Neuropathic pain was induced by spinal nerve ligation (SNL)." | 1.42 | Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. ( Heo, BH; Kim, WM; Kim, YC; Lin, H; Yoon, MH, 2015) |
| "Gabapentin was used as a reference drug in the study." | 1.42 | Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice. ( Guo, W; Han, WJ; Hong, ZY; Huang, ZL; Li, YD; Liu, YY; Qu, WM; Wang, TX; Yin, D, 2015) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 1.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)." | 1.42 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "Tranexamic acid (TXA) is an antifibrinolytic agent widely used to reduce blood loss during surgery." | 1.42 | Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn. ( Baba, H; Kamiya, Y; Kohno, T; Ohashi, M; Ohashi, N; Sasaki, M, 2015) |
| "Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures." | 1.42 | Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015) |
| "In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i." | 1.40 | The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014) |
| "Oxaliplatin induced mechanical allodynia, cold hyperalgesia and chemical/inflammatory supersensitivity at both hindpaw and vibrissal levels in mice and rats." | 1.40 | Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents. ( Bastian, G; Bourgoin, S; Hamon, M; Kayser, V; Michot, B, 2014) |
| "Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals." | 1.40 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "Bortezomib (0." | 1.40 | Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice. ( Andoh, T; Kitamura, R; Kuraishi, Y; Mizoguchi, S; Saito, Y; Takahata, H, 2014) |
| "In this study, on a rat model of chronic pain, we determined how persistent pain altered behavioral responses to morphine reward measured by the paradigm of unbiased conditioned place preference (CPP), focusing on GABAergic synaptic activity in neurons of the central nucleus of the amygdala (CeA), an important brain region for emotional processing of both pain and reward." | 1.40 | Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function. ( Hou, YY; Lu, YG; Pan, ZZ; Tao, W; Wang, W; Zhang, Z, 2014) |
| "Both drugs did not affect cold allodynia, whereas pregabalin (30 mg/kg) attenuated heat hyperalgesia (80% vs." | 1.40 | Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice. ( Cios, A; Filipek, B; Malawska, B; Mogilski, S; Sałat, K; Sałat, R; Więckowski, K; Wyska, E, 2014) |
| "Tramadol was active against all four endpoints in the Chung model with similar effects in the CCI model, apart from tactile allodynia." | 1.40 | Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. ( Castagné, V; Le Cudennec, C, 2014) |
| "The selected endpoints were tactile allodynia, tactile hyperalgesia, heat hyperalgesia and cold allodynia." | 1.40 | Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. ( Castagné, V; Le Cudennec, C, 2014) |
| "Neuropathic pain is a chronic condition resulting from neuronal damage." | 1.40 | Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects. ( Amano, Y; Fukasawa, H; Ito, A; Muratake, H; Nagae, M; Shudo, K; Sugiyama, K; Suzuki, H, 2014) |
| "Koumine treatment of diabetic rats decreased neuropathic pain behavior as early as after the first administration." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| "Koumine was given at a dose range of 0." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| "Diabetic rats developed mechanical hyperalgesia within 3 weeks after streptozocin injection and exhibited reduced SNCV and impaired myelin/axonal structure." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| " Noteworthy, the repeated administration of AT-RvD1 and RvD2 also prevented the depressive-like behavior in reserpine-treated animals, according to assessment of immobility time, although the chronic administration of pregabalin failed to affect this parameter." | 1.40 | Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014) |
| "It may be associated with allodynia and increased pain sensitivity." | 1.40 | Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. ( Caffino, L; Castelnovo, LF; Cavalli, E; Colciago, A; Faroni, A; Magnaghi, V; Pajardi, G; Procacci, P, 2014) |
| "Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression." | 1.40 | Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain. ( Caffino, L; Castelnovo, LF; Cavalli, E; Colciago, A; Faroni, A; Magnaghi, V; Pajardi, G; Procacci, P, 2014) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Mechanical allodynia was fully developed by 28-30days post-immunization (p." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Neuropathic pain is a debilitating condition that is often resistant to common analgesics, such as opioids, but is sensitive to some antidepressants, an effect that seems to be mediated by spinal cord 5-HT3 receptors." | 1.39 | The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model. ( Bonacorso, HG; Fachinetto, R; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Pinheiro, Fde V; Pinheiro, Kde V; Villarinho, JG; Zanatta, N, 2013) |
| " Below we describe the preliminary evaluation of support vector machine in the regression mode (SVR) application for the prediction of maximal antiallodynic effect of a new derivative of dihydrofuran-2-one (LPP1) used in combination with pregabalin (PGB) in the streptozocin-induced neuropathic pain model in mice." | 1.39 | The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy. ( Sałat, K; Sałat, R, 2013) |
| "The selected neuropathic pain model was the spared nerve injury (SNI) model and the endpoints were burrowing and measures of paw posture in Sprague Dawley rats." | 1.39 | A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain. ( de Lannoy, IA; Dykstra, C; Higgins, GA; Lau, W; Lee, DK; Silenieks, LB; Thevarkunnel, S, 2013) |
| "One feature of neuropathic pain is a reduced spinal gamma-aminobutyric acid (GABA)-ergic inhibitory function." | 1.39 | Effect of antioxidant treatment on spinal GABA neurons in a neuropathic pain model in the mouse. ( Chung, JM; Chung, K; Kim, HY; Lu, Y; Wang, J; Yowtak, J, 2013) |
| "Mechanical allodynia in paclitaxel-treated Sprague Dawley (SD) rats was measured using a dynamic plantar aesthesiometer before and after treatment with E139 (10 and 20 mg/kg) or its vehicle for four consecutive days from day 7 after first administration of paclitaxel (16 mg/kg on two alternate days)." | 1.39 | The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents. ( Edafiogho, IO; Masocha, W; Thangamani, D, 2013) |
| "Neuropathic pain is a chronic neurodegenerative disease." | 1.39 | Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. ( Krishnan, UM; Muthuraman, A; Shanmugam, P; Singh, N; Thiagarajan, VR, 2013) |
| "Thermal escape latencies, mechanical allodynia using von Frey hairs, and observation of behavior/morbidity and body weights were assessed." | 1.39 | Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. ( Park, HJ; Pirie, E; Shtaerman, Y; Skahen, J; Stokes, JA; Yaksh, TL, 2013) |
| "Cisplatintreated mice display allodynia and an activation of DRG activated transcription factor 3, which is paralleled by its effects on behavior in the CPP system, wherein gabapentin, but not ketorolac, in the presence of the cisplatin polyneuropathy, is positively rewarding, confirming that this neuropathy is an aversive (painful) state that is ameliorated by gabapentin." | 1.39 | Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept. ( Park, HJ; Pirie, E; Shtaerman, Y; Skahen, J; Stokes, JA; Yaksh, TL, 2013) |
| "co-treatment with ketamine and pregabalin at sub-effect low doses may be a useful therapeutic method for the treatment of neuropathic pain patients." | 1.39 | Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013) |
| "pregabalin (10, 30, 100 µg) on mechanical allodynia and thermal hyperalgesia were measured." | 1.39 | Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013) |
| "Thiopental sodium was intravenously administered in mice and sleeping time was measured." | 1.39 | Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation. ( Kawamura, M; Namba, H; Okai, H; Okazaki, R; Taguchi, K; Yoshida, H, 2013) |
| "To induce hyperalgesia, Sprague Dawley (SD) rats were subcutaneously injected with fentanyl four times at 15-min intervals (60 μg/kg per injection), resulting in total dose of 240 μg/kg over 1 h, and morphine 10 mg/kg twice daily for 7 days." | 1.38 | Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012) |
| "NPC-treated animals showed decreased hyperalgesia and allodynia 1-3week post-transplantation; vehicle-injected CCI rats continued displaying pain behaviors." | 1.38 | Intraspinal transplantation of GABAergic neural progenitors attenuates neuropathic pain in rats: a pharmacologic and neurophysiological evaluation. ( Gajavelli, S; Hentall, ID; Jergova, S; Sagen, J; Varghese, MS, 2012) |
| "The threshold of mechanical hyperalgesia was also significantly elevated." | 1.38 | Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats. ( Ahmed, AA; Al-Rasheed, NM; Attia, HN; Kenawy, SA; Maklad, YA, 2012) |
| "Morphine was less potent in neuroma pain than in mechanical allodynia." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "After TNT injury, mechanical allodynia and neuroma pain are observed." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The L5 spinal nerve ligation induced tactile allodynia, an increase of CD11b expression, and an increase in the protein expression level of the voltage-dependent Ca(2+) channel α(2)/δ-1 subunit in the spinal dorsal horn on the injured side." | 1.38 | Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model. ( Adachi-Akahane, S; Ito, M; Kuroda, M; Morimoto, S; Oda, S; Sugiyama, A, 2012) |
| "Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group." | 1.38 | Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012) |
| "Gabapentin has been shown to be effective in reducing postoperative narcotic usage, a reduction that may be associated with a reduction in opioid-induced tolerance and hyperalgesia." | 1.38 | The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats. ( Abreu, M; Aguado, D; Benito, J; Garcia-Fernandez, J; Gómez de Segura, IA, 2012) |
| "Persistent inflammation is associated with a shift in spinal GABA(A) signaling from inhibition to excitation such that GABA(A)-receptor activation contributes to inflammatory hyperalgesia." | 1.38 | Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro. ( Gold, MS; Lu, SG; Zhu, Y, 2012) |
| "Inflammation was associated with a significant increase in the magnitude of GABA-induced depolarization as well as the percentage of neurons in which GABA evoked a Ca(2+) transient." | 1.38 | Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro. ( Gold, MS; Lu, SG; Zhu, Y, 2012) |
| "The percentage allodynia relief was only 60% for carbamazepine and 80% for pregabalin by single administration, whereas their co-administration relieved allodynia by 100%." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Allodynia was determined using the von Frey hair test and dose-effect curves and isobolograms were used to investigate drug interactions." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Carbamazepine and pregabalin ameliorate neuropathic pain synergistically at higher doses." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Neuropathic pain was induced by L5 nerve ligation in Sprague-Dawley rats." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Using behavioral approaches in vivo, we found that D3KO animals exhibit reduced paw withdrawal latencies to thermal pain stimulation (Hargreaves' test) over wild type (WT) controls." | 1.38 | Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse. ( Baran, CA; Brewer, KL; Clemens, S; Keeler, BE, 2012) |
| "The effect of disc degeneration on behavioral measures of chronic pain has not been evaluated in this model." | 1.37 | Behavioral signs of chronic back pain in the SPARC-null mouse. ( Millecamps, M; Sage, EH; Stone, LS; Tajerian, M, 2011) |
| "Mechanical allodynia was assessed by measuring the forepaw withdrawal threshold to von Frey filaments, and cold allodynia was evaluated by measuring the time spent in lifting or licking the forepaw after applying acetone to it." | 1.37 | A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011) |
| "Our rat forelimb model of neuropathic pain may be useful for studying human neuropathic pain and screening for valuable drug candidates." | 1.37 | A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011) |
| "Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of Ca(v)α2δ-1 in dorsal spinal cord." | 1.37 | Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011) |
| "SCI-induced neuropathic pain can be manifested as both tactile allodynia (a painful sensation to a non-noxious stimulus) and hyperalgesia (an enhanced sensation to a painful stimulus)." | 1.37 | Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011) |
| "The antihyperalgesic effect of PBN on mechanical hyperalgesia was attenuated by intrathecal bicuculline, a GABA(A) receptor blocker." | 1.37 | Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. ( Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J, 2011) |
| "Neuropathic pain was induced by a tight ligation of the L5 spinal nerve (SNL)." | 1.37 | Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. ( Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J, 2011) |
| "Gabapentin is an anticonvulsant and adjuvant analgesic." | 1.37 | Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011) |
| "Subcutaneous inoculation of vG reduced mechanical hyperalgesia, thermal hyperalgesia and cold allodynia in rats with PDN." | 1.37 | Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons. ( Chattopadhyay, M; Fink, DJ; Mata, M, 2011) |
| "In morphine-treated animals, evoked spinal neuronal responses were enhanced to a subset of thermal and mechanical stimuli." | 1.37 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| "Opioid-induced hyperalgesia is recognized in the laboratory and the clinic, generating central hyperexcitability in the absence of peripheral pathology." | 1.37 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| "In opioid-induced hyperalgesia, which extends to colonic distension, a serotonergic facilitatory system may be up-regulated, creating an environment that is permissive for pregabalin-mediated analgesia without peripheral pathology." | 1.37 | Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Porreca, F; Sikandar, S, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "FS stress enhanced formalin-induced hyperalgesia, increased pain-elicited c-Fos expression, decreased basal and delayed pain-induced GABA release, and increased basal and induced glutamate release." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg." | 1.37 | The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011) |
| "In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "Then, behavioral signs of neuropathic pain were observed for 8 weeks." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "The cold allodynia was assessed by the tail immersion test (i." | 1.36 | Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats. ( Go, DH; Han, JB; Kim, SK; Min, BI; Park, JH; Sun, B, 2010) |
| "Hyperalgesia is one of the debilitating complications of diabetes." | 1.36 | Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray. ( Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z, 2010) |
| "The static allodynia endpoint was modeled by using three population PD approaches: 1) the behavior of the injured paw using a three-category ordinal logistic regression model; 2) paw withdrawal threshold (PWT) (g) between the injured and uninjured paw using the Hill equation with a baseline function; and 3) the baseline normalized difference in PWT between the injured and uninjured paw." | 1.36 | Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain. ( Bender, G; Bies, RR; Bramwell, S; Danhof, M; DeJongh, J; Field, MJ; Florian, JA; Marshall, S; Tan, KK, 2010) |
| "Neuropathic pain is a common problem following spinal cord injury (SCI)." | 1.36 | Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. ( Ahmed, MM; Hasbargen, T; Kahle, KT; Li, L; Miranpuri, G; Resnick, D; Sun, D, 2010) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| " The PWT in PSL mice was dose-dependently increased by intraperitoneal injection of gabapentin, but the anti-allodynic effects varied according to its dosing time." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "These findings suggest that the dosing time-dependent difference in the anti-allodynic effects of gabapentin is attributable to the circadian oscillation of α2δ-1 subunit expression in the DRG and indicate that the optimizing its dosing schedule helps to achieve rational pharmacotherapy for neuropathic pain." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "Neuropathic pain is characterized by hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to NSAIDs or even opioids." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks." | 1.35 | Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E, 2009) |
| "Dercum's disease which is also termed lipomatosis dolorosa is a rare and relatively unknown disease." | 1.35 | Dercum's disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview. ( Lange, U; Oelzner, P; Uhlemann, C, 2008) |
| "In addition severe hyperalgesia can be triggered by light pressure and touch." | 1.35 | Dercum's disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview. ( Lange, U; Oelzner, P; Uhlemann, C, 2008) |
| "The ability of bicuculline to alleviate allodynia and formalin-evoked hyperalgesia in diabetic rats is consistent with a reversal of the properties of GABA predicted by reduced spinal KCC2 and suggests that reduced KCC2 expression and increased GABA release contribute to spinally mediated hyperalgesia in diabetes." | 1.35 | Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters. ( Calcutt, NA; Jolivalt, CG; Lee, CA; Ramos, KM, 2008) |
| "Hyperalgesia was no less prevalent or severe after partial than after total axotomy." | 1.35 | Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesia. ( Lee, JW; Oaklander, AL; Siegel, SM, 2009) |
| "Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Gabapentin and duloxetine reversed mechanical hyperalgesia but did not normalize gait in any nerve injury model." | 1.35 | Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| "Inhibition of the allodynia with receptor antagonists indicated that each agent induces allodynia by a distinct mechanism." | 1.35 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "These transient allodynia models are a useful addition to the toolbox of preclinical pain models." | 1.35 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| " correlated with blood concentrations within 4 h after dosing, and maximal efficacy was obtained 2 h after dosing when the maximal blood concentration was achieved at either dose." | 1.35 | Effect of a new alpha 2 delta ligand PD-217014 on visceral hypersensitivity induced by 2,4,6-trinitrobenzene sulfonic acid in rats. ( Kawai, M; Kurebayashi, Y; Ninomiya, N; Ohashi, K; Taylor, C, 2008) |
| "Neuropathic pain is a long-lasting clinical problem that is often refractory to medical management." | 1.35 | A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. ( Cao, X; Cao, Z; He, X; Li, W; Liu, L; Liu, W; Liu, Z; Miao, L; Xiao, Z; Xue, L, 2008) |
| "When diazepam was given only 1h before the formalin test, it slightly but significantly reduced pain scores during late phase in FS rats but not in SS rats." | 1.35 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| "We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 1.35 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| "Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia." | 1.35 | Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008) |
| "Opioid-induced hyperalgesia can develop rapidly after opioid exposure." | 1.35 | Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2008) |
| "Hyperalgesia was induced in male Sprague-Dawley rats with subcutaneous fentanyl (four injections, 20, 60, or 100 microg/kg per injection at 15-min intervals)." | 1.35 | Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2008) |
| "TENS reduces hyperalgesia through activation of receptor-mediated pathways at the level of the spinal cord, and supraspinally." | 1.34 | Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats. ( Lisi, TL; Maeda, Y; Sluka, KA; Vance, CG, 2007) |
| "Muscle hyperalgesia (withdrawal threshold to compression of the muscle) and cutaneous hyperalgesia of the paw (withdrawal threshold to von Frey filaments) were measured before and after induction of hyperalgesia and after treatment with pregabalin (saline, 10 to 100 mg/kg i." | 1.34 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Chronic muscle pain is a problem with high prevalence in clinical practice and its pharmacological treatment is difficult." | 1.34 | Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "A complete reversal of hyperalgesia was seen with lacosamide at 30mg/kg." | 1.34 | Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF. ( Beyreuther, BK; Geis, C; Sommer, C; Stöhr, T, 2007) |
| "Gabapentin is a structural analogue of gamma-aminobutyric acid with strong anticonvulsant and analgesic activities." | 1.34 | The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia. ( Curros-Criado, MM; Herrero, JF, 2007) |
| "Gabapentin was studied in the absence and in the presence of sensitization due to arthritis and neuropathy, combining noxious mechanical and repetitive electrical stimulation (wind-up)." | 1.34 | The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia. ( Curros-Criado, MM; Herrero, JF, 2007) |
| "gabapentin were strongly suppressed." | 1.33 | Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse. ( Honda, M; Kasuya, N; Ono, H; Shimizu, S; Takasu, K; Tanabe, M, 2005) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| "Secondary mechanical allodynia and hyperalgesia were measured at 5 and 15 min after capsaicin injection, respectively." | 1.33 | CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. ( Bassani, F; Bergamaschi, M; Tonino Bolzoni, P; Villetti, G, 2005) |
| "Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, allodynia and hyperalgesia." | 1.33 | Development and expression of neuropathic pain in CB1 knockout mice. ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006) |
| "The development of mechanical and thermal allodynia, and thermal hyperalgesia was evaluated by using the von Frey filaments, cold-plate and plantar tests, respectively." | 1.33 | Development and expression of neuropathic pain in CB1 knockout mice. ( Castañé, A; Célérier, E; Ledent, C; Maldonado, R; Martín, M; Parmentier, M; Valverde, O, 2006) |
| "When misoprostol was perfused in combination with the peripheral injection of formalin, we observed an increase of glutamate and an increase followed by a stronger decrease in GABA release." | 1.33 | Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. ( Berrino, L; de Novellis, V; Maione, S; Marabese, I; Mariani, L; Oliva, P; Palazzo, E; Rossi, F; Scafuro, M; Siniscalco, D, 2006) |
| "Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury." | 1.33 | Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006) |
| "Pretreatment with atropine (0." | 1.33 | Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury. ( Honda, M; Ono, H; Takasu, K; Tanabe, M, 2006) |
| "The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)." | 1.33 | Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006) |
| "Neuropathic pain is associated with a number of disease states of diverse aetiology that can share common pathophysiological mechanisms." | 1.33 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "Hindpaw mechanical allodynia was dose-dependently reversed by gabapentin (50 and 100 mg/kg, s." | 1.33 | Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Rode, F, 2006) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "Gabapentin has been shown to be useful in treatment of different conditions which may be caused by increased neuronal excitability." | 1.32 | Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin. ( Haller, H; Leblhuber, F; Schmidhammer, R; Trenkler, J, 2003) |
| " Hill slope coefficients for the tested anticonvulsants indicate that the dose-response curve was less steep for gabapentin than for phenytoin, carbamazepine and ethosuximide." | 1.32 | Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. ( Jevtovic-Todorovic, V; Rastogi, AJ; Todorovic, SM, 2003) |
| "Gabapentin did however produce significant dose-related reversal of tactile allodynia in the rat following a single administration." | 1.32 | Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "Gabapentin was poorly active against mechanical hyperalgesia in both the rat and guinea-pig following a single oral administration (100 mg x kg(-1)), although upon repeated administration it produced up to 70 and 90% reversal in rat and guinea-pig, respectively." | 1.32 | Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "Oxcarbazepine is a recently introduced AED that is effective in treating epilepsy and has an improved side-effect profile compared to existing therapies." | 1.32 | Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. ( Bevan, S; Fox, A; Gentry, C; Kesingland, A; Patel, S, 2003) |
| "3." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "Both clinical and preclinical models of postsurgical pain are being used more frequently in the early evaluation of new chemical entities." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "The present study investigated whether mechanical allodynia following contusive spinal cord injury (SCI) of the thoracic segments 12 and 13 of the rat was associated with a reduction in gamma-aminobutyric acid (GABA)ergic inhibition adjacent to the site of injury." | 1.32 | Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. ( Drew, GM; Duggan, AW; Siddall, PJ, 2004) |
| "The human experimental hyperalgesia model, the heat-capsaicin sensitization model, was induced in 25 healthy male volunteers." | 1.31 | Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization. ( Dahl, JB; Dirks, J; Petersen, KL; Rowbotham, MC, 2002) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "Both thermal hyperalgesia and tactile allodynia were reversed when transplants were placed either one or two weeks after partial nerve injury, compared to maintenance of these behaviors with the injury alone." | 1.31 | Only early intervention with gamma-aminobutyric acid cell therapy is able to reverse neuropathic pain after partial nerve injury. ( Cejas, P; Eaton, MJ; Karmally, S; Lopez, T; Martinez, MA; Stubley, LA, 2001) |
| "Tactile allodynia was quantitated using the threshold to withdrawal of the hind paw on probing with von Frey filaments." | 1.31 | Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. ( Malan, TP; Mata, HP; Porreca, F, 2002) |
| "Isoguvacine and baclofen each reversed tactile allodynia and thermal hyperalgesia produced by spinal nerve ligation." | 1.31 | Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. ( Malan, TP; Mata, HP; Porreca, F, 2002) |
| "1." | 1.30 | Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. ( Field, MJ; Hughes, J; Lewis, AS; McCleary, S; Oles, RJ; Singh, L, 1997) |
| "Gabapentin is an anticonvulsant that may represent a novel class of drugs, which has novel spinal antihyperalgesic activity." | 1.30 | The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat. ( Jun, JH; Yaksh, TL, 1998) |
| "Secondary hyperalgesia exhibited a tendency toward recovery over time." | 1.30 | Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia. ( Jones, DL; Sorkin, LS, 1998) |
| "Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy." | 1.30 | Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999) |
| "Gabapentin was without effect in controls but suppressed (P < 0." | 1.30 | Gabapentin prevents hyperalgesia during the formalin test in diabetic rats. ( Calcutt, NA; Ceseña, RM, 1999) |
| "To investigate whether neuropathic pain is sensitive to spinal GABA levels, GABA was injected intrathecally after nerve injury and sensory behaviors were evaluated." | 1.30 | A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury. ( Eaton, MJ; Karmally, S; Martinez, MA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (4.09) | 18.2507 |
| 2000's | 108 (33.96) | 29.6817 |
| 2010's | 187 (58.81) | 24.3611 |
| 2020's | 10 (3.14) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 2 |
| Lewis, LG | 2 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Zaręba, P | 1 |
| Gryzło, B | 1 |
| Malawska, K | 1 |
| Sałat, K | 4 |
| Höfner, GC | 1 |
| Nowaczyk, A | 1 |
| Fijałkowski, Ł | 1 |
| Rapacz, A | 1 |
| Podkowa, A | 1 |
| Furgała, A | 1 |
| Żmudzki, P | 1 |
| Wanner, KT | 1 |
| Malawska, B | 2 |
| Kulig, K | 1 |
| Park, SE | 1 |
| Neupane, C | 1 |
| Noh, C | 1 |
| Sharma, R | 1 |
| Shin, HJ | 1 |
| Pham, TL | 1 |
| Lee, GS | 1 |
| Park, KD | 1 |
| Lee, CJ | 1 |
| Kang, DW | 1 |
| Lee, SY | 1 |
| Kim, HW | 3 |
| Park, JB | 2 |
| Liu, S | 1 |
| Bonalume, V | 1 |
| Gao, Q | 1 |
| Chen, JT | 1 |
| Rohr, K | 1 |
| Hu, J | 1 |
| Carr, R | 1 |
| Zhang, Y | 3 |
| Yang, J | 5 |
| Sevilla, A | 1 |
| Weller, R | 1 |
| Wu, J | 1 |
| Su, C | 1 |
| Zheng, C | 1 |
| Rodriguez-Blanco, YF | 1 |
| Gitlin, M | 1 |
| Candiotti, KA | 1 |
| Maegawa, H | 1 |
| Usami, N | 1 |
| Kudo, C | 1 |
| Hanamoto, H | 1 |
| Niwa, H | 1 |
| Senba, E | 2 |
| Kami, K | 1 |
| Sun, L | 1 |
| Liu, R | 1 |
| Guo, F | 1 |
| Wen, MQ | 1 |
| Ma, XL | 1 |
| Li, KY | 1 |
| Sun, H | 1 |
| Xu, CL | 1 |
| Li, YY | 1 |
| Wu, MY | 1 |
| Zhu, ZG | 1 |
| Li, XJ | 1 |
| Yu, YQ | 3 |
| Chen, Z | 2 |
| Li, XY | 1 |
| Duan, S | 1 |
| Tashima, R | 1 |
| Koga, K | 2 |
| Yoshikawa, Y | 1 |
| Sekine, M | 1 |
| Watanabe, M | 2 |
| Tozaki-Saitoh, H | 1 |
| Furue, H | 1 |
| Yasaka, T | 1 |
| Tsuda, M | 2 |
| Boccella, S | 1 |
| Guida, F | 2 |
| Iannotta, M | 1 |
| Iannotti, FA | 1 |
| Infantino, R | 1 |
| Ricciardi, F | 1 |
| Cristiano, C | 1 |
| Vitale, RM | 1 |
| Amodeo, P | 1 |
| Marabese, I | 4 |
| Belardo, C | 1 |
| de Novellis, V | 4 |
| Paino, S | 1 |
| Palazzo, E | 4 |
| Calignano, A | 1 |
| Di Marzo, V | 2 |
| Maione, S | 4 |
| Luongo, L | 1 |
| Louis, JV | 1 |
| Lu, Y | 4 |
| Pieschl, R | 1 |
| Tian, Y | 2 |
| Hong, Y | 1 |
| Dandapani, K | 1 |
| Naidu, S | 1 |
| Vikramadithyan, RK | 1 |
| Dzierba, C | 1 |
| Sarvasiddhi, SK | 1 |
| Nara, SJ | 1 |
| Bronson, J | 1 |
| Macor, JE | 1 |
| Albright, C | 1 |
| Kostich, W | 1 |
| Li, YW | 1 |
| Wang, CT | 1 |
| Mao, CJ | 1 |
| Zhang, XQ | 1 |
| Zhang, CY | 1 |
| Lv, DJ | 1 |
| Yang, YP | 1 |
| Xia, KL | 1 |
| Liu, JY | 1 |
| Wang, F | 2 |
| Hu, LF | 1 |
| Xu, GY | 1 |
| Liu, CF | 1 |
| Matsuzaki, Y | 1 |
| Honda, K | 1 |
| Eto, F | 1 |
| Furukawa, T | 1 |
| Migita, K | 1 |
| Irie, K | 1 |
| Mishima, K | 1 |
| Ueno, S | 1 |
| Saffarpour, S | 1 |
| Shaabani, M | 1 |
| Naghdi, N | 1 |
| Farahmandfar, M | 1 |
| Janzadeh, A | 1 |
| Nasirinezhad, F | 2 |
| Yaksh, TL | 8 |
| Schwarcz, R | 1 |
| Snodgrass, HR | 1 |
| Nicodemus, JM | 1 |
| Enriquez, C | 1 |
| Marquez, A | 1 |
| Anaya, CJ | 1 |
| Jolivalt, CG | 2 |
| Corona-Ramos, JN | 1 |
| Déciga-Campos, M | 2 |
| Romero-Piña, M | 1 |
| Medina, LA | 1 |
| Martínez-Racine, I | 1 |
| Jaramillo-Morales, OA | 2 |
| García-López, P | 1 |
| López-Muñoz, FJ | 3 |
| Sahn, JJ | 1 |
| Mejia, GL | 1 |
| Ray, PR | 1 |
| Martin, SF | 1 |
| Price, TJ | 3 |
| Espinosa-Juárez, JV | 1 |
| Luo, WJ | 1 |
| Yang, F | 6 |
| Sun, W | 3 |
| Zheng, W | 1 |
| Wang, XL | 2 |
| Wu, FF | 1 |
| Wang, JL | 1 |
| Wang, JS | 2 |
| Guan, SM | 1 |
| Chen, J | 3 |
| Jeong, KY | 1 |
| Kang, JH | 1 |
| Ahmad, N | 4 |
| Subhan, F | 5 |
| Islam, NU | 1 |
| Shahid, M | 5 |
| Rahman, FU | 1 |
| Sewell, RDE | 2 |
| Chaumette, T | 1 |
| Chapuy, E | 2 |
| Berrocoso, E | 1 |
| Llorca-Torralba, M | 1 |
| Bravo, L | 1 |
| Mico, JA | 1 |
| Chalus, M | 1 |
| Eschalier, A | 3 |
| Ardid, D | 1 |
| Marchand, F | 2 |
| Sors, A | 1 |
| Crowe, MS | 1 |
| Wilson, CD | 1 |
| Leishman, E | 1 |
| Prather, PL | 1 |
| Bradshaw, HB | 1 |
| Banks, ML | 1 |
| Kinsey, SG | 1 |
| Barragán-Iglesias, P | 1 |
| Oidor-Chan, VH | 1 |
| Loeza-Alcocer, E | 1 |
| Pineda-Farias, JB | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pain Phenotyping of Patients With Bone Cancer Pain[NCT03908853] | 70 participants (Anticipated) | Observational | 2019-02-05 | Recruiting | |||
| Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage[NCT04126408] | 40 participants (Actual) | Interventional | 2020-01-13 | Completed | |||
| The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals: Randomized, Double-Blind Study[NCT04768738] | 46 participants (Actual) | Interventional | 2020-02-01 | Completed | |||
| Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World Setting[NCT05475769] | 98 participants (Anticipated) | Observational | 2022-03-01 | Recruiting | |||
| Effect of Fentanyl on Expression of Main Opioid Receptor (OPRM1) on Human Granulosa Cells During Ultrasound-guided Transvaginal Oocyte Retrieval.[NCT03248076] | 30 participants (Anticipated) | Observational | 2017-04-01 | Recruiting | |||
| Opioid-Induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin[NCT01821430] | Phase 2 | 4 participants (Actual) | Interventional | 2013-03-31 | Terminated (stopped due to poor recruitment) | ||
| Placebo-Controlled Study of Pregabalin for the Pain of Acute Herpes Zoster[NCT00352651] | Phase 2 | 34 participants (Anticipated) | Interventional | 2006-06-30 | Terminated (stopped due to "This study should be terminated as the study has been closed for years and the investigator has since retired. No records are available.~Thank you, Marlene") | ||
| Intrathecal Immunoglobulin for Treatment of Adult Patients With Tetanus: a Randomized Controlled 2x2 Factorial Trial[NCT02999815] | Phase 1/Phase 2 | 272 participants (Actual) | Interventional | 2017-02-13 | Completed | ||
| Effect of Minocycline on Neuropathic Pain[NCT01869907] | Phase 4 | 60 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Randomized Phase II Trial Evaluating Activity and Tolerability of Fixed Dose of Oxycodone and Increasing Dose of Pregabalin Versus Increasing Dose of Oxycodone and Fixed Dose of Pregabalin for the Treatment of Oncological Neuropathic Pain[NCT00637975] | Phase 2 | 80 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097] | Phase 4 | 0 participants (Actual) | Interventional | 2019-09-30 | Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.) | ||
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| Study of the Brain With Optic Functional Neuroimaging in Patients With Chronic Pain Using Transcranial Direct Current Stimulation[NCT01904097] | Phase 2 | 34 participants (Anticipated) | Interventional | 2013-03-31 | Recruiting | ||
| Randomized Clinical Trial Comparing the Use of Perioperative Epidural Analgesia to Conventional Intravenous Narcotics and NSAIDS for Patients Undergoing Laparoscopic Colorectal Resection[NCT02086123] | 87 participants (Actual) | Interventional | 2012-05-31 | Completed | |||
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for gamma-aminobutyric acid and Allodynia
| Article | Year |
|---|---|
Managing difficult pain conditions in the cancer patient.
Topics: Amines; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Breakthrough Pain; Cyclohexanec | 2014 |
Therapeutic Basis of Clinical Pain Modulation.
Topics: Adrenergic Neurons; Amygdala; Analgesics; Analgesics, Opioid; Anesthetics; Animals; Autonomic Nervou | 2015 |
Painful Diabetic Neuropathy: Prevention or Suppression?
Topics: Analgesics; Animals; Calcium Channels, T-Type; Diabetic Neuropathies; gamma-Aminobutyric Acid; Human | 2016 |
[GABA(B) receptors and sensitization to pain].
Topics: 14-3-3 Proteins; Allosteric Regulation; Animals; Baclofen; Calcium Channels; Calcium-Binding Protein | 2009 |
[Pregabalin and postoperative hyperalgesia. A review].
Topics: Analgesics; Animals; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Hype | 2011 |
[Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia].
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors | 2011 |
[Prevention of postoperative hyperalgesia].
Topics: Amantadine; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Excit | 2012 |
Role of cation-chloride-cotransporters (CCC) in pain and hyperalgesia.
Topics: Analgesics; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; K Cl- Cotransporters; Pain; Posterior Ho | 2005 |
Postoperative pain--clinical implications of basic research.
Topics: Amines; Analgesia; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma | 2007 |
The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord.
Topics: Animals; Excitatory Amino Acids; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hyperalgesia; Neura | 1997 |
3-substituted GABA analogs with central nervous system activity: a review.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gam | 1999 |
16 trials available for gamma-aminobutyric acid and Allodynia
| Article | Year |
|---|---|
Determination of the effective dose of pregabalin on human experimental pain using the sequential up-down method.
Topics: Adult; Analgesics; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; gamma-A | 2014 |
Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development.
Topics: Adult; Amines; Analgesics; Analgesics, Non-Narcotic; Brain; Capsaicin; Cyclohexanecarboxylic Acids; | 2016 |
Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects.
Topics: Adolescent; Adult; Alkaloids; Analgesics; Analgesics, Opioid; Analysis of Variance; Capsaicin; Cross | 2008 |
Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Case-Control Studies; Cold Temperature; C | 2009 |
Gabapentin improves cold-pressor pain responses in methadone-maintained patients.
Topics: Adult; Amines; Analgesics, Non-Narcotic; Cold Temperature; Cyclohexanecarboxylic Acids; Double-Blind | 2010 |
Effect of a single dose of pregabalin on herpes zoster pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; California; Cross-Over Studies; Do | 2011 |
Preoperative pregabalin administration significantly reduces postoperative opioid consumption and mechanical hyperalgesia after transperitoneal nephrectomy.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Double-Blind Method; Drug Administration | 2012 |
The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica.
Topics: Adult; Analysis of Variance; Capsaicin; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combi | 2012 |
The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.
Topics: Acetates; Adult; Amines; Analgesics, Opioid; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diazep | 2004 |
Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia.
Topics: Adult; Amines; Analgesics; Capsaicin; Central Nervous System; Cyclohexanecarboxylic Acids; Double-Bl | 2004 |
A single dose of gabapentin reduces acute pain and allodynia in patients with herpes zoster.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Anticonvulsants; Cross-Over Studi | 2005 |
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans.
Topics: Adult; Amines; Analgesics; Analysis of Variance; Capsaicin; Central Nervous System; Cross-Over Studi | 2005 |
Multiple dose gabapentin attenuates cutaneous pain and central sensitisation but not muscle pain in healthy volunteers.
Topics: Adult; Amines; Analgesics; Central Nervous System; Cyclohexanecarboxylic Acids; Dose-Response Relati | 2006 |
CHF3381, a N-methyl-D-aspartate receptor antagonist and monoamine oxidase-A inhibitor, attenuates secondary hyperalgesia in a human pain model.
Topics: Adult; Amines; Analgesics; Capsaicin; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blind | 2006 |
Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers.
Topics: Administration, Oral; Adult; Analgesics; Aprepitant; Cross-Over Studies; Cyclooxygenase Inhibitors; | 2007 |
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior, | 2007 |
291 other studies available for gamma-aminobutyric acid and Allodynia
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; GABA Plasma Membrane Transport Proteins; GABA | 2020 |
Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model.
Topics: Analgesics; Animals; gamma-Aminobutyric Acid; Hyperalgesia; Mice; Monoamine Oxidase Inhibitors; Neur | 2022 |
Pre-Synaptic GABA
Topics: Animals; Freund's Adjuvant; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Nociceptors | 2022 |
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobuty | 2020 |
Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.
Topics: Animals; Cranial Nerves; Dopamine; Extracellular Signal-Regulated MAP Kinases; Facial Nerve Injuries | 2020 |
Potentiation of spinal GABA inhibition as a therapeutic target for chronic neuropathic pain: from transplantation to physical exercise.
Topics: Exercise; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Neural Inhibition; Neuralgia; Spinal Cord | 2020 |
Parabrachial nucleus circuit governs neuropathic pain-like behavior.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; | 2020 |
A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior.
Topics: Animals; gamma-Aminobutyric Acid; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Neuralgia; Noc | 2021 |
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
Topics: Amino Acid Sequence; Animals; Anxiety; Behavior, Animal; Chlorocebus aethiops; Cognition; COS Cells; | 2021 |
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Topics: Amines; Animals; Autoradiography; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2017 |
Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 5,7-Dihydroxytryptamine; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; Ind | 2017 |
Activations of muscarinic M
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Disease M | 2017 |
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liqu | 2017 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine | 2017 |
Murine model and mechanisms of treatment-induced painful diabetic neuropathy.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Animal; Enzyme | 2017 |
The Effect of Gabapentin and Tramadol in Cancer Pain Induced by Glioma Cell in Rat Femur.
Topics: Amines; Analgesics; Animals; Bone Neoplasms; Brain Neoplasms; Cancer Pain; Cell Line, Tumor; Cell Su | 2017 |
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury.
Topics: Amines; Analgesics; Animals; Antipsychotic Agents; Chronic Disease; Constriction, Pathologic; Cycloh | 2017 |
Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Follow-Up Studies; | 2017 |
Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Amino | 2018 |
Gabapentin and its salicylaldehyde derivative alleviate allodynia and hypoalgesia in a cisplatin-induced neuropathic pain model.
Topics: Aldehydes; Amines; Animals; Cisplatin; Cyclohexanecarboxylic Acids; Drug Interactions; Female; Gabap | 2017 |
Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2018 |
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Cyclohexanecarboxyl | 2017 |
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
Topics: Amines; Analgesics; Animals; Benzodioxoles; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 2017 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Peripheral GABA
Topics: Animals; Antibodies; Freund's Adjuvant; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma | 2018 |
[Effects of HCN2 in the development of peripheral neuropathic pain in rats].
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Ganglia, Spinal; | 2017 |
Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.
Topics: Analgesics; Animals; Disease Models, Animal; Flavones; gamma-Aminobutyric Acid; Glutamic Acid; Hyper | 2019 |
Neurochemical effects of motor cortex stimulation in the periaqueductal gray during neuropathic pain.
Topics: Analgesia; Animals; Bicuculline; Deep Brain Stimulation; Efferent Pathways; GABA Antagonists; gamma- | 2019 |
The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain.
Topics: Animals; Bone Neoplasms; Cancer Pain; Cell Communication; Cell Line, Tumor; Female; GABA Plasma Memb | 2019 |
Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
Topics: Animals; Choice Behavior; Disease Models, Animal; Food; gamma-Aminobutyric Acid; Hyperalgesia; Ligat | 2019 |
Nerve injury drives a heightened state of vigilance and neuropathic sensitization in
Topics: Animals; Arousal; Biomarkers; Cell Death; Drosophila; GABAergic Neurons; gamma-Aminobutyric Acid; Hy | 2019 |
Mechanism of dorsal root ganglion stimulation for pain relief in painful diabetic polyneuropathy is not dependent on GABA release in the dorsal horn of the spinal cord.
Topics: Animals; Diabetic Neuropathies; Electric Stimulation Therapy; Electrodes, Implanted; Female; gamma-A | 2020 |
The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model.
Topics: Analgesics; Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Dose-Response Relations | 2013 |
Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein.
Topics: Analgesics, Opioid; Animals; Brain; Diprenorphine; Dose-Response Relationship, Drug; Electric Stimul | 2013 |
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb | 2013 |
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications; | 2013 |
The application of support vector regression for prediction of the antiallodynic effect of drug combinations in the mouse model of streptozocin-induced diabetic neuropathy.
Topics: 4-Butyrolactone; Algorithms; Analgesics; Animals; Computer Simulation; Diabetes Mellitus, Experiment | 2013 |
A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain.
Topics: Animals; Behavior, Animal; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Evaluation of analgesic, antioxidant, cytotoxic and metabolic effects of pregabalin for the use in neuropathic pain.
Topics: 3T3-L1 Cells; Analgesics; Animals; Antioxidants; Cell Death; Diabetes Mellitus, Experimental; Diabet | 2013 |
Effect of antioxidant treatment on spinal GABA neurons in a neuropathic pain model in the mouse.
Topics: Action Potentials; Animals; Antioxidants; Behavior, Animal; Cell Count; Cyclic N-Oxides; Dose-Respon | 2013 |
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh | 2014 |
Gabapentin attenuates morphine tolerance through interleukin-10.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Antibodies; Cyclohexanecarboxylic Acids; Cytokine | 2014 |
Differential pharmacological alleviation of oxaliplatin-induced hyperalgesia/allodynia at cephalic versus extra-cephalic level in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Analgesics; Animals; Cold Temperature; Cyclohexaneca | 2014 |
The anticonvulsant enaminone E139 attenuates paclitaxel-induced neuropathic pain in rodents.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanes; Female; | 2013 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
Comparison of the effects of single doses of elcatonin and pregabalin on oxaliplatin-induced cold and mechanical allodynia in rats.
Topics: Analgesics; Animals; Antineoplastic Agents; Calcitonin; Cold Temperature; gamma-Aminobutyric Acid; H | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh | 2014 |
Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice.
Topics: Adrenergic Neurons; Amines; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cyclohexaneca | 2014 |
Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function.
Topics: Analgesics, Opioid; Animals; Central Amygdaloid Nucleus; Chronic Pain; Conditioning, Psychological; | 2014 |
Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice.
Topics: 4-Butyrolactone; Analgesics; Animals; Antineoplastic Agents; gamma-Aminobutyric Acid; Hot Temperatur | 2014 |
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Amino | 2014 |
Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects.
Topics: Administration, Oral; Analgesics; Animals; Brain; Disease Models, Animal; Dose-Response Relationship | 2014 |
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin | 2015 |
Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy.
Topics: Amines; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experim | 2014 |
Mechanism of GABA involvement in post-traumatic trigeminal neuropathic pain: activation of neuronal circuitry composed of PKCγ interneurons and pERK1/2 expressing neurons.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalgesia; Interneurons; Male; MAP Kin | 2015 |
A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
Topics: Analgesics; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Docosahexaeno | 2014 |
Validation and additional support for an experimental animal model of fibromyalgia.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Female; Fibromya | 2015 |
Gabapentin prevents oxaliplatin-induced mechanical hyperalgesia in mice.
Topics: Actin Depolymerizing Factors; Amines; Animals; Antineoplastic Agents; Cold Temperature; Cyclohexanec | 2014 |
Effect of histone deacetylase inhibitor JNJ-26481585 in pain.
Topics: Amines; Animals; Antineoplastic Agents; Calcium Channels; Cyclohexanecarboxylic Acids; Gabapentin; g | 2015 |
Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression.
Topics: Adenoviridae; Agrin; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; gamma-Aminobut | 2014 |
Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.
Topics: Animals; Baclofen; gamma-Aminobutyric Acid; Gene Expression; Humans; Hyperalgesia; Ligands; Myelin P | 2014 |
Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat.
Topics: Amines; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2015 |
Transdermal administration of aqueous pregabalin solution as a potential treatment option for patients with neuropathic pain to avoid central nervous system-mediated side effects.
Topics: Administration, Cutaneous; Analgesics; Animals; Central Nervous System; Dizziness; Drug-Related Side | 2014 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorodeoxyglucose F18; | 2014 |
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Dis | 2014 |
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level.
Topics: Animals; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Gene Expression Regulation; Hum | 2014 |
Thrombospondin-4 and excitatory synaptogenesis promote spinal sensitization after painful mechanical joint injury.
Topics: Action Potentials; Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Excitatory | 2015 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D | 2015 |
Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cell Line, Tumor; G Protein-Coupled Inwardly-Rectifying | 2015 |
Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy.
Topics: Animals; Behavior, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Hyperalgesia; Male; Neuralgia; | 2015 |
Effects of pregabalin on central sensitization in patients with migraine.
Topics: Adult; Analgesics; Central Nervous System Sensitization; Chi-Square Distribution; Female; gamma-Amin | 2015 |
Differences in cisplatin-induced mechanical allodynia in male and female mice.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Disease | 2015 |
Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.
Topics: Acetates; Action Potentials; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2015 |
Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents, Phytogenic; Cell Count; Cell Tran | 2015 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB | 2015 |
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid | 2015 |
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Respons | 2015 |
Pressure pain sensitivity map of multifocal nummular headache: a case report.
Topics: Adolescent; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric | 2015 |
Upregulation of α₂δ-1 Calcium Channel Subunit in the Spinal Cord Contributes to Pelvic Organ Cross-Sensitization in a Rat Model of Experimentally-Induced Endometriosis.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Calcium Channels; Calcium Channels, L-Type; Chronic P | 2015 |
Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice.
Topics: Analgesics; Animals; Calcium Channels; Carrier Proteins; Circadian Rhythm; Diabetes Mellitus, Type 1 | 2015 |
Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats.
Topics: Analgesics; Animals; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyperalges | 2015 |
Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice.
Topics: Amines; Analgesics; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Electroencephalography; G | 2015 |
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
Topics: Administration, Topical; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 2015 |
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Tranexamic acid evokes pain by modulating neuronal excitability in the spinal dorsal horn.
Topics: Animals; Behavior, Animal; Biomarkers; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases | 2015 |
Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Animal; G | 2009 |
Identifying local and descending inputs for primary sensory neurons.
Topics: Afferent Pathways; Animals; Defective Viruses; Efferent Pathways; Enkephalins; Forelimb; GABAergic N | 2015 |
Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
Topics: Animals; Behavior, Animal; Benzylamines; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; | 2015 |
Peripheral Neuritis Trauma in Pigs: A Neuropathic Pain Model.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Re | 2016 |
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.
Topics: Amines; Analgesics; Animals; Arthritis; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapen | 2016 |
Gabapentin Use in the Neonatal Intensive Care Unit.
Topics: Amines; Analgesics; Benzodiazepines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut | 2016 |
Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela | 2016 |
Pharmacokinetic/Pharmacodynamic Relationship of Gabapentin in a CFA-induced Inflammatory Hyperalgesia Rat Model.
Topics: Amines; Analgesics; Animals; Biological Availability; Brain; Computer Simulation; Cyclohexanecarboxy | 2016 |
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
Topics: Amines; Analgesics; Animals; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disea | 2016 |
Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury.
Topics: Amines; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Carbenoxolone; Connexin | 2016 |
Neuropeptide S modulates the amygdaloidal HCN activities (Ih) in rats: Implication in chronic pain.
Topics: Amygdala; Animals; Chronic Pain; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Hyperpolariza | 2016 |
Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia.
Topics: Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors; D | 2016 |
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Topics: Animals; Disease Models, Animal; Exons; gamma-Aminobutyric Acid; Hyperalgesia; K Cl- Cotransporters; | 2016 |
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Topics: Amines; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antico | 2016 |
Insular balance of glutamatergic and GABAergic signaling modulates pain processing.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Excitato | 2016 |
Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
Topics: Activating Transcription Factor 3; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease | 2016 |
mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain.
Topics: Action Potentials; Animals; Antagomirs; Antineoplastic Agents, Phytogenic; Disease Models, Animal; D | 2016 |
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Topics: Amines; Animals; Behavior, Animal; Cathepsins; Cyclohexanecarboxylic Acids; Dipeptides; Disease Mode | 2016 |
Potential Contribution of Antioxidant Mechanism in the Defensive Effect of Lycopene Against Partial Sciatic Nerve Ligation Induced Behavioral, Biochemical and Histopathological Modification in Wistar Rats.
Topics: Amines; Animals; Antioxidants; Carotenoids; Catalase; Cyclohexanecarboxylic Acids; Gabapentin; gamma | 2016 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.
Topics: Amides; Amines; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Ethanolamines; Gabapentin; gam | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; | 2016 |
Combined glutamate and glutamine levels in pain-processing brain regions are associated with individual pain sensitivity.
Topics: Adult; Brain; Brain Mapping; Cross-Sectional Studies; Female; gamma-Aminobutyric Acid; Glutamic Acid | 2016 |
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.
Topics: Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Cyclohexanec | 2017 |
6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain.
Topics: Amines; Animals; Computer Simulation; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Female; Fl | 2016 |
Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Freund's Adjuvant; Gabapentin; gamma-Amino | 2017 |
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli | 2017 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constri | 2017 |
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci | 2017 |
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric | 2017 |
Gabapentin decreases microglial cells and reverses bilateral hyperalgesia and allodynia in rats with chronic myositis.
Topics: Amines; Animals; Astrocytes; Behavior, Animal; Cell Count; Chronic Disease; Cyclohexanecarboxylic Ac | 2017 |
An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Functional Lateral | 2017 |
Pharmacological and antihyperalgesic properties of the novel α2/3 preferring GABA
Topics: Animals; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; gamm | 2017 |
Dercum's disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview.
Topics: Adipose Tissue; Adiposis Dolorosa; Analgesics; Female; gamma-Aminobutyric Acid; Humans; Hyperalgesia | 2008 |
Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn.
Topics: Animals; Denervation; Disease Models, Animal; Functional Laterality; gamma-Aminobutyric Acid; Hypera | 2008 |
Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin.
Topics: Administration, Oral; Amines; Analgesics; Animals; Bone Neoplasms; Cyclohexanecarboxylic Acids; Disu | 2008 |
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bicu | 2008 |
Effects of endothelial NOS antagonism within the periaqueductal gray on cardiovascular responses and neurotransmission during mechanical, heat, and cold nociception.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Dose-Response | 2008 |
Allodynia and hyperalgesia in diabetic rats are mediated by GABA and depletion of spinal potassium-chloride co-transporters.
Topics: Animals; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Hyperalgesia; Hyperesthesia; K Cl | 2008 |
Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesia.
Topics: Animals; Axotomy; Disease Models, Animal; Functional Laterality; gamma-Aminobutyric Acid; Glial Fibr | 2009 |
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Analysis of Variance; Animals; Ankle Joint; Arthritis, E | 2009 |
Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65.
Topics: Animals; Behavior, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hot Temperature; Hypera | 2009 |
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan; | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium | 2009 |
Synthesis and in vivo evaluation of 3-substituted gababutins.
Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Calcium Channels; Carrageenan; Cyclohexanecarboxy | 2010 |
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Cyclopentanes; Disea | 2010 |
Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus, E | 2010 |
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Rel | 2010 |
Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats.
Topics: Animals; Cold Temperature; Denervation; Disease Models, Animal; Electroacupuncture; GABA Antagonists | 2010 |
Alteration of GABAergic and glycinergic mechanisms by lidocaine injection in the rostral ventromedial medulla of neuropathic rats.
Topics: Anesthetics, Local; Animals; Female; gamma-Aminobutyric Acid; Glycine; Hyperalgesia; Injections; Lid | 2010 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic N | 2010 |
Effect of analgesic standards on persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR).
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Dermatologic Surgical Pro | 2010 |
Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Calcium Channels; Chronic Disease; Drug Interactions; gamma-Aminobutyric Acid; | 2010 |
Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury.
Topics: Animals; Bumetanide; Chronic Disease; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; K Cl- Cot | 2010 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Behavioral signs of chronic back pain in the SPARC-null mouse.
Topics: Age Factors; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Chronic Diseas | 2011 |
A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves.
Topics: Amines; Analgesics; Animals; Behavior, Animal; CD11b Antigen; Cold Temperature; Cyclohexanecarboxyli | 2011 |
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Topics: Amines; Animals; Calcium Channels; Circadian Rhythm; Cyclohexanecarboxylic Acids; Disease Models, An | 2010 |
Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin.
Topics: Amines; Animals; Cerebral Cortex; Cyclohexanecarboxylic Acids; Enkephalins; Excitatory Amino Acid An | 2010 |
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2011 |
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.
Topics: Analysis of Variance; Animals; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Dose-Response R | 2011 |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyog | 2011 |
Analgesic effects of tramadol, tramadol-gabapentin, and buprenorphine in an incisional model of pain in rats (Rattus norvegicus).
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buprenorphine; Cyclohexanecarb | 2011 |
Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cauda Equina; Cyclohexanecarboxylic Acids; Disease Models | 2011 |
Vector-mediated release of GABA attenuates pain-related behaviors and reduces Na(V)1.7 in DRG neurons.
Topics: Animals; Behavior, Animal; Cells, Cultured; Diabetic Neuropathies; Female; gamma-Aminobutyric Acid; | 2011 |
Pregabalin suppresses spinal neuronal hyperexcitability and visceral hypersensitivity in the absence of peripheral pathophysiology.
Topics: Analgesics; Analgesics, Opioid; Animals; Dilatation; Electrophysiology; gamma-Aminobutyric Acid; Hyp | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; | 2011 |
Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Amines; Analgesics; Analysis of Variance; Animals; Cyclohex | 2011 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis.
Topics: Analgesics; Animals; Back Pain; Cartilage, Articular; Disease Models, Animal; gamma-Aminobutyric Aci | 2011 |
Pharmacology of intracisternal or intrathecal glycine, muscimol, and baclofen in strychnine-induced thermal hyperalgesia of mice.
Topics: Animals; Baclofen; Drug Delivery Systems; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; | 2011 |
Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.
Topics: Amines; Analgesics, Opioid; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Tolerance; Fent | 2012 |
Peripheral and spinal GABAergic regulation of incisional pain in rats.
Topics: Animals; Baclofen; Behavior, Animal; Chronic Pain; gamma-Aminobutyric Acid; Hyperalgesia; Muscimol; | 2012 |
Intraspinal transplantation of GABAergic neural progenitors attenuates neuropathic pain in rats: a pharmacologic and neurophysiological evaluation.
Topics: Action Potentials; Analysis of Variance; Animals; Disease Models, Animal; Embryo, Mammalian; Embryon | 2012 |
Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Behavior, Animal; Butea; Calci | 2013 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Protective effects of combined therapy of gliclazide with curcumin in experimental diabetic neuropathy in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; C-Peptide; Curc | 2012 |
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarb | 2012 |
Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model.
Topics: Amines; Analgesics; Animals; Calcium Channels; CD11b Antigen; Cyclohexanecarboxylic Acids; Disease M | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Int | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo | 2012 |
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.
Topics: Acetone; Amines; Analgesics; Animals; Behavior, Animal; Carotenoids; Constriction; Crocus; Cyclohexa | 2012 |
The effects of gabapentin on acute opioid tolerance to remifentanil under sevoflurane anesthesia in rats.
Topics: Adjuvants, Anesthesia; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Ani | 2012 |
Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats.
Topics: Amines; Animals; Arthritis; Calcium Channels, L-Type; Chemokine CX3CL1; CX3C Chemokine Receptor 1; C | 2012 |
Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro.
Topics: Animals; Blotting, Western; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Inflammation; Ma | 2012 |
Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.
Topics: Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Dia | 2012 |
GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain.
Topics: Analgesics, Opioid; Animals; gamma-Aminobutyric Acid; Hyperalgesia; Immersion; Immunohistochemistry; | 2012 |
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; C | 2013 |
Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2012 |
Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats.
Topics: Amines; Analgesics, Opioid; Animals; Behavior, Animal; Benzimidazoles; Capsaicin; Cyclohexanecarboxy | 2012 |
Increased excitability of spinal pain reflexes and altered frequency-dependent modulation in the dopamine D3-receptor knockout mouse.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Animals, Newborn; B | 2012 |
Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats.
Topics: Animals; Behavior, Animal; Calcium; Female; gamma-Aminobutyric Acid; Glutathione; Hyperalgesia; Lipi | 2014 |
Enhanced GABAergic activity in the mouse primary somatosensory cortex is insufficient to alleviate chronic pain behavior with reduced expression of neuronal potassium-chloride cotransporter.
Topics: Animals; Blotting, Western; Calcium; Chronic Pain; Electric Stimulation; GABA Antagonists; gamma-Ami | 2012 |
Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Ani | 2013 |
Persistent hyperalgesia in the cisplatin-treated mouse as defined by threshold measures, the conditioned place preference paradigm, and changes in dorsal root ganglia activated transcription factor 3: the effects of gabapentin, ketorolac, and etanercept.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineopla | 2013 |
Specific thalamic nuclei function as novel 'nociceptive discriminators' in the endogenous control of nociception in rats.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Motor Activity | 2013 |
Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Hyperalgesia; | 2013 |
Orofacial sensory changes after streptozotocin-induced diabetes in rats.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Facial Pain; gamma-Amin | 2013 |
Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.
Topics: Animals; Brain Stem; Carrageenan; Face; gamma-Aminobutyric Acid; Grooming; Hyperalgesia; Injections, | 2002 |
Gabapentin suppresses cutaneous hyperalgesia following heat-capsaicin sensitization.
Topics: Acetates; Adult; Amines; Analgesics; Capsaicin; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino | 2002 |
Is gabapentin a "Broad-spectrum" analgesic?
Topics: Acetates; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Huma | 2002 |
Modulation of spinal nociception by GluR5 kainate receptor ligands in acute and hyperalgesic states and the role of gabaergic mechanisms.
Topics: Anesthesia; Animals; Behavior, Animal; Bicuculline; Electric Stimulation; Electrophysiology; Female; | 2002 |
Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism.
Topics: Analgesics; Animals; Bridged Bicyclo Compounds, Heterocyclic; gamma-Aminobutyric Acid; Hyperalgesia; | 2002 |
Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia.
Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Calcium Cha | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Suppression by gabapentin of pain-related mechano-responses in mice given orthotopic tumor inoculation.
Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Hyperal | 2003 |
Magnesium chloride and ruthenium red attenuate the antiallodynic effect of intrathecal gabapentin in a rat model of postoperative pain.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channels; Cyclo | 2003 |
Gabapentin: the first preemptive anti-hyperalgesic for opioid withdrawal hyperalgesia?
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin; g | 2003 |
Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain.
Topics: Animals; Chronic Disease; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Hyperalgesia; Male; Pai | 2003 |
Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.
Topics: Animals; Baclofen; Bupivacaine; Cerebral Cortex; gamma-Aminobutyric Acid; Hot Temperature; Hyperalge | 2003 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
Hyperalgesic effects of gamma-aminobutyric acid transporter I in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Carrier Proteins; Dose-Response Relationsh | 2003 |
Treatment of chronic neuropathic pain after traumatic central cervical cord lesion with gabapentin.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Arm; Carbamazepine; Central Cord Syndrome; Cervical Ver | 2003 |
Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Cyc | 2003 |
Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Gabapentin; | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease | 2004 |
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA | 2004 |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, S | 2004 |
Differential analgesic sensitivity of two distinct neuropathic pain models.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Cyclohexanecarboxylic A | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age | 2005 |
Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-A | 2005 |
Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Benzylamines; Chronic Disease; Cyclohexanecarb | 2005 |
Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Drug Interactions; Ex | 2005 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob | 2005 |
Gene transfer of glutamic acid decarboxylase reduces neuropathic pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Transfer Techniques; Genetic Therapy; | 2005 |
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclohexanecarboxyli | 2005 |
Development and expression of neuropathic pain in CB1 knockout mice.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2006 |
Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release.
Topics: Animals; Carrageenan; Chemical Phenomena; Chemistry, Physical; Cyclooxygenase Inhibitors; Dinoprosto | 2006 |
Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia.
Topics: Acetates; Acrylamides; Animals; Benzyl Compounds; Dimethyl Sulfoxide; Extracellular Fluid; Formaldeh | 2006 |
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang | 2006 |
Hyperalgesia induced by REM sleep loss: a phenomenon in search of a mechanism.
Topics: Acetylcholine; Adenosine; Anxiety; Chronic Disease; Depression; Drug Therapy; Drug-Related Side Effe | 2006 |
Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
Topics: Adrenergic alpha-2 Receptor Antagonists; Amines; Analgesics; Animals; Atropine; Cholinesterases; Cyc | 2006 |
Motor cortex stimulation for central pain following a traumatic brain injury.
Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju | 2006 |
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D | 2006 |
Venlafaxine compromises the antinociceptive actions of gabapentin in rat models of neuropathic and persistent pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclohexanols; Dose-Response Relationship, | 2006 |
Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats.
Topics: Afferent Pathways; Amino Acids; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dis | 2006 |
Physiological properties of spinal lamina II GABAergic neurons in mice following peripheral nerve injury.
Topics: Animals; Constriction; Electrophysiology; Fluorescent Dyes; gamma-Aminobutyric Acid; Green Fluoresce | 2006 |
[Post-operative pain therapy of a chronic pain patient].
Topics: Adult; Amines; Analgesics; Analgesics, Opioid; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Co | 2006 |
Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.
Topics: Amines; Analgesics; Animals; Anti-Anxiety Agents; Anxiety Disorders; Cells, Cultured; Cyclohexanecar | 2007 |
Subarachnoid transplant of a human neuronal cell line attenuates chronic allodynia and hyperalgesia after excitotoxic spinal cord injury in the rat.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Differentiation; Cell Line; Cell Transplantation; | 2007 |
Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats.
Topics: Analysis of Variance; Animals; Carrageenan; Dose-Response Relationship, Radiation; gamma-Aminobutyri | 2007 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats.
Topics: Analgesics; Animals; Carrageenan; Chronic Disease; Disease Models, Animal; Dose-Response Relationshi | 2007 |
Optimizing the transplant dose of a human neuronal cell line graft to treat SCI pain in the rat.
Topics: Animals; Brain Tissue Transplantation; Cell Count; Cell Differentiation; Cell Line; gamma-Aminobutyr | 2007 |
Modulation of cardiovascular responses and neurotransmission during peripheral nociception following nNOS antagonism within the periaqueductal gray.
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2007 |
Modulation of persistent nociceptive inputs in the anterior pretectal nucleus of the rat.
Topics: Afferent Pathways; Animals; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mesencephalon; Nociceptors; | 2007 |
Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF.
Topics: Acetamides; Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Excitatory Amino Acid An | 2007 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Topics: Action Potentials; Animals; Behavior, Animal; Benzhydryl Compounds; Benzoates; Dose-Response Relatio | 2007 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic | 2007 |
The antinociceptive effect of systemic gabapentin is related to the type of sensitization-induced hyperalgesia.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapent | 2007 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mi | 2008 |
alpha2delta ligand: a new, smart pill for visceral pain in patients with hypersensitive irritable bowel syndrome?
Topics: Analgesics; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Irritable Bowel Syndrome; Ligands; Pain T | 2007 |
Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats.
Topics: Analgesics; Animals; Colon; gamma-Aminobutyric Acid; Humans; Hyperalgesia; Irritable Bowel Syndrome; | 2007 |
Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model.
Topics: Adrenergic Agents; Afferent Pathways; Analgesics; Animals; Behavior, Animal; Brain Stem; Disease Mod | 2007 |
The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Behavior, Animal; Dicarboxylic Acids; Dose-Response R | 2008 |
Effect of a new alpha 2 delta ligand PD-217014 on visceral hypersensitivity induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Topics: Analgesics; Animals; Binding Sites; Bridged Bicyclo Compounds; Calcium Channels; Calcium Channels, L | 2008 |
The prokineticin receptor agonist Bv8 increases GABA release in the periaqueductal grey and modifies RVM cell activities and thermoceptive reflexes in the rat.
Topics: Action Potentials; Animals; Autoradiography; Dose-Response Relationship, Drug; gamma-Aminobutyric Ac | 2007 |
A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury.
Topics: Animals; Behavior, Animal; gamma-Aminobutyric Acid; Ganglia, Spinal; Gene Transfer Techniques; Genet | 2008 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper | 2008 |
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Topics: Acute Disease; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gab | 2008 |
Gabapentin prevents delayed and long-lasting hyperalgesia induced by fentanyl in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Fentanyl; Gabapentin | 2008 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Roles of monoaminergic, glycinergic and GABAergic inhibitory systems in the spinal cord in rats with peripheral mononeuropathy.
Topics: Analysis of Variance; Animals; Biogenic Monoamines; Dizocilpine Maleate; Excitatory Amino Acid Antag | 1996 |
Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents.
Topics: Acetates; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarbox | 1997 |
Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response | 1998 |
The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
S-(+)-3-isobutylgaba and its stereoisomer reduces the amount of inflammation and hyperalgesia in an acute arthritis model in the rat.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis | 1998 |
Systemic gabapentin and S(+)-3-isobutyl-gamma-aminobutyric acid block secondary hyperalgesia.
Topics: Acetates; Amines; Animals; Anticonvulsants; Burns; Cyclohexanecarboxylic Acids; Dose-Response Relati | 1998 |
Gabapentin prevents hyperalgesia during the formalin test in diabetic rats.
Topics: Acetates; Amines; Analgesics; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diab | 1999 |
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excita | 1999 |
Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats.
Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimen | 1999 |
A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury.
Topics: Animals; Cold Temperature; Drug Administration Schedule; Female; gamma-Aminobutyric Acid; Hyperalges | 1999 |
Behavioral effects of RS-45041-190, a selective I2 imidazoline ligand, in rats.
Topics: Acetates; Amines; Analgesics; Animals; Carrageenan; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 1999 |
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Carrageenan; Cells, | 2000 |
Morphine and gabapentin decrease mechanical hyperalgesia and escape/avoidance behavior in a rat model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Mode | 2000 |
Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord.
Topics: Acetates; Amines; Animals; Antimanic Agents; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Exc | 2000 |
Antinociceptive effect of pregabalin in septic shock-induced rectal hypersensitivity in rats.
Topics: Analgesics, Non-Narcotic; Animals; Calcium Channels; Dose-Response Relationship, Drug; gamma-Aminobu | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Gabapentin antinociception in mice with acute herpetic pain induced by herpes simplex virus infection.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Drug Tolerance | 2001 |
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation; | 2001 |
Only early intervention with gamma-aminobutyric acid cell therapy is able to reverse neuropathic pain after partial nerve injury.
Topics: Animals; Cell Transplantation; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Hyperesthesia | 2001 |
The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Res | 2001 |
Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease M | 2001 |
Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve.
Topics: Age Factors; Animals; Aspartic Acid; Causalgia; Down-Regulation; gamma-Aminobutyric Acid; Glutamic A | 2002 |
Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain.
Topics: Animals; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; | 2002 |